Thomas Illig

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. ncbi request reprint Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma
    C Vollmert
    Institute of Epidemiology, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Clin Exp Allergy 34:1841-50. 2004
  2. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
  3. pmc The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
    Michaela Schedel
    University Children s Hospital, Ludwig Maximilian s University Munich, Germany
    Respir Res 7:91. 2006
  4. pmc Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:2. 2010
  5. ncbi request reprint The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome
    Thomas Illig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 52:2861-4. 2003
  6. ncbi request reprint Genetics of asthma and related phenotypes
    Thomas Illig
    GSF Research Centre for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Paediatr Respir Rev 3:47-51. 2002
  7. ncbi request reprint Genetics of type 2 diabetes: impact of interleukin-6 gene variants
    T Illig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Gesundheitswesen 67:S122-6. 2005
  8. ncbi request reprint Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg
    Eva Maria Sedlmeier
    Institute of Epidemiology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Eur J Endocrinol 156:377-85. 2007
  9. pmc Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    BMC Med Genet 9:9. 2008
  10. pmc Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
    Cornelia Huth
    Institute of Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Ann Med 41:128-38. 2009

Detail Information

Publications121 found, 100 shown here

  1. ncbi request reprint Single nucleotide polymorphism screening and association analysis--exclusion of integrin beta 7 and vitamin D receptor (chromosome 12q) as candidate genes for asthma
    C Vollmert
    Institute of Epidemiology, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Clin Exp Allergy 34:1841-50. 2004
    ....
  2. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  3. pmc The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations
    Michaela Schedel
    University Children s Hospital, Ludwig Maximilian s University Munich, Germany
    Respir Res 7:91. 2006
    ..Thus, we tried to further elucidate the role of ADAM33 polymorphisms (SNPs) in a genetic analysis of German case control and longitudinal populations...
  4. pmc Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 11:2. 2010
    ..The aim of this study was to analyse whether FAAH alleles are associated with early and late onset obesity...
  5. ncbi request reprint The endotoxin receptor TLR4 polymorphism is not associated with diabetes or components of the metabolic syndrome
    Thomas Illig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 52:2861-4. 2003
  6. ncbi request reprint Genetics of asthma and related phenotypes
    Thomas Illig
    GSF Research Centre for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Paediatr Respir Rev 3:47-51. 2002
    ..The results between the different studies often vary. To date no major gene for asthma has been detected. Therefore more extensive genetic approaches will be necessary in the future...
  7. ncbi request reprint Genetics of type 2 diabetes: impact of interleukin-6 gene variants
    T Illig
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Gesundheitswesen 67:S122-6. 2005
    ..20, 95 % ci 0.90 - 1.59, p = 0.21)...
  8. ncbi request reprint Gene variants of monocyte chemoattractant protein 1 and components of metabolic syndrome in KORA S4, Augsburg
    Eva Maria Sedlmeier
    Institute of Epidemiology, GSF National Research Centre for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Eur J Endocrinol 156:377-85. 2007
    ..The present study investigated the association of nine MCP-1 single nucleotide polymorphisms (SNPs) with MetS, type 2 diabetes mellitus and metabolic risk factors...
  9. pmc Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    BMC Med Genet 9:9. 2008
    ..Since several studies have suggested that type 2 diabetes might be associated with changes in the innate immune response, we sought to investigate the association between genetic variants in the TLR4 gene and incident type 2 diabetes...
  10. pmc Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
    Cornelia Huth
    Institute of Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Ann Med 41:128-38. 2009
    ..Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results...
  11. ncbi request reprint Fibrinogen genes modify the fibrinogen response to ambient particulate matter
    Annette Peters
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Ingolstaedter Landstrasse, Neuherberg 85764, Germany
    Am J Respir Crit Care Med 179:484-91. 2009
    ..Ambient particulate matter has been associated with systemic inflammation indicated by blood markers such as fibrinogen, implicated in promoting atherothrombosis...
