C Gillen

Summary

Country: Germany

Publications

  1. ncbi request reprint Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor
    C Gillen
    Department of Molecular Pharmacology, Grunenthal GmbH, Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:116-21. 2000
  2. ncbi request reprint Identification and characterization of a Ca2+ -sensitive interaction of the vanilloid receptor TRPV1 with tubulin
    C Goswami
    Freie Universitat Berlin, Institute für Chemie Biochemie, Berlin, Germany
    J Neurochem 91:1092-103. 2004
  3. pmc Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay
    H J Behrendt
    Grunenthal GmbH, Molecular Pharmacology, Aachen 52099, Germany
    Br J Pharmacol 141:737-45. 2004
  4. ncbi request reprint Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line
    R Jahnel
    Arbeitsgruppe Neurochemie and Arbeitsgruppe Molekulare Medizin, Institut für Chemie Biochemie, Freie Universitat Berlin, Germany
    Eur J Biochem 268:5489-96. 2001
  5. ncbi request reprint Muscarinic toxin-like proteins from cobra venom
    V V Kukhtina
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Eur J Biochem 267:6784-9. 2000
  6. ncbi request reprint Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury
    F Bosse
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Glia 32:313-27. 2000
  7. ncbi request reprint A new class of Spiegelmers containing 2'-fluoro-nucleotides
    S Helmling
    NOXXON Pharma AG, Berlin, Germany
    Nucleosides Nucleotides Nucleic Acids 22:1035-8. 2003
  8. ncbi request reprint A second alternative transcript of the gap junction gene connexin32 is expressed in murine Schwann cells and modulated in injured sciatic nerve
    G Sohl
    Abt Molekulargenetik, Universitat Bonn, Germany
    Eur J Cell Biol 69:267-75. 1996
  9. ncbi request reprint Proton conductance of human transient receptor potential-vanilloid type-1 expressed in oocytes of Xenopus laevis and in Chinese hamster ovary cells
    S D Vulcu
    Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacherstrasse 67, D 55101 Mainz, Germany
    Neuroscience 125:861-6. 2004
  10. ncbi request reprint Full-lenth cloning, expression and cellular localization of rat plasmolipin mRNA, a proteolipid of PNS and CNS
    C Gillen
    Department of Neurology, University of Dusseldorf, Moorenstrasse 5, D 40558 Düsseldorf, Germany
    Eur J Neurosci 8:405-14. 1996

Collaborators

  • H J Behrendt
  • R Jahnel
  • F Hucho
  • S D Vulcu
  • C Goswami
  • F Bosse
  • S Helmling
  • M Dreger
  • V V Kukhtina
  • H W Muller
  • O Bogen
  • H Nawrath
  • J F Liewald
  • J Rupp
  • S Stark
  • S Klussmann
  • S Vonhoff
  • E Moyroud
  • W Schroeder
  • F Kleinjung
  • I Roehl
  • G Bahrenberg
  • G Sohl
  • J Kurreck
  • O Bender
  • V I Tsetlin
  • C Weise
  • U Pippirs
  • S Wnendt
  • G Petzold
  • R Greiner-Petter
  • V G Starkov
  • T A Muranova
  • Y N Utkin
  • P Franke
  • M Gleichmann
  • K Willecke

