Carsten Gruendker

Summary

Country: Germany

Publications

  1. pmc In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol
    Robert Michael Hermann
    Department of Radiotherapy and Radiooncology, University Hospital Goettingen, Robert Koch Str, 40, 37075, Goettingen, Germany
    Radiat Oncol 3:19. 2008
  2. ncbi request reprint Gonadotropin-releasing hormone receptor-targeted gene therapy of gynecologic cancers
    Carsten Gründker
    Department of Gynecology and Obstetrics, Robert Koch Street 40, D 37099 Göttingen, Germany
    Mol Cancer Ther 4:225-31. 2005
  3. pmc Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, D 37075 Gottingen, Germany
    Reprod Biol Endocrinol 1:65. 2003
  4. doi request reprint Effective targeted chemotherapy using AEZS-108 (AN-152) for LHRH receptor-positive pancreatic cancers
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, Gottingen 37075, Germany
    Oncol Rep 26:629-35. 2011
  5. pmc Gonadotropin-releasing hormone type II antagonist induces apoptosis in MCF-7 and triple-negative MDA-MB-231 human breast cancer cells in vitro and in vivo
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, 37075 Gottingen, Germany
    Breast Cancer Res 12:R49. 2010
  6. doi request reprint GnRH-II antagonists induce apoptosis in human endometrial, ovarian, and breast cancer cells via activation of stress-induced MAPKs p38 and JNK and proapoptotic protein Bax
    Stefanie Fister
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Cancer Res 69:6473-81. 2009
  7. ncbi request reprint Gonadotropin-releasing hormone (GnRH) agonist triptorelin inhibits estradiol-induced serum response element (SRE) activation and c-fos expression in human endometrial, ovarian and breast cancer cells
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, D 37099 Göttingen, Germany
    Eur J Endocrinol 151:619-28. 2004
  8. ncbi request reprint Antiproliferative effects of antiestrogens and inhibitors of growth factor receptor signaling on endometrial cancer cells
    Martin Block
    Department of Gynaecology and Obstetrics, Georg August University, Gottingen, Germany
    Anticancer Res 30:2025-31. 2010
  9. ncbi request reprint Increase of doxorubicin-induced apoptosis after knock-down of gonadotropin-releasing hormone receptor expression in human endometrial, ovarian and breast cancer cells
    Stefanie Fister
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Gynecol Endocrinol 24:24-9. 2008
  10. doi request reprint Expression of osteoprotegerin and receptor activator of nuclear factor-kappaB ligand (RANKL) in HCC70 breast cancer cells and effects of treatment with gonadotropin-releasing hormone on RANKL expression
    Antje Schubert
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Gynecol Endocrinol 24:331-8. 2008

Collaborators

Detail Information

Publications44

  1. pmc In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol
    Robert Michael Hermann
    Department of Radiotherapy and Radiooncology, University Hospital Goettingen, Robert Koch Str, 40, 37075, Goettingen, Germany
    Radiat Oncol 3:19. 2008
    ..As the majority of prostate cancers (PC) express estrogen receptors, we evaluated the combination of radiation and estrogenic stimulation (estrogen and genistein) on the radiosensitivity of PC cells in vitro...
  2. ncbi request reprint Gonadotropin-releasing hormone receptor-targeted gene therapy of gynecologic cancers
    Carsten Gründker
    Department of Gynecology and Obstetrics, Robert Koch Street 40, D 37099 Göttingen, Germany
    Mol Cancer Ther 4:225-31. 2005
    ....
  3. pmc Role of gonadotropin-releasing hormone (GnRH) in ovarian cancer
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, D 37075 Gottingen, Germany
    Reprod Biol Endocrinol 1:65. 2003
    ..These data suggest that in ovarian cancer cells the antiproliferative effects of GnRH-I antagonist Cetrorelix and GnRH-II are not mediated through the GnRH-I receptor...
  4. doi request reprint Effective targeted chemotherapy using AEZS-108 (AN-152) for LHRH receptor-positive pancreatic cancers
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, Gottingen 37075, Germany
    Oncol Rep 26:629-35. 2011
    ..The cytotoxic LHRH agonist AEZS-108 (AN-152) seems to be a suitable drug for treatment of LHRH receptor-positive human pancreatic cancers with little toxicity...
