Florian Grabellus

Summary

Country: Germany

Publications

  1. doi Neoadjuvant treatment improves capsular integrity and the width of the fibrous capsule of high-grade soft-tissue sarcomas
    F Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at West German Cancer Center WTZ, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Eur J Surg Oncol 39:61-7. 2013
  2. doi Size-based clinical response evaluation is insufficient to assess clinical response of sarcomas treated with isolated limb perfusion with TNF-α and melphalan
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, Essen, Germany
    Ann Surg Oncol 19:3375-85. 2012
  3. doi The BRAF V600E mutation in papillary thyroid carcinoma is associated with glucose transporter 1 overexpression
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Thyroid 22:377-82. 2012
  4. doi Glucose transporter 1 expression, tumor proliferation, and iodine/glucose uptake in thyroid cancer with emphasis on poorly differentiated thyroid carcinoma
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Clin Nucl Med 37:121-7. 2012
  5. pmc Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis
    Max D Kauther
    Department of Trauma Surgery, University Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    BMC Musculoskelet Disord 12:186. 2011
  6. doi Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrences
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, 45122 Essen, Germany
    Ann Surg Oncol 16:676-86. 2009
  7. doi Tumor vascularization and histopathologic regression of soft tissue sarcomas treated with isolated limb perfusion with TNF-α and melphalan
    Florian Grabellus
    Institute of Pathology and Neuropathology, Sarcoma Center, West German Cancer Center, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    J Surg Oncol 103:371-9. 2011
  8. doi [Giant cell tumors of soft tissue arising in surgical scars]
    F Grabellus
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Deutschland
    Pathologe 30:401-6. 2009
  9. doi Overexpression of the drug resistance-associated protein metallothionein does not correlate with response of sarcomas to isolated limb perfusion treatment
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, Essen, Germany
    J Surg Oncol 101:465-70. 2010
  10. doi MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Tumour Biol 31:157-63. 2010

Detail Information

Publications54

  1. doi Neoadjuvant treatment improves capsular integrity and the width of the fibrous capsule of high-grade soft-tissue sarcomas
    F Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at West German Cancer Center WTZ, University of Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Eur J Surg Oncol 39:61-7. 2013
    ..Neoadjuvant treatment is thought to improve resection with margin-negative surgery in locally advanced soft-tissue sarcomas (STS). Treatment-induced alterations of the tumor peripheryhave not yet been microscopically evaluated...
  2. doi Size-based clinical response evaluation is insufficient to assess clinical response of sarcomas treated with isolated limb perfusion with TNF-α and melphalan
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, Essen, Germany
    Ann Surg Oncol 19:3375-85. 2012
    ..Based on our experience, we assume that anatomic radiological response criteria are insufficient to assess the degree of regression after TM-ILP...
  3. doi The BRAF V600E mutation in papillary thyroid carcinoma is associated with glucose transporter 1 overexpression
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Thyroid 22:377-82. 2012
    ..In this study, we hypothesized that the common BRAF V600E mutation was associated with GLUT1 overexpression and proliferation in papillary thyroid carcinomas (PTCs)...
  4. doi Glucose transporter 1 expression, tumor proliferation, and iodine/glucose uptake in thyroid cancer with emphasis on poorly differentiated thyroid carcinoma
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Clin Nucl Med 37:121-7. 2012
    ..We investigated the relationship among GLUT1 expression, proliferation, iodine concentration, and glucose uptake in different TC types, with emphasis on "poorly differentiated thyroid carcinoma" (PDTC)...
  5. pmc Calcitonin substitution in calcitonin deficiency reduces particle-induced osteolysis
    Max D Kauther
    Department of Trauma Surgery, University Duisburg Essen, Hufelandstr 55, 45147 Essen, Germany
    BMC Musculoskelet Disord 12:186. 2011
    ..This study investigates the impact of CT (calcitonin) deficiency and CT substitution under in-vivo circumstances on particle-induced osteolysis in Calca -/- mice...
