C Grasshoff

Summary

Country: Germany

Publications

  1. ncbi request reprint Anaesthetic drugs: linking molecular actions to clinical effects
    Christian Grasshoff
    Department of Anesthesiology, Experimental Anesthesiology Section, University of Tuebingen, Schaffhausenstr 113, D 72072 Tuebingen, Germany
    Curr Pharm Des 12:3665-79. 2006
  2. ncbi request reprint Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks
    Christian Grasshoff
    Department of Anesthesiology, Experimental Anesthesiology Section, Eberhard Karls University, Schaffhausenstrasse 113, D 72072 Tuebingen, Germany
    Toxicology 229:206-13. 2007
  3. ncbi request reprint Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics
    Christian Grasshoff
    Experimental Anesthesiology Section, Department of Anesthesiology and Intensive Care, Eberhard Karls University, Tuebingen, Germany
    Mol Pharmacol 72:780-7. 2007
  4. ncbi request reprint Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats
    C Grasshoff
    Experimental Anaesthesiology Section, Department of Anaesthesiology University of Tuebingen, Tuebingen, Germany
    Br J Anaesth 97:687-94. 2006
  5. ncbi request reprint Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro
    Christian Grasshoff
    Department of Anesthesiology, University of Tuebingen, Tuebingen, Germany
    Anesthesiology 106:1147-55. 2007
  6. ncbi request reprint Effects of propofol on N-methyl-D-aspartate receptor-mediated calcium increase in cultured rat cerebrocortical neurons
    C Grasshoff
    Eberhard Karls University, Department of Anaesthesiology and Intensive Care, Tuebingen, Germany
    Eur J Anaesthesiol 22:467-70. 2005
  7. ncbi request reprint Ketamine reduces cholinergic modulated GABA release from rat striatal slices
    Christian Grasshoff
    Institute of Pharmacology and Toxicology, German Armed Forces Medical Academy, Neuherberg Strasse 11, 80937 München, Germany
    Toxicol Lett 156:361-7. 2005
  8. ncbi request reprint Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets
    Christian Grasshoff
    Section of Experimental Anesthesiology, Department of Anesthesiology, University of Tuebingen, Germany
    Anesthesiology 101:1167-76. 2004
  9. ncbi request reprint Depression of spinal network activity by thiopental: shift from phasic to tonic GABA(A) receptor-mediated inhibition
    C Grasshoff
    Department of Anesthesiology and Intensive Care, Eberhard Karls University, Schaffhausenstrasse 113, D 72072 Tuebingen, Germany
    Neuropharmacology 55:793-802. 2008
  10. doi request reprint Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis
    Berthold Drexler
    Department of Anaesthesiology, Experimental Anaesthesiology Section, Eberhard Karls University, Schaffhausenstrasse 113, 72072 Tuebingen, Germany
    Toxicol Lett 198:342-7. 2010