  12. doi request reprint Matrix metalloproteinase 1 (MMP1) is associated with early-onset lung cancer
    Wiebke Sauter
    Institute of Epidemiology, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    Cancer Epidemiol Biomarkers Prev 17:1127-35. 2008
    ..0-1.5). The haplotype analysis supported these findings, especially for subgroups with high smoking intensity. In summary, we identified MMP1 to be associated with an increased risk for lung cancer, which was modified by smoking...
  13. ncbi request reprint APOA5 variants and metabolic syndrome in Caucasians
    Harald Grallert
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    J Lipid Res 48:2614-21. 2007
    ..Furthermore, the data suggest a different mechanism of APOA5 impact on MetS in Caucasians, as variant c.56C>G (not analyzed in the Japanese study) and not -1131T>C, as in the Japanese subjects, was associated with MetS...
  14. ncbi request reprint Common variants of LRRK2 are not associated with sporadic Parkinson's disease
    Saskia Biskup
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Ann Neurol 58:905-8. 2005
    ..No association could be demonstrated. We have therefore no evidence for the existence of a common variant in LRRK2 that has a strong influence on Parkinson's disease risk...
  15. ncbi request reprint Do FADS genotypes enhance our knowledge about fatty acid related phenotypes?
    Eva Lattka
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Clin Nutr 29:277-87. 2010
    ....
  16. pmc Acute-phase serum amyloid A protein and its implication in the development of type 2 diabetes in the KORA S4/F4 study
    Carola Marzi
    Department of Molecular Epidemiology, German Research Centerfor Environmental Health, Neuherberg, Germany
    Diabetes Care 36:1321-6. 2013
    ..We sought to investigate whether elevated levels of acute-phase serum amyloid A (A-SAA) protein precede the onset of type 2 diabetes independently of other risk factors, including parameters of glucose metabolism...
  17. ncbi request reprint FADS gene cluster polymorphisms: important modulators of fatty acid levels and their impact on atopic diseases
    Eva Lattka
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, Neuherberg, Germany
    J Nutrigenet Nutrigenomics 2:119-28. 2009
    ..This review focuses on current knowledge of the impact of genetic polymorphisms on LC-PUFA metabolism and on their potential role in the development of atopic diseases...
  18. doi request reprint Evidence for an association between genetic variants of the fatty acid desaturase 1 fatty acid desaturase 2 ( FADS1 FADS2) gene cluster and the fatty acid composition of erythrocyte membranes
    Peter Rzehak
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Neuherberg 85764, Germany
    Br J Nutr 101:20-6. 2009
    ..We provide the first replication of the association of the FADS1 FADS2 gene cluster with PUFA in blood phospholipids. For the first time, such associations were also shown for PUFA in cell membranes...
  19. doi request reprint Childhood obesity is associated with changes in the serum metabolite profile
    Simone Wahl
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Obes Facts 5:660-70. 2012
    ..Therefore, investigation of serum metabolite concentrations in obese children might give new insights into biological mechanisms associated with childhood obesity...
  20. pmc Gene-gene interaction between APOA5 and USF1: two candidate genes for the metabolic syndrome
    Paula Singmann
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Neuherberg, Germany
    Obes Facts 2:235-42. 2009
    ..USF1 is a transcription factor for APOA5...
  21. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
  22. ncbi request reprint Calpain-10 variants and haplotypes are associated with polycystic ovary syndrome in Caucasians
    Caren Vollmert
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Am J Physiol Endocrinol Metab 292:E836-44. 2007
    ..557, P=0.0011). By investigating a broad panel of CAPN10 variants, our results pointed to an allele dose-dependent association of UCSNP-56 and ins/del-19 with PCOS...
  23. doi request reprint Association of the MC4R V103I polymorphism with the metabolic syndrome: the KORA Study
    Iris M Heid
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Obesity (Silver Spring) 16:369-76. 2008
    ..This study aims to provide epidemiological evidence for showing the association of this polymorphism with features of the metabolic syndrome and with parameters related to energy expenditure and dietary habits as potential mediators...
  24. pmc Novel biomarkers for pre-diabetes identified by metabolomics
    Rui Wang-Sattler
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Syst Biol 8:615. 2012
    ..The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D...