Detail Information

Publications10

  1. ncbi request reprint Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor
    C Gillen
    Department of Molecular Pharmacology, Grunenthal GmbH, Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 362:116-21. 2000
    ..These data indicate that the metabolite (+)-M1 is responsible for the mu-opioid-derived analgesic effect...
  2. ncbi request reprint Identification and characterization of a Ca2+ -sensitive interaction of the vanilloid receptor TRPV1 with tubulin
    C Goswami
    Freie Universitat Berlin, Institute für Chemie Biochemie, Berlin, Germany
    J Neurochem 91:1092-103. 2004
    ..The Ca2+ -sensitivity of this interaction suggests that the microtubule cytoskeleton at the cell membrane may be a downstream effector of TRPV1 activation...
  3. pmc Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay
    H J Behrendt
    Grunenthal GmbH, Molecular Pharmacology, Aachen 52099, Germany
    Br J Pharmacol 141:737-45. 2004
    ..6. In conclusion, in the present study, we identified 10 new agonists and three antagonists of TRPM8. We found that, in contrast to VR1, TRPM8 is inhibited rather than potentiated by protons...
  4. ncbi request reprint Biochemical characterization of the vanilloid receptor 1 expressed in a dorsal root ganglia derived cell line
    R Jahnel
    Arbeitsgruppe Neurochemie and Arbeitsgruppe Molekulare Medizin, Institut für Chemie Biochemie, Freie Universitat Berlin, Germany
    Eur J Biochem 268:5489-96. 2001
    ..In the light of conflicting literature data on biochemical characteristics of VR1, our data suggest that dorsal root ganglion-derived F-11 cells provide a powerful experimental system for the study of VR1 biochemistry...
  5. ncbi request reprint Muscarinic toxin-like proteins from cobra venom
    V V Kukhtina
    Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia
    Eur J Biochem 267:6784-9. 2000
    ..MTLP-1 showed no inhibitory effect on alpha-cobratoxin binding to the nicotinic acetylcholine receptor from Torpedo californica at concentrations up to 20 microM...
  6. ncbi request reprint Cellular localization of the disintegrin CRII-7/rMDC15 mRNA in rat PNS and CNS and regulated expression in postnatal development and after nerve injury
    F Bosse
    Molecular Neurobiology Laboratory, Department of Neurology, Heinrich Heine University of Dusseldorf, Dusseldorf, Germany
    Glia 32:313-27. 2000
    ..In situ hybridization on paraffin sections showed the cellular localization of CRII-7/rMDC15 mRNA in Schwann cells and endothelial cells of peripheral nerve and in various neuronal populations in brain and spinal cord...
  7. ncbi request reprint A new class of Spiegelmers containing 2'-fluoro-nucleotides
    S Helmling
    NOXXON Pharma AG, Berlin, Germany
    Nucleosides Nucleotides Nucleic Acids 22:1035-8. 2003
    ..Synthesis of 2'-fluoro-nucleosides from L-arabinose in order to perform the synthesis of 2'-fluoro-Spiegelmers binding to a neuropeptide...
  8. ncbi request reprint A second alternative transcript of the gap junction gene connexin32 is expressed in murine Schwann cells and modulated in injured sciatic nerve
    G Sohl
    Abt Molekulargenetik, Universitat Bonn, Germany
    Eur J Cell Biol 69:267-75. 1996
    ..submitted for publication, 1995). Thus, the murine Cx32 gene is likely to be regulated by three alternative promoters that appear to be activated in a cell type-specific manner...
  9. ncbi request reprint Proton conductance of human transient receptor potential-vanilloid type-1 expressed in oocytes of Xenopus laevis and in Chinese hamster ovary cells
    S D Vulcu
    Department of Pharmacology, Johannes Gutenberg University, Obere Zahlbacherstrasse 67, D 55101 Mainz, Germany
    Neuroscience 125:861-6. 2004
    ..We conclude that TRPV1 conducts protons, in addition to Na(+), K(+), Mg(2+), and Ca(2+). The proton conductance may help to initiate action potentials and to translocate H(+) dependent on TRPV1 activation and membrane potential...
  10. ncbi request reprint Full-lenth cloning, expression and cellular localization of rat plasmolipin mRNA, a proteolipid of PNS and CNS
    C Gillen
    Department of Neurology, University of Dusseldorf, Moorenstrasse 5, D 40558 Düsseldorf, Germany
    Eur J Neurosci 8:405-14. 1996
    ..Our data indicate a function of plasmolipin during myelination in the central as well as in the peripheral nervous system...