Magdalena Gotz

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. pmc Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina
    Lin Ma
    IMCH, HBI, University of Calgary, T2N 4N1, Canada
    Neural Dev 2:11. 2007
  2. ncbi request reprint Radial glial cells defined and major intermediates between embryonic stem cells and CNS neurons
    Magdalena Gotz
    Institute of Stem Cell Research, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg Munich, Germany
    Neuron 46:369-72. 2005
  3. ncbi request reprint Cortical development: the art of generating cell diversity
    Magdalena Gotz
    GSF, National Research Centre for Environment and Health, Institute for Stem Cell Research, Neuherberg Munich, Germany
    Development 132:3327-32. 2005
  4. ncbi request reprint The cell biology of neurogenesis
    Magdalena Gotz
    Institute for Stem Cell Research, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Nat Rev Mol Cell Biol 6:777-88. 2005
  5. pmc Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation
    Tessa Walcher
    Institute of Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg Munich, Germany
    Development 140:1123-36. 2013
  6. doi request reprint A radial glia-specific role of RhoA in double cortex formation
    Silvia Cappello
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, 85764 Neuherberg, Germany
    Neuron 73:911-24. 2012
  7. doi request reprint The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex
    Maki Asami
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg Munich, Germany
    Development 138:5067-78. 2011
  8. doi request reprint Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells
    Dilek Colak
    Helmhotz Center Munich, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 28:434-46. 2008
  9. doi request reprint AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
    Luisa Pinto
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, Neuherberg Munich, Germany corrected
    Nat Neurosci 12:1229-37. 2009
  10. ncbi request reprint The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex
    Marcos R Costa
    National Research Center for Environment and Health, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 27:11376-88. 2007

Detail Information

Publications39

  1. pmc Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina
    Lin Ma
    IMCH, HBI, University of Calgary, T2N 4N1, Canada
    Neural Dev 2:11. 2007
    ..Here we report a similar role for two tumor suppressor genes, the Zac1 zinc finger transcription factor and that encoding the cytokine TGFbetaII, in the developing retina...
  2. ncbi request reprint Radial glial cells defined and major intermediates between embryonic stem cells and CNS neurons
    Magdalena Gotz
    Institute of Stem Cell Research, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg Munich, Germany
    Neuron 46:369-72. 2005
    ....
  3. ncbi request reprint Cortical development: the art of generating cell diversity
    Magdalena Gotz
    GSF, National Research Centre for Environment and Health, Institute for Stem Cell Research, Neuherberg Munich, Germany
    Development 132:3327-32. 2005
    ..What emerged from this meeting is an equally fascinating answer, namely that precursor diversity at rather early stages of development anticipates later cell type diversity...
  4. ncbi request reprint The cell biology of neurogenesis
    Magdalena Gotz
    Institute for Stem Cell Research, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Nat Rev Mol Cell Biol 6:777-88. 2005
    ..Here, we discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis...
  5. pmc Functional dissection of the paired domain of Pax6 reveals molecular mechanisms of coordinating neurogenesis and proliferation
    Tessa Walcher
    Institute of Stem Cell Research, Helmholtz Center Munich, 85764 Neuherberg Munich, Germany
    Development 140:1123-36. 2013
    ..Thus, Pax6 achieves its key roles in the developing forebrain by utilizing particular subdomains to coordinate patterning, neurogenesis and proliferation simultaneously...
  6. doi request reprint A radial glia-specific role of RhoA in double cortex formation
    Silvia Cappello
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, 85764 Neuherberg, Germany
    Neuron 73:911-24. 2012
    ..These data not only demonstrate that RhoA is largely dispensable for migration in neurons but also showed that defects in radial glial cells, rather than neurons, can be sufficient to produce SBH...
  7. doi request reprint The role of Pax6 in regulating the orientation and mode of cell division of progenitors in the mouse cerebral cortex
    Maki Asami
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg Munich, Germany
    Development 138:5067-78. 2011
    ..Taken together, our work reveals several direct effects that the transcription factor Pax6 has on the machinery that mediates the orientation and mode of cell division...
