Research Topics
Species | Jana GodauSummaryCountry: Germany Publications
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Publications
Substantia nigra hypoechogenicity: definition and findings in restless legs syndromeJana Godau
Hertie Institute of Clinical Brain Research, Division of Neurodegeneration, University of Tubingen, Germany
Mov Disord 22:187-92. 2007..Further studies are needed to investigate its significance for the pathophysiology of this frequent movement disorder and possible clinical applications...- Sonographic abnormalities of brainstem structures in restless legs syndromeJana Godau
Hertie Institute for Clinical Brain Research and Center of Neurology, Department of Neurodegeneration, Hoppe Seyler Str 3, University of Tuebingen, 72076 Tuebingen, Germany
Sleep Med 9:782-9. 2008..The aim of this study was to validate SN hypoechogenicity as a morphological marker for RLS in a large patient cohort and to investigate further RLS-associated brain abnormalities using TCS... 
Transcranial sonography in restless legs syndromeJana Godau
Department of Neurodegeneration, Hertie Institute of Clinical Brain Research and German Center of Neurodegenerative Diseases DZNE, Tubingen, Germany
Int Rev Neurobiol 90:199-215. 2010..The diagnostic parameters for patients with idiopathic and various forms of symptomatic RLS will be discussed as well as the current knowledge about the pathophysiology underlying these sonographical abnormalities...
Poor trail making test performance is directly associated with altered dual task prioritization in the elderly--baseline results from the TREND studyMarkus A Hobert
Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Center of Neurology, University of Tuebingen, Tuebingen, Germany
PLoS ONE 6:e27831. 2011..To disentangle these options we investigated the associations between Trail Making Test performance--which specifically measures cognitive flexibility and working memory--and dual task costs, a measure of prioritization...- Poor effect of guideline based treatment of restless legs syndrome in clinical practiceJana Godau
Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and Centre of Neurology, University of Tubingen, Germany
J Neurol Neurosurg Psychiatry 81:1390-5. 2010..In contrast, epidemiological data demonstrate generally insufficient RLS treatment in clinical practice... - Increased serum insulin-like growth factor 1 in early idiopathic Parkinson's diseaseJana Godau
Hertie Institute for Clinical Brain Research, Department of Neurodegeneration, Hoppe Seyler Str 3, D 72076 Tubingen, Germany
J Neurol Neurosurg Psychiatry 81:536-8. 2010..The aim of this study was to measure serum IGF-1 in patients with PD and assess its correlation with the clinical presentation... - Role of transcranial ultrasound in the diagnosis of movement disordersJana Godau
Department of Neurodegeneration, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
Neuroimaging Clin N Am 20:87-101. 2010..This article provides information about the ultrasound procedure, its specific diagnostic value, and its limitations. Pathophysiologic mechanisms leading to changes in the reflection of ultrasound waves are discussed... - Sonographic substantia nigra hypoechogenicity in polyneuropathy and restless legs syndromeJana Godau
Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
Mov Disord 24:133-7. 2009..2% of patients with idiopathic RLS exhibited SN hypoechogenicity. SN echogenicity did not differ significantly between PNP patients with and without RLS. Thus, TCS seems not suitable for the diagnosis of RLS in patients with PNP... - Multiregional brain iron deficiency in restless legs syndromeJana Godau
Hertie Institute for Clinical Brain Research and Center of Neurology, University of Tuebingen, Tuebingen, Germany
Mov Disord 23:1184-7. 2008..61, P < 0.001). This indicates multiregional (global) brain iron deficiency in RLS and proposes SN echogenicity as a potential morphological marker for brain iron status. (c) 2008 Movement Disorder Society... - Serum insulinlike growth factor 1 as possible marker for risk and early diagnosis of Parkinson diseaseJana Godau
Hertie Institute for Clinical Brain Research, Hoppe Seyler Strasse 3, D 72076, Tubingen, Germany
Arch Neurol 68:925-31. 2011..The level of serum insulinlike growth factor 1 (IGF-1) is increased in idiopathic Parkinson disease (PD)... - Lowered serum amyloid-β1-42 autoantibodies in individuals with lifetime depressionWalter Maetzler
Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, Center of Neurology, University of Tubingen, Tubingen, Germany
J Alzheimers Dis 32:95-100. 2012..7 ± 482.4; p = 0.048). Titers against S100b and α-synuclein were comparable between the cohorts. These data suggest an AD-like impairment of the humoral immune response in a relevant proportion of individuals with depression... - Pre-motor signs of PD are related to SN hyperechogenicity assessed by TCS in an elderly populationInga Liepelt
Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Hoppe Seyler Str 3, D 72076 Tuebingen, Germany
Neurobiol Aging 32:1599-606. 2011..Co-occurrence of these markers is more probable in SN+ subjects. These findings may have implications for the design of high-risk cohorts for PD... - Cortical hypometabolism assessed by a metabolic ratio in Parkinson's disease primarily reflects cognitive deterioration-[18F]FDG-PETInga Liepelt
Hertie Institute for Clinical Brain Research, Department of Neurodegenerative Diseases, University of Tuebingen, Tuebingen, Germany
Mov Disord 24:1504-11. 2009..Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment... - Enlarged substantia nigra hyperechogenicity and risk for Parkinson disease: a 37-month 3-center study of 1847 older personsDaniela Berg
Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center of Neurodegenerative Diseases, Hoppe Seyler Strasse 3, 72076 Tubingen, Germany
Arch Neurol 68:932-7. 2011..To evaluate whether enlarged substantia nigra hyperechogenicity (SN+) is associated with an increased risk for Parkinson disease (PD) in a healthy elderly population... - Enlarged hyperechogenic substantia nigra as a risk marker for Parkinson's diseaseDaniela Berg
Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
Mov Disord 28:216-9. 2013..Recently, we reported a 17.4-fold increased risk for PD in individuals with SN+ older than 50 years within 3 years... - Rivastigmine for the treatment of dementia in patients with progressive supranuclear palsy: Clinical observations as a basis for power calculations and safety analysisIuga Liepelt
Center of Neurology, Department of Neurodegeneration, and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
Alzheimers Dement 6:70-4. 2010..In subtests, meaningful results can be obtained with even lower numbers (five patients for a verbal fluency test, and 14 patients for a logical memory task)... - Transcranial sonography reveals cerebellar, nigral, and forebrain abnormalities in Friedreich's ataxiaMatthis Synofzik
Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, and German Research Center for Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany
Neurodegener Dis 8:470-5. 2011..Its use for assessing cerebellar neurodegeneration, however, has not yet been investigated.Here we investigated whether TCS allows to assess particular features of cerebellar as well as midbrain and forebrain abnormalities in FA... - Three-dimensional magnetic resonance spectroscopic imaging in the substantia nigra of healthy controls and patients with Parkinson's diseaseAdriane Gröger
Department of Neurodegeneration, Hertie Institute for Clinical Brain Research and German Center for Neurodegenerative Disease DZNE, University of Tuebingen, Tuebingen, Germany
Eur Radiol 21:1962-9. 2011..Regional variations of spectroscopic data between the rostral and caudal regions of the substantia nigra as well as the midbrain tegmentum areas were evaluated in healthy controls and patients with Parkinson's disease... - Transcranial sonography in movement disordersDaniela Berg
Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
Lancet Neurol 7:1044-55. 2008..Thus, this neuroimaging method could be recommended for general application in the diagnosis and differential diagnosis of PD... - Enlarged hyperechogenic substantia nigra is related to motor performance and olfaction in the elderlyDaniela Berg
Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
Mov Disord 25:1464-9. 2010..Whether the association of SN+ with both impaired motor performance and hyposmia as seen in this study predicts an increased risk for the development of PD needs to be evaluated in the follow-up investigations... - Substantia nigra hyperechogenicity assessed by transcranial sonography is related to neuropsychological impairment in the elderly populationInga Liepelt
Center of Neurology, Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, University of Tubingen, Hoppe Seyler Str 3, 72076 Tubingen, Germany
