A D Gruber

Summary

Country: Germany

Publications

  1. pmc Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation
    Marcus Gereke
    Immune Regulation Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Respir Res 8:47. 2007
  2. pmc Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity
    Asja Wagener
    Humboldt Universitat zu Berlin, Department for Crop and Animal Sciences, Invalidenstraße 42, 10115 Berlin, Germany
    Lipids Health Dis 9:99. 2010
  3. pmc HEPACAM1 and 2 are differentially regulated in canine mammary adenomas and carcinomas and its lymph node metastases
    Robert Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    BMC Vet Res 6:15. 2010
  4. pmc Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles
    Robert Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    BMC Cancer 10:618. 2010
  5. pmc THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo
    Annalisa Mancini
    Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl Neuberg Str, 1, D 30623 Hannover, Germany
    BMC Biol 8:1. 2010
  6. doi request reprint Peliosis hepatis in cats is not associated with Bartonella henselae infections
    A U Buchmann
    Department of Veterinary Pathology, Freie Universitaet Berlin, Robert von Ostertag Strasse 15, Berlin, Germany
    Vet Pathol 47:163-6. 2010
  7. ncbi request reprint Unusual biphasic disease in domestic pigeons (Columba livia f. domestica) following experimental infection with Sarcocystis calchasi
    P Olias
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    Avian Dis 54:1032-7. 2010
  8. doi request reprint Tandem duplication of KIT exon 11 influences the proteome of canine mast cell tumours
    P Schlieben
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163, Berlin, Germany
    J Comp Pathol 148:318-22. 2013
  9. doi request reprint The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163, Berlin, Germany
    Vet Pathol 47:446-54. 2010
  10. doi request reprint RAD51 protein expression is increased in canine mammary carcinomas
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, Berlin, Germany
    Vet Pathol 47:98-101. 2010