  8. doi request reprint Adult neurogenesis requires Smad4-mediated bone morphogenic protein signaling in stem cells
    Dilek Colak
    Helmhotz Center Munich, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 28:434-46. 2008
    ..Thus, BMP-mediated signaling via Smad4 is required to initiate neurogenesis from adult neural stem cells and suppress the alternative fate of oligodendrogliogenesis...
  9. doi request reprint AP2gamma regulates basal progenitor fate in a region- and layer-specific manner in the developing cortex
    Luisa Pinto
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, Neuherberg Munich, Germany corrected
    Nat Neurosci 12:1229-37. 2009
    ..Thus, AP2gamma acts as a regulator of basal progenitor fate, linking regional and laminar specification in the mouse developing cerebral cortex...
  10. ncbi request reprint The marginal zone/layer I as a novel niche for neurogenesis and gliogenesis in developing cerebral cortex
    Marcos R Costa
    National Research Center for Environment and Health, Institute for Stem Cell Research, 85764 Neuherberg Munich, Germany
    J Neurosci 27:11376-88. 2007
    ....
  11. ncbi request reprint Distinct modes of neuron addition in adult mouse neurogenesis
    Jovica Ninkovic
    Institute for Stem Cell Research, Gesellschaft für Strahlenforschung National Research Institute for Environment and Health, 85764 Neuherberg Munich, Germany
    J Neurosci 27:10906-11. 2007
    ..Thus, neuron addition is distinct and tightly regulated in the neuronal networks that incorporate new neurons life long...
  12. ncbi request reprint The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface
    Silvia Cappello
    GSF, National Research Center for Environment and Health, Institute for Stem Cell Research, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Munich, Germany
    Nat Neurosci 9:1099-107. 2006
    ..These cells then undergo mitoses at basal positions and acquire the fate of basal progenitors. Thus, cdc42 has a crucial role at the apical pole of progenitors, thereby regulating the position of mitoses and cell fate...
  13. ncbi request reprint Neuronal fate determinants of adult olfactory bulb neurogenesis
    Michael A Hack
    GSF National Research Center for Environment and Health, Institute for Stem Cell Research, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Nat Neurosci 8:865-72. 2005
    ..Together, these data explain both extrinsic and intrinsic mechanisms controlling neuronal identity in adult neurogenesis...
  14. doi request reprint Stab wound injury of the zebrafish telencephalon: a model for comparative analysis of reactive gliosis
    Emily Violette Baumgart
    Institute for Stem Cell Research, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Glia 60:343-57. 2012
    ..Invasive injury in the adult zebrafish telencephalon may therefore provide a useful model to untangle the molecular mechanisms involved in these beneficial glial reactions...
  15. doi request reprint The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA
    Jovica Ninkovic
    Helmholtz Zentrum Munchen, Institute of Stem Cell Research, Ingolstädter Landstraße 1, D 85764 Neuherberg, Germany
    Neuron 68:682-94. 2010
    ..Strikingly, Pax6 utilizes different DNA-binding domains for its well-known role in fate specification and this role of regulating the survival of specific neuronal subtypes in the mature, healthy brain...
  16. ncbi request reprint Par-complex proteins promote proliferative progenitor divisions in the developing mouse cerebral cortex
    Marcos R Costa
    GSF National Research Institute for Environment and Health, Institute for Stem Cell Research, Ingolstadter Landstr 1, 85764, Neuherberg Munich, Germany
    Development 135:11-22. 2008
    ..Taken together, our data demonstrate a key role for the apically located Par-complex proteins in promoting self-renewing progenitor cell divisions at the expense of neurogenic differentiation in the developing cerebral cortex...
  17. ncbi request reprint Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
    Pontus C Holm
    Institute for Stem Cell Research, National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 34:99-119. 2007
    ..Most intriguingly, this analysis revealed time- and region-specific differences in Pax6-mediated transcription, explaining the specific function of Pax6 at early and later stages of neurogenesis...
