Benedikt Berninger

Summary

Affiliation: GSF-National Research Center for Environment and Health
Country: Germany

Publications

  1. ncbi request reprint Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells
    Benedikt Berninger
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Eur J Neurosci 25:2581-90. 2007
  2. ncbi request reprint Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia
    Benedikt Berninger
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    J Neurosci 27:8654-64. 2007
  3. doi request reprint Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex
    Christophe Heinrich
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Protoc 6:214-28. 2011
  4. doi request reprint Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells
    Marisa Karow
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Schillerstrasse 46, D 80336 Munich, Germany
    Cell Stem Cell 11:471-6. 2012
  5. doi request reprint Neuronal network formation from reprogrammed early postnatal rat cortical glial cells
    Robert Blum
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Cereb Cortex 21:413-24. 2011
  6. pmc Directing astroglia from the cerebral cortex into subtype specific functional neurons
    Christophe Heinrich
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    PLoS Biol 8:e1000373. 2010
  7. doi request reprint Reprogramming of postnatal astroglia of the mouse neocortex into functional, synapse-forming neurons
    Christophe Heinrich
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Methods Mol Biol 814:485-98. 2012
  8. doi request reprint Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
    Felipe Ortega
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Cell Biol 15:602-13. 2013
  9. doi request reprint Primary culture and live imaging of adult neural stem cells and their progeny
    Felipe Ortega
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Methods Mol Biol 1052:1-11. 2013
  10. pmc Adult generation of glutamatergic olfactory bulb interneurons
    Monika S Brill
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Neurosci 12:1524-33. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Directing neurotransmitter identity of neurones derived from expanded adult neural stem cells
    Benedikt Berninger
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Eur J Neurosci 25:2581-90. 2007
    ..Thus, in-vitro expanded adult NSCs have the competence to become directed towards distinct functional neurotransmitter phenotypes when the appropriate transcriptional cues are provided...
  2. ncbi request reprint Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia
    Benedikt Berninger
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    J Neurosci 27:8654-64. 2007
    ..Our data demonstrate that single TFs are capable of inducing a remarkable functional reprogramming of astroglia toward a truly neuronal identity...
  3. doi request reprint Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex
    Christophe Heinrich
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Protoc 6:214-28. 2011
    ..Moreover, it can be a useful model for studies of lineage conversion from non-neuronal cells, with potential for brain regenerative medicine...
  4. doi request reprint Reprogramming of pericyte-derived cells of the adult human brain into induced neuronal cells
    Marisa Karow
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Schillerstrasse 46, D 80336 Munich, Germany
    Cell Stem Cell 11:471-6. 2012
    ..Our results raise the possibility of functional conversion of endogenous cells in the adult human brain to induced neuronal fates...
  5. doi request reprint Neuronal network formation from reprogrammed early postnatal rat cortical glial cells
    Robert Blum
    Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, 80336 Munich, Germany
    Cereb Cortex 21:413-24. 2011
    ..The "proof-of-principle" results imply that a single transcription factor may be sufficient to instruct a neuronal network from a glia-like cell source...
  6. pmc Directing astroglia from the cerebral cortex into subtype specific functional neurons
    Christophe Heinrich
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    PLoS Biol 8:e1000373. 2010
    ..Moreover, neuronal reprogramming of astroglia is not restricted to postnatal stages but can also be achieved from terminally differentiated astroglia of the adult cerebral cortex following injury-induced reactivation...
  7. doi request reprint Reprogramming of postnatal astroglia of the mouse neocortex into functional, synapse-forming neurons
    Christophe Heinrich
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Methods Mol Biol 814:485-98. 2012
    ..e., excitatory, and GABAergic, i.e., inhibitory, neurons, respectively...
  8. doi request reprint Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling
    Felipe Ortega
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Cell Biol 15:602-13. 2013
    ....
  9. doi request reprint Primary culture and live imaging of adult neural stem cells and their progeny
    Felipe Ortega
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Methods Mol Biol 1052:1-11. 2013
    ..Video time-lapse microscopy experiments using this cell preparation allow for studying the steps involved in the generation of fast-dividing precursors and neuroblasts from slow-dividing astroglia/NSCs...
  10. pmc Adult generation of glutamatergic olfactory bulb interneurons
    Monika S Brill
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich, Germany
    Nat Neurosci 12:1524-33. 2009
    ..Taken together, our data indicate that SEZ progenitors not only produce a population of adult-born glutamatergic juxtaglomerular neurons, but may also provide a previously unknown source of progenitors for endogenous repair...
  11. pmc Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb
    Aditi Deshpande
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    Proc Natl Acad Sci U S A 110:E1152-61. 2013
    ..The development of connectivity revealed by our study may suggest common principles for incorporating newly generated neurons into a preexisting circuit...
  12. doi request reprint Using an adherent cell culture of the mouse subependymal zone to study the behavior of adult neural stem cells on a single-cell level
    Felipe Ortega
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Germany
    Nat Protoc 6:1847-59. 2011
    ..This culture provides an experimental system for studying instructive or permissive effects of signal molecules on aNSC modes of cell division and lineage progression...
  13. doi request reprint A fight for survival: the challenges faced by a newborn neuron integrating in the adult hippocampus
    Matteo Bergami
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, Munich D 80336, Germany
    Dev Neurobiol 72:1016-31. 2012
    ....
  14. pmc A dlx2- and pax6-dependent transcriptional code for periglomerular neuron specification in the adult olfactory bulb
    Monika S Brill
    Department of Physiological Genomics, Institute of Physiology, Ludwig Maximilians University Munich, D 80336 Munich, Germany
    J Neurosci 28:6439-52. 2008
    ..Thus, Dlx2 wields a dual function by first instructing generic neurogenesis from adult precursors and subsequently specifying PGN subtypes in conjunction with Pax6...
  15. ncbi request reprint Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling
    Iris H Henn
    Department of Biochemistry, Adolf Butenandt Institute, D 80336 Munich, Germany
    J Neurosci 27:1868-78. 2007
    ..Thus, our results support a direct link between the neuroprotective activity of parkin and ubiquitin signaling in the IKK/NF-kappaB pathway...
  16. pmc Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes
    Matteo Bergami
    Department of Human and General Physiology, University of Bologna, I 40126 Bologna, Italy
    J Cell Biol 183:213-21. 2008
    ..Thus, astrocytes contain an endocytic compartment competent for pro-BDNF recycling, suggesting a specialized form of bidirectional communication between neurons and glia...
  17. ncbi request reprint Synaptic modification in neural circuits: a timely action
    Benedikt Berninger
    Department of Neuroimmunology, Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Bioessays 24:212-22. 2002
    ..Ultimately, this synaptic property might also be fundamental for the cognitive process by which we structure our experience through cause and effect relations...