Jochen Graw

Summary

Country: Germany

Publications

  1. ncbi request reprint Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development
    Nicole Haubst
    GSF National Research Center for Environment and Health, Institute for Stem Cell Research, Neuherberg, Germany
    Development 131:6131-40. 2004
  2. doi request reprint Eye development
    Jochen Graw
    Helmholtz Center Munich German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    Curr Top Dev Biol 90:343-86. 2010
  3. ncbi request reprint Levels of p27 sensitize to dual PI3K/mTOR inhibition
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Cancer Ther 10:1450-9. 2011
  4. doi request reprint The KORA Eye Study: a population-based study on eye diseases in Southern Germany (KORA F4)
    Jochen Graw
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Invest Ophthalmol Vis Sci 52:7778-86. 2011
  5. pmc Are mouse lens epithelial cells more sensitive to γ-irradiation than lymphocytes?
    Kristina Bannik
    National Research Center for Environmental Health, Institute of Developmental Genetics, Helmholtz Center Munich, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Radiat Environ Biophys 52:279-86. 2013
  6. pmc Novel small-eye allele in paired box gene 6 (Pax6) is caused by a point mutation in intron 7 and creates a new exon
    Oliver Puk
    Helmholtz Center Munich, German Research Center for Environmental Health, German Mouse Clinic, Institute of Developmental Genetics, Neuherberg, Germany
    Mol Vis 19:877-84. 2013
  7. pmc Molecular analysis of cataract families in India: new mutations in the CRYBB2 and GJA3 genes and rare polymorphisms
    Sathiyavedu T Santhiya
    Dr ALM Postgraduate Institute of Basic Medical Sciences, Department of Genetics, University of Madras, Taramani, Chennai, India
    Mol Vis 16:1837-47. 2010
  8. pmc Relative roles of the different Pax6 domains for pancreatic alpha cell development
    Petra Dames
    Ludwig Maximilians Universitat, Klinikum Grosshadern, Medizinische Klinik, Munchen, Germany
    BMC Dev Biol 10:39. 2010
  9. doi request reprint Genetics of crystallins: cataract and beyond
    Jochen Graw
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Exp Eye Res 88:173-89. 2009
  10. ncbi request reprint Mouse models of cataract
    Jochen Graw
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    J Genet 88:469-86. 2009

Detail Information

Publications53

  1. ncbi request reprint Molecular dissection of Pax6 function: the specific roles of the paired domain and homeodomain in brain development
    Nicole Haubst
    GSF National Research Center for Environment and Health, Institute for Stem Cell Research, Neuherberg, Germany
    Development 131:6131-40. 2004
    ..These results therefore demonstrate a key role of the PD in brain development and implicate splicing as a pivotal factor regulating the potent neurogenic role of Pax6...
  2. doi request reprint Eye development
    Jochen Graw
    Helmholtz Center Munich German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    Curr Top Dev Biol 90:343-86. 2010
    ..The relevance to human disorders is one of the major aspects covered throughout the review...
  3. ncbi request reprint Levels of p27 sensitize to dual PI3K/mTOR inhibition
    Misu Lee
    Institute of Pathology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Cancer Ther 10:1450-9. 2011
    ..Our data suggest that NVP-BEZ235 may represent an effective therapeutic modality for pituitary adenomas and that p27Kip1 levels represent a potential predictor of response to dual PI3K/mTOR inhibition...
  4. doi request reprint The KORA Eye Study: a population-based study on eye diseases in Southern Germany (KORA F4)
    Jochen Graw
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Invest Ophthalmol Vis Sci 52:7778-86. 2011
    ....
  5. pmc Are mouse lens epithelial cells more sensitive to γ-irradiation than lymphocytes?
    Kristina Bannik
    National Research Center for Environmental Health, Institute of Developmental Genetics, Helmholtz Center Munich, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Radiat Environ Biophys 52:279-86. 2013
    ..25 Gy. The observed difference in DNA repair between the LECs from C57BL/6J mice compared to the LECs from JF1 mice and to the lymphocytes of both strains warrants further experiments to identify the underlying molecular mechanisms...
