Edna Grunblatt

Summary

Country: Germany

Publications

  1. ncbi Monoamine oxidase-B inhibition in Alzheimer's disease
    Peter Riederer
    Neurochemical Laboratory, Clinic for Psychiatry and Psychotherapy, Bayerische Julius Maximilians Universität Würzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Neurotoxicology 25:271-7. 2004
  2. ncbi Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat
    Edna Grunblatt
    Institute of Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Laboratories, Bayerische Julius Maximilians University of Würzburg, D 97080 Wurzburg, Germany
    J Alzheimers Dis 9:261-71. 2006
  3. ncbi Comparison analysis of gene expression patterns between sporadic Alzheimer's and Parkinson's disease
    Edna Grunblatt
    Neurochemistry Laboratory, National Parkinson Foundation Centre of Excellence Laboratories, Clinic and Policlinic for Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Alzheimers Dis 12:291-311. 2007
  4. ncbi Gene expression profile in streptozotocin rat model for sporadic Alzheimer's disease
    E Grunblatt
    Department of Neurochemistry, Clinic for Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 111:367-86. 2004
  5. ncbi The benefits of microarrays as tools for studying neuropsychiatric disorders
    Edna Grunblatt
    Bayerische Julius Maximilians University of Würzburg, Clinic for Psychiatry and Psychotherapy, Neurochemical Laboratory, Germany
    Drugs Today (Barc) 40:147-56. 2004
  6. ncbi Oxidative stress related markers in the "VITA" and the centenarian projects
    E Grunblatt
    Clinic for Psychiatry and Psychotherapy, Department Clinical Neurochemistry, Bayerische Julius Maximilians University, Fuchsleinstr 15, Wurzburg, Germany
    Neurobiol Aging 26:429-38. 2005
  7. ncbi Association study of BDNF and CNTF polymorphism to depression in non-demented subjects of the "VITA" study
    E Grunblatt
    Ludwig Boltzmann Society, L Boltzmann Institute of Aging Research, Vienna, Austria
    J Affect Disord 96:111-6. 2006
  8. ncbi Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
    Edna Grunblatt
    Clinical Neurochemistry and National Parkinson Foundation Centre of Excellence Laboratory, Clinic for Psychiatry and Psychotherapy, Bayrische Julius Maximilian University of Würzburg, Wurzburg, Germany
    J Neurochem 101:757-70. 2007
  9. doi Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study
    Edna Grunblatt
    Ludwig Boltzmann Society, L Boltzmann Institute of Aging Research, Vienna, Austria
    J Psychiatr Res 43:298-308. 2009
  10. doi Methyl- and acetyltransferases are stable epigenetic markers postmortem
    Camelia Maria Monoranu
    Department of Neuropathology, Institute of Pathology, University of Wurzburg, Wurzburg, Germany
    Cell Tissue Bank 12:289-97. 2011

