Christian Gieger

Summary

Country: Germany

Publications

  1. pmc Human serum metabolic profiles are age dependent
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Aging Cell 11:960-7. 2012
  2. pmc Differences between human plasma and serum metabolite profiles
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