Thomas Gp Grunewald

Summary

Country: Germany

Publications

  1. pmc The LIM and SH3 domain protein family: structural proteins or signal transducers or both?
    Thomas G P Grunewald
    Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Pediatric Oncology Center, Kolner Platz 1, D 80804 Munich, Germany
    Mol Cancer 7:31. 2008
  2. pmc Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma
    Thomas G P Grunewald
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstr, 12, D 97080 Wuerzburg, Germany
    BMC Cancer 7:198. 2007
  3. ncbi request reprint Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase
    Christian Keicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Biochem Biophys Res Commun 324:308-16. 2004
  4. ncbi request reprint Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells
    Thomas G P Grunewald
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Grombühlstr 12, D 97080 Wurzburg, Germany
    Exp Cell Res 312:974-82. 2006
  5. doi request reprint Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase
    Julia Traenka
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Thromb Haemost 102:520-8. 2009
  6. doi request reprint Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma
    Christopher Traenka
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Wuerzburg, Germany
    Cancer Res 70:8003-14. 2010
  7. pmc Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides
    Katharina Werner
    Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstrasse 12, Wuerzburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 384:169-76. 2011
  8. ncbi request reprint Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Endocrinol Metab 290:E423-33. 2006
  9. ncbi request reprint Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146
    Elke Butt
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 278:15601-7. 2003
  10. ncbi request reprint Dynamic interaction between Src and C-terminal Src kinase in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton
    Martin Vielreicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, D 97080 Wurzburg, Germany
    J Biol Chem 282:33623-31. 2007

Collaborators

  • Stepan Gambaryan
  • Elke Butt
  • Katrin Marcus
  • Ulrike Kammerer
  • Arnd Honig
  • Andrey Korshunov
  • Stefan M Pfister
  • Christof R Hauck
  • Jörg Geiger
  • Katharina Werner
  • Helmut E Meyer
  • Christopher Traenka
  • Julia Traenka
  • Martin Vielreicher
  • Christian Keicher
  • Yu Shi
  • Yoshiaki Hirako
  • Frank Schwede
  • Hans Gottfried Genieser
  • Hendrik Witt
  • Michael D Taylor
  • Marina Ryzhova
  • Thomas Hielscher
  • Jörg Felsberg
  • Stephanie Riester
  • Wolfram Scheurlen
  • Marc Remke
  • Guido Reifenberger
  • Paul A Northcott
  • Andreas von Deimling
  • Andreas E Kulozik
  • Axel Benner
  • Sebastian Bender
  • Peter Lichter
  • Albert Sickmann
  • Petra Thalheimer
  • Urs Lewandrowski
  • Achim Obergfell
  • Ulrich Walter
  • Gregory Harms
  • Elfriede Schulze
  • Annika Opitz
  • Cassian Sitaru
  • Achim D Gruber
  • Hans Dieter Volk
  • Kathrin Laabeta
  • Katsushi Owaribe
  • Yuji Nishizawa
  • Anke Friedrich
  • Matthias Gaestel
  • Alexey Kotlyarov
  • Detlef Zillikens