  5. pmc Gonadotropin-releasing hormone type II antagonist induces apoptosis in MCF-7 and triple-negative MDA-MB-231 human breast cancer cells in vitro and in vivo
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, 37075 Gottingen, Germany
    Breast Cancer Res 12:R49. 2010
    ..In addition, we ascertained whether knockdown of GnRH-I receptor expression affects GnRH-II antagonist-induced apoptosis and apoptotic signaling...
  6. doi request reprint GnRH-II antagonists induce apoptosis in human endometrial, ovarian, and breast cancer cells via activation of stress-induced MAPKs p38 and JNK and proapoptotic protein Bax
    Stefanie Fister
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Cancer Res 69:6473-81. 2009
    ....
  7. ncbi request reprint Gonadotropin-releasing hormone (GnRH) agonist triptorelin inhibits estradiol-induced serum response element (SRE) activation and c-fos expression in human endometrial, ovarian and breast cancer cells
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, D 37099 Göttingen, Germany
    Eur J Endocrinol 151:619-28. 2004
    ..In this study, we demonstrate that the GnRH agonist triptorelin inhibits estradiol (E2)-induced cancer cell proliferation...
  8. ncbi request reprint Antiproliferative effects of antiestrogens and inhibitors of growth factor receptor signaling on endometrial cancer cells
    Martin Block
    Department of Gynaecology and Obstetrics, Georg August University, Gottingen, Germany
    Anticancer Res 30:2025-31. 2010
    ..The aim of our study was to investigate single-agent and dual-agent therapeutic strategies in estrogen receptor-positive human EC cells...
  9. ncbi request reprint Increase of doxorubicin-induced apoptosis after knock-down of gonadotropin-releasing hormone receptor expression in human endometrial, ovarian and breast cancer cells
    Stefanie Fister
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Gynecol Endocrinol 24:24-9. 2008
    ..After knock-down of GnRH receptor expression doxorubicin-induced apoptosis was decreased, indicating that GnRH agonists do not suppress chemotherapeutic drug-induced apoptosis in T-47-D breast cancer cells...
  10. doi request reprint Expression of osteoprotegerin and receptor activator of nuclear factor-kappaB ligand (RANKL) in HCC70 breast cancer cells and effects of treatment with gonadotropin-releasing hormone on RANKL expression
    Antje Schubert
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Gynecol Endocrinol 24:331-8. 2008
    ..Since the osteolytic activity depends on the receptor activator of nuclear factor-kappaB (NFkappaB) ligand (RANKL)/osteoprotegerin (OPG) ratio, we analyzed RANKL and OPG expression in different breast-cancer cell lines...
  11. ncbi request reprint Gonadotropin-releasing hormone type II antagonists induce apoptotic cell death in human endometrial and ovarian cancer cells in vitro and in vivo
    Stefanie Fister
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, D 37075 Gottingen, Germany
    Cancer Res 67:1750-6. 2007
    ..Thus, GnRH-II antagonists seem to be suitable drugs for an efficacious and less toxic endocrine therapy for endometrial and ovarian cancers...
  12. doi request reprint Luteinizing hormone-releasing hormone receptor-targeted chemotherapy using AN-152
    Gunter Emons
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Neuroendocrinology 90:15-8. 2009
    ..A phase II study was started in January 2008...
  13. doi request reprint Targeted chemotherapy for triple-negative breast cancers via LHRH receptor
    Crispin Föst
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Oncol Rep 25:1481-7. 2011
    ..The cytotoxic LHRH agonist AEZS-108 (AN-152) seems to be a suitable drug for an efficacious therapy for triple-negative breast cancers with little toxicity...
  14. ncbi request reprint Luteinizing hormone-releasing hormone induces JunD-DNA binding and extends cell cycle in human ovarian cancer cells
    Andreas R Günthert
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, D 37075 Gottingen, Germany
    Biochem Biophys Res Commun 294:11-5. 2002
    ....
  15. ncbi request reprint GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs
    Nicola Eicke
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, D 37075 Gottingen, Germany
    Eur J Endocrinol 153:605-12. 2005
    ..Western blot analysis of the same gel using rabbit anti-human GnRH-II receptor antiserum identified this band as GnRH-II receptor-like antigen...
  16. ncbi request reprint Analyzes of three common thrombophilic gene mutations in German women with recurrent abortions
    Hans Ulrich Pauer
    Department of Gynecology and Obstetrics, University of Goettingen, Goettingen, Germany
    Acta Obstet Gynecol Scand 82:942-7. 2003
    ..Several etiological factors have been proposed as a cause for recurrent fetal abortions. Changes in blood coagulation during pregnancy may play an important role in the occurrence of recurrent abortions (RA)...
