T Griga

Summary

Country: Germany

Publications

  1. ncbi request reprint Collagenous colitis: implications for the role of vascular endothelial growth factor in repair mechanisms
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    Eur J Gastroenterol Hepatol 16:397-402. 2004
  2. ncbi request reprint Tuberculous involvement of the oesophagus with oesophagobroncheal fistula
    T Griga
    Department of Gastroenterology and Hepatology, University Hospital Bergmannsheil, Bochum, Germany
    Dig Liver Dis 34:528-31. 2002
  3. ncbi request reprint Immunohistochemical localization of vascular endothelial growth factor in colonic mucosa of patients with inflammatory bowel disease
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Hepatogastroenterology 49:116-23. 2002
  4. ncbi request reprint Association between the promoter polymorphism T/C at position -159 of the CD14 gene and anti-inflammatory therapy in patients with inflammatory bowel disease
    T Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Eur J Med Res 10:183-6. 2005
  5. ncbi request reprint CD14 expression on monocytes and soluble CD14 plasma levels in correlation to the promotor polymorphism of the endotoxin receptor CD14 gene in patients with inactive Crohn's disease
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Bochum, Germany
    Hepatogastroenterology 52:808-11. 2005
  6. ncbi request reprint Overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis in two cases
    T Griga
    Department of Gastroenterology and Hepatology, University Hospital Bergmannsheil, Bochum, Germany
    Eur J Gastroenterol Hepatol 12:559-64. 2000
  7. ncbi request reprint A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Hepatogastroenterology 54:784-6. 2007
  8. ncbi request reprint Interleukin-4 inhibits the increased production of vascular endothelial growth factor by peripheral blood mononuclear cells in patients with inflammatory bowel disease
    T Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Hepatogastroenterology 47:1604-7. 2000
  9. ncbi request reprint A polymorphism in the CD14 gene is associated with Crohn disease
    W Klein
    Abteilung fuer Molekulare Humangenetik, Ruhr Universitaet, Bochum, Germany
    Scand J Gastroenterol 37:189-91. 2002
  10. ncbi request reprint Interaction of polymorphisms in the CARD15 and CD14 genes in patients with Crohn disease
    W Klein
    Abteilung für Humangenetik, Ruhr Universitat, Bochum, Germany
    Scand J Gastroenterol 38:834-6. 2003

