Christian Gieger

Summary

Country: Germany

Publications

  1. pmc New gene functions in megakaryopoiesis and platelet formation
    Christian Gieger
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Nature 480:201-8. 2011
  2. pmc Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    BMC Neurol 11:134. 2011
  3. pmc Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays
    Arnd Gross
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107 Leipzig, Germany
    BMC Genet 12:67. 2011
  4. pmc Human gene expression sensitivity according to large scale meta-analysis
    Pei Hao
    Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    BMC Bioinformatics 10:S56. 2009
  5. pmc CONAN: copy number variation analysis software for genome-wide association studies
    Lukas Forer
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria
    BMC Bioinformatics 11:318. 2010
  6. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012
  7. pmc Human serum metabolic profiles are age dependent
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Aging Cell 11:960-7. 2012
  8. pmc Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS Genet 8:e1003005. 2012
  9. pmc Body fat free mass is associated with the serum metabolite profile in a population-based study
    Carolin Jourdan
    Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e40009. 2012
  10. doi request reprint Rare sequence variants in ANO3 and GNAL in a primary torsion dystonia series and controls
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    Mov Disord 29:143-7. 2014

Detail Information

Publications32

  1. pmc New gene functions in megakaryopoiesis and platelet formation
    Christian Gieger
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Nature 480:201-8. 2011
    ..Taken together, our findings advance understanding of novel gene functions controlling fate-determining events during megakaryopoiesis and platelet formation, providing a new example of successful translation of GWAS to function...
  2. pmc Novel SCARB2 mutation in action myoclonus-renal failure syndrome and evaluation of SCARB2 mutations in isolated AMRF features
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    BMC Neurol 11:134. 2011
    ..To test the hypothesis whether isolated appearance of individual AMRF syndrome features could be related to heterozygote SCARB2 mutations, we screened for SCARB2 mutations in unrelated patients showing isolated AMRF features...
  3. pmc Population-genetic comparison of the Sorbian isolate population in Germany with the German KORA population using genome-wide SNP arrays
    Arnd Gross
    Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Haertelstrasse 16 18, 04107 Leipzig, Germany
    BMC Genet 12:67. 2011
    ..We also aim to separate effects of over-sampling of families in the Sorbs sample from effects of genetic isolation and compare the power of genetic association studies between the samples...
  4. pmc Human gene expression sensitivity according to large scale meta-analysis
    Pei Hao
    Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    BMC Bioinformatics 10:S56. 2009
    ..Systematical study of this concept is required because of its important implications in microarray analysis etc. J.H. Ohn et al. first studied this gene property with yeast transcriptional profiling data...
  5. pmc CONAN: copy number variation analysis software for genome-wide association studies
    Lukas Forer
    Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria
    BMC Bioinformatics 11:318. 2010
    ....
  6. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012
    ..Its flexible design enables both the use of prior knowledge and the generation of new knowledge on connection of multiple phenotypes. A software program for PSEA based on GWAS results is available upon request...
  7. pmc Human serum metabolic profiles are age dependent
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Aging Cell 11:960-7. 2012
    ..The use of metabolomics will increase our understanding of aging networks and may lead to discoveries that help enhance healthy aging...
  8. pmc Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS Genet 8:e1003005. 2012
    ..Our approach is generic in nature and can be directly transferred to metabolomics data from different experimental platforms...
  9. pmc Body fat free mass is associated with the serum metabolite profile in a population-based study
    Carolin Jourdan
    Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e40009. 2012
    ..To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study...
  10. doi request reprint Rare sequence variants in ANO3 and GNAL in a primary torsion dystonia series and controls
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    Mov Disord 29:143-7. 2014
    ..Rare autosomal-dominant mutations in ANO3 and GNAL have been recently shown to represent novel genetic factors underlying primary torsion dystonia (PTD) with predominantly craniocervical involvement...
  11. pmc On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies
    Ann Kristin Petersen
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    BMC Bioinformatics 13:120. 2012
    ..So far, only a rule of thumb was applied to determine the significance of the p-gain...
  12. pmc A genome-wide perspective of genetic variation in human metabolism
    Thomas Illig
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 42:137-41. 2010
    ..5 x 10(-179). These loci explained 5.6%-36.3% of the observed variance in metabolite concentrations. For several loci, associations with clinically relevant parameters have been reported previously...
  13. pmc Tobacco smoking leads to extensive genome-wide changes in DNA methylation
    Sonja Zeilinger
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 8:e63812. 2013
    ..The results of our study confirm the broad effect of tobacco smoking on the human organism, but also show that quitting tobacco smoking presumably allows regaining the DNA methylation state of never smokers...