  17. ncbi request reprint Analogs of GnRH-I and GnRH-II inhibit epidermal growth factor-induced signal transduction and resensitize resistant human breast cancer cells to 4OH-tamoxifen
    Andreas R Günthert
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, D 37075 Gottingen, Germany
    Eur J Endocrinol 153:613-25. 2005
    ..Through this mechanism, they probably reverse acquired resistance to 4OH-tamoxifen mediated through overexpression or activation of receptors of the c-erbB family...
  18. ncbi request reprint Antiproliferative effects of the GnRH antagonist cetrorelix and of GnRH-II on human endometrial and ovarian cancer cells are not mediated through the GnRH type I receptor
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, D 37070 Gottingen, Germany
    Eur J Endocrinol 151:141-9. 2004
    ..We were also able to show that the proliferation of human endometrial and ovarian cancer cells was dose- and time-dependently reduced by GnRH-II to a greater extent than by GnRH-I agonists...
  19. doi request reprint Signal transduction of the melatonin receptor MT1 is disrupted in breast cancer cells by electromagnetic fields
    Rainer Girgert
    Department of Gynecology and Obstetrics, University of Gottingen, Gottingen, Germany
    Bioelectromagnetics 31:237-45. 2010
    ..These results convincingly prove the negative effect of EMF on the antiestrogenic effect of melatonin in breast cancer cells...
  20. doi request reprint Kisspeptin-10 inhibits bone-directed migration of GPR54-positive breast cancer cells: Evidence for a dose-window effect
    Teresa Olbrich
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Gynecol Oncol 119:571-8. 2010
    ..In this study we have analyzed whether Kp-10 treatment affects bone-directed migration of GPR54-positive breast cancer cells...
  21. ncbi request reprint Luteinizing hormone-releasing hormone (LHRH) inhibits apoptosis induced by cytotoxic agent and UV-light but not apoptosis mediated through CD95 in human ovarian and endometrial cancer cells
    Andreas R Günthert
    Department of Gynecology and Obstetrics, Georg August University, D 37075 Gottingen, Germany
    Anticancer Res 24:1727-32. 2004
    ..LHRH analogs protect human endometrial and ovarian cancer cells from DNA-replication-dependent cytotoxic agent and UV-light-induced apoptosis, but not from CD95-mediated apoptosis...
  22. ncbi request reprint Electromagnetic fields alter the expression of estrogen receptor cofactors in breast cancer cells
    Rainer Girgert
    Department of Gynecology and Obstetrics, University of Gottingen, Gottingen, Germany
    Bioelectromagnetics 29:169-76. 2008
    ..Electromagnetic fields may contribute to the induction of tamoxifen resistance in vivo...
  23. ncbi request reprint Expression of gonadotropin-releasing hormone II (GnRH-II) receptor in human endometrial and ovarian cancer cells and effects of GnRH-II on tumor cell proliferation
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, D 37070 Gottingen, Germany
    J Clin Endocrinol Metab 87:1427-30. 2002
    ..001). In the GnRH-II receptor positive but GnRH-I receptor negative ovarian cancer cell line SK-OV-3 native GnRH-II but not GnRH-I agonist Triptorelin had antiproliferative effects...
  24. ncbi request reprint Hormonal heterogeneity of endometrial cancer
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Adv Exp Med Biol 630:166-88. 2008
    ..This chapter reviews the current knowledge of the molecular mechanisms commonly associated with development of type I and type II endometrial cancer...
  25. ncbi request reprint Internalization of cytotoxic analog AN-152 of luteinizing hormone-releasing hormone induces apoptosis in human endometrial and ovarian cancer cell lines independent of multidrug resistance-1 (MDR-1) system
    Andreas R Günthert
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Strasse 40, D 37075 Gottingen, Germany
    Am J Obstet Gynecol 191:1164-72. 2004
    ..The surface expression of multidrug resistance-1 (MDR-1) gene product P-glycoprotein (Pgp) was measured by flow cytometry...