  6. doi Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrences
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, 45122 Essen, Germany
    Ann Surg Oncol 16:676-86. 2009
    ..Isolated limb perfusion (TM-ILP) is an effective limb-sparing treatment for primarily nonresectable soft tissue sarcomas (STS). Surgical margins of STS after ILP were yet not systematically studied...
  7. doi Tumor vascularization and histopathologic regression of soft tissue sarcomas treated with isolated limb perfusion with TNF-α and melphalan
    Florian Grabellus
    Institute of Pathology and Neuropathology, Sarcoma Center, West German Cancer Center, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    J Surg Oncol 103:371-9. 2011
    ..Some tumors show an insufficient association between radiological and pathological response. We investigated STS after TM-ILP with a primary emphasis on histologic regression patterns...
  8. doi [Giant cell tumors of soft tissue arising in surgical scars]
    F Grabellus
    Institut für Pathologie und Neuropathologie, Universitatsklinikum Essen, Universitat Duisburg Essen, Deutschland
    Pathologe 30:401-6. 2009
    ....
  9. doi Overexpression of the drug resistance-associated protein metallothionein does not correlate with response of sarcomas to isolated limb perfusion treatment
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at the West German Cancer Center, University of Duisburg Essen, Essen, Germany
    J Surg Oncol 101:465-70. 2010
    ..Objective of this study was to investigate the influence of MT expression on tumor responses in HILP-TM-treated soft tissue (STSs) and bone sarcomas (BS)...
  10. doi MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    Tumour Biol 31:157-63. 2010
    ..A clear influence of polysomy 7 on MET protein expression could not be statistically demonstrated for this cohort. Moreover, gene fusions with the ability to cause MET overexpression do not occur in chordomas...
  11. doi The XbaI G>T polymorphism of the glucose transporter 1 gene modulates 18F-FDG uptake and tumor aggressiveness in breast cancer
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    J Nucl Med 51:1191-7. 2010
    ..We investigated the relevance of single-nucleotide polymorphisms (SNPs) in the glucose transporter 1 (GLUT1) gene to the uptake of (18)F-FDG and tumor aggressiveness in breast cancer...
  12. doi The prevalence of the c-kit exon 10 variant, M541L, in aggressive fibromatosis does not differ from the general population
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital Essen, Essen, Germany
    J Clin Pathol 64:1021-4. 2011
    ..1621 A>C) in aggressive fibromatosis (AF) was recently determined to be 2.5-fold higher than in healthy controls. It was thus hypothesised that M541L could be associated with the development of AF...
  13. ncbi Induction of the matrix metalloproteinase-2 activation system in arteries by tensile stress. Involvement of the p38 MAP-kinase pathway
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, Essen, Germany
    Pathol Res Pract 203:135-43. 2007
    ..The regulation of the vascular gelatinolytic system by MAP kinases suggests a therapeutic option against cardiovascular diseases at the level of MAPK signal transduction...
  14. pmc DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors
    Susanne Simon
    Sarcoma Center, Departments of Medical Oncology, Pathology and Neuropathology, Trauma and Orthopedic Surgery, Visceral and Transplant Surgery, West German Cancer Center, University Duisburg Essen, University Hospital Essen, Germany
    Cancer Res 73:3661-70. 2013
    ..In summary, our findings establish the oncogenic activity of DOG1 in GIST involving modulation of IGF/IGF receptor signaling in the tumor microenvironment through the antiangiogenic factor IGFBP5...
  15. pmc Growth patterns of lung metastases from sarcoma: prognostic and surgical implications from histology
    Stefan Welter
    Division of Thoracic Surgery, Ruhrlandklinik, Essen, Germany
    Interact Cardiovasc Thorac Surg 15:612-7. 2012
    ..The objective of the present study was to evaluate the prognostic impact of intrapulmonary growth patterns of sarcoma metastases...