  25. pmc Discovery of sexual dimorphisms in metabolic and genetic biomarkers
    Kirstin Mittelstrass
    Unit of Molecular Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 7:e1002215. 2011
    ..Our study provides new important insights into sex-specific differences of cell regulatory processes and underscores that studies should consider sex-specific effects in design and interpretation...
  26. ncbi request reprint Association of the interleukin-1 receptor antagonist gene with asthma
    Henning Gohlke
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Am J Respir Crit Care Med 169:1217-23. 2004
    ..The most frequent haplotype constructed from these SNPs was 1.4-fold overtransmitted in the German family sample...
  27. pmc Estimating the single nucleotide polymorphism genotype misclassification from routine double measurements in a large epidemiologic sample
    Iris M Heid
    Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Am J Epidemiol 168:878-89. 2008
    ..In situations with more substantial error, the presented approach using duplicate genotyping and the MC-SIMEX method is practical and helpful for quantifying the genotyping error and its impact...
  28. pmc Tobacco smoking leads to extensive genome-wide changes in DNA methylation
    Sonja Zeilinger
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 8:e63812. 2013
    ..The results of our study confirm the broad effect of tobacco smoking on the human organism, but also show that quitting tobacco smoking presumably allows regaining the DNA methylation state of never smokers...
  29. ncbi request reprint IL-6 promoter polymorphisms and quantitative traits related to the metabolic syndrome in KORA S4
    Harald Grallert
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Germany
    Exp Gerontol 41:737-45. 2006
    ..The association with height seems to be the central factor indicating an influence of IL-6 on growth through impaired bone metabolism. However, the complex relationships need further investigation...
  30. doi request reprint Haplotype misclassification resulting from statistical reconstruction and genotype error, and its impact on association estimates
    Claudia Lamina
    Institute of Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    Ann Hum Genet 74:452-62. 2010
    ..Our findings give a sense of the impact of haplotype error under realistic scenarios and underscore the importance of high-quality genotyping, in which case the bias in haplotype association estimates is negligible...
  31. doi request reprint SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
    Angela Doring
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Nat Genet 40:430-6. 2008
    ..The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women...
  32. ncbi request reprint DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study
    Melanie Kolz
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Heart J 29:1250-8. 2008
    ..This study evaluated the association of gene polymorphisms with differences in C-reactive protein concentrations and assessed its intra-individual variability as a marker of individual response...
  33. doi request reprint Genetic variants of the FADS1 FADS2 gene cluster as related to essential fatty acid metabolism
    Eva Lattka
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Curr Opin Lipidol 21:64-9. 2010
    ..The present review summarizes the recent association studies on FADS genotypes and LC-PUFA levels and suggests ideas how FADS genotypes can be integrated in future research...
  34. pmc Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764, Neuherberg, Germany
    Eur J Epidemiol 29:325-36. 2014
    ..Taken together, our results provide a basis for a deeper functional understanding of the action and side-effects of antihypertensive and lipid-lowering drugs in the general population. ..
  35. pmc A genome-wide perspective of genetic variation in human metabolism
    Thomas Illig
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 42:137-41. 2010
    ..5 x 10(-179). These loci explained 5.6%-36.3% of the observed variance in metabolite concentrations. For several loci, associations with clinically relevant parameters have been reported previously...
  36. pmc Linkage disequilibrium patterns and tagSNP transferability among European populations
    Jakob C Mueller
    Institute of Human Genetics, GSF National Research Centre for Environment and Health, Neuherberg, Germany
    Am J Hum Genet 76:387-98. 2005
    ..Simulations based on our data set show the extent to which further gain in tagSNP efficiency and transferability can be achieved by increased SNP density...
  37. doi request reprint Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the
    Eva Lattka
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Am J Clin Nutr 93:382-91. 2011
    ....
  38. doi request reprint Variation in the human lipidome associated with coffee consumption as revealed by quantitative targeted metabolomics
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Mol Nutr Food Res 53:1357-65. 2009
    ..In summary, we demonstrate strong positive associations between coffee consumption and two classes of sphingomyelins and a negative association between coffee consumption and long- and medium-chain acylcarnitines...