Detail Information

Publications26

  1. ncbi request reprint Collagenous colitis: implications for the role of vascular endothelial growth factor in repair mechanisms
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Ruhr University, Bochum, Germany
    Eur J Gastroenterol Hepatol 16:397-402. 2004
    ..Therefore, we investigated the expression of vascular endothelial growth factor in the colonic mucosa of patients with collagenous colitis before and after long-term treatment with oral budesonide...
  2. ncbi request reprint Tuberculous involvement of the oesophagus with oesophagobroncheal fistula
    T Griga
    Department of Gastroenterology and Hepatology, University Hospital Bergmannsheil, Bochum, Germany
    Dig Liver Dis 34:528-31. 2002
    ..The patient was immunocompromised due to treatment with azathioprine that she was receiving for multiple sclerosis. The fistula was successfully treated by antituberculous chemotherapy alone...
  3. ncbi request reprint Immunohistochemical localization of vascular endothelial growth factor in colonic mucosa of patients with inflammatory bowel disease
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Hepatogastroenterology 49:116-23. 2002
    ..The present investigation examines the localization of VEGF at the site of inflammation in colonic mucosa of patients with Crohn's disease and ulcerative colitis...
  4. ncbi request reprint Association between the promoter polymorphism T/C at position -159 of the CD14 gene and anti-inflammatory therapy in patients with inflammatory bowel disease
    T Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Eur J Med Res 10:183-6. 2005
    ..Genetic stratification will lead to the development of individualized therapies in inflammatory bowel disease...
  5. ncbi request reprint CD14 expression on monocytes and soluble CD14 plasma levels in correlation to the promotor polymorphism of the endotoxin receptor CD14 gene in patients with inactive Crohn's disease
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Bochum, Germany
    Hepatogastroenterology 52:808-11. 2005
    ..We studied the correlation between the CD14 genotype (CC, CT, TT) and the membrane-bound CD14 monocyte expression and soluble CD14 in patients with inactive Crohn's disease...
  6. ncbi request reprint Overlap syndrome between autoimmune hepatitis and primary sclerosing cholangitis in two cases
    T Griga
    Department of Gastroenterology and Hepatology, University Hospital Bergmannsheil, Bochum, Germany
    Eur J Gastroenterol Hepatol 12:559-64. 2000
    ..We report two additional cases, one case showing an association with Crohn's disease...
  7. ncbi request reprint A polymorphism in the macrophage migration inhibitory factor gene is involved in the genetic predisposition of Crohn's disease and associated with cumulative steroid doses
    Thomas Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Buerkle de la Camp Platz 1, 44789 Bochum, Germany
    Hepatogastroenterology 54:784-6. 2007
    ..We evaluated whether the single nucleotide polymorphism (SNP) G/C at position -173 of the MIF gene contributes to the predisposition to IBD and higher amounts of steroid therapy...
  8. ncbi request reprint Interleukin-4 inhibits the increased production of vascular endothelial growth factor by peripheral blood mononuclear cells in patients with inflammatory bowel disease
    T Griga
    Department of Gastroenterology, University Hospital Bergmannsheil, Burkle de la Camp Platz 1, D 44789 Bochum, Germany
    Hepatogastroenterology 47:1604-7. 2000
    ..There is no current information about the influence of immunoregulatory cytokines on VEGF in IBD. The present study examines the effect of interleukin-4 on the increased VEGF production of PBMCs in patients with IBD...
  9. ncbi request reprint A polymorphism in the CD14 gene is associated with Crohn disease
    W Klein
    Abteilung fuer Molekulare Humangenetik, Ruhr Universitaet, Bochum, Germany
    Scand J Gastroenterol 37:189-91. 2002
    ..Although genetic factors play an important role in the pathogenesis, little is known about the genes accountable. Immune response to intestinal bacteria seems to be crucial in the pathogenesis of IBD...
  10. ncbi request reprint Interaction of polymorphisms in the CARD15 and CD14 genes in patients with Crohn disease
    W Klein
    Abteilung für Humangenetik, Ruhr Universitat, Bochum, Germany
    Scand J Gastroenterol 38:834-6. 2003
    ..These variations are neither necessary nor sufficient for the genetic predisposition of CD. Further genetic and environmental factors play a crucial role in the pathogenesis of CD...
  11. ncbi request reprint The IL-10 gene is not involved in the predisposition to inflammatory bowel disease
    W Klein
    Abteilung für Molekulare Humangenetik, Ruhr Universitat, Bochum, Germany
    Electrophoresis 21:3578-82. 2000
    ..Therefore, polymorphisms of the IL-10 gene are not demonstrably involved in the predisposition of IBD in our cohorts of patients...
  12. ncbi request reprint A polymorphism in the IL11 gene is associated with ulcerative colitis
    W Klein
    Abteilung fuer Molekulare Humangenetik, Ruhr Universitaet, Bochum, Germany
    Genes Immun 3:494-6. 2002
    ..A1 homozygous individuals were significantly increased among the patients with UC (P < 0.002 and (P < 0.003, respectively) but not with CD. Altered expression of IL11 appears to be involved in the genetic predisposition of UC...
  13. ncbi request reprint The G2964A polymorphism of the STAT6 gene in inflammatory bowel disease
    W Klein
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Dig Liver Dis 37:159-61. 2005