Collaborators

Detail Information

Publications42

  1. pmc Phenotypic alterations in type II alveolar epithelial cells in CD4+ T cell mediated lung inflammation
    Marcus Gereke
    Immune Regulation Group, Helmholtz Centre for Infection Research, Braunschweig, Germany
    Respir Res 8:47. 2007
    ..This model was utilized to assess the profile of inflammatory mediators expressed by alveolar epithelial target cells triggered by antigen-specific recognition in CD4+ T cell-mediated lung inflammation...
  2. pmc Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity
    Asja Wagener
    Humboldt Universitat zu Berlin, Department for Crop and Animal Sciences, Invalidenstraße 42, 10115 Berlin, Germany
    Lipids Health Dis 9:99. 2010
    ..Here, we studied the expression patterns of the different Ppar genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes...
  3. pmc HEPACAM1 and 2 are differentially regulated in canine mammary adenomas and carcinomas and its lymph node metastases
    Robert Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    BMC Vet Res 6:15. 2010
    ..The role and expression pattern of HEPACAM2 has not been analyzed so far. In the present study we quantified gene expression levels of HEPACAM1 and 2 to evaluate their possible role during the carcinogenesis of canine mammary tumours...
  4. pmc Metastatic canine mammary carcinomas can be identified by a gene expression profile that partly overlaps with human breast cancer profiles
    Robert Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    BMC Cancer 10:618. 2010
    ..In this study, we analyzed the gene expression signatures associated with mammary tumor metastasis and asked for parallels with the human equivalent...
  5. pmc THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo
    Annalisa Mancini
    Institut fuer Biochemie, OE4310, Medizinische Hochschule Hannover, Carl Neuberg Str, 1, D 30623 Hannover, Germany
    BMC Biol 8:1. 2010
    ..THO complex (THOC) components are not essential for bulk poly (A)+ RNA export in higher eukaryotes, but for the nuclear export of subset of mRNAs, however, their exact role is still unclear...
  6. doi request reprint Peliosis hepatis in cats is not associated with Bartonella henselae infections
    A U Buchmann
    Department of Veterinary Pathology, Freie Universitaet Berlin, Robert von Ostertag Strasse 15, Berlin, Germany
    Vet Pathol 47:163-6. 2010
    ..henselae nucleic acid or antigen in any of the affected liver specimens. These findings suggest that, unlike in humans and dogs, peliosis hepatis in cats may not be significantly associated with a B. henselae infection...
  7. ncbi request reprint Unusual biphasic disease in domestic pigeons (Columba livia f. domestica) following experimental infection with Sarcocystis calchasi
    P Olias
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    Avian Dis 54:1032-7. 2010
    ..The findings further characterize the new highly pathogenic disease in domestic pigeons, which clinically mimics paramyxovirosis and salmonellosis in both phases of the disease and exclude chickens as further intermediate host species...
  8. doi request reprint Tandem duplication of KIT exon 11 influences the proteome of canine mast cell tumours
    P Schlieben
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163, Berlin, Germany
    J Comp Pathol 148:318-22. 2013
    ....
  9. doi request reprint The combined expression pattern of BMP2, LTBP4, and DERL1 discriminates malignant from benign canine mammary tumors
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163, Berlin, Germany
    Vet Pathol 47:446-54. 2010
    ..This pilot study identified a complex mRNA expression pattern of 3 genes that was able to identify malignancy in laser-microdissected tumor cells for each individual tumor, instead of group means as used in previous studies...
  10. doi request reprint RAD51 protein expression is increased in canine mammary carcinomas
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, Berlin, Germany
    Vet Pathol 47:98-101. 2010
    ..Nevertheless, the increased RAD51 mRNA expression in metastases could not be confirmed by immunohistochemistry...
  11. doi request reprint Loss of p27 expression in canine mammary tumors and their metastases
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    Res Vet Sci 88:300-3. 2010
    ....
  12. doi request reprint Canine cutaneous peripheral nerve sheath tumours versus fibrosarcomas can be differentiated by neuroectodermal marker genes in their transcriptome
    R Klopfleisch
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    J Comp Pathol 148:197-205. 2013
    ..Furthermore, the genes associated with the fibrosarcoma phenotype may serve as markers to differentiate fibrosarcomas from other tumour types...
  13. doi request reprint Potential markers for detection of circulating canine mammary tumor cells in the peripheral blood
    A Da Costa
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    Vet J 190:165-8. 2011
    ..These CTC markers are thus candidate markers for identifying canine mammary CTC in the peripheral blood and may serve as prognostic factors for metastatic behavior in the future...
  14. doi request reprint Increased Derlin-1 expression in metastases of canine mammary adenocarcinomas
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, Germany
    J Comp Pathol 142:79-83. 2010
    ..Weak Derl-1 protein expression was also found in vascular endothelial cells and fibrocytes and occasionally in lymphatic lining cells...
  15. doi request reprint Insulin receptor is expressed in normal canine mammary gland and benign adenomas but decreased in metastatic canine mammary carcinomas similar to human breast cancer