  6. pmc Novel small-eye allele in paired box gene 6 (Pax6) is caused by a point mutation in intron 7 and creates a new exon
    Oliver Puk
    Helmholtz Center Munich, German Research Center for Environmental Health, German Mouse Clinic, Institute of Developmental Genetics, Neuherberg, Germany
    Mol Vis 19:877-84. 2013
    ..Within a mutagenesis screen, we identified the new mouse mutant Aey80 with small eyes; homozygous mutants were not obtained. The aim of the study was its molecular characterization...
  7. pmc Molecular analysis of cataract families in India: new mutations in the CRYBB2 and GJA3 genes and rare polymorphisms
    Sathiyavedu T Santhiya
    Dr ALM Postgraduate Institute of Basic Medical Sciences, Department of Genetics, University of Madras, Taramani, Chennai, India
    Mol Vis 16:1837-47. 2010
    ..The aim of the study was to resolve the genetic etiology in families having inherited cataracts...
  8. pmc Relative roles of the different Pax6 domains for pancreatic alpha cell development
    Petra Dames
    Ludwig Maximilians Universitat, Klinikum Grosshadern, Medizinische Klinik, Munchen, Germany
    BMC Dev Biol 10:39. 2010
    ..We ask the question of how the differentiation of pancreatic endocrine cells, in particular that of alpha-cells, is affected by selective inactivation of either one of the three major domains of Pax6...
  9. doi request reprint Genetics of crystallins: cataract and beyond
    Jochen Graw
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Exp Eye Res 88:173-89. 2009
    ..Mutations in the human CRYM gene lead to non-syndromic deafness, and mutations in the Cryz gene of guinea pigs cause cataracts...
  10. ncbi request reprint Mouse models of cataract
    Jochen Graw
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    J Genet 88:469-86. 2009
    ..By further understanding the pleiotropic effects of these genes, we might recognize cataracts as an easily visible biomarker for a number of systemic syndromes...
  11. doi request reprint Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype
    Oliver Puk
    Institute of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 49:1525-32. 2008
    ..The purpose of the study was the characterization of the novel small-eye mutant Aey12 in the mouse...
  12. ncbi request reprint Genetic and allelic heterogeneity of Cryg mutations in eight distinct forms of dominant cataract in the mouse
    Jochen Graw
    Institute of Developmental Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 45:1202-13. 2004
    ..The purpose of this study was the characterization of eight new dominant cataract mutations...
  13. doi request reprint Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2G257D mutant mouse
    Oliver Puk
    Institute of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 50:5653-61. 2009
    ..The purpose of this study was the morphologic and genetic characterization of the novel eye size mutant Aca23 in the mouse...
  14. doi request reprint A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: a novel model for dry-eye disease?
    Oliver Puk
    Institutes of Developmental Genetics, Helmholtz Center Munich German Research Center for Environmental Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 50:4311-8. 2009
    ..The purpose of the present study was to characterize a new slit-eye phenotype in the mouse...
  15. ncbi request reprint Three novel Pax6 alleles in the mouse leading to the same small-eye phenotype caused by different consequences at target promoters
    Jochen Graw
    Institute of Developmental Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 46:4671-83. 2005
    ..To characterize three new mouse small-eye mutants detected during ethylnitrosourea mutagenesis programs...
  16. pmc Pleiotropic effects in Eya3 knockout mice
    Torben Soker
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    BMC Dev Biol 8:118. 2008
    ..The functions of its mammalian orthologs Eya1-4 are only partially understood and no mouse model exists for Eya3. Therefore, we characterized the phenotype of a new Eya3 knockout mouse mutant...
  17. ncbi request reprint Electroretinography as a screening method for mutations causing retinal dysfunction in mice
    Claudia Dalke
    GSF National Research Center for Environment and Health, Institutes of Developmental Genetics, Clinical Cooperation Group Ophthalmogenetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 45:601-9. 2004
    ..To detect mice with hereditary retinal impairment, a high-throughput electroretinography (ERG) screening system was established...
  18. ncbi request reprint Crygf(Rop): the first mutation in the Crygf gene causing a unique radial lens opacity
    Jochen Graw
    National Research Center for Environment and Health GSF, Institute of Mammalian Genetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 43:2998-3002. 2002
    ..The Rop (radial opacity) mutation, which was recovered in a mutagenicity screen after paternal treatment with procarbazine, was analyzed to determine phenotype, chromosomal localization, candidate genes, and molecular lesion...