  16. pmc p53 modulation as a therapeutic strategy in gastrointestinal stromal tumors
    Joern Henze
    Department of Medical Oncology, West German Cancer Center, University Duisburg Essen Medical School, Essen, Germany
    PLoS ONE 7:e37776. 2012
    ....
  17. pmc The pathologic response of resected synovial sarcomas to hyperthermic isolated limb perfusion with melphalan and TNF-α: a comparison with the whole group of resected soft tissue sarcomas
    Benjamin Schwindenhammer
    Institute of Pathology and Neuropathology, University Hospital of Essen and Sarcoma Center at West German Cancer Center WTZ, University of Duisburg Essen, Hufelandstrasse 55, 45122, Essen, Germany
    World J Surg Oncol 11:185. 2013
    ..The data on the effectiveness of HILP-TM for the treatment of STSs are mainly based on various STS types. The aim of this study was to investigate the responses of synovial sarcomas (SS) to TM-HILP...
  18. doi Impact of KIT and PDGFRA gene mutations on prognosis of patients with gastrointestinal stromal tumors after complete primary tumor resection
    Ying Yong Hou
    Department of General, Visceral, and Transplantation Surgery, University Hospital Essen, Essen, Germany
    J Gastrointest Surg 13:1583-92. 2009
    ..To investigate the impact of KIT and PDGFRA gene mutations on the prognosis of gastrointestinal stromal tumors (GIST)...
  19. doi Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma
    Henrike Westekemper
    Department of Ophthalmology, University of Duisburg Essen, Germany
    Br J Ophthalmol 95:853-8. 2011
    ....
  20. doi Hyalinizing trabecular tumour of the thyroid-differential expression of distinct miRNAs compared with papillary thyroid carcinoma
    Sien Yi Sheu
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Germany
    Histopathology 56:632-40. 2010
    ..To compare the expression pattern of five microRNAs (miRNAs) (146b, -181b, -21, -221, -222) of papillary thyroid carcinoma (PTC) and hyalinizing trabecular tumour of the thyroid (HTT)...
  21. doi Increased shedding of soluble TNF-receptor 1 during hyperthermic TNF-α-based isolated limb perfusion
    Florian Grabellus
    Institute of Pathology and Neuropathology, West German Cancer Center, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Int J Hyperthermia 27:33-41. 2011
    ..Shedding of soluble TNF-receptor (sTNF-R) negatively modulates the effects of TNF-α, whereas hyperthermia (HT) induces shedding. Here, we investigated whether sTNF-R shedding in response to HT occurs during HILP...
  22. pmc High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome
    Klaus Jürgen Schmitz
    Institute of Pathology, University Hospital of Essen Duisburg, Essen, Germany
    Breast Cancer Res 7:R194-203. 2005
    ..In particular, with regard to lymph node-negative breast cancer it is important to identify high-risk patients who would benefit from further adjuvant therapy...
  23. ncbi Unusual aggressive course of a giant cell tumor of soft tissue during immunosuppressive therapy
    Florian Grabellus
    Institute of Pathology and Neuropathology, University Hospital of Essen, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Virchows Arch 448:847-51. 2006
    ..Therefore, we suggest that in patients with immunosuppression, even low malignant cancerous lesions should be carefully observed, as their local behavior may be aggressive with development of metastasis...
  24. doi Diagnostic accuracy of dual-time-point 18F-FDG PET/CT for the detection of axillary lymph node metastases in breast cancer patients
    Steffen Hahn
    Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University at Duisburg Essen, Germany
    Acta Radiol 53:518-23. 2012
    ..The diagnostic accuracy of FDG-PET/CT for the detection of axillary lymph node metastases in breast cancer patients acquired 60 min after FDG administration is reported to be only moderate, especially due to low sensitivity...
