Marcus Conrad

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. ncbi request reprint Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF National Research Center for Environment and Health, Marchioninistr 25, D 81377 Munich, Germany
    Biol Chem 388:1019-25. 2007
  2. pmc The role of thioredoxin reductases in brain development
    Jonna Soerensen
    Department of Comparative Medicine, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 3:e1813. 2008
  3. doi request reprint Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death
    Alexander Seiler
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany
    Cell Metab 8:237-48. 2008
  4. doi request reprint Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Marchioninistr 25, 81377 Munich, Germany
    Biochim Biophys Acta 1790:1575-85. 2009
  5. ncbi request reprint Optimized vector for conditional gene targeting in mouse embryonic stem cells
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Marchioninistr 25, D 81377, Munich, Germany
    Biotechniques 34:1136-8, 1140. 2003
  6. pmc Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Marchioninistr 25, D 81377 Munich, Germany
    Mol Cell Biol 24:9414-23. 2004
  7. pmc The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability
    M Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Munich, Germany
    Mol Cell Biol 25:7637-44. 2005
  8. pmc Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development
    Cemile Jakupoglu
    Department of Comparative Medicine, Institute of Clinical Molecular Biology and Tumor Genetics, GSF, Marchioninistr 25, D 81377 Munich, Germany
    Mol Cell Biol 25:1980-8. 2005
  9. ncbi request reprint Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase
    Manuela Schneider
    Department of Comparative Medicine, GSF Research Centre for Environment and Health, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    Gene Expr Patterns 6:489-94. 2006
  10. pmc Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity
    Manuela Schneider
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians University, Marchioninistrasse 15, Munich, Germany
    Neoplasia 12:254-63. 2010

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF National Research Center for Environment and Health, Marchioninistr 25, D 81377 Munich, Germany
    Biol Chem 388:1019-25. 2007
    ....
  2. pmc The role of thioredoxin reductases in brain development
    Jonna Soerensen
    Department of Comparative Medicine, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 3:e1813. 2008
    ..Of note, neuron-specific inactivation of Txnrd1 did not result in cerebellar hypoplasia, suggesting a vital role for Txnrd1 in Bergmann glia or neuronal precursor cells...
  3. doi request reprint Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death
    Alexander Seiler
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Marchioninistrasse 25, 81377 Munich, Germany
    Cell Metab 8:237-48. 2008
    ..Since oxidative stress is common in the etiology of many human disorders, the identified pathway reveals promising targets for future therapies...
  4. doi request reprint Transgenic mouse models for the vital selenoenzymes cytosolic thioredoxin reductase, mitochondrial thioredoxin reductase and glutathione peroxidase 4
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Marchioninistr 25, 81377 Munich, Germany
    Biochim Biophys Acta 1790:1575-85. 2009
    ....
  5. ncbi request reprint Optimized vector for conditional gene targeting in mouse embryonic stem cells
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Marchioninistr 25, D 81377, Munich, Germany
    Biotechniques 34:1136-8, 1140. 2003
  6. pmc Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Marchioninistr 25, D 81377 Munich, Germany
    Mol Cell Biol 24:9414-23. 2004
    ..We conclude that TrxR2 plays a pivotal role in both hematopoiesis and heart function...
  7. pmc The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability
    M Conrad
    Institute of Clinical Molecular Biology and Tumour Genetics, GSF Research Centre for Environment and Health, Munich, Germany
    Mol Cell Biol 25:7637-44. 2005
    ..We conclude that nPHGPx, by acting as a protein thiol peroxidase in vivo, contributes to the structural stability of sperm chromatin...
  8. pmc Cytoplasmic thioredoxin reductase is essential for embryogenesis but dispensable for cardiac development
    Cemile Jakupoglu
    Department of Comparative Medicine, Institute of Clinical Molecular Biology and Tumor Genetics, GSF, Marchioninistr 25, D 81377 Munich, Germany
    Mol Cell Biol 25:1980-8. 2005
    ..Our results indicate that Txnrd1 plays an essential role during embryogenesis in most developing tissues except the heart...
  9. ncbi request reprint Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase
    Manuela Schneider
    Department of Comparative Medicine, GSF Research Centre for Environment and Health, Ingolstaedter Landstr 1, D 85764 Neuherberg, Germany
    Gene Expr Patterns 6:489-94. 2006
    ..This strongly suggests that it is the cytosolic form of PHGPx that is indispensable for embryonic development...