  19. pmc Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans
    Natalia S Pellegata
    Institutes of Pathology, GSF National Research Center for Environment and Health, 85764 Neuherberg, Germany
    Proc Natl Acad Sci U S A 103:15558-63. 2006
    ..Our findings demonstrate that germ-line mutations in p27(Kip1) can predispose to the development of multiple endocrine tumors in both rats and humans...
  20. doi request reprint Microphthalmia, parkinsonism, and enhanced nociception in Pitx3 ( 416insG ) mice
    Michael Rosemann
    Institute of Radiation Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Mamm Genome 21:13-27. 2010
    ..It is the first mouse mutant carrying a point mutation within the coding region of Pitx3...
  21. ncbi request reprint Mutation analysis of congenital cataracts in Indian families: identification of SNPS and a new causative allele in CRYBB2 gene
    Sathiyavedu T Santhiya
    Dr ALM Postgraduate Institute of Basic Medical Sciences, Department of Genetics, University of Madras, Taramani, Chennai, India
    Invest Ophthalmol Vis Sci 45:3599-607. 2004
    ..To study some functional candidate genes in cataract families of Indian descent...
  22. doi request reprint Novel allele of crybb2 in the mouse and its expression in the brain
    Koustav Ganguly
    Institutes of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 49:1533-41. 2008
    ..O377 was identified as a new dominant cataract mutation in mice after radiation experiments. The purpose of this study was to genetically characterize the mutation and to analyze its biological consequences...
  23. ncbi request reprint Congenital hereditary cataracts
    Jochen Graw
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Neuherberg, Germany
    Int J Dev Biol 48:1031-44. 2004
    ..Nevertheless, there still remains a long list of mutations to be characterized and functionally investigated both in mouse and man indicating a broad genetic heterogeneity in that which clinicians simply refer to as a "cataract"...
  24. ncbi request reprint Variation of the response to the optokinetic drum among various strains of mice
    Oliver Puk
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Front Biosci 13:6269-75. 2008
    ..In conclusion, C57BL/6, 129 and JF1 represent appropriate inbred strains for high throughput screenings with the optokinetic drum...
  25. pmc Microphakia and congenital cataract formation in a novel Lim2(C51R) mutant mouse
    Oliver Puk
    Helmholtz Center Munich, German Research Center for Environmental Health, Institutes of Developmental Genetics, Neuherberg, Germany
    Mol Vis 17:1164-71. 2011
    ..Within a mutagenesis screen, we identified the new mouse mutant Aca47 with small lenses and reduced axial eye lengths. The aim of the actual study was the molecular and morphological characterization of the mouse mutant Aca47...
  26. pmc Crybb2 coding for βB2-crystallin affects sensorimotor gating and hippocampal function
    Minxuan Sun
    Institute of Developmental Genetics, Helmholtz Center Munich National Research Center for Environmental Health, Ingolstadter Landstrasse 1, 85764, Neuherberg, Germany
    Mamm Genome 24:333-48. 2013
    ..Moreover, our results are the first to demonstrate that βB2-crystallin has a role in hippocampal function and behavioral phenotypes. This model can now be further explored by future experiments. ..
  27. ncbi request reprint Mapping of a novel MEN-like syndrome locus to rat chromosome 4
    Kamilla Piotrowska
    Institute of Pathology, GSF National Research Center for Environment and Health, D 85764 Neuherberg, Germany
    Mamm Genome 15:135-41. 2004
    ..The identification of the MENX gene should contribute to our understanding of the genetic mechanisms of neuroendocrine tissue tumorigenesis and may assist in developing new and more appropriate therapeutic strategies for these diseases...
  28. pmc The GJA8 allele encoding CX50I247M is a rare polymorphism, not a cataract-causing mutation
    Jochen Graw
    Helmholtz Center Munich German Research Center for Environmental Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Mol Vis 15:1881-5. 2009
    ..The aim of this study was the genetic, cellular, and physiological characterization of a connexin50 (CX50) variant identified in a child with congenital cataracts...
  29. doi request reprint Allelic loss of chromosomes 8 and 19 in MENX-associated rat pheochromocytoma
    Alena Shyla
    Institute of Pathology, Helmholtz Zentrum München German Research Center for Environment and Health, Neuherberg, Germany
    Int J Cancer 126:2362-72. 2010
    ..Because of the high concordance of affected loci between rat and human tumors, studies of the MENX-associated pheochromocytomas should facilitate the identification of novel candidate genes implicated in their human counterpart...