  14. doi request reprint Genetic associations with lipoprotein subfractions provide information on their biological nature
    Ann Kristin Petersen
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg 85764, Germany
    Hum Mol Genet 21:1433-43. 2012
    ..Future clinical studies are now needed to investigate their biomedical relevance...
  15. pmc Niemann-Pick C disease gene mutations and age-related neurodegenerative disorders
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 8:e82879. 2013
    ..Misdiagnosed NPC patients were not present in our samples. However, further assessment of NPC disease genes in age-related neurodegeneration is warranted...
  16. pmc Rare variants in PLXNA4 and Parkinson's disease
    Eva C Schulte
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat, Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 8:e79145. 2013
    ....
  17. pmc Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood
    Divya Mehta
    Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Eur J Hum Genet 21:48-54. 2013
    ..Our data demonstrate that eQTLs in whole blood are highly robust and reproducible across studies and highlight the relevance of whole-blood eQTL mapping in prioritization of GWAS candidate genes in humans...
  18. pmc Novel biomarkers for pre-diabetes identified by metabolomics
    Rui Wang-Sattler
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Syst Biol 8:615. 2012
    ..The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D...
  19. doi request reprint Genetic variation in metabolic phenotypes: study designs and applications
    Karsten Suhre
    Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar
    Nat Rev Genet 13:759-69. 2012
    ..We discuss such design considerations and applications in this Review...
  20. pmc Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 5:e13953. 2010
    ....
  21. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
  22. doi request reprint A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
    ..Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria...
  23. doi request reprint Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions
    Iris M Heid
    Institute of Epidemiology, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Circ Cardiovasc Genet 1:10-20. 2008
    ..We aimed to identify gene regions that influence HDLC levels by a genome-wide association analysis in the population-based KORA (Cooperative Health Research in the Region of Augsburg) study...
  24. pmc Discovery of sexual dimorphisms in metabolic and genetic biomarkers
    Kirstin Mittelstrass
    Unit of Molecular Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 7:e1002215. 2011
    ..Our study provides new important insights into sex-specific differences of cell regulatory processes and underscores that studies should consider sex-specific effects in design and interpretation...
  25. doi request reprint Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon
    Derek Spieler
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Genome Res 24:592-603. 2014
    ..Thus, in vivo and in vitro analysis of a common SNP with small effect size showed allele-dependent function in the prospective basal ganglia representing the first neurodevelopmental region implicated in RLS. ..
  26. pmc Metabolomic markers reveal novel pathways of ageing and early development in human populations
    Cristina Menni
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Epidemiology I, Helmholtz Zentrum Munchen, Neuherberg, Germany, Pfizer Research Laboratories, Groton, CT, USA, Worldwide R and D, Pfizer Inc, Cambridge, MA, USA, School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, Metabolon Inc, 617 Davis Drive, Durham, NC 27713, USA Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, National University of Singapore
    Int J Epidemiol 42:1111-9. 2013
    ..Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age...
  27. doi request reprint The role of SCARB2 as susceptibility factor in Parkinson's disease
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Mov Disord 28:538-40. 2013
    ..An association between the common SNP rs6812193, upstream of SCARB2, and PD has been reported previously. The role of exonic variants in the SCARB2 gene in PD has not been examined...
  28. doi request reprint Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function
    Rajesh Rawal
    Institute of Genetic Epidemiology, Helmholtz Zentrum Mu nchen, 85764 Neuherberg, Germany
    Hum Mol Genet 21:3275-82. 2012
    ..Together, these four quantitative trait loci accounted for ∼3.3% of the variance in TSH serum levels. These results contribute to our understanding of genetic factors and physiological mechanisms mediating thyroid function...
  29. pmc Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies
    Harald Grallert
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Heart J 33:238-51. 2012
    ..We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association study as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium...
  30. pmc Human metabolic individuality in biomedical and pharmaceutical research
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Nature 477:54-60. 2011
    ..The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research...
  31. pmc A genome-wide association study identifies three loci associated with mean platelet volume
    Christa Meisinger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Am J Hum Genet 84:66-71. 2009
    ..These findings may not only enhance our understanding of platelet activation and function, but may also provide a focus for several novel research avenues...
  32. pmc Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
    Cornelia Huth
    Institute of Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Ann Med 41:128-38. 2009
    ..Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results...