  39. pmc Body fat free mass is associated with the serum metabolite profile in a population-based study
    Carolin Jourdan
    Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e40009. 2012
    ..To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study...
  40. doi request reprint Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years
    Peter Rzehak
    Institute of Epidemiology, German Research Center for Environmental Health, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Obes Facts 3:173-80. 2010
    ..However, little is known about the longitudinal dynamics of these polymorphisms on body mass index (BMI), overweight, and obesity...
  41. pmc A genome-wide association study identifies three loci associated with mean platelet volume
    Christa Meisinger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Am J Hum Genet 84:66-71. 2009
    ..These findings may not only enhance our understanding of platelet activation and function, but may also provide a focus for several novel research avenues...
  42. ncbi request reprint Elevated levels of interleukin-18 predict the development of type 2 diabetes: results from the MONICA/KORA Augsburg Study, 1984-2002
    Barbara Thorand
    GF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 54:2932-8. 2005
    ..This association is independent of a generalized proinflammatory state, but subjects with elevated levels of several inflammatory markers seem to be particularly prone to develop type 2 diabetes...
  43. pmc BMI at age 8 years is influenced by the type 2 diabetes susceptibility genes HHEX-IDE and CDKAL1
    Christiane Winkler
    Institut fuer Diabetes forschung der Forschergruppe Diabetes e V at Helmholtz Center Munich, Neuherberg, Germany
    Diabetes 59:2063-7. 2010
    ..To determine whether HHEX-IDE and CDKAL1 genes, which are associated with birth weight and susceptibility to type 2 diabetes, continue to influence growth during childhood...
  44. pmc Early onset lung cancer, cigarette smoking and the SNP309 of the murine double minute-2 (MDM2) gene
    Kirstin Mittelstrass
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Epidemiology, Munich Neuherberg, Germany
    BMC Cancer 8:113. 2008
    ..Our results indicate that the MDM2 SNP309 is not significantly associated with lung carcinogenesis but point towards gender-specific differences...
  45. ncbi request reprint Multiple regions of alpha-synuclein are associated with Parkinson's disease
    Jakob C Mueller
    Institute for Human Genetics, GSF National Research Centre for Environment and Health, Neuherberg, Germany
    Ann Neurol 57:535-41. 2005
    ..These findings indicate locus heterogeneity for the pathogenesis of Parkinson's disease in different genetic or physiological environments, related to sex and age...
  46. pmc Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS Genet 8:e1003005. 2012
    ..Our approach is generic in nature and can be directly transferred to metabolomics data from different experimental platforms...
  47. pmc Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 5:e13953. 2010
    ....
  48. pmc Meta-analysis of the INSIG2 association with obesity including 74,345 individuals: does heterogeneity of estimates relate to study design?
    Iris M Heid
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 5:e1000694. 2009
    ..The importance of study design might be under-recognized in gene discovery and association replication so far...
  49. doi request reprint Genetic variants in the USF1 gene are associated with low-density lipoprotein cholesterol levels and incident type 2 diabetes mellitus in women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002
    C Holzapfel
    Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Eur J Endocrinol 159:407-16. 2008
    ..The aim of our study was to examine the associations between USF1 polymorphisms and lipid parameters as well as incident type 2 diabetes mellitus (T2DM) in German Caucasians...
  50. pmc Mapping the genetic architecture of gene regulation in whole blood
    Katharina Schramm
    Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany Institute of Human Genetics, Technical University Munich, Munchen, Germany
    PLoS ONE 9:e93844. 2014
    ..We aimed to assess whether whole blood expression quantitative trait loci (eQTLs) with effects in cis and trans are robust and can be used to identify regulatory pathways affecting disease susceptibility...
  51. ncbi request reprint Variants in the neuronal nitric oxide synthase (nNOS, NOS1) gene are associated with restless legs syndrome
    Juliane Winkelmann
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Munich, Germany
    Mov Disord 23:350-8. 2008
    ..Potential usage of NO modulating agents as new treatment options for RLS have become a challenging aspect for future research of this disorder...