  30. ncbi request reprint Identification of a novel, putative cataract-causing allele in CRYAA (G98R) in an Indian family
    Sathiyavedu T Santhiya
    Dr ALM Postgraduate Institute of Basic Medical Sciences, Department of Genetics, University of Madras, Taramani, Chennai, India
    Mol Vis 12:768-73. 2006
    ..The visual impairment started as problem in distant vision at the age of 16 years, to diminishing vision by the age of 24...
  31. pmc The pathologic effect of a novel neomorphic Fgf9(Y162C) allele is restricted to decreased vision and retarded lens growth
    Oliver Puk
    German Research Center for Environmental Health, Institute of Developmental Genetics, Neuherberg, Germany
    PLoS ONE 6:e23678. 2011
    ..Our data point to a role of Fgf9 signalling in primary and secondary lens fiber cell growth. The results underline the importance of allelic series to fully understand multiple functions of a gene...
  32. doi request reprint First mutation in the βA2-crystallin encoding gene is associated with small lenses and age-related cataracts
    Oliver Puk
    Institutes of Developmental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 52:2571-6. 2011
    ..A new mouse mutant with small lenses was identified within a mutagenesis screen. The aim of the study was to determine its molecular and morphologic characterization...
  33. doi request reprint Mouse phenotyping
    Helmut Fuchs
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 München Neuherberg, Germany
    Methods 53:120-35. 2011
    ..mousclinic.de; [1]). The GMC is a member of the EUMODIC consortium which created the European standard workflow EMPReSSslim for the systemic phenotyping of mouse models (http://www.eumodic.org/[2])...
  34. ncbi request reprint Further genetic heterogeneity for autosomal dominant human sutural cataracts
    Norman Klopp
    GSF National Research Center for Environment and Health, Institutes of Developmental Genetics, Neuherberg, Germany
    Ophthalmic Res 35:71-7. 2003
    ..The phenotype in this family is due to a mutation in another sutural cataract gene yet to be identified...
  35. pmc Rapamycin extends murine lifespan but has limited effects on aging
    Frauke Neff
    Institute of Pathology, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    J Clin Invest 123:3272-91. 2013
    ..Therefore, our data largely dissociate rapamycin's longevity effects from effects on aging itself. ..
  36. pmc Ethylnitrosourea-induced base pair substitution affects splicing of the mouse gammaE-crystallin encoding gene leading to the expression of a hybrid protein and to a cataract
    Jochen Graw
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, D 85764 Neuherberg, Germany
    Genetics 161:1633-40. 2002
    ..Histological analysis of the cataractous lenses indicated that the expression of the new protein disrupts the cellular structure of the eye lens...
  37. ncbi request reprint Congenital cataract and macular hypoplasia in humans associated with a de novo mutation in CRYAA and compound heterozygous mutations in P
    Jochen Graw
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, D 85764, Neuherberg, Germany
    Graefes Arch Clin Exp Ophthalmol 244:912-9. 2006
    ..To test the hypothesis that a de-novo mutation had occurred in one of the parental germ lines, a functional candidate gene approach was applied...
  38. pmc Requirement of the RNA-editing enzyme ADAR2 for normal physiology in mice
    Marion Horsch
    Institute of Experimental Genetics, Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    J Biol Chem 286:18614-22. 2011
    ..Our extended phenotypic analysis covering ∼320 parameters identified significant changes related to absence of ADAR2 in behavior, hearing ability, allergy parameters and transcript profiles of brain...
  39. ncbi request reprint "Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?
    Sabine M Hoelter
    Institute of Developmental Genetics, Helmholtz Center Munich German Research Center for Environmental Health GmbH, 85764 Neuherberg, Germany
    Front Biosci 13:5810-23. 2008
    ..These results emphasize the importance of comprehensive behavioural and physiological phenotyping...
  40. pmc Mutation in intron 6 of the hamster Mitf gene leads to skipping of the subsequent exon and creates a novel animal model for the human Waardenburg syndrome type II
    Jochen Graw
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Genetics 164:1035-41. 2003
    ..Therefore, the Wh(V203) hamster mutant provides a novel model for this particular syndrome...
  41. ncbi request reprint V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in mice
    Jochen Graw
    GSF National Research Center for Environment and Health, Institute of Mammalian Genetics, D 85764 Neuherberg, Germany
    Mamm Genome 13:452-5. 2002
    ..5 pH units in the 10 amino acids surrounding position 76. The Crygd(Aey4) additionally demonstrates the importance of the integrity of the Cryg gene cluster for lens transparency...