  25. pmc Trabectedin in metastatic soft tissue sarcomas: Role of pretreatment and age
    Mathias Hoiczyk
    Sarcoma Center, Departments of Medical Oncology, Surgical Oncology and Pathology, West German Cancer Center, University Hospital Essen, University Duisburg Essen, D 45122 Essen, Germany
    Int J Oncol 43:23-8. 2013
    ..Port-associated complications were observed at an unusually high rate. This suggests a drug-specific local toxicity that merits further investigation...
  26. ncbi Heat shock protein 72 and apoptosis indicate cardiac decompensation during early multiple organ failure in sheep
    Hideo A Baba
    Institut fur Pathologie, Universitat Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Intensive Care Med 30:1405-13. 2004
    ..Inducible heat shock protein 72 (HSP 72) preserves myocardial function and prevents apoptosis. We investigated the expression and localization of HSP 72 and apoptosis in our previously described new model of multiple organ failure...
  27. doi Preoperative assessment of hilar cholangiocarcinoma by dual-modality PET/CT
    Jun Li
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    J Surg Oncol 98:438-43. 2008
    ..The purpose of the current study was to evaluate the accuracy of (18)F-FDG PET/CT in staging hilar cholangiocarcinoma...
  28. ncbi Recurrent high-grade leiomyosarcoma with heterologous osteosarcomatous differentiation
    Florian Grabellus
    Institute of Pathology, University Hospital of Essen, University Duisburg Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Virchows Arch 448:85-9. 2006
    ..The identification of areas with osteosarcomatous dedifferentiation in soft tissue sarcomas can be of clinical importance because of a possible change in oncologic treatment strategies...
  29. ncbi Diffuse sclerosing variant of papillary thyroid carcinoma: lack of BRAF mutation but occurrence of RET/PTC rearrangements
    Sien Yi Sheu
    Institute of Pathology and Neuropathology, University Hospital of Essen, Essen, Germany
    Mod Pathol 20:779-87. 2007
    ..Additionally, this rare variant of papillary thyroid carcinoma may represent a tumour type susceptible to RET-targeted therapies...
  30. doi Expression of MCSP and PRAME in conjunctival melanoma
    Henrike Westekemper
    Department of Ophthalmology, University Hospital of Essen, Hufelandstrasse 55, Essen, Germany
    Br J Ophthalmol 94:1322-7. 2010
    ....
  31. doi Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model
    Semra Aydin
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Eur J Haematol 87:10-9. 2011
    ..This model could be useful for evaluating the biological basis of CLL growth in the context of the hematopoietic microenvironment as well as preclinical testing of novel compounds...
  32. doi Targeting Bcl-2 family proteins modulates the sensitivity of B-cell lymphoma to rituximab-induced apoptosis
    Claudia Stolz
    Department of Medicine Cancer Research, West German Cancer Center, University Hospital Essen, Essen, USA
    Blood 112:3312-21. 2008
    ..Pharmacologic modulation of Bcl-2 family proteins or their upstream regulators is a promising strategy to overcome rituximab resistance...
  33. doi Tartrate-resistant acid phosphatase 5b and C-terminal telopeptides of type I collagen as markers for diagnosis of aseptic loosening after total hip replacement
    Stefan Landgraeber
    Department of Orthopaedics, University of Duisburg Essen, Essen, Germany
    Arch Orthop Trauma Surg 130:441-5. 2010
    ..These methods are associated with radiation exposure and some of them have an increased morbidity. Furthermore, in some cases the results are not conclusive...
  34. pmc Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors
    Thomas Mühlenberg
    Sarcoma Center, West German Cancer Center, University of Essen, Medical School, Essen, Germany
    Cancer Res 69:6941-50. 2009
    ..These results provide preclinical evidence for a disease-specific effect of HDACI in KIT-positive GIST, which could translate into therapeutic activity...
  35. doi Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas
    Klaus G Griewank
    Department of Dermatology, Institute of Pathology and Neuropathology, University Hospital, University Duisburg Essen, Essen, Germany
    Clin Cancer Res 19:3143-52. 2013
    ..Once the tumor has metastasized, treatment options are limited and the prognosis is poor. To date, little is known of the genetic alterations in conjunctival melanomas...