Detail Information

Publications14

  1. pmc The LIM and SH3 domain protein family: structural proteins or signal transducers or both?
    Thomas G P Grunewald
    Department of Pediatrics, Klinikum rechts der Isar, Technische Universitat Munchen, Pediatric Oncology Center, Kolner Platz 1, D 80804 Munich, Germany
    Mol Cancer 7:31. 2008
    ..The increased expression of LASP-1 in breast tumours correlates with high rates of nodal-metastasis and refers to a possible relevance as a prognostic marker...
  2. pmc Nuclear localization and cytosolic overexpression of LASP-1 correlates with tumor size and nodal-positivity of human breast carcinoma
    Thomas G P Grunewald
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstr, 12, D 97080 Wuerzburg, Germany
    BMC Cancer 7:198. 2007
    ....
  3. ncbi request reprint Phosphorylation of mouse LASP-1 on threonine 156 by cAMP- and cGMP-dependent protein kinase
    Christian Keicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Str 2, D 97080 Wurzburg, Germany
    Biochem Biophys Res Commun 324:308-16. 2004
    ..Immunoblotting of LASP-1 in various mouse and human tissues detected a similar prominent expression in non-muscle tissue. Altogether, our data suggest so far no functional differences between human and mouse LASP-1...
  4. ncbi request reprint Silencing of LASP-1 influences zyxin localization, inhibits proliferation and reduces migration in breast cancer cells
    Thomas G P Grunewald
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Grombühlstr 12, D 97080 Wurzburg, Germany
    Exp Cell Res 312:974-82. 2006
    ..The data provide evidence for an essential role of LASP-1 in tumor cell growth and migration, possibly by influencing the localization of zyxin...
  5. doi request reprint Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase
    Julia Traenka
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, D 97080 Wuerzburg, Germany
    Thromb Haemost 102:520-8. 2009
    ..Concomitant with adhesion, LASP-1 translocated from the cytosol along the arms of the pseudopodia into the leading lamellae of the spreading platelets, indicating a crucial role of the protein in platelet cytoskeleton rearrangement...
  6. doi request reprint Role of LIM and SH3 protein 1 (LASP1) in the metastatic dissemination of medulloblastoma
    Christopher Traenka
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Wuerzburg, Germany
    Cancer Res 70:8003-14. 2010
    ....
  7. pmc Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides
    Katharina Werner
    Institute for Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Grombuehlstrasse 12, Wuerzburg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 384:169-76. 2011
    ....
  8. ncbi request reprint Regulation of aldosterone production from zona glomerulosa cells by ANG II and cAMP: evidence for PKA-independent activation of CaMK by cAMP
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Wurzburg, Germany
    Am J Physiol Endocrinol Metab 290:E423-33. 2006
    ..Our results suggest that ZG cells, in addition to PKA and Epac/Rap proteins, contain other as yet unidentified cAMP mediator(s) involved in regulating CaMK activity and aldosterone secretion...
  9. ncbi request reprint Actin binding of human LIM and SH3 protein is regulated by cGMP- and cAMP-dependent protein kinase phosphorylation on serine 146
    Elke Butt
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, Josef Schneider Strasse 2, D 97080 Wurzburg, Germany
    J Biol Chem 278:15601-7. 2003
    ..Taken together, these data suggest that phosphorylation of LASP by cGK and cAK may be involved in cytoskeletal organization and cell motility...
  10. ncbi request reprint Dynamic interaction between Src and C-terminal Src kinase in integrin alphaIIbbeta3-mediated signaling to the cytoskeleton
    Martin Vielreicher
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wurzburg, D 97080 Wurzburg, Germany
    J Biol Chem 282:33623-31. 2007
    ..The novel experimental FRET approach reported here for the inactivation of Src can be readily applied to other integrin and signaling pathways, including closely related Src family kinase members...
  11. ncbi request reprint Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, Germany
    Blood 103:2593-600. 2004
    ..One explanation for these discrepancies is the novel finding that extracellular cGMP analogs potently and rapidly inhibit thrombin-, thromboxane-, and VWF-induced human platelet signaling and activation by a cGK-independent mechanism...
  12. ncbi request reprint The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini
    Yoshiaki Hirako
    J Invest Dermatol 121:1554-6. 2003
  13. pmc Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination
    Yu Shi
    Institute of Biochemistry, Medical School Hannover, 30625 Hannover, Germany
    Mol Cell Biol 23:7732-41. 2003
    ..We conclude that the differences between the phenotypes of MK5- and MK2-deficient mice result from clearly different functional properties of both enzymes...
  14. ncbi request reprint cGMP-dependent protein kinase type II regulates basal level of aldosterone production by zona glomerulosa cells without increasing expression of the steroidogenic acute regulatory protein gene
    Stepan Gambaryan
    Institute of Clinical Biochemistry and Pathobiochemistry Medical University Clinic Wuerzburg, Josef Schneider Strasse 2, 97080 Wuerzburg, Germany
    J Biol Chem 278:29640-8. 2003
    ..The results presented indicate that PKG II activity in ZG cells is important for maintaining basal aldosterone production...