  52. ncbi request reprint Common genetic variants of the FADS1 FADS2 gene cluster and their reconstructed haplotypes are associated with the fatty acid composition in phospholipids
    Linda Schaeffer
    GSF National Research Center for Environment and Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Hum Mol Genet 15:1745-56. 2006
    ..0 x 10(-13)). Carriers of the rare alleles of several SNPs and their respective haplotypes had a lower prevalence of allergic rhinitis and atopic eczema. No association was found for total and specific IgE levels...
  53. pmc An interferon-induced helicase (IFIH1) gene polymorphism associates with different rates of progression from autoimmunity to type 1 diabetes
    Christiane Winkler
    Forschergruppe Diabetes e V at Helmholtz Center Munich, Neuherberg, Germany
    Diabetes 60:685-90. 2011
    ..The aim of this study was to determine whether these associations are with the development of autoimmunity and/or progression to diabetes...
  54. doi request reprint A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
    ..Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria...
  55. pmc First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study
    Christina Holzapfel
    Else Kröner Fresenius Centre for Nutritional Medicine, Technische Universitat Munchen, Munich, Germany
    J Epidemiol Community Health 65:174-6. 2011
    ....
  56. ncbi request reprint Significant association of the interleukin-6 gene polymorphisms C-174G and A-598G with type 2 diabetes
    T Illig
    Institute of Epidemiology, GSF National Research Centre for Environment and Health, D 85764 Neuherberg, Germany
    J Clin Endocrinol Metab 89:5053-8. 2004
    ....
  57. pmc Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood
    Divya Mehta
    Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Eur J Hum Genet 21:48-54. 2013
    ..Our data demonstrate that eQTLs in whole blood are highly robust and reproducible across studies and highlight the relevance of whole-blood eQTL mapping in prioritization of GWAS candidate genes in humans...
  58. pmc Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study
    Tao Xu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Ingolstädter Landstraße 1, Neuherberg 85764, Germany
    BMC Med 11:60. 2013
    ..Here, we extend our metabolomics study with a large prospective study including female smokers and quitters...
  59. ncbi request reprint Congenital cataract and macular hypoplasia in humans associated with a de novo mutation in CRYAA and compound heterozygous mutations in P
    Jochen Graw
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, D 85764, Neuherberg, Germany
    Graefes Arch Clin Exp Ophthalmol 244:912-9. 2006
    ..To test the hypothesis that a de-novo mutation had occurred in one of the parental germ lines, a functional candidate gene approach was applied...
  60. ncbi request reprint Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians
    Iris M Heid
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:375-84. 2006
    ..Our data on a large number of healthy subjects suggest a clear modulation of adiponectin concentrations by variants of APM1, which are not merely a concomitant effect in the course of type 2 diabetes or coronary artery disease...
  61. pmc Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study
    Rui Wang-Sattler
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 3:e3863. 2008
    ..Our findings provide new insight into the pathophysiology of smoking addiction. Activation of the enzyme alkyl-DHAP by small molecules may provide novel routes for therapy...
  62. ncbi request reprint Large-scale determination of SNP allele frequencies in DNA pools using MALDI-TOF mass spectrometry
    Monika Werner
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Hum Mutat 20:57-64. 2002
    ..The described method reduces costs and time and enables genotyping of up to thousands of samples by taking advantage of the high-throughput MALDI-TOF technology...
  63. ncbi request reprint Asthma and IL-4 receptor alpha gene variants
    M Wjst
    German Asthma Genetics Group, Munich, Germany
    Eur J Immunogenet 29:263-8. 2002
    ..As there could be interactions with multiple genetic and environmental factors, IL4Ralpha could still be involved in asthma pathogenesis...
  64. ncbi request reprint KORA-gen--resource for population genetics, controls and a broad spectrum of disease phenotypes
    H E Wichmann
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Gesundheitswesen 67:S26-30. 2005
    ..KORA-gen can be used by external partners. Interested parties can inform themselves interactively via internet about the available data and the rules of access. The genotypic data base is a common resource of all partners...