  36. ncbi Resolved hypersensitivity myocarditis after ventricular circulatory assist
    Florian Grabellus
    Institute of Pathology, University of Essen, Essen, Germany
    Ann Thorac Surg 76:2102-4. 2003
    ..Ten months later this lesion showed complete reversibility within specimens of the explanted heart, maybe as a result of the termination of inotropic therapy after implantation of the left ventricular assist device...
  37. ncbi Impact of intraoperative radiotherapy (IORT) on survival of patients with unresectable hilar cholangiocarcinoma
    Gernot Maximilian Kaiser
    Department of General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany
    Hepatogastroenterology 55:1951-4. 2008
    ..The aim of this study was to compare the efficacy of IORT to surgery alone in patients with unresectable hilar cholangiocarcinoma...
  38. doi Growth patterns of lung metastases from sarcomas
    Stefan Welter
    Department of Thoracic Surgery, Ruhrlandklinik Essen, Essen, Germany
    Virchows Arch 459:213-9. 2011
    ..Almost half of all pulmonary sarcoma metastases could be identified with aggressive patterns of local growth, and only 17.2% are surrounded by a pseudocapsule which might allow safe resection margins...
  39. doi Adiponectin attenuates osteolysis in aseptic loosening of total hip replacements
    Stefan Landgraeber
    Department of Orthopaedics, University Hospital Essen, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany Electronic address
    Acta Biomater 10:384-93. 2014
    ..These findings support a prominent role of APN in the development of particle-induced osteolysis and APN may be therapeutically useful in patients with aseptic loosening. ..
  40. ncbi Resection of residual disease in patients with metastatic gastrointestinal stromal tumors responding to treatment with imatinib
    Sebastian Bauer
    Department of Internal Medicine Cancer Research, University of Essen Medical School, Essen, Germany
    Int J Cancer 117:316-25. 2005
    ..Further trials investigating a combined surgical and pre/postoperative treatment with imatinib in patients with advanced metastatic GIST are warranted...
  41. ncbi A novel nonobese diabetic/severe combined immunodeficient xenograft model for chronic lymphocytic leukemia reflects important clinical characteristics of the disease
    Jan Dürig
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Cancer Res 67:8653-61. 2007
    ..These results suggest that this model reflects the heterogeneity and important clinical characteristics of the disease, and thus may serve as a tool for preclinical drug testing and investigation of the pathophysiology of CLL...
  42. pmc Magnetic resonance colonography without bowel cleansing: a prospective cross sectional study in a screening population
    Christiane A Kuehle
    Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Gut 56:1079-85. 2007
    ..To evaluate the diagnostic accuracy of magnetic resonance colonography (MRC) without bowel cleansing in a screening population and compare the results to colonoscopy as a standard of reference...
  43. ncbi Feasibility of real-time magnetic resonance-guided stent-graft placement in a swine model of descending aortic dissection
    Holger Eggebrecht
    Department of Cardiology, University of Duisburg Essen, Germany
    Eur Heart J 27:613-20. 2006
    ..Endovascular stent-graft placement for thoracic aortic disease is usually performed under X-ray guidance. The feasibility of rtMRI-guided stent-graft placement is currently not known...
  44. doi RANKL-associated suppression of particle-induced osteolysis in an aged model of Calcitonin and α-CGRP deficiency
    Max D Kauther
    Department of Trauma Surgery, University of Duisburg Essen, Essen, Germany
    Biomaterials 34:2911-9. 2013
    ..CT/α-CGRP modulates bone cell activity in PIO in aged mice in a way that is distinct from young animals. This may have implications for the treatment of PIO in the periprosthetic surface of joint replacements in an aging population...