  18. pmc Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type
    Gregor Alexander Pilz
    Institute of Stem Cell Research, Helmholtz Center Munich, Ingolstadter Landstr 1, Neuherberg, 85764 Munich, Germany
    Nat Commun 4:2125. 2013
    ..This implies key roles of this new type of radial glia in ontogeny and phylogeny. ..
  19. pmc Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain
    Annalisa Buffo
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Proc Natl Acad Sci U S A 105:3581-6. 2008
    ....
  20. ncbi request reprint The BAF complex interacts with Pax6 in adult neural progenitors to establish a neurogenic cross-regulatory transcriptional network
    Jovica Ninkovic
    Institute for Stem Cell Research, Helmholtz Centre Munich German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany Physiological Genomics, Medical Faculty, University of Munich, Schillerstrasse 46, 80633 Munich, Germany
    Cell Stem Cell 13:403-18. 2013
    ..Taken together, elements of our work identify a tripartite effector network activated by Pax6-BAF that programs neuronal fate. ..
  21. doi request reprint Restrictions in time and space--new insights into generation of specific neuronal subtypes in the adult mammalian brain
    Franziska Weinandy
    Institute of Stem Cell Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Ingolstadter Landstr 1, 85764 München Neuherberg, Germany
    Eur J Neurosci 33:1045-54. 2011
    ..These new insights are then considered in regard to the choice of cells with the appropriate region-specific identity for repair strategies...
  22. doi request reprint Prospective isolation of functionally distinct radial glial subtypes--lineage and transcriptome analysis
    Luisa Pinto
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Institute of Stem Cell Research, Ingolstadter Landstr 1, 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 38:15-42. 2008
    ..This analysis therefore identifies, for the first time, the lineage origin of basal progenitors and the molecular differences of this lineage in comparison to directly neurogenic and gliogenic radial glia...
  23. doi request reprint Late origin of glia-restricted progenitors in the developing mouse cerebral cortex
    Marcos R Costa
    Institute for Stem Cell Research, Helmholtz Zentrum Munchen, National Research Center for Environment and Health, Neuherberg, Germany
    Cereb Cortex 19:i135-43. 2009
    ..The latter are responsible for the generation of glial-restricted progenitors at mid- and late neurogenesis...
  24. ncbi request reprint Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes
    Nicole Haubst
    Institute for Stem Cell Research, GSF, National Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg Munich, Germany
    Development 133:3245-54. 2006
    ..Thus, although BM attachment seems dispensable for precursor cells, an intact BM is required for adequate neuronal composition of the cerebral cortex...
  25. doi request reprint Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development
    Silvia Cappello
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, Neuherberg, Germany
    Nat Genet 45:1300-8. 2013
    ..These effects were countered by concurrent knockdown of Yap, a transcriptional effector of the Hippo signaling pathway. These findings implicate Dchs1 and Fat4 upstream of Yap as key regulators of mammalian neurogenesis...
  26. doi request reprint The transcription factor Otx2 regulates choroid plexus development and function
    Pia A Johansson
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, Neuherberg, 85764 Munich, Germany
    Development 140:1055-66. 2013
    ..Thus, Otx2 acts as a master regulator of ChP development, thereby influencing one of the principal sources of signaling in the developing brain, the CSF...
  27. doi request reprint The specific role of histone deacetylase 2 in adult neurogenesis
    Melanie Jawerka
    Institute for Stem Cell Research, HelmholtzZentrum Munich, German Research Center for Environmental Health, Neuherberg Munich, Germany
    Neuron Glia Biol 6:93-107. 2010
    ..This cell-autonomous function of HDAC2 exclusively in adult neurogenesis reveals clear differences in the molecular mechanisms regulating neurogenesis during development and in adulthood...
  28. doi request reprint In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells
    Ruth Beckervordersandforth
    Institute for Stem Cell Research, Helmholtz Centre Munich German Research Centre for Environmental Health, Neuherberg Munich, Germany
    Cell Stem Cell 7:744-58. 2010
    ..Our work reveals candidate molecular regulators for unique features of aNSCs and facilitates future selective analysis of aNSCs in other functional contexts, such as aging and injury...