  65. ncbi request reprint [How about the uncertainty in the haplotypes in the population-based KORA studies?]
    I M Heid
    Institute of Epidemiology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Gesundheitswesen 67:S132-6. 2005
    ..It is a further aim of our project to elucidate the extent of this problem and to develop strategies for reducing it...
  66. ncbi request reprint Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study)
    C Holzapfel
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Ingolstadter Landstrasse 1, D 85764, Neuherberg, Germany
    Eur J Endocrinol 157:R1-5. 2007
    ....
  67. pmc Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study
    Karl Heinz Ladwig
    Institute of Epidemiology II, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 8:e64762. 2013
    ..We analysed the impact of Posttraumatic Stress Disorder (PTSD) on TL in the general population and postulated a dose-dependent TL association in subjects suffering from partial PTSD compared to full PTSD...
  68. pmc Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Zentrum Munchen, National Research Center for Environment and Health, Neuherberg, Germany
    PLoS Genet 5:e1000504. 2009
    ..In addition, these findings strongly support the hypothesis that transport proteins are key in regulating serum uric acid levels...
  69. ncbi request reprint Further genetic heterogeneity for autosomal dominant human sutural cataracts
    Norman Klopp
    GSF National Research Center for Environment and Health, Institutes of Developmental Genetics, Neuherberg, Germany
    Ophthalmic Res 35:71-7. 2003
    ..The phenotype in this family is due to a mutation in another sutural cataract gene yet to be identified...
  70. ncbi request reprint Air pollution and inflammatory response in myocardial infarction survivors: gene-environment interactions in a high-risk group
    Annette Peters
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Inhal Toxicol 19:161-75. 2007
    ....
  71. doi request reprint Common variants in FCER1A influence total serum IgE levels from cord blood up to six years of life
    C M Chen
    Helmholtz Zentrum Munchen, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Allergy 64:1327-32. 2009
    ..In a recent genome wide scan, a functional promoter variant (rs2251746) in the gene encoding the alpha chain of the high affinity receptor for immunoglobulin E (IgE) (FCER1A) was identified as major determinant of serum IgE levels...
  72. ncbi request reprint Mortality excess in individuals with elevated IgA anti-transglutaminase antibodies: the KORA/MONICA Augsburg cohort study 1989-1998
    Marie Helene Metzger
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Eur J Epidemiol 21:359-65. 2006
    ..We examined the hypothesis that elevated IgA anti-tTG antibodies were associated with higher all-cause mortality risk...
  73. pmc Differences between human plasma and serum metabolite profiles
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 6:e21230. 2011
    ..However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices. The effects on metabolite concentration profiles have not been fully characterized...
  74. ncbi request reprint STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study
    Gabriele Duetsch
    GSF National Research Centre for Environment and Health, Institute of Epidemiology, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Hum Mol Genet 11:613-21. 2002
    ..0010). From these findings we conclude that the human STAT6 gene is rather involved in the development of eosinophilia and changes in total IgE levels than contributing to the pathogenesis of asthma...
  75. pmc Network-based SNP meta-analysis identifies joint and disjoint genetic features across common human diseases
    Matthias Arnold
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    BMC Genomics 13:490. 2012
    ..However, GWA data can be efficiently used to identify overlapping loci with analogous or contrasting effects on different diseases...
  76. pmc SLC30A8 (ZnT8) Polymorphism is Associated with Young Age at Type 1 Diabetes Onset
    Henning Gohlke
    Institute of Epidemiology, Helmholtz Zentrum, Neuherberg, Germany
    Rev Diabet Stud 5:25-7. 2008
    ..01) and compared to controls (69% and 48%; p < 0.03). These data suggest that genetic susceptibility for beta-cell dysfunction in the presence of autoimmunity may lead to accelerated progression and early manifestation of the disease...
  77. pmc Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A
    Carola Marzi
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 6:e1001213. 2010
    ..5-p13 region in the regulation of baseline A-SAA levels and provide confirmative evidence of the importance of the 1p31 region for inflammatory processes and the close interplay between A-SAA, leptin, and other acute-phase proteins...