  45. ncbi Contrast-enhanced dark lumen PET/CT and MR colonography in a rodent polyp model: initial results with histopathologic correlation
    Christiane A Kuehle
    Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    AJR Am J Roentgenol 185:1045-7. 2005
    ..The objective of this study was to assess the feasibility of PET/CT for the detection of colorectal masses in a rodent polyp model in an intraindividual comparison with dark-lumen MR colonography...
  46. ncbi Dynamic regulation of MEK/Erks and Akt/GSK-3beta in human end-stage heart failure after left ventricular mechanical support: myocardial mechanotransduction-sensitivity as a possible molecular mechanism
    Hideo A Baba
    Institute of Pathology, University of Essen, Essen, Germany
    Cardiovasc Res 59:390-9. 2003
    ....
  47. pmc Association between apoptotis and CD4(+)/CD8(+) T-lymphocyte ratio in aseptic loosening after total hip replacement
    Stefan Landgraeber
    Department of Orthopaedics, University of Duisburg Essen, Essen, Germany
    Int J Biol Sci 5:182-91. 2009
    ..It is possible that these findings may lead to a new understanding of particle-induced osteolysis...
  48. doi Chemically induced rat Schwann cell neoplasia as a model for early-stage human peripheral nerve sheath tumors: phenotypic characteristics and dysregulated gene expression
    Bernd Koelsch
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    J Neuropathol Exp Neurol 72:404-15. 2013
    ..These data suggest that the signaling pathways underlying early malignant progression of Schwann cells might be targeted to prevent tumor growth and/or to treat more advanced lesions...
  49. ncbi Toluidine blue for the intraoperative staining of the ureters. Studies on the safe administration in rats
    Frank Petrat
    Institut fur Physiologische Chemie, Universitatsklinikum, Universitat Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Langenbecks Arch Surg 397:983-93. 2012
    ..We here assessed the minimum TB dose required, and its safest and most suitable form of intravenous administration for the intraoperative staining of the ureters in rats...
  50. pmc Expression of GLUT1 is associated with increasing grade of malignancy in non-invasive and invasive urothelial carcinomas of the bladder
    Henning Reis
    Institute of Pathology and Neuropathology, University Hospital of Essen, University of Duisburg Essen, Essen, Germany
    Oncol Lett 2:1149-1153. 2011
    ..The increase of GLUT1 expression may reflect a preinvasive metabolic switch in terms of enhanced cell metabolism concomitant to known genetic alterations. A further increase in invasive carcinomas may be related to hypoxic conditions...
  51. ncbi Melanotic schwannoma of the neck mimicking a malignant melanoma
    Klaus Jürgen Schmitz
    Institute of Pathology, University of Duisburg Essen, Hufelandstr 55, 45122 Essen, Germany
    Eur Arch Otorhinolaryngol 262:182-5. 2005
    ..Although the occurrence of multiple schwannomas points to a hereditary syndrome, our patient did not fulfill the criteria of Carney's syndrome or other known syndromes, suggesting a so far unknown genetic background...
  52. ncbi Reduction of hypoxia-inducible heme oxygenase-1 in the myocardium after left ventricular mechanical support
    Florian Grabellus
    Institute of Pathology, University of Essen, Essen, Germany
    J Pathol 197:230-7. 2002
    ..This supports the concept that restoration of cardiac normoxia by mechanical unloading, particularly in the subendocardium, may be in part responsible for the phenomenon of 'reverse remodelling'...
  53. ncbi Prognostic relevance of activated Akt kinase in node-negative breast cancer: a clinicopathological study of 99 cases
    Klaus Jürgen Schmitz
    Institute of Pathology, University of Essen, Germany
    Mod Pathol 17:15-21. 2004
    ....
  54. ncbi Left ventricular assist device support reverses altered cardiac expression and function of natriuretic peptides and receptors in end-stage heart failure
    Michaela Kuhn
    Institute of Pharmacology and Toxicology and Interdisciplinary Center for Clinical Research, Universitatsklinikum Munster, Domagkstrasse 12, D 48129 Munster, Germany
    Cardiovasc Res 64:308-14. 2004
    ....