J Neural Transm 115:993-9. 2008..02). Binary logistic regression analysis revealed that, besides UPDRS-III (P<0.001) and positive family history for PD (P<0.01), LogII (P<0.05) seems to be independently associated with SN+... - The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson's disease: a prospective blinded studyAlexandra Gaenslen
Center of Neurology, Department of Neurodegeneration and Hertie Institute of Clinical Brain Research, University of Tubingen, Germany
Lancet Neurol 7:417-24. 2008..We aimed to determine the diagnostic value of TCS in the early stages of parkinsonian syndromes, when the clinical symptoms often do not enable a definite diagnosis to be made... - Characterizing POLG ataxia: clinics, electrophysiology and imagingMatthis Synofzik
Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
Cerebellum 11:1002-11. 2012..POLG-A presents with a high load of distinct non-ataxia features, namely, sensory neuropathy, external ophthalmoplegia, ptosis, epilepsy and/or hyperkinetic movement disorders. Involvement of the corticospinal tract, however, is rare... - Cognitive profiles in Parkinson's disease and their relation to dementia: a data-driven approachInga Liepelt-Scarfone
Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Hoppe Seyler Str 3, 72076 Tuebingen, Germany German Center of Neurodegenerative Diseases DZNE, 72076 Tuebingen, Germany
Int J Alzheimers Dis 2012:910757. 2012..Importantly, these profiles were independent of motor progression... - Autoantibodies against amyloid and glial-derived antigens are increased in serum and cerebrospinal fluid of Lewy body-associated dementiasWalter Maetzler
Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany
J Alzheimers Dis 26:171-9. 2011..The potential of neural-derived IgG autoantibodies as part of a biomarker panel for the diagnosis of Lewy body-associated dementias should be further evaluated... - The regional distribution of T2-relaxation times in MR images of the substantia nigra and crus cerebriConstantin Mänz
Department of Diagnostic and Interventional Neuroradiology, University of Tubingen, Hope Seyler Str 3, 72076, Tubingen, Germany
Neuroradiology 52:745-50. 2010..The purpose of our study was to evaluate the depiction of the SN and the CC on calculated R2 maps by analyzing the regional distribution of T2 values in both regions... - Influence of different cut-off values on the diagnosis of mild cognitive impairment in Parkinson's diseaseInga Liepelt-Scarfone
Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, Germany
Parkinsons Dis 2011:540843. 2011..Thus, the use of defined cut-off values for the definition of PD-MCI is highly relevant for comparison purposes. Strict cut-off values may have a higher predictive value for dementia... - Neuroimaging: current role in detecting pre-motor Parkinson's diseaseJana Godau
Center of Neurology, Hertie Institute for Clinical Brain Research, Department of Neurodegeneration and German Center of Neurodegenerative Diseases DZNE, University of Tubingen, Tubingen, Germany
Mov Disord 27:634-43. 2012.... - AFQ056 treatment of levodopa-induced dyskinesias: results of 2 randomized controlled trialsDaniela Berg
University of Tubingen, Hertie Institute of Clinical Brain Research and German Center for Neurodegenerative Diseases, Tubingen, Germany
Mov Disord 26:1243-50. 2011..AFQ056 showed a clinically relevant and significant antidyskinetic effect without changing the antiparkinsonian effects of dopaminergic therapy. © 2011 Movement Disorder Society... - The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's diseaseAlexandra Gaenslen
Department of Neurodegeneration, Hertie Institute of Clinical Brain Research, Tubingen, Germany
Mov Disord 26:653-8. 2011..This time be called the prodromal phase of PD... - Restless legs and substantia nigra hypoechogenicity are common features in Friedreich's ataxiaMatthis Synofzik
Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, Tubingen, Germany
Cerebellum 10:9-13. 2011..Similar to patients with idiopathic RLS, reduced SN echogenicity is a frequent finding in FA, possibly indicating regional changes in subcellular brain iron regulation in FA... - Rotigotine in the Long-Term Treatment of Severe RLS with Augmentation: A Series of 28 CasesJana Godau
Hertie Institute for Clinical Brain Research, University of Tübingen Center of Neurology, Hoppe Seyler Straße 3, 72076 Tubingen, Germany
Sleep Disord 2011:468952. 2011..9%), application site reaction (28.6%), and nausea (14.3%). In the clinical setting, rotigotine seems to be valuable for the long-term treatment of patients with severe RLS and augmentation...