    ..The transcription factor STAT6 is involved in the regulation of the TH1/TH2 immune response. Increased production of TH1 cytokines is crucial in the pathogenesis of Crohn's disease...
  14. ncbi request reprint A case-control study of tyrosine phosphatase (PTPN22) confirms the lack of association with Crohn's disease
    S E N Wagenleiter
    Department of Human Genetics, Ruhr University, 44780 Bochum, Germany
    Int J Immunogenet 32:323-4. 2005
    ..This study revealed evidence that PTPN22 variation may have no influence in the genetic predisposition to CD, at least not in another well-characterized Caucasian cohort...
  15. ncbi request reprint The polymorphism at position -174 of the IL-6 gene is not associated with inflammatory bowel disease
    W Klein
    Abteilung fuer Molekulare Humangenetik, Ruhr Universitaet, Bochum, Germany
    Eur J Gastroenterol Hepatol 13:45-7. 2001
    ..Genetic factors play an important role in the pathogenesis, but little is known about the accountable genes. Increased secretion of pro-inflammatory cytokines appears crucial in the initiation of the inflammatory response...
  16. ncbi request reprint Oral mesalazine for the treatment of Crohn's disease: clinical efficacy with respect to pharmacokinetic properties
    A Tromm
    Department of Gastroenterology and Hepatology, BG Kliniken Bergmannsheil University Clinic, Bochum, Germany
    Hepatogastroenterology 46:3124-35. 1999
    ..However, the distinct therapeutic goal (acute phase treatment, maintenance therapy or post-operative prophylaxis), the involved areas of the gut and the specific release of the drug administered have to be considered...
  17. ncbi request reprint Cutaneous manifestations in inflammatory bowel disease
    A Tromm
    Klinik fur Innere Medizin, Evangelisches Krankenhaus Hattingen GmbH, Akademisches Lehrkrankenhaus der Ruhr Universität Bochum
    Z Gastroenterol 39:137-44. 2001
    ....
  18. ncbi request reprint [Association of primary sclerosing cholangitis and sarcoidosis]
    B Scherr
    Abteilung für Gastroenterologie und Hepatologie, Universitatsklinik, Ruhr Universitat Bochum
    Med Klin (Munich) 96:550-4. 2001
    ..Primary sclerosing cholangitis and sarcoidosis are rarely associated diseases...
  19. ncbi request reprint Interleukin-4 and interleukin-4 receptor gene polymorphisms in inflammatory bowel diseases
    W Klein
    Molekulare Humangenetik, Ruhr Universitaet, 44780 Bochum, Germany
    Genes Immun 2:287-9. 2001
    ..03). This allele entails reduced expression of IL-4. The reason for these contrasting findings may be discussed in the context of a putatively predisposing allele in linkage disequilibrium with the alleles of the interleukin-4 gene...
  20. ncbi request reprint Orthograde whole gut irrigation with mannite versus paromomycine + lactulose as prophylaxis of hepatic encephalopathy in patients with cirrhosis and upper gastrointestinal bleeding: results of a controlled randomized trial
    A Tromm
    Dept of Gastroenterology and Hepatology, University Clinic Ruhr University, Bochum, Germany
    Hepatogastroenterology 47:473-7. 2000
    ..The aim of the present study was to evaluate the efficacy of the mannite lavage in a controlled randomized trial with respect to the Child-Pugh classification...
  21. ncbi request reprint The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease
    Jurgen Glas
    Chirurgische Klinik und Poliklinik Innenstadt, Klinikum der Universitat Munchen, Munich, Germany
    Int Immunol 19:621-6. 2007
    ..As there are several partly functional polymorphisms within the promoter region potentially influencing HLA-G expression, further studies in IBD are necessary in the context of differential expression of HLA-G between UC and CD...
  22. pmc On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors
    Sonja E N Wagenleiter
    Department of Human Genetics, Ruhr University, Bochum, Germany
    J Negat Results Biomed 4:8. 2005
    ..Using this step-wise process we were unable to demonstrate evidence for genetic predisposition of the chosen apoptosis- and immunity-related genes with respect to susceptibility for CD...
  23. ncbi request reprint A polymorphism of the NFKBIA gene is associated with Crohn's disease patients lacking a predisposing allele of the CARD15 gene
    Wolfram Klein
    Abteilung für Humangenetik, Ruhr Universitat, Bochum, Germany
    Int J Colorectal Dis 19:153-6. 2004
    ..Nuclear factor kappa-B (NFkappaB) plays a crucial role in diseases associated with dysregulated immune response. NFkappaB inhibitor alpha downregulates the activity of NFkappaB...
  24. ncbi request reprint A polymorphism of the bactericidal/permeability increasing protein (BPI) gene is associated with Crohn's disease
    Wolfram Klein
    Department of Human Genetics, Ruhr University, Bochum, Germany
    J Clin Gastroenterol 39:282-3. 2005
    ..The bactericidal/permeability increasing protein (BPI) is involved in the elimination of gram-negative bacteria. A functionally relevant single nucleotide polymorphism of the BPI gene causes an amino acid exchange (Glu216Lys)...
  25. ncbi request reprint The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
    Jurgen Glas
    Department of Medicine II Grosshadern, University of Munich, Germany
    Am J Gastroenterol 103:682-91. 2008
    ....
  26. ncbi request reprint Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes
    Jurgen Glas
    Chirurgische Klinik und Poliklinik Innenstadt, Munchen, Germany
    Inflamm Bowel Dis 12:606-11. 2006
    ..Furthermore, potential interactions of the -94ins/delATTG polymorphism with the IKBL and the IL-1RN genes should be determined...