J Favor

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. ncbi request reprint The mutagenic activity of ethylnitrosourea at low doses in spermatogonia of the mouse as assessed by the specific-locus test
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, D 85758, Neuherberg, Germany
    Mutat Res 405:221-6. 1998
  2. pmc Type IV procollagen missense mutations associated with defects of the eye, vascular stability, the brain, kidney function and embryonic or postnatal viability in the mouse, Mus musculus: an extension of the Col4a1 allelic series and the identification of
    Jack Favor
    Institute of Human Genetics, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    Genetics 175:725-36. 2007
  3. ncbi request reprint The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea
    J Favor
    Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Mutat Res 374:193-9. 1997
  4. ncbi request reprint Mechanisms of mutation induction in germ cells of the mouse as assessed by the specific locus test
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764, Neuherberg, Germany
    Mutat Res 428:227-36. 1999
  5. ncbi request reprint Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Mamm Genome 11:520-5. 2000
  6. pmc Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Neuherberg D 85764, Germany
    Genetics 159:1689-700. 2001
  7. ncbi request reprint Transmitted mutational events induced in mouse germ cells following acrylamide or glycidamide exposure
    Jack Favor
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Mutat Res 580:21-30. 2005
  8. ncbi request reprint Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern
    C Grimm
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Dev Genet 23:299-316. 1998
  9. ncbi request reprint The mouse Cat4 locus maps to chromosome 8 and mutants express lens-corneal adhesion
    J Favor
    Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Mamm Genome 8:403-6. 1997
  10. pmc The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney
    J Favor
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Oberschleissheim, Germany
    Proc Natl Acad Sci U S A 93:13870-5. 1996

Collaborators

Detail Information

Publications52

  1. ncbi request reprint The mutagenic activity of ethylnitrosourea at low doses in spermatogonia of the mouse as assessed by the specific-locus test
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, D 85758, Neuherberg, Germany
    Mutat Res 405:221-6. 1998
    ..This is interpreted to be due to the differences between a mathematical abstraction and the biological realities of the system being studied...
  2. pmc Type IV procollagen missense mutations associated with defects of the eye, vascular stability, the brain, kidney function and embryonic or postnatal viability in the mouse, Mus musculus: an extension of the Col4a1 allelic series and the identification of
    Jack Favor
    Institute of Human Genetics, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    Genetics 175:725-36. 2007
    ..We suggest that the spontaneous intraorbital hemorrhages observed in the mouse are a clinically relevant phenotype with a relatively high predictive value to identify carriers of COL4A1 or COL4A2 mutations...
  3. ncbi request reprint The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea
    J Favor
    Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Mutat Res 374:193-9. 1997
    ..Biologically plausible explanations of the discrepancy are presented...
  4. ncbi request reprint Mechanisms of mutation induction in germ cells of the mouse as assessed by the specific locus test
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764, Neuherberg, Germany
    Mutat Res 428:227-36. 1999
    ..e) With the cloning of all 7 marker loci mutation analysis at the molecular level will allow a more direct assessment of the mutation process in future studies...
  5. ncbi request reprint Saturation mutagenesis for dominant eye morphological defects in the mouse Mus musculus
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Mamm Genome 11:520-5. 2000
    ....
  6. pmc Molecular characterization of Pax6(2Neu) through Pax6(10Neu): an extension of the Pax6 allelic series and the identification of two possible hypomorph alleles in the mouse Mus musculus
    J Favor
    Institute of Mammalian Genetics, GSF Research Center for Environment and Health, Neuherberg D 85764, Germany
    Genetics 159:1689-700. 2001
    ..Pax6(7Neu) is a base pair substitution in the Kozak sequence and results in a reduced level of Pax6 translation product. The Pax6(4Neu) and Pax6(7Neu) alleles may be very useful for gene-dosage studies...
  7. ncbi request reprint Transmitted mutational events induced in mouse germ cells following acrylamide or glycidamide exposure
    Jack Favor
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Mutat Res 580:21-30. 2005
    ..This discrepancy should be resolved. Finally, it is noted that no experiments have studied the mutagenic potential of acrylamide to increase the frequency of transmitted mutational events following exposure in the female germ line...