  26. ncbi request reprint Induction of apoptosis by AN-152, a cytotoxic analog of luteinizing hormone-releasing hormone (LHRH), in LHRH-R positive human breast cancer cells is independent of multidrug resistance-1 (MDR-1) system
    Andreas R Günthert
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Breast Cancer Res Treat 87:255-64. 2004
    ..These receptors can be used for targeted chemotherapy with agents like AN-152, in which doxorubicin is linked to analog [D-Lys6]LHRH. We compared the effects of AN-152 and doxorubicin in human breast cancer cells...
  27. ncbi request reprint Funneling before and after anti-incontinence surgery--a prognostic indicator? Part 2: tension-free vaginal tape
    Lena Harms
    Department of Gynecology and Obstetrics, Georg August University Goettingen, Goettingen, Germany
    Int Urogynecol J Pelvic Floor Dysfunct 18:289-94. 2007
    ..The TVT procedure significantly reduces bladder neck funneling. Both preoperative and persistent postoperative funneling are associated with an increased probability of therapeutic failure or recurrence...
  28. ncbi request reprint Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts
    Volker Viereck
    Department of Obstetrics and Gynecology, Georg August University of Goettingen, Goettingen, D 37075, Germany
    Biochem Biophys Res Commun 291:680-6. 2002
    ..Since, OPG production increases with osteoblastic cell maturation, enhancement of OPG by bisphosphonates could be related to their stimulatory effects on osteoblastic differentiation...
  29. ncbi request reprint Raloxifene concurrently stimulates osteoprotegerin and inhibits interleukin-6 production by human trabecular osteoblasts
    Volker Viereck
    Department of Obstetrics and Gynecology, Georg August University of Goettingen, Goettingen, Germany D 37075
    J Clin Endocrinol Metab 88:4206-13. 2003
    ..Because OPG production increases with osteoblastic maturation, enhancement of OPG production by raloxifene could be related to its stimulatory effects on osteoblastic differentiation...
  30. doi request reprint Exposure of mcf-7 breast cancer cells to electromagnetic fields up-regulates the plasminogen activator system
    Rainer Girgert
    Department of Obstetrics and Gynecology, University of Gottingen, Germany
    Int J Gynecol Cancer 19:334-8. 2009
    ..The use of our newly established exposure system for EMFs may allow us to study the signaling processes involved in the induction of a metastatic phenotype of breast cancer cells...
  31. doi request reprint Dose escalation and pharmacokinetic study of AEZS-108 (AN-152), an LHRH agonist linked to doxorubicin, in women with LHRH receptor-positive tumors
    Gunter Emons
    University Clinic Göttingen, Gottingen, Germany
    Gynecol Oncol 119:457-61. 2010
    ..The objectives of this first study in humans with AESZ-108 were to determine the maximum tolerated dose and to characterize the dose-limiting toxicity, pharmacokinetics, preliminary efficacy, and hormonal effects...
  32. ncbi request reprint Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts
    Volker Viereck
    Department of Obstetrics and Gynecology, Georg August University of Goettingen, Germany
    J Cell Biochem 84:725-35. 2002
    ..Thus, dietary sources of phytoestrogens may help to prevent bone resorption and bone loss by enhanced osteoblastic production of OPG...
  33. ncbi request reprint Recurrent pregnancy loss and its relation to FV Leiden, FII G20210A and polymorphisms of plasminogen activator and plasminogen activator inhibitor
    Cornelia E Wolf
    Department of Transfusion Medicine, University of Gottingen, Gottingen, Germany
    Pathophysiol Haemost Thromb 33:134-7. 2003
    ..9/49 women with RPL showed coagulation disorders with heterozygous FV Leiden mutation (5), FXII (1), protein C (1) or protein S (2) deficiency. However, due to the small number of patients studied, no definite conclusion can be drawn...
  34. ncbi request reprint Isopropanolic extract of black cohosh stimulates osteoprotegerin production by human osteoblasts
    Volker Viereck
    Department of Obstetrics and Gynecology, Georg August University of Gottingen, Gottingen, Germany
    J Bone Miner Res 20:2036-43. 2005
    ..The iCR effect, abrogated by the pure estrogen receptor antagonist ICI 182,780, also enhanced ALP activity (4-fold) and osteocalcin expression (3-fold), possibly contributing to the skeletal effects of black cohosh...
  35. ncbi request reprint Mesengenic progenitor cells derived from human placenta
    Gerald G Wulf
    Department of Hematology and Oncology, Georg August University Goettingen, 37075 Goettingen, Germany
    Tissue Eng 10:1136-47. 2004
    ..In conclusion, we propose human term placenta as an easily accessible, ample source of multipotent mesengenic progenitor cells...