  29. ncbi request reprint Radial glial cell heterogeneity--the source of diverse progeny in the CNS
    Luisa Pinto
    Institute of Stem Cell Research, GSF National Research Center for Health and Environment, Ingolstadter Landstr 1, D 85764 Neuherberg München, Germany
    Prog Neurobiol 83:2-23. 2007
    ....
  30. doi request reprint Prospective isolation of adult neural stem cells from the mouse subependymal zone
    Judith Fischer
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, Neuherberg, Germany
    Nat Protoc 6:1981-9. 2011
    ..This protocol, which can be completed in 7 h, allows the assessment of quantitative changes in SEZ NSCs and the examination of their molecular and functional characteristics...
  31. ncbi request reprint Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis
    Tetsuji Mori
    Institute of Stem Cell Research, GSF National Research Center for Environment and Health, Neuherberg Munich, Germany
    Glia 54:21-34. 2006
    ..Taken together, this mouse line will allow dissecting the molecular pathways regulating the diverse functions of astrocytes as precursors, support cells, repair cells, and cells involved in neuronal information processing...
  32. ncbi request reprint Signaling in adult neurogenesis: from stem cell niche to neuronal networks
    Jovica Ninkovic
    Institute of Stem Cell Research, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, Neuherberg, Germany
    Curr Opin Neurobiol 17:338-44. 2007
    ..Moreover, new insights have been gained into how neuronal diversity is instructed in adult neurogenesis, prompting a new view of stem and progenitor cell heterogeneity in the adult mammalian brain...
  33. ncbi request reprint Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells
    Benedikt Berninger
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Eur J Neurosci 25:2581-90. 2007
    ..Thus, in-vitro expanded adult NSCs have the competence to become directed towards distinct functional neurotransmitter phenotypes when the appropriate transcriptional cues are provided...
  34. ncbi request reprint Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia
    Benedikt Berninger
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    J Neurosci 27:8654-64. 2007
    ..Our data demonstrate that single TFs are capable of inducing a remarkable functional reprogramming of astroglia toward a truly neuronal identity...
  35. ncbi request reprint Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development
    Nicole Haubst
    GSF National Research Center for Environment and Health, Institute for Stem Cell Research, Neuherberg, Germany
    Development 131:6131-40. 2004
    ..These results therefore demonstrate a key role of the PD in brain development and implicate splicing as a pivotal factor regulating the potent neurogenic role of Pax6...
  36. doi request reprint Fate specification in the adult brain--lessons for eliciting neurogenesis from glial cells
    Jovica Ninkovic
    Helmholtz Centre Munich German Research Centre for Environmental Health GmbH, Institute for Stem Cell Research, Neuherberg Munich, Germany
    Bioessays 35:242-52. 2013
    ..The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches...
  37. doi request reprint Stem cells niches during development--lessons from the cerebral cortex
    Pia A Johansson
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, Neuherberg Munich, Germany
    Curr Opin Neurobiol 20:400-7. 2010
    ....
  38. ncbi request reprint The transcription factors Emx1 and Emx2 suppress choroid plexus development and promote neuroepithelial cell fate
    Julia von Frowein
    GSF National Research Center for Environment and Health, Institute for Stem Cell Research, Ingolstadter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Dev Biol 296:239-52. 2006
    ..These observations indicate that the expression levels of Emx1 and/or Emx2 restrict the prospective choroid plexus territory, a novel role of these transcription factors...
  39. pmc Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair
    Annalisa Buffo
    Institute for Stem Cell Research, National Research Center for Environment and Health, Neuherberg Munich, Germany
    Proc Natl Acad Sci U S A 102:18183-8. 2005
    ..These data, therefore, imply Olig2 as a repressor of neurogenesis in cells reacting to brain injury and open innovative perspectives toward evoking endogenous neuronal repair...