Collaborators

Detail Information

Publications30

  1. ncbi Monoamine oxidase-B inhibition in Alzheimer's disease
    Peter Riederer
    Neurochemical Laboratory, Clinic for Psychiatry and Psychotherapy, Bayerische Julius Maximilians Universität Würzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Neurotoxicology 25:271-7. 2004
    ..This article gives a short review on MAO-B inhibitors and their mechanism for neuroprotective effects in AD...
  2. ncbi Gene expression alterations in brain areas of intracerebroventricular streptozotocin treated rat
    Edna Grunblatt
    Institute of Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Laboratories, Bayerische Julius Maximilians University of Würzburg, D 97080 Wurzburg, Germany
    J Alzheimers Dis 9:261-71. 2006
    ..Additionally, similarities to neuronal cell death in sporadic Alzheimer's disease may become apparent...
  3. ncbi Comparison analysis of gene expression patterns between sporadic Alzheimer's and Parkinson's disease
    Edna Grunblatt
    Neurochemistry Laboratory, National Parkinson Foundation Centre of Excellence Laboratories, Clinic and Policlinic for Psychiatry and Psychotherapy, University of Wurzburg, Germany
    J Alzheimers Dis 12:291-311. 2007
    ..Knowledge of selective gene expression profile can lead to better understanding of disease pathology and development of specific diagnosis and effective therapy...
  4. ncbi Gene expression profile in streptozotocin rat model for sporadic Alzheimer's disease
    E Grunblatt
    Department of Neurochemistry, Clinic for Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Neural Transm 111:367-86. 2004
    ..These pathways may reveal molecular events causing the neuronal death in SAD...
  5. ncbi The benefits of microarrays as tools for studying neuropsychiatric disorders
    Edna Grunblatt
    Bayerische Julius Maximilians University of Würzburg, Clinic for Psychiatry and Psychotherapy, Neurochemical Laboratory, Germany
    Drugs Today (Barc) 40:147-56. 2004
    ..Additionally, some current results from microarray technology conducted in neuropsychiatry are presented...
  6. ncbi Oxidative stress related markers in the "VITA" and the centenarian projects
    E Grunblatt
    Clinic for Psychiatry and Psychotherapy, Department Clinical Neurochemistry, Bayerische Julius Maximilians University, Fuchsleinstr 15, Wurzburg, Germany
    Neurobiol Aging 26:429-38. 2005
    ..These results point to the possibility that a combination of MAO-B and SOD activity levels might be useful tools for an early diagnosis of AD...
  7. ncbi Association study of BDNF and CNTF polymorphism to depression in non-demented subjects of the "VITA" study
    E Grunblatt
    Ludwig Boltzmann Society, L Boltzmann Institute of Aging Research, Vienna, Austria
    J Affect Disord 96:111-6. 2006
    ..Both these neurotrophic factors were intensely investigated with regard to depression without conclusive results...
  8. ncbi Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
    Edna Grunblatt
    Clinical Neurochemistry and National Parkinson Foundation Centre of Excellence Laboratory, Clinic for Psychiatry and Psychotherapy, Bayrische Julius Maximilian University of Würzburg, Wurzburg, Germany
    J Neurochem 101:757-70. 2007
    ..Brain insulin system dysfunction is discussed as possible pathological core in the generation of hyperphosphorylated tau protein as a morphological marker of sporadic Alzheimer's disease...
  9. doi Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study
    Edna Grunblatt
    Ludwig Boltzmann Society, L Boltzmann Institute of Aging Research, Vienna, Austria
    J Psychiatr Res 43:298-308. 2009
    ..In this study, we attempted to find various factors and markers for both AD and depression in a longitudinal cohort, the Vienna-Transdanube-Aging (VITA)-study...
  10. doi Methyl- and acetyltransferases are stable epigenetic markers postmortem
    Camelia Maria Monoranu
    Department of Neuropathology, Institute of Pathology, University of Wurzburg, Wurzburg, Germany
    Cell Tissue Bank 12:289-97. 2011
    ..In conclusion, preservation of acetyltransferase- and methyltransferase-activities provides possible evidence of stability for epigenetic studies using postmortem tissue...
  11. doi Association of a functional NOS1 promoter repeat with Alzheimer's disease in the VITA cohort
    Andreas Reif
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Alzheimers Dis 23:327-33. 2011
    ..As demonstrated, ex1f-VNTR interacted with the apolipoprotein E ε4 risk allele (OR in the presence of both risk alleles 3.63; 95% CI: 1.45-9.12). These findings provide further evidence for an association of NOS1 with AD...
  12. doi Genetic variation in the choline O-acetyltransferase gene in depression and Alzheimer's disease: the VITA and Milano studies
    Edna Grunblatt
    Ludwig Boltzmann Society, L Boltzmann Institute of Aging Research, Vienna, Austria
    J Psychiatr Res 45:1250-6. 2011
    ....
  13. doi Investigation of association of serotonin transporter and monoamine oxidase-A genes with Alzheimer's disease and depression in the VITA study cohort: a 90-month longitudinal study
    Claus Jürgen Scholz
    Interdisciplinary Centre for Clinical Research IZKF, University Hospital of Wurzburg, Wurzburg, Germany
    Am J Med Genet B Neuropsychiatr Genet 165:184-91. 2014
    ..Still, reinvestigation in a larger cohort similar to this, as well as a meta-analysis, is important to confirm these results...
  14. doi Increased xanthine oxidase in the thalamus and putamen in depression
    Tanja Maria Michel
    Neurochemistry Laboratory, Department of Psychiatry and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 11:314-20. 2010
    ..Our findings contribute to the growing body of evidence suggesting that oxidative stress plays a pivotal role in certain brain areas in recurrent depressive disorder...
  15. doi Pilot study: peripheral biomarkers for diagnosing sporadic Parkinson's disease
    Edna Grunblatt
    Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Research Laboratories, Neurochemistry Laboratory, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    J Neural Transm 117:1387-93. 2010