  36. ncbi request reprint GnRH-II agonist [D-Lys6]GnRH-II inhibits the EGF-induced mitogenic signal transduction in human endometrial and ovarian cancer cells
    Nicola Eicke
    Department of Gynecology and Obstetrics, Georg August University, D 37070 Gottingen, Germany
    Int J Oncol 29:1223-9. 2006
    ..These data indicate, that the effects of GnRH-II are not due to a cross-reaction with the GnRH-I receptor. In conclusion these data suggest that the signaling of GnRH-II agonist [D-Lys6]GnRH-II is comparable to that of GnRH-I analogs...
  37. ncbi request reprint GnRH analogs reduce invasiveness of human breast cancer cells
    Julia von Alten
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, D 37075 Gottingen, Germany
    Breast Cancer Res Treat 100:13-21. 2006
    ..Their proliferation is time- and dose-dependently reduced by GnRH-I and GnRH-II agonists by counteracting of the mitogenic signal transduction...
  38. doi request reprint Agonists and antagonists of GnRH-I and -II reduce metastasis formation by triple-negative human breast cancer cells in vivo
    Antje Schubert
    Department of Gynecology and Obstetrics, Georg August University, Robert Koch Street 40, 37075 Gottingen, Germany
    Breast Cancer Res Treat 130:783-90. 2011
    ..Side effects were not detectable. In conclusion, GnRH analogs seem to be suitable drugs for an efficacious therapy for triple-negative, GnRH receptor-positive human breast cancers to prevent metastasis formation...
  39. ncbi request reprint Factor XII deficiency is strongly associated with primary recurrent abortions
    Hans Ulrich Pauer
    Department of Gynecology and Obstetrics, University Hospital of Goettingen, Goettingen, Germany
    Fertil Steril 80:590-4. 2003
    ..To evaluate factor XII deficiency in women with primary and secondary recurrent abortion...
  40. ncbi request reprint Biology of the gonadotropin-releasing hormone system in gynecological cancers
    Carsten Gründker
    Department of Gynecology and Obstetrics, Georg August University of Gottingen, Robert Koch Strasse 40, D 37070 Gottingen, Germany
    Eur J Endocrinol 146:1-14. 2002
    ..Furthermore, GnRH induces activation of the c-Jun N-terminal kinase/activator protein-1 (AP-1) pathway independent of the known AP-1 activators, protein kinase or mitogen activated protein kinase...
  41. doi request reprint Sertoli-Leydig cell tumour in a 13-year-old girl
    Bettina Bottcher
    Department of Gynecology and Obstetrics, Georg August University Gottingen, Robert Koch Strasse, 37077 Gottingen, Germany
    Gynecol Endocrinol 27:107-9. 2011
    ..We describe the case of a Sertoli-Leydig cell tumour in a 13-year-old girl who presented with symptoms of hyperandrogenism. We give an overview over current literature and discuss options of therapy of rare Sertoli-Leydig cell tumours...
  42. ncbi request reprint Atorvastatin stimulates the production of osteoprotegerin by human osteoblasts
    Volker Viereck
    Department of Obstetrics and Gynecology, Georg August University, Goettingen, Germany
    J Cell Biochem 96:1244-53. 2005
    ..In summary, our data suggest that atorvastatin enhances osteoblastic differentiation and production of OPG. This may contribute to the bone-sparing effects of statins...
  43. ncbi request reprint Urethral hypermobility after anti-incontinence surgery - a prognostic indicator?
    Volker Viereck
    Department of Gynecology and Obstetrics, Georg August University Goettingen, Goettingen, Germany
    Int Urogynecol J Pelvic Floor Dysfunct 17:586-92. 2006
    ..Patients in whom hypermobility of the bladder neck diagnosed before surgery persists after colposuspension have a higher risk of recurrence and are more likely to develop postoperative complications than those without this hypermobility...
  44. doi request reprint Peripartum cardiomyopathy--a new treatment option by inhibition of prolactin secretion
    Boriana G Jahns
    Department of Gynecology and Obstetrics, Georg August University, Gottingen, Germany
    Am J Obstet Gynecol 199:e5-6. 2008
    ..Recent experimental data implicate a causal role of prolactin. We report a patient with PPCM who responded well to treatment with Bromocriptine in addition to standard therapy of heart failure...