Stephan Gruber

Summary

Country: Germany

Publications

  1. Gruber S. MukBEF on the march: taking over chromosome organization in bacteria?. Mol Microbiol. 2011;81:855-9 pubmed publisher
    ..Thus, chromosome organization and segregation in bacteria appear to be governed by up to three distinct condensin complexes, indicating that this process could be much more sophisticated than previously appreciated. ..
  2. Soh Y, Bürmann F, Shin H, Oda T, Jin K, Toseland C, et al. Molecular basis for SMC rod formation and its dissolution upon DNA binding. Mol Cell. 2015;57:290-303 pubmed publisher
    ..These findings uncover a conserved architectural theme in SMC complexes, provide a mechanistic basis for Smc's dynamic engagement with chromosomes, and offer a molecular explanation for defects in Cornelia de Lange syndrome. ..
  3. Gruber S, Veening J, Bach J, Blettinger M, Bramkamp M, Errington J. Interlinked sister chromosomes arise in the absence of condensin during fast replication in B. subtilis. Curr Biol. 2014;24:293-8 pubmed publisher
    ..Prokaryotic condensin likely prevents the formation of sister DNA interconnections at the replication fork or promotes their resolution behind the fork. ..
  4. Gruber S. Multilayer chromosome organization through DNA bending, bridging and extrusion. Curr Opin Microbiol. 2014;22:102-10 pubmed publisher
    ..Here, I highlight different modes of chromosome organization in bacteria and on this basis consider models for the function of SMC protein complexes, whose mechanism of action is only poorly understood so far. ..
  5. Palecek J, Gruber S. Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes. Structure. 2015;23:2183-2190 pubmed publisher
    ..Based on architectural rather than sequence similarity, we propose an adapted model for the evolution of the SMC protein complexes and discuss potential functional similarities between bacterial Smc/ScpAB and eukaryotic Smc5/6. ..
  6. Minnen A, Bürmann F, Wilhelm L, Anchimiuk A, Diebold Durand M, Gruber S. Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA. Cell Rep. 2016;14:2003-16 pubmed publisher
    ..Our findings define an intermediate state in the process of chromosome organization by Smc. ..