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    Vet Comp Oncol 8:293-301. 2010
    ..However, decreased INSR expression carcinomas and their metastases render questionable its impact at late stages of carcinogenesis...
  16. doi request reprint Canine cutaneous histiocytomas are clonal lesions as defined by X-linked clonality testing
    N M Delcour
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Str 15, 14163 Berlin, Germany
    J Comp Pathol 149:192-8. 2013
    ..Analysis of 11 histiocytomas identified a non-random X chromosome inactivation of one androgen receptor allele. CCH may, therefore, be a clonal lesion and of neoplastic nature. ..
  17. doi request reprint Iron overload syndrome in the black rhinoceros (Diceros bicornis): microscopical lesions and comparison with other rhinoceros species
    P Olias
    Department of Veterinary Pathology, Faculty of Veterinary Medicine, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Comp Pathol 147:542-9. 2012
    ....
  18. doi request reprint Identification of six potential markers for the detection of circulating canine mammary tumour cells in the peripheral blood identified by microarray analysis
    A Da Costa
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    J Comp Pathol 146:143-51. 2012
    ..The six mRNA markers may be suitable for detection of canine mammary CTCs and allow the analysis of their spatiotemporal distribution in dogs with mammary tumours...
  19. doi request reprint Differences in the proteome of high-grade versus low-grade canine cutaneous mast cell tumours
    P Schlieben
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    Vet J 194:210-4. 2012
    ..It is noteworthy that some of the proteins identified have been proposed as therapeutic targets for human oncology and it will be interesting to evaluate their therapeutic and diagnostic potential for canine MCTs...
  20. doi request reprint All subunits of the interleukin-2 receptor are expressed by canine cutaneous mast cell tumours
    A Meyer
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Comp Pathol 149:19-29. 2013
    ..The decrease in IL-2R expression with increasing histological evidence of malignancy suggests that the IL-2R may be more relevant for early MCT development and well-differentiated tumours...
  21. doi request reprint The metastatic cascade is reflected in the transcriptome of metastatic canine mammary carcinomas
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    Vet J 190:236-43. 2011
    ..Gene expression profiling of metastatic carcinomas, therefore, identified molecular pathways and functional gene families that are deregulated during malignant progression in canine mammary tumors...
  22. doi request reprint Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas
    R Klopfleisch
    Institute of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    Vet Pathol 46:416-22. 2009
    ..Further experimental studies are needed to clarify whether these changes in gene expression are a direct carcinogenetic stimulus or a protective response due to genetic instability during tumor progression...
  23. doi request reprint Iron storage disease in red deer (Cervus elaphus elaphus) is not associated with mutations in the HFE gene
    P Olias
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, 14163 Berlin, Germany
    J Comp Pathol 145:207-13. 2011
    ....
  24. doi request reprint Derlin-1 and stanniocalcin-1 are differentially regulated in metastasizing canine mammary adenocarcinomas
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    J Comp Pathol 141:113-20. 2009
    ..Taken together, these results suggest that malignant behaviour of canine mammary adenocarcinoma is associated with reduced transcription of the stanniocalcin-1 gene and overexpression of the derlin-1 gene...
  25. doi request reprint Diagnostic value of morphometry in feline hypertrophic cardiomyopathy
    O Kershaw
    Department of Veterinary Pathology, Freie Universitaet Berlin, Robert von Ostertag Strasse 15, Berlin 14163, Germany
    J Comp Pathol 147:73-83. 2012
    ..The results do not uphold the hypothesis that increased cardiomyocyte diameter is a principal change in feline HCM...
  26. doi request reprint T-cell receptor γ chain variable and joining region genes of subgroup 1 are clonally rearranged in feline B- and T-cell lymphoma
    A Th A Weiss
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Str 15, 14163 Berlin, Germany
    J Comp Pathol 144:123-34. 2011
    ..2, 1.3 and 1.5. V region variants 2 and 4 were not identified in either tumour type. Some feline B-cell lymphomas had a clonally rearranged TCR, a finding reported in human, but not canine, B-cell lymphoma...
  27. doi request reprint Leukoencephalomalacia and laminar neuronal necrosis following smoke inhalation in a dog
    A Th A Weiss
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Str 15, 14163 Berlin, Germany
    Vet Pathol 48:1016-9. 2011
    ..This is the first report of delayed posthypoxic leukoencephalopathy in a nonhuman animal...
  28. doi request reprint Downregulation of transforming growth factor β (TGFβ) and latent TGFβ binding protein (LTBP)-4 expression in late stage canine mammary tumours
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Berlin, Germany
    Vet J 186:379-84. 2010
    ....
  29. ncbi request reprint Pathogenicity of Mycoplasma lipofaciens strain ML64 for turkey embryos
    M Lierz
    Institute for Poultry Diseases, Freie Universitaet Berlin, Berlin, Germany
    Avian Pathol 36:389-93. 2007
    ..In addition, lateral transmission between turkey poults hatched from infected eggs and poults from non-infected controls was observed in the incubator...
  30. ncbi request reprint First case of canine peritoneal larval cestodosis caused by Mesocestoides lineatus in Germany