  42. pmc Innovations in phenotyping of mouse models in the German Mouse Clinic
    Helmut Fuchs
    German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg Munich, Germany
    Mamm Genome 23:611-22. 2012
    ..Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs)...
  43. ncbi request reprint A 6-bp deletion in the Crygc gene leading to a nuclear and radial cataract in the mouse
    Jochen Graw
    National Research Center for Environment and Health Forschungszentrum für Umwelt und Gesundheit, Institute of Mammalian Genetics, Neuherberg, Germany
    Invest Ophthalmol Vis Sci 43:236-40. 2002
    ..The purpose of this study was to establish the linkage of the mutation to a particular chromosome to allow molecular characterization. Moreover, the mutants were examined morphologically...
  44. doi request reprint Longitudinal fundus and retinal studies with SD-OCT: a comparison of five mouse inbred strains
    Oliver Puk
    German Mouse Clinic, Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstrasse 1, Neuherberg, Germany
    Mamm Genome 24:198-205. 2013
    ..Consequently, progressive changes of these parameters are suitable indicators for pathologic outliers...
  45. ncbi request reprint Variations of eye size parameters among different strains of mice
    Oliver Puk
    Institutes of Developmental Genetics, GSF National Research Center for Environment and Health, D 85764, Neuherberg, Germany
    Mamm Genome 17:851-7. 2006
    ..Finally, wild-type intervals (mean +/- 3 SD) for axial length, anterior chamber depth, and cornea and lens thicknesses were calculated allowing a quick identification of pathologic outliers...
  46. doi request reprint Lens density tracking in mice by Scheimpflug imaging
    Oliver Puk
    German Mouse Clinic, Institute of Developmental Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Mamm Genome 24:295-302. 2013
    ..We show that lens densitometry by Scheimpflug imaging in mouse eyes can resolve differences of less than 1 %, making it possible to detect differences in cataract development in different mouse strains, even if they are small. ..
  47. ncbi request reprint Developmental genetics in ophthalmology
    Jochen Graw
    Institute of Developmental Genetics, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Ophthalmic Genet 24:1-33. 2003
    ..Since at least one of them is also expressed in the retina and the brain, effects on these tissues have to be considered, too...
  48. ncbi request reprint Mouse mutants as models for congenital retinal disorders
    Claudia Dalke
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Exp Eye Res 81:503-12. 2005
    ..Here we review some mouse models, which are related to hereditary disorders (mostly congenital) including retinitis pigmentosa, Leber's congenital amaurosis, macular disorders and optic atrophy...
  49. ncbi request reprint Systemic first-line phenotyping
    Valerie Gailus-Durner
    Institute of Experimental Genetics, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Methods Mol Biol 530:463-509. 2009
    ..Using the example of the German Mouse Clinic (GMC) we will introduce the reader to the different aspects of the organization of a mouse clinic and present selected methods used in first-line phenotyping...
  50. doi request reprint Pitx3 directly regulates Foxe3 during early lens development
    Nafees Ahmad
    Helmholtz Center Munich, Institute of Developmental Genetics, Neuherberg, Germany
    Int J Dev Biol 57:741-51. 2013
    ..These findings enhance our understanding of the molecular cascades which subserve lens development...
  51. ncbi request reprint Recessive transmission of a multiple endocrine neoplasia syndrome in the rat
    Andreas Fritz
    Institute of Pathology, GSF National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, D 85764 Neuherberg, Germany
    Cancer Res 62:3048-51. 2002
    ....
  52. ncbi request reprint The genetic and molecular basis of congenital eye defects
    Jochen Graw
    GSF National Research Center for Environment and Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Nat Rev Genet 4:876-88. 2003
    ..A better understanding of how this intricate organ develops at the genetic and cellular level is central to our understanding of the pathologies that afflict it...
  53. ncbi request reprint Haemophilia A: from mutation analysis to new therapies
    Jochen Graw
    GSF National Research Centre for Environment and Health, Institute of Developmental Genetics, D 85764 Neuherberg, Germany
    Nat Rev Genet 6:488-501. 2005
    ..Haemophilia is also the most attractive model for developing gene-therapy protocols, as the normal life expectancy of haemophiliacs allows the side effects of gene therapy, as well as its efficiency, to be monitored over long periods...