Research Topics
| Bernhard FrankenbergerSummaryAffiliation: GSF-National Research Center for Environment and Health Country: Germany Publications
| Collaborators
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Detail Information
Publications
Influence of CD80, interleukin-2, and interleukin-7 expression in human renal cell carcinoma on the expansion, function, and survival of tumor-specific CTLsBernhard Frankenberger
Institute of Molecular Immunology, Forschungszentrum für Umwelt und Gesundheit National Research Center for Environment and Health, Marchioninistrasse 25, 81377 Munich, Germany
Clin Cancer Res 11:1733-42. 2005..The effect of these modifications on proliferation, function, and survival of autologous and allogeneic tumor-specific CTLs was assessed...- Cell-based vaccines for renal cell carcinoma: genetically-engineered tumor cells and monocyte-derived dendritic cellsBernhard Frankenberger
Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Marchioninistrasse 25, 81377 Munich, Germany
World J Urol 23:166-74. 2005.... - Phase 1 trial of allogeneic gene-modified tumor cell vaccine RCC-26/CD80/IL-2 in patients with metastatic renal cell carcinomaAlexander Buchner
Department of Urology, Ludwig Maximilian University of Munich, 81377 Munich, Germany
Hum Gene Ther 21:285-97. 2010..These results suggest that this vaccine could be useful in combination therapies and/or minimal residual disease... - Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075Stefani Spranger
Institute of Molecular Immunology, German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany
J Immunol 185:738-47. 2010..Thereby, mature DCs prepared within 3 d using such maturation mixtures displayed optimal functions required for vaccine development... - Generation of clinical grade dendritic cells with capacity to produce biologically active IL-12p70Anke Zobywalski
Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Munich, Germany
J Transl Med 5:18. 2007..We therefore developed new maturation cocktails allowing DCs to produce biologically active IL-12p70 for large-scale cancer vaccine development... - Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional aviditySusanne Wilde
Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Marchioninistrasse 25, Munich, Germany
Blood 114:2131-9. 2009..This approach allows high-avidity T cells and TCR specific for tumor-associated self-peptides to be easily obtained for direct adoptive T-cell therapy or for isolation of therapeutic transgenic TCR sequences... - TCR-transgenic lymphocytes specific for HMMR/Rhamm limit tumor outgrowth in vivoStefani Spranger
Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany
Blood 119:3440-9. 2012..Our findings clearly limit the use of HMMR-TCR therapy to MHC- mismatched HSC transplantation, in which HLA-A2 differences can be used to restrict recognition to patient HSCs and leukemia... - NOD/scid IL-2Rg(null) mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivoStefani Spranger
Institute of Molecular Immunology, Helmholtz Zentrum Munchen, Marchioninistrasse 25, 81377 Munich, Germany
J Transl Med 10:30. 2012..This led to selection of a simple and rapid protocol for engraftment and vaccine evaluation that encompassed 4 weeks... - Third generation dendritic cell vaccines for tumor immunotherapyBernhard Frankenberger
Institute of Molecular Immunology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany
Eur J Cell Biol 91:53-8. 2012.... - RNA transfer by electroporation into mature dendritic cells leading to reactivation of effector-memory cytotoxic T lymphocytes: a quantitative analysisMiran Javorovic
Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Munich, Germany
Mol Ther 12:734-43. 2005.... - Human antitumor CD8+ T cells producing Th1 polycytokines show superior antigen sensitivity and tumor recognitionSusanne Wilde
Institute of Molecular Immunology, Helmholtz Center Munich, German
J Immunol 189:598-605. 2012..Thus, Th1 polycytokine secretion served as a suitable parameter to rapidly demark cytotoxic CD8(+) T cell clones for further TCR evaluation... - Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignanciesIngrid G Schuster
Institute of Molecular Immunology, Forschungszeutrum für Umwelt und Gesundheit GSF National Research Center for Environment and Health, Munich, Germany
Blood 110:2931-9. 2007..Allorestricted TCRs with specificity for naturally presented FMNL1-derived epitopes may represent promising reagents for the development of adoptive therapies in lymphoma and other malignant diseases... - Three-day dendritic cells for vaccine development: antigen uptake, processing and presentationMaja Bürdek
German Research Center for Environmental Health, Institute of Molecular Immunology, Marchioninistr, 25, 81377 Munchen, Germany
J Transl Med 8:90. 2010.... - Prostate cancer lesions are surrounded by FOXP3+, PD-1+ and B7-H1+ lymphocyte clustersKathleen Ebelt
Institute of Molecular Immunology, Clinical Cooperation Group Immune Monitoring, Helmholtz Center Munich, German Research Center for Environmental Health, Marchioninistr 25, Munich 81377, Germany
Eur J Cancer 45:1664-72. 2009..Expression of molecules associated with inhibition and exhaustion of lymphocytes may reflect events contributing to ineffective immune responses against cancer cells... - Immune suppression in renal cell carcinomaBernhard Frankenberger
Institute of Molecular Immunology, GSF National Research Center for Environment and Health, Marchioninistrasse 25, 81377 Munich, Germany
Semin Cancer Biol 17:330-43. 2007..Understanding these complex host-tumor interactions has broad implications for successful application of cytokine therapy and other forms of immunotherapy for RCC... - Activated B cells mediate efficient expansion of rare antigen-specific T cellsCaroline Zentz
Clinical Cooperative Group Molecular Oncology, GSF National Research Center for Environment and Health, Munich, Germany
Hum Immunol 68:75-85. 2007..These results strongly encourage the use of CD40-stimulated B cells as APCs in immunotherapy... - Melanoma-associated antigen tyrosinase but not Melan-A/MART-1 expression and presentation dissociate during the heat shock responseValeria Milani
Clinical Cooperation Group of Hyperthermia, Internal Medicine Department III, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377 Munich, Germany
Int Immunol 17:257-68. 2005..Moreover, these results document the maintenance of immunological homeostasis during recovery from heat treatment, thus challenging the view that tumor cells subjected to heat shock become resistant to CTL recognition...