  78. pmc Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies
    Harald Grallert
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Heart J 33:238-51. 2012
    ..We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association study as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium...
  79. doi request reprint Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
    P Achenbach
    Diabetes Research Institute of Forschergruppe Diabetes e V, Helmholtz Center Munich, Ingolstaedter Landstr 1, 85764, Neuherberg, Germany
    Diabetologia 52:1881-8. 2009
    ..Our aim was to determine the relationships between autoantibodies to zinc transporter 8 (ZnT8), genotypes of the ZnT8-encoding gene SLC30A8 and type 1 diabetes risk...
  80. ncbi request reprint Variants of the transcription factor 7-like 2 gene (TCF7L2) are strongly associated with type 2 diabetes but not with the metabolic syndrome in the MONICA/KORA surveys
    C Marzi
    GSF National Research Center for Environment and Health, Institute of Epidemiology, Neuherberg, Germany
    Horm Metab Res 39:46-52. 2007
    ..These findings support replication evidence that TCF7L2 variants increase type 2 diabetes risk. TCF7L2 may primarily affect pancreatic beta cell function...
  81. doi request reprint Air temperature and inflammatory responses in myocardial infarction survivors
    Alexandra Schneider
    Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Epidemiology 19:391-400. 2008
    ..The objective of this study was to analyze the association between air temperature and C-reactive protein, interleukin-6 and fibrinogen in postmyocardial infarction patients...
  82. doi request reprint Air temperature and the occurrence of myocardial infarction in Augsburg, Germany
    Kathrin Wolf
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, 85764 Neuherberg, Germany
    Circulation 120:735-42. 2009
    ..The objective of this study was to examine in detail the registry-based myocardial infarction (MI) rates and coronary deaths in relation to air temperature in the area of Augsburg, Germany...
  83. ncbi request reprint Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany
    Anke Hinney
    Department of Child and Adolescent Psychiatry, Rheinische Kliniken Essen, University of Duisburg Essen, Virchowstrasse 174, 45147 Essen, Germany
    J Clin Endocrinol Metab 91:1761-9. 2006
    ..Autosomal dominant inheritance of mutations in the melanocortin-4 receptor gene (MC4R) is currently regarded as the most relevant genetic cause for extreme obesity and affects 2-4% of extremely obese individuals...
  84. pmc Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years
    Albert Rosenberger
    Department of Genetic Epidemiology, Georg August University of Gottingen, Medical School, Germany
    BMC Cancer 8:60. 2008
    ..This study was set up to investigate the role of candidate genes in the susceptibility to lung cancer patients younger than 51 years at diagnosis...
  85. ncbi request reprint A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  86. ncbi request reprint The ATGL gene is associated with free fatty acids, triglycerides, and type 2 diabetes
    Veit Schoenborn
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular Clinical Pharmacology, Innsbruck Medical University, Schopfstrasse 41, A 6020 Innsbruck, Austria
    Diabetes 55:1270-5. 2006
    ..These results complement previous findings of functional studies in mammals and elucidate a potential role of ATGL in pathways involved in components of the metabolic syndrome...
  87. ncbi request reprint The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians
    Vitolds Mackevics
    First Department of Internal Medicine, St Johann Spital, Paracelsus Private Medical University Salzburg, Austriaia
    Eur J Hum Genet 14:349-56. 2006
    ..However, we could not confirm an association of this gene locus with metabolic parameters of the insulin resistance syndrome...
  88. ncbi request reprint A functional polymorphism within plasminogen activator urokinase (PLAU) is associated with Alzheimer's disease
    Matthias Riemenschneider
    Neurochemistry and Neurogenetics Laboratory, Department of Psychiatry and Psychotherapy, Technische Universitat Munchen, Ismaningerstrasse 22, 81675 Munich, Germany
    Hum Mol Genet 15:2446-56. 2006
    ..Further functional investigations are warranted to elucidate the specific role of PLAU, respectively, PLAU variants in the metabolism of Abeta proteins...