    ..This result supports previous studies of gene expression profiling and may facilitate the development of biomarkers for early diagnosis of PD...
  16. doi Alzheimer's disease and type 2 diabetes: two diseases, one common link?
    Jasmin Bartl
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 14:233-40. 2013
    ..AD may represent a brain-specific form of insulin resistance...
  17. doi Gene expression as peripheral biomarkers for sporadic Alzheimer's disease
    Edna Grunblatt
    Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Research Laboratories, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    J Alzheimers Dis 16:627-34. 2009
    ..In conclusion, gene expression profiling might be a promising method to investigating a large population with the aim of developing an early diagnosis of AD...
  18. doi Brain tryptophan rather than pH-value is altered as consequence of artificial postmortem interval and storage conditions
    Edna Grunblatt
    National Parkinson Foundation Centre of Excellence Research Laboratory, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    Neurochem Int 57:819-22. 2010
    ..In conclusion, from these results PMI intervals until autopsy should be kept as short as possible and storage until autopsy should be at 4°C in order to preserve brain tissue quality as much as possible...
  19. doi Altered mRNA expression of monoaminergic candidate genes in the blood of children with attention deficit hyperactivity disorder and autism spectrum disorder
    Regina Taurines
    Hospital of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 12:104-8. 2011
    ....
  20. ncbi Early impairment in dopaminergic neurotransmission in brains of SIV-infected rhesus monkeys due to microglia activation
    Carsten Scheller
    Institute for Virology and Immunobiology, University of Wurzburg, Wurzburg, Germany
    J Neurochem 95:377-87. 2005
    ..Our data demonstrate that putamen dopaminergic function is impaired during SIV infection and indicate that microglia may trigger endogenous mechanisms involved in the dysfunction of dopaminergic systems...
  21. doi Different effects of soluble and aggregated amyloid β42 on gene/protein expression and enzyme activity involved in insulin and APP pathways
    Jasmin Bartl
    Department of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Wurzburg, Wurzburg, Germany
    J Neural Transm 120:113-20. 2013
    ..MAO-B activity was enhanced after treatment with aggregated peptides and strongly inhibited after soluble Aβ(42) treatment. Our data might provide insights into selective effects of specific forms of Aβ(42) aggregates in AD...
  22. ncbi Association study of the 5-HTTLPR polymorphism and depression in 75-Year-Old nondemented subjects from the Vienna Transdanube Aging (VITA) study
    Edna Grunblatt
    Ludwig Boltzmann Society, Ludwig Boltzmann Institute of Aging Research, Vienna, Austria
    J Clin Psychiatry 67:1373-8. 2006
    ..We studied the association of this polymorphism in old age and depression in the Vienna Transdanube Aging (VITA) study, excluding subjects with dementia...
  23. ncbi Preclinical versus clinical neuroprotection
    Edna Grunblatt
    Department of Neurochemistry, Clinic and Polyclinic of Psychiatry and Psychotherapy, Bayerische Julius Maximilians University of Würzburg, Wurzburg, Germany
    Adv Neurol 91:309-28. 2003
  24. doi Diabetes type II: a risk factor for depression-Parkinson-Alzheimer?
    Peter Riederer
    Clinical Neurochemistry, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, National Parkinson Foundation Centre of Excellence Laboratories, University of Wurzburg, Fuchsleinstr 15, 97080 Wurzburg, Germany
    Neurotox Res 19:253-65. 2011
    ....
  25. doi Effects of methylphenidate: the cellular point of view
    Jasmin Bartl
    Clinical Neurochemistry Laboratory, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, University of Wurzburg, Germany
    Atten Defic Hyperact Disord 2:225-32. 2010
    ..These data point to diverse effects of MPH on cell metabolism independent of inhibiting DAT...
  26. doi The link between iron, metabolic syndrome, and Alzheimer's disease
    Edna Grunblatt
    Department of Child and Adolescent Psychiatry, University of Zurich, Neumuensterallee 9, 8032, Zurich, Switzerland
    J Neural Transm 118:371-9. 2011
    ..Therefore, this review sets to cover the current literature regarding OS and iron in MetS and T2DM and the similarities to mechanisms in AD both in human subjects as well as in animal models...
  27. doi Commonalities in the genetics of Alzheimer's disease and Parkinson's disease
    Edna Grunblatt
    University of Wurzburg, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, Neurochemistry Laboratory, Fuchsleinstr 15, D 97080 Wurzburg, Germany
    Expert Rev Neurother 8:1865-77. 2008
    ..Therefore, early and specific diagnosis is required as well as new therapy approaches for the growing burden of AD and PD...
  28. doi Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers
    Gerald Stober
    Department of Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Wurzburg, Germany
    World J Biol Psychiatry 10:127-55. 2009
    ....
  29. doi Tryptophan is a marker of human postmortem brain tissue quality
    Edna Grunblatt
    Clinical Neurochemistry, National Parkinson Foundation Centre of Excellence Research Laboratory, Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, University of Wurzburg, Fuchsleinstr 15, Würzburg D 97080, Germany
    J Neurochem 110:1400-8. 2009
    ..045) with increased postmortem interval; which might indicate increased protein degradation. Therefore, TRP concentration might be one useful and convenient marker for estimating the quality of human postmortem brain tissue...
  30. doi Is the treatment with psychostimulants in children and adolescents with attention deficit hyperactivity disorder harmful for the dopaminergic system?
    Manfred Gerlach
    Department for Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Wurzburg, Fuchsleinstrasse 15, 97080, Wurzburg, Germany
    Atten Defic Hyperact Disord 5:71-81. 2013
    ....