Detail Information

Publications16

  1. ncbi request reprint Anaesthetic drugs: linking molecular actions to clinical effects
    Christian Grasshoff
    Department of Anesthesiology, Experimental Anesthesiology Section, University of Tuebingen, Schaffhausenstr 113, D 72072 Tuebingen, Germany
    Curr Pharm Des 12:3665-79. 2006
    ..Such agents would be especially beneficial for the treatment of newborn children, elderly patients and patients undergoing ambulatory surgery...
  2. ncbi request reprint Effects of cholinergic overstimulation on isoflurane potency and efficacy in cortical and spinal networks
    Christian Grasshoff
    Department of Anesthesiology, Experimental Anesthesiology Section, Eberhard Karls University, Schaffhausenstrasse 113, D 72072 Tuebingen, Germany
    Toxicology 229:206-13. 2007
    ....
  3. ncbi request reprint Modulation of presynaptic beta3-containing GABAA receptors limits the immobilizing actions of GABAergic anesthetics
    Christian Grasshoff
    Experimental Anesthesiology Section, Department of Anesthesiology and Intensive Care, Eberhard Karls University, Tuebingen, Germany
    Mol Pharmacol 72:780-7. 2007
    ....
  4. ncbi request reprint Effects of isoflurane and enflurane on GABAA and glycine receptors contribute equally to depressant actions on spinal ventral horn neurones in rats
    C Grasshoff
    Experimental Anaesthesiology Section, Department of Anaesthesiology University of Tuebingen, Tuebingen, Germany
    Br J Anaesth 97:687-94. 2006
    ..As GABAA and glycine receptors are potential candidates we investigated the impact of both receptor systems in mediating the depressant effects of isoflurane and enflurane on spinal neurones in rats...
  5. ncbi request reprint Cholinergic modulation of sevoflurane potency in cortical and spinal networks in vitro
    Christian Grasshoff
    Department of Anesthesiology, University of Tuebingen, Tuebingen, Germany
    Anesthesiology 106:1147-55. 2007
    ..Because GABAA receptors are major targets of general anesthetics, the authors investigated interactions between acetylcholine and sevoflurane in spinal and cortical networks...
  6. ncbi request reprint Effects of propofol on N-methyl-D-aspartate receptor-mediated calcium increase in cultured rat cerebrocortical neurons
    C Grasshoff
    Eberhard Karls University, Department of Anaesthesiology and Intensive Care, Tuebingen, Germany
    Eur J Anaesthesiol 22:467-70. 2005
    ....
  7. ncbi request reprint Ketamine reduces cholinergic modulated GABA release from rat striatal slices
    Christian Grasshoff
    Institute of Pharmacology and Toxicology, German Armed Forces Medical Academy, Neuherberg Strasse 11, 80937 München, Germany
    Toxicol Lett 156:361-7. 2005
    ..This reduction of striatal GABA release may therefore contribute to the beneficial effect of both drugs in pathological situations of cholinergic overstimulation, e.g. during intoxication with acetylcholine esterase inhibitors...
  8. ncbi request reprint Propofol and sevoflurane depress spinal neurons in vitro via different molecular targets
    Christian Grasshoff
    Section of Experimental Anesthesiology, Department of Anesthesiology, University of Tuebingen, Germany
    Anesthesiology 101:1167-76. 2004
    ..The relevant molecular targets of the commonly used volatile anesthetic sevoflurane in the spinal cord are largely unknown, but indirect evidence suggests a mechanism of action distinct from propofol...
  9. ncbi request reprint Depression of spinal network activity by thiopental: shift from phasic to tonic GABA(A) receptor-mediated inhibition
    C Grasshoff
    Department of Anesthesiology and Intensive Care, Eberhard Karls University, Schaffhausenstrasse 113, D 72072 Tuebingen, Germany
    Neuropharmacology 55:793-802. 2008
    ..With increasing concentrations of the drug, inhibition via sIPSCs is limited by negative feedback on interneuronal firing whereas action potential-independent GABAergic inhibition due to tonic currents gains progressively in impact...
  10. doi request reprint Interactions between atropine and etomidate in cortical and spinal networks during cholinergic crisis
    Berthold Drexler
    Department of Anaesthesiology, Experimental Anaesthesiology Section, Eberhard Karls University, Schaffhausenstrasse 113, 72072 Tuebingen, Germany
    Toxicol Lett 198:342-7. 2010
    ..Atropine reversed this decrease. Hence, etomidate is potentially applicable for induction of anaesthesia in patients suffering from severe cholinergic crisis, preconditioned that atropine is co-applied...
  11. ncbi request reprint Anaesthesia in patients suffering from organophosphorus intoxication--interactions between general anaesthetics and acetylcholine in cortical networks in vitro
    Christian Grasshoff
    Department of Anesthesiology, Experimental Anesthesiology Section, University of Tuebingen, Schaffhausenstr 113, D 72072 Tuebingen, Germany
    Toxicology 233:214-22. 2007
    ..These findings imply that in patients suffering from organophosphorus intoxication dose requirements for general anaesthetics are considerably increased...
  12. ncbi request reprint Organotypic cultures as tools for testing neuroactive drugs - link between in-vitro and in-vivo experiments
    B Drexler
    Department of Anaesthesiology, Experimental Anaesthesiology Section, Eberhard Karls University, Schaffhausenstrasse 113, 72072 Tuebingen, Germany
    Curr Med Chem 17:4538-50. 2010
    ....
  13. ncbi request reprint [The GABA(A) receptor family: possibilities for the development of better anesthetics]
    B Drexler
    Abteilung für Anaesthesiologie und Intensivmedizin, Universitatsklinikum, Tubingen
    Anaesthesist 55:287-95. 2006
    ..These findings form the basis for the development of new drugs, acting highly specific and with fewer side-effects...
  14. ncbi request reprint The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices
    Christian Grasshoff
    Institute of Pharmacology and Toxicology, German Armed Forces Medical Academy, Muenchen, Germany
    Toxicology 184:149-56. 2003
    ..These results clearly indicate that AChE inhibition by soman in rat striatum can directly lead to enhanced release of GABA through M-cholinoceptors...
  15. ncbi request reprint The effect of propofol on increased superoxide concentration in cultured rat cerebrocortical neurons after stimulation of N-methyl-d-aspartate receptors
    Christian Grasshoff
    Institute of Pharmacology and Toxicology, GAF Medical Academy, Munich, Germany
    Anesth Analg 95:920-2, table of contents. 2002
    ....
  16. doi request reprint Atropine increases sevoflurane potency in cortical but not spinal networks during cholinergic overstimulation
    Berthold Drexler
    Department of Anaesthesiology, Experimental Anesthesiology Section, Eberhard Karls University, Schaffhausenstrasse 113, 72072 Tuebingen, Germany
    Toxicology 268:98-103. 2010
    ..Thus, in a clinical setting, we recommend that anaesthetic drugs should be co-applied with atropine for adequate performance of general anaesthesia...