  89. ncbi request reprint Variation of the N-acetyltransferase 2 gene in a Romanian and a Kyrgyz population
    Sylvia Rabstein
    Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Institute of Ruhr University of Bochum, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Cancer Epidemiol Biomarkers Prev 15:138-41. 2006
    ..2% versus 51.4% in Romanians). We found pronounced ethnic differences in NAT2 genotypes with yet unknown effect on the health risks for environmental or occupational exposures in minority populations...
  90. pmc Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility
    Michael N Weedon
    Am J Hum Genet 73:1208-12. 2003
  91. ncbi request reprint ERCC2 genotypes and a corresponding haplotype are linked with breast cancer risk in a German population
    Christina Justenhoven
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, D 70376 Stuttgart, Germany
    Cancer Epidemiol Biomarkers Prev 13:2059-64. 2004
    ..49; 95% CI, 2.30-5.28). To our knowledge, this is the first study assigning breast cancer risk to both the ERCC2 genotype encoding Asp(312)Asp and the haplotype encoding Asp(312)/Gln(751)...
  92. ncbi request reprint MALDI-TOF MS and TaqMan assisted SNP genotyping of DNA isolated from formalin-fixed and paraffin-embedded tissues (FFPET)
    Malgorzata Jaremko
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Hum Mutat 25:232-8. 2005
    ..Our study shows for the first time that MALDI-TOF MS and TaqMan genotyping procedures provide reliable data, and are therefore applicable in studies that require large scale FFPET genotyping...
  93. ncbi request reprint Common variants in myocardial ion channel genes modify the QT interval in the general population: results from the KORA study
    Arne Pfeufer
    Institute of Human Genetics, Technical University Munich, Munich, Germany
    Circ Res 96:693-701. 2005
    ....
  94. ncbi request reprint G-Protein-coupled receptor polymorphisms are associated with asthma in a large German population
    Michael S D Kormann
    University Children s Hospital, Ludwig Maximilian s University Munich, Lindwurmstrasse 4, D 80337 München, Germany
    Am J Respir Crit Care Med 171:1358-62. 2005
    ..Initial association studies in a Finnish and Canadian population suggested an association with asthma and elevated serum IgE levels...
  95. ncbi request reprint Association of NOD1 polymorphisms with atopic eczema and related phenotypes
    Stephan Weidinger
    The Department of Dermatology and Allergy Biederstein, Technical University, Munich, Germany
    J Allergy Clin Immunol 116:177-84. 2005
    ..NOD1 is located on chromosome 7p14-p15, a region that has been linked with atopy. Recently, polymorphisms of the closely related NOD2 have been associated with atopy-related traits...
  96. ncbi request reprint No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples
    Beate Glaser
    Department of Psychological Medicine, Cardiff University, Cardiff, United Kingdom
    Biol Psychiatry 58:78-80. 2005
    ..It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susceptibility to schizophrenia in females ()...
  97. ncbi request reprint Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression
    Johannes Schumacher
    Institute of Human Genetics, University of Bonn, Bonn
    Biol Psychiatry 58:307-14. 2005
    ....
  98. ncbi request reprint Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes
    Thomas G Schulze
    Division of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health J5, 68159 Mannheim, Germany
    Am J Psychiatry 162:2101-8. 2005
    ....
  99. ncbi request reprint One-carbon metabolism and breast cancer risk: no association of MTHFR, MTR, and TYMS polymorphisms in the GENICA study from Germany
    Christina Justenhoven
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, D 70376 Stuttgart, Germany
    Cancer Epidemiol Biomarkers Prev 14:3015-8. 2005
  100. ncbi request reprint SNP-based analysis of genetic substructure in the German population
    Michael Steffens
    Institute of Medical Biometry, Informatics and Epidemiology, Rheinische Friedrich Wilhelms University, Bonn, Germany
    Hum Hered 62:20-9. 2006
    ..Two of the three samples, POPGEN (n = 720) and SHIP (n = 709), are from north and north-east Germany, respectively, and one sample, KORA (n = 730), is from southern Germany...
  101. ncbi request reprint Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis
    Stephan Weidinger
    J Invest Dermatol 127:724-6. 2007