Research Topics
Genomes and Genes | Marcus ConradSummaryAffiliation: GSF-National Research Center for Environment and Health Country: Germany Publications
| Collaborators
|
Detail Information
Publications
Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammalsMarcus Conrad
Institute of Clinical Molecular Biology and Tumour Genetics, GSF National Research Center for Environment and Health, Marchioninistr 25, D 81377 Munich, Germany
Biol Chem 388:1019-25. 2007....
The role of thioredoxin reductases in brain developmentJonna Soerensen
Department of Comparative Medicine, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
PLoS ONE 3:e1813. 2008..Of note, neuron-specific inactivation of Txnrd1 did not result in cerebellar hypoplasia, suggesting a vital role for Txnrd1 in Bergmann glia or neuronal precursor cells...
Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell deathAlexander Seiler
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany
Cell Metab 8:237-48. 2008..Since oxidative stress is common in the etiology of many human disorders, the identified pathway reveals promising targets for future therapies...- Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4Marcus Conrad
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Marchioninistr 25, 81377 Munich, Germany
Biochim Biophys Acta 1790:1575-85. 2009.... - Optimized vector for conditional gene targeting in mouse embryonic stem cellsMarcus Conrad
Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Marchioninistr. 25, D-81377, Munich, Germany
Biotechniques 34:1136-8, 1140. 2003 - Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart functionMarcus Conrad
Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Marchioninistr 25, D 81377 Munich, Germany
Mol Cell Biol 24:9414-23. 2004..We conclude that TrxR2 plays a pivotal role in both hematopoiesis and heart function... - The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stabilityM Conrad
Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Munich, Germany
Mol Cell Biol 25:7637-44. 2005..We conclude that nPHGPx, by acting as a protein thiol peroxidase in vivo, contributes to the structural stability of sperm chromatin... - Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac developmentCemile Jakupoglu
Department of Comparative Medicine, Institute of Clinical Molecular Biology and Tumor Genetics, GSF, Marchioninistr 25, D 81377 Munich, Germany
Mol Cell Biol 25:1980-8. 2005..Our results indicate that Txnrd1 plays an essential role during embryogenesis in most developing tissues except the heart... - Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidaseManuela Schneider
Department of Comparative Medicine, GSF Research Centre for Environment and Health, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
Gene Expr Patterns 6:489-94. 2006..This strongly suggests that it is the cytosolic form of PHGPx that is indispensable for embryonic development... - Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activityManuela Schneider
Walter Brendel Center of Experimental Medicine, Ludwig Maximilians University, Marchioninistrasse 15, Munich, Germany
Neoplasia 12:254-63. 2010..Thus, we conclude that GPx4, through controlling 12/15-LOX activity, is an important regulator of tumor angiogenesis as well as vessel maturation... - Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivationPankaj Kumar Mandal
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany
Cancer Res 70:9505-14. 2010..Thus, our findings establish for the first time that a concomitant inhibition of the two major antioxidant systems is highly effective in killing tumor, highlighting a promising strategy to combat cancer... - Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzymeAlexander M Mannes
Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Clinical Molecular Biology and Tumor Genetics, Munich, Germany
FASEB J 25:2135-44. 2011..In summary, both catalytic efficiency and the expression level of GPx4 control the balance between cell survival and proliferation... - Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protectionJan Horstkotte
Medizinische Klinik und Poliklinik I, Munich Heart Alliance, Klinikum Grosshadern of the Ludwig Maximilians University, Munich, Germany
Circulation 124:2892-902. 2011..Here, we investigated whether mitochondrial thioredoxin reductase is protective against myocardial ischemia/reperfusion injury... - Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx)Stéphanie G Moreno
Institute of Clinical Molecular Biology and Tumor Genetics, GSF Research Centre for Environment and Health, Marchioninistr 25, D 81377 Munich, Germany
Biol Chem 384:635-43. 2003..These findings have to be taken into account when studying either the differential regulation of PHGPx and snGPx expression in testis or the impact of putative mutations in snGPx on male fertility in man... - B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenanceRoland Geisberger
Department of Comparative Medicine, GSF Research Centre for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
Biol Chem 388:1083-90. 2007..In addition, B-cell proliferation and activation in response to CD40 and IL-4 was unaltered in Txnrd2-deficient B-cells... - EpCAM is involved in maintenance of the murine embryonic stem cell phenotypeBárbara Gonzalez
Clinical Cooperation Group Molecular Oncology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, and Head and Neck Research Department, Ludwig Maximilians University of Munich, Munich, Germany
Stem Cells 27:1782-91. 2009..Thus, murine EpCAM is a transmembrane protein, which is essential but by itself is not sufficient for maintenance of the ES cell phenotype... - Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studiesMarcus Conrad
Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Marchioninistrasse 25, Munich, Germany
Antioxid Redox Signal 12:851-65. 2010..In this review, we focus on results obtained from the application of mouse molecular genetics in mouse physiology and discuss these insights into the physiological actions of selenoproteins in light of evidence from human genetics... - Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathyDirk Sibbing
Deutsches Herzzentrum Munchen, Munich, Germany
Eur Heart J 32:1121-33. 2011..Cardiac-specific deletion of Txnrd2 in mice results in dilated cardiomyopathy (DCM). The aim of this study was to investigate whether TXNRD2 mutations explain a fraction of monogenic DCM cases... - Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferationRob D Chapman
GSF Research Centre for Environment and Health, Institute for Clinical Molecular Biology and Tumour Genetics, Munich, Germany
Mol Cell Biol 25:7665-74. 2005..We conclude that all other nonconsensus CTD repeats are dispensable for the transcription and pre-mRNA processing of genes essential for proliferation... - Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrateClaudia Kiermayer
Department of Comparative Medicine, GSF Research Center for Environment and Health, Neuherberg, Germany
Genesis 45:11-6. 2007..p. Oral tamoxifen administration is thus a convenient and cost-saving way for gene induction, and, most importantly, it reduces stress and avoids adverse effects in mice...