  8. ncbi request reprint Aphakia (ak), a mouse mutation affecting early eye development: fine mapping, consideration of candidate genes and altered Pax6 and Six3 gene expression pattern
    C Grimm
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Neuherberg, Germany
    Dev Genet 23:299-316. 1998
    ..As a consequence of the arrested lens development, other ocular tissues that require for their development information from the intact lens, such as iris, ciliary muscle, retina, and vitreous body, are absent or formed abnormally...
  9. ncbi request reprint The mouse Cat4 locus maps to chromosome 8 and mutants express lens-corneal adhesion
    J Favor
    Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Mamm Genome 8:403-6. 1997
    ..Thus, on the basis of phenotype and map position, Cat4 may be a mouse model of human ASOD. The genes Junb, Jund1, Mel, and Zfp42 are discussed as possible candidates for Cat4...
  10. pmc The mouse Pax2(1Neu) mutation is identical to a human PAX2 mutation in a family with renal-coloboma syndrome and results in developmental defects of the brain, ear, eye, and kidney
    J Favor
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Oberschleissheim, Germany
    Proc Natl Acad Sci U S A 93:13870-5. 1996
    ..The mid-hindbrain phenotype is similar to Wnt1 and En1 mutant phenotypes, suggesting the conservation of gene regulatory networks between vertebrates and Drosophila...
  11. ncbi request reprint Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus
    W Pretsch
    GSF National Research Center for Environment and Health, Institute for Mammalian Genetics, Neuherberg, Germany
    Mamm Genome 9:144-9. 1998
    ..Each of the sequence alterations has a potential impact on the structure of the LDHA protein, which is consistent with the decreased LDH activity and biochemical and physiological alterations...
  12. pmc Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus
    Jack Favor
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    Genetics 179:1345-55. 2008
    ....
  13. ncbi request reprint Loss of heterozygosity at the dilute-short ear (Myo5a-Bmp5) region of the mouse: mitotic recombination or double non-disjunction?
    J Favor
    Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Genet Res 72:199-204. 1998
    ..Our results indicate the mutational event to be due to mitotic recombination and not double non-disjunction...
  14. ncbi request reprint Molecular analysis of four lactate dehydrogenase-A mutants in the mouse
    R Sandulache
    Institut fur Saugetiergenetik, GSF Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Oberschleissheim, Germany
    Mamm Genome 5:777-80. 1994
    ..All ENU-induced mutations were A/T-->G/C transitions. The mutation events could be correlated with the biochemical and physiological alterations observed in affected mice...
  15. ncbi request reprint Three murine cataract mutants (Cat2) are defective in different gamma-crystallin genes
    N Klopp
    Institute of Mammalian Genetics, GSF National Research Center for Environment and Health, Neuherberg, D 85764, Germany
    Genomics 52:152-8. 1998
    ..All three mutations are predicted to alter protein folding of the gamma-crystallins and result in lens cataract, but the phenotype for each is quite distinctive...
  16. pmc A mutation affecting the lactate dehydrogenase locus Ldh-1 in the mouse. II. Mechanism of the LDH-A deficiency associated with hemolytic anemia
    W Pretsch
    GSF Forschungszentrum für Umwelt und Gesundheit, Institut fur Saugetiergenetik, Neuherberg, Germany
    Genetics 135:161-70. 1993
    ..This discrepancy is likely due to the fact that in human erythrocytes both LDH-A and LDH-B subunits are expressed such that homozygotes for a LDH-A or LDH-B deficiency would not result in a comparably extreme LDH activity deficiency...
  17. ncbi request reprint A precise localization of a mouse gene encoding increased phosphoglycerate mutase activity (Pgam1e1) on chromosome 19
    W Pretsch
    GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Institut fur Saugetiergenetik, Neuherberg, Ingolstadter Landstrasse 1, D 85764 Oberschleissheim, Germany
    Mamm Genome 7:619. 1996
  18. ncbi request reprint A comparison of enzyme activity mutation frequencies in germ cells of mice (Mus musculus) and golden hamsters (Mesocricetus auratus) after exposure to 2 + 2 Gy gamma-irradiation
    W Pretsch
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolstädter Landstrabetae 1, D 85764 Neuherberg, Germany
    Mutagenesis 15:39-43. 2000
    ..A critical assumption for the extrapolation of experimental mutagenesis studies to humans is that no species effects exist in sensitivity to mutation induction by irradiation. Our results do not contradict this assumption...
  19. ncbi request reprint Electroretinography as a screening method for mutations causing retinal dysfunction in mice
    Claudia Dalke
    GSF National Research Center for Environment and Health, Institutes of Developmental Genetics, Clinical Cooperation Group Ophthalmogenetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 45:601-9. 2004
    ..To detect mice with hereditary retinal impairment, a high-throughput electroretinography (ERG) screening system was established...
  20. doi request reprint Novel allele of crybb2 in the mouse and its expression in the brain
    Koustav Ganguly
    Institutes of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 49:1533-41. 2008
    ..O377 was identified as a new dominant cataract mutation in mice after radiation experiments. The purpose of this study was to genetically characterize the mutation and to analyze its biological consequences...
  21. pmc Pleiotropic effects in Eya3 knockout mice
    Torben Soker
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    BMC Dev Biol 8:118. 2008
    ..The functions of its mammalian orthologs Eya1-4 are only partially understood and no mouse model exists for Eya3. Therefore, we characterized the phenotype of a new Eya3 knockout mouse mutant...
  22. ncbi request reprint A second locus encoding elevated phosphoglycerate mutase activity (Pgam2e) maps to mouse chromosome 4
    W Pretsch
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Mamm Genome 8:296-7. 1997
  23. pmc Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes
    Jack Favor
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Lanstrasse 1 D 85764, Neuherberg, Germany
    Genetics 182:1077-88. 2009
    ..Our results suggest that deletion of Rcn1 directly or indirectly contributes to the eye phenotype in Pax6 contiguous gene deletions...
  24. ncbi request reprint Recommendations for statistical designs of in vivo mutagenicity tests with regard to subsequent statistical analysis
    I D Adler
    GSF Institut für Säugetiergenetik, D 85758 Neuherberg, Germany
    Mutat Res 417:19-30. 1998
    ..Use of negative historical controls was allowed in certain circumstances for interpretation of results from micronucleus tests and chromosomal aberration tests...
  25. pmc Ethylnitrosourea-induced base pair substitution affects splicing of the mouse gammaE-crystallin encoding gene leading to the expression of a hybrid protein and to a cataract
    Jochen Graw
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, D 85764 Neuherberg, Germany
    Genetics 161:1633-40. 2002
    ..Histological analysis of the cataractous lenses indicated that the expression of the new protein disrupts the cellular structure of the eye lens...
  26. doi request reprint Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice
    Michael Rosemann
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Mamm Genome 21:13-27. 2010
    ..It is the first mouse mutant carrying a point mutation within the coding region of Pitx3...
  27. ncbi request reprint Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus
    Walter Pretsch
    Institute of Human Genetics, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764, Neuherberg, Germany
    Mamm Genome 18:686-92. 2007
    ....
  28. ncbi request reprint A 6-bp deletion in the Crygc gene leading to a nuclear and radial cataract in the mouse
    Jochen Graw
    National Research Center for Environment and Health Forschungszentrum für Umwelt und Gesundheit, Institute of Mammalian Genetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 43:236-40. 2002
    ..The purpose of this study was to establish the linkage of the mutation to a particular chromosome to allow molecular characterization. Moreover, the mutants were examined morphologically...
  29. ncbi request reprint Multilocus inheritance determines predisposition to alpha-radiation induced bone tumourigenesis in mice
    Michael Rosemann
    Institute of Pathology, Clinical Cooperation Group Osteosarcoma, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Int J Cancer 118:2132-8. 2006
    ..This mechanism can be of particular importance in genetically heterogeneous populations such as man...
  30. ncbi request reprint Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters
    Jochen Graw
    Institute of Developmental Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 46:4671-83. 2005
    ..To characterize three new mouse small-eye mutants detected during ethylnitrosourea mutagenesis programs...
  31. ncbi request reprint Bone tumorigenesis induced by alpha-particle radiation: mapping of genetic loci influencing predisposition in mice
    Michael Rosemann
    Institute of Pathology at the GSF National Research Center for Environment and Health, Neuherberg, Germany
    Radiat Res 157:426-34. 2002
    ..This study demonstrates the presence of a genetic component that modulates predisposition to radiation-induced osteosarcoma...
  32. ncbi request reprint Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development
    Nicole Haubst
    GSF National Research Center for Environment and Health, Institute for Stem Cell Research, Neuherberg, Germany
    Development 131:6131-40. 2004
    ..These results therefore demonstrate a key role of the PD in brain development and implicate splicing as a pivotal factor regulating the potent neurogenic role of Pax6...
  33. ncbi request reprint Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse
    Jochen Graw
    Institute of Developmental Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 45:1202-13. 2004
    ..The purpose of this study was the characterization of eight new dominant cataract mutations...
  34. ncbi request reprint Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity
    Jochen Graw
    National Research Center for Environment and Health GSF, Institute of Mammalian Genetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 43:2998-3002. 2002
    ..The Rop (radial opacity) mutation, which was recovered in a mutagenicity screen after paternal treatment with procarbazine, was analyzed to determine phenotype, chromosomal localization, candidate genes, and molecular lesion...
  35. pmc Hereditary lactate dehydrogenase A-subunit deficiency as cause of early postimplantation death of homozygotes in Mus musculus
    S Merkle
    Institut fur Saugetiergenetik, GSF Forschungszentrum für Umwelt und Gesundheit GmbH, Neuherberg, Germany
    Genetics 131:413-21. 1992
    ..The distinct physiological consequences of the total absence of a functioning LDH-A subunit in mice and humans are discussed.(ABSTRACT TRUNCATED AT 250 WORDS)..
  36. ncbi request reprint Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus
    W Schmahl
    Institut fur Pathologie, GSF Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Germany
    Acta Neuropathol 86:126-35. 1993
    ..Consequently, there is an impairment of the peripheral migration of putative neurons so that the neonatal lesion pattern of the neocortical roof becomes dominated by a broad spectrum of neuronal migration disorders...
  37. ncbi request reprint Variations of eye size parameters among different strains of mice
    Oliver Puk
    Institutes of Developmental Genetics, GSF National Research Center for Environment and Health, D 85764, Neuherberg, Germany
    Mamm Genome 17:851-7. 2006
    ..Finally, wild-type intervals (mean +/- 3 SD) for axial length, anterior chamber depth, and cornea and lens thicknesses were calculated allowing a quick identification of pathologic outliers...
  38. doi request reprint Systemic first-line phenotyping
    Valerie Gailus-Durner
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Methods Mol Biol 530:463-509. 2009
    ..Using the example of the German Mouse Clinic (GMC) we will introduce the reader to the different aspects of the organization of a mouse clinic and present selected methods used in first-line phenotyping...
  39. ncbi request reprint A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding
    Mary F Lyon
    Mammalian Genetics Unit, Harwell, Didcot, OX11 0RD, UK
    Hum Mol Genet 12:585-94. 2003
    ..The Ofl mutant therefore provides a valuable model system for the study of Maf, and its interacting factors, in normal and abnormal lens and anterior segment development...
  40. ncbi request reprint Replicated anterior zeugopod (raz): a polydactylous mouse mutant with lowered Shh signaling in the limb bud
    Ottheinz Krebs
    Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig Maximilian University, Munich, Germany
    Development 130:6037-47. 2003
    ..We propose that the double anterior zeugopod and symmetrical central polydactyly are due to an increased and uniform concentration of the Gli3 repressor form because of lowered Shh signaling...
  41. ncbi request reprint Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+/- mouse
    Inga J Murawski
    Department of Pediatrics, Montreal Children s Hospital, McGill University, Quebec, Canada
    Am J Physiol Renal Physiol 293:F1736-45. 2007
    ..Our results provide the first evidence that VUR may arise from a delay in urinary tract maturation and an explanation for the clinical observation that VUR resolves over time in some affected children...
  42. ncbi request reprint Pax2.1 is required for the development of thyroid follicles in zebrafish
    Thomas Wendl
    Institute for Developmental Biology, University of Cologne, Gyrhofstrasse 17, D 50923 Köln, Germany
    Development 129:3751-60. 2002
    ..Thus, in zebrafish, some remaining thyroid hormone synthesis takes place independent of the pathway leading to thyroid follicle formation. We suggest that the noi(-/-) mutant serves as a new zebrafish model for hypothyroidism...
  43. pmc Endogenous retroviral insertion in Cryge in the mouse No3 cataract mutant
    Nabanita Nag
    Section on Molecular Structure and Functional Genomics, National Eye Institute, National Institutes of Health, Building 7, Room 201 Bethesda, MD 20892, USA
    Genomics 89:512-20. 2007
    ..However, the severity of cataract is also strain dependent suggesting that genetic background modifiers also play a role in the development of opacity...
  44. ncbi request reprint Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content
    Maia Zaiko
    Diabetes Unit, Department of Medicine, University Hospital Geneva, 24 Micheli du Crest, 1211 Geneva, Switzerland
    Eur J Endocrinol 150:389-95. 2004
    ..We have concluded that Pax2 may be implicated in the prenatal determination of the relative proportion of the endocrine and exocrine tissues of the pancreas...
  45. ncbi request reprint Xcat, a novel mouse model for Nance-Horan syndrome inhibits expression of the cytoplasmic-targeted Nhs1 isoform
    Kristen M Huang
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Hum Mol Genet 15:319-27. 2006
    ..Inhibition of expression of the exon 1 containing isoform results in the abnormal phenotype of Xcat...
  46. ncbi request reprint Organization and annotation of the Xcat critical region: elimination of seven positional candidate genes
    Kristen M Huang
    F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Genomics 83:893-901. 2004
    ..The expression of Rai2 was quantitatively identical in wild-type and Xcat mutant eyes. These results indicate that the Xcat mutation is within a novel, undiscovered gene...
  47. ncbi request reprint Genetic and phenotypic analysis of Tcm, a mutation affecting early eye development
    Ken S Wang
    F M Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Stellar Chance Bldg Rm 315, 422 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Mamm Genome 16:332-43. 2005
    ..These results indicate that the causitive Tcm mutation falls within a noncoding regulatory region of one of the five candidate genes or in an undescribed gene...
  48. ncbi request reprint An ENU-induced mutation in Rs1h causes disruption of retinal structure and function
    Monica M Jablonski
    Department of Ophthalmology, University of Tennessee Health Science Center and Tennessee Mouse Genome Consortium, Memphis, TN, USA
    Mol Vis 11:569-81. 2005
    ..Herein we present its retinal phenotype and genetic basis...
  49. pmc Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification
    Tertius A Hough
    Mammalian Genetics Unit and Mary Lyon Centre, Medical Research Council, Harwell, Oxfordshire OX11 0RD, United Kingdom
    Proc Natl Acad Sci U S A 101:13566-71. 2004
    ....
  50. ncbi request reprint Molecular interaction between projection neuron precursors and invading interneurons via stromal-derived factor 1 (CXCL12)/CXCR4 signaling in the cortical subventricular zone/intermediate zone
    Marie Catherine Tiveron
    Institut de Biologie du Developpement de Marseille Luminy, Centre National de la Recherche Scientifique Université de Mediterranée, 13288 Marseille, France
    J Neurosci 26:13273-8. 2006
    ..These results represent the first evidence for a molecular interaction between precursors of projection neurons and invading interneurons during corticogenesis...
  51. ncbi request reprint "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?
    Sabine M Hoelter
    Institute of Developmental Genetics, Helmholtz Center Munich German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany
    Front Biosci 13:5810-23. 2008
    ..These results emphasize the importance of comprehensive behavioural and physiological phenotyping...
  52. ncbi request reprint Introducing the German Mouse Clinic: open access platform for standardized phenotyping
    Valerie Gailus-Durner
    Nat Methods 2:403-4. 2005