    N Wirtherle
    Institute for Parasitology and Tropical Veterinary Medicine, Freie Universitaet Berlin, Konigsweg 67, D 14163 Berlin, Germany
    Parasitol Int 56:317-20. 2007
    ..75% identity with a Mesocestoides lineatus isolate published in the NCBI GenBank. This is the first case of canine peritoneal larval cestodosis (CPLC) in Germany and the first evidence of M. lineatus as causal agent for CPLC...
  31. doi request reprint Primary unilateral fibroleiomyoma of the ovary in a pregnant mare: a case report
    B Carstanjen
    Equine Clinic, College of Veterinary Medicine, Freie Universitat Berlin, 14163 Berlin, Germany
    Reprod Domest Anim 44:952-7. 2009
    ..This case report describes an ovarian fibroleiomyoma in a pregnant multiparous broodmare with a history of intermittent signs of colic...
  32. doi request reprint Pulmonary abnormalities in dogs with leptospirosis
    B Kohn
    Small Animal Clinic, Faculty of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany
    J Vet Intern Med 24:1277-82. 2010
    ..Leptospirosis in dogs is a multiorgan disease affecting mostly kidneys and liver...
  33. doi request reprint Molecular carcinogenesis of canine mammary tumors: news from an old disease
    R Klopfleisch
    Department of Veterinary Pathology, College of Veterinary Medicine, reie Universität Berlin, Robert von Ostertag Str 15, D 14163 Berlin, Germany
    Vet Pathol 48:98-116. 2011
    ..Clearly, this is only the beginning of an understanding of the molecular mechanisms of CMT and their application in clinical patient management...
  34. doi request reprint Does the taking of biopsies affect the metastatic potential of tumours? A systematic review of reports on veterinary and human cases and animal models
    R Klopfleisch
    Freie Universitat Berlin, Institute of Veterinary Pathology, 14163 Berlin, Germany
    Vet J 190:e31-42. 2011
    ..The overall risk therefore appears to be negligible when compared to the valuable information obtained from biopsies in veterinary practice...
  35. doi request reprint Multiple cystic intestinal duplications in a cat
    O Kershaw
    Freie Universitaet Berlin, Robert von Ostertag Strasse 15, Berlin, Germany
    Vet Pathol 45:188-90. 2008
    ..The remaining 2 cysts had similar structures except for granulation tissue lining the lumen. The lesion was diagnosed as multiple cystic duplications in the midjejunum, which is unknown to the veterinary literature to date...
  36. ncbi request reprint A soluble secreted glycoprotein (eCLCA1) is overexpressed due to goblet cell hyperplasia and metaplasia in horses with recurrent airway obstruction
    F Range
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, D 14163 Berlin, Germany
    Vet Pathol 44:901-11. 2007
    ..Taken together, the results suggest that eCLCA1 mediates its effect as a soluble constituent of airway mucins that is overexpressed in RAO airways because of goblet cell hyperplasia and metaplasia, not transcriptional upregulation...
  37. doi request reprint Weigners fixative-an alternative to formalin fixation for histology with improved preservation of nucleic acids
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Berlin, Germany
    Vet Pathol 50:191-9. 2013
    ..Weigners may therefore be a promising alternative to cryopreservation and may be embraced by people affected by formalin allergies...
  38. doi request reprint CD25 is expressed by canine cutaneous mast cell tumors but not by cutaneous connective tissue mast cells
    A Meyer
    Department of Veterinary Pathology, College of Veterinary Medicine, Freie Universitat Berlin, Robert von Ostertag Strasse 15, 14163 Berlin, Germany
    Vet Pathol 49:988-97. 2012
    ..Because of the low number of CD25-positive tumor cells in high-grade tumors, the usefulness of CD25 as a tumor marker is, however, questionable...
  39. doi request reprint Differential expression of cell cycle regulators p21, p27 and p53 in metastasizing canine mammary adenocarcinomas versus normal mammary glands
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strabe 15, 14163 Berlin, Germany
    Res Vet Sci 87:91-6. 2009
    ..Taken together the results suggest that loss of p21 overexpression is associated with tumor metastasis while reduced cell cycle inhibition by p27 is associated with malignant progression...
  40. doi request reprint A novel Sarcocystis-associated encephalitis and myositis in racing pigeons
    P Olias
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Strasse 15, Berlin, Germany
    Avian Pathol 38:121-8. 2009
    ..The clinical, histopathological, electron microscopic and genetic data are unlike any previously described protozoan infections in pigeons, suggesting a novel, severe disease due to an as yet undescribed Sarcocystis species...
  41. ncbi request reprint Excavation of a buried treasure--DNA, mRNA, miRNA and protein analysis in formalin fixed, paraffin embedded tissues
    R Klopfleisch
    Department of Veterinary Pathology, Freie Universitat Berlin, Robert von Ostertag Straße 15, Berlin, Germany
    Histol Histopathol 26:797-810. 2011
    ..In addition, methods and general problems of DNA, miRNA, mRNA and protein extraction and the current knowledge on the feasibility and accuracy of quantitative gene expression analysis in FFPE tissues is summarized...
  42. ncbi request reprint Oronasal fistula in a 53-year-old hippopotamus (Hippopotamus amphibius)
    P Wittschen
    Department of Veterinary Pathology, Freie Universitaet Berlin, Robert von Ostertag Strasse 15, 14163 Berlin
    J Comp Pathol 137:253-5. 2007
    ..There was no evidence of rhinitis or aspiration pneumonia. Unrelated findings consisted of a follicular thyroid adenoma and generalized muscle atrophy...