  10. pmc Absence of glutathione peroxidase 4 affects tumor angiogenesis through increased 12/15-lipoxygenase activity
    Manuela Schneider
    Walter Brendel Center of Experimental Medicine, Ludwig Maximilians University, Marchioninistrasse 15, Munich, Germany
    Neoplasia 12:254-63. 2010
    ..Thus, we conclude that GPx4, through controlling 12/15-LOX activity, is an important regulator of tumor angiogenesis as well as vessel maturation...
  11. doi request reprint Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation
    Pankaj Kumar Mandal
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Munich, Germany
    Cancer Res 70:9505-14. 2010
    ..Thus, our findings establish for the first time that a concomitant inhibition of the two major antioxidant systems is highly effective in killing tumor, highlighting a promising strategy to combat cancer...
  12. doi request reprint Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme
    Alexander M Mannes
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Clinical Molecular Biology and Tumor Genetics, Munich, Germany
    FASEB J 25:2135-44. 2011
    ..In summary, both catalytic efficiency and the expression level of GPx4 control the balance between cell survival and proliferation...
  13. doi request reprint Mitochondrial thioredoxin reductase is essential for early postischemic myocardial protection
    Jan Horstkotte
    Medizinische Klinik und Poliklinik I, Munich Heart Alliance, Klinikum Grosshadern of the Ludwig Maximilians University, Munich, Germany
    Circulation 124:2892-902. 2011
    ..Here, we investigated whether mitochondrial thioredoxin reductase is protective against myocardial ischemia/reperfusion injury...
  14. ncbi request reprint Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx)
    Stéphanie G Moreno
    Institute of Clinical Molecular Biology and Tumor Genetics, GSF Research Centre for Environment and Health, Marchioninistr 25, D 81377 Munich, Germany
    Biol Chem 384:635-43. 2003
    ..These findings have to be taken into account when studying either the differential regulation of PHGPx and snGPx expression in testis or the impact of putative mutations in snGPx on male fertility in man...
  15. ncbi request reprint B- and T-cell-specific inactivation of thioredoxin reductase 2 does not impair lymphocyte development and maintenance
    Roland Geisberger
    Department of Comparative Medicine, GSF Research Centre for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Biol Chem 388:1083-90. 2007
    ..In addition, B-cell proliferation and activation in response to CD40 and IL-4 was unaltered in Txnrd2-deficient B-cells...
  16. doi request reprint EpCAM is involved in maintenance of the murine embryonic stem cell phenotype
    Bárbara Gonzalez
    Clinical Cooperation Group Molecular Oncology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, and Head and Neck Research Department, Ludwig Maximilians University of Munich, Munich, Germany
    Stem Cells 27:1782-91. 2009
    ..Thus, murine EpCAM is a transmembrane protein, which is essential but by itself is not sufficient for maintenance of the ES cell phenotype...
  17. doi request reprint Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies
    Marcus Conrad
    Institute of Clinical Molecular Biology and Tumor Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Marchioninistrasse 25, Munich, Germany
    Antioxid Redox Signal 12:851-65. 2010
    ..In this review, we focus on results obtained from the application of mouse molecular genetics in mouse physiology and discuss these insights into the physiological actions of selenoproteins in light of evidence from human genetics...
  18. doi request reprint Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy
    Dirk Sibbing
    Deutsches Herzzentrum Munchen, Munich, Germany
    Eur Heart J 32:1121-33. 2011
    ..Cardiac-specific deletion of Txnrd2 in mice results in dilated cardiomyopathy (DCM). The aim of this study was to investigate whether TXNRD2 mutations explain a fraction of monogenic DCM cases...
  19. pmc Role of the mammalian RNA polymerase II C-terminal domain (CTD) nonconsensus repeats in CTD stability and cell proliferation
    Rob D Chapman
    GSF Research Centre for Environment and Health, Institute for Clinical Molecular Biology and Tumour Genetics, Munich, Germany
    Mol Cell Biol 25:7665-74. 2005
    ..We conclude that all other nonconsensus CTD repeats are dispensable for the transcription and pre-mRNA processing of genes essential for proliferation...
  20. ncbi request reprint Optimization of spatiotemporal gene inactivation in mouse heart by oral application of tamoxifen citrate
    Claudia Kiermayer
    Department of Comparative Medicine, GSF Research Center for Environment and Health, Neuherberg, Germany
    Genesis 45:11-6. 2007
    ..p. Oral tamoxifen administration is thus a convenient and cost-saving way for gene induction, and, most importantly, it reduces stress and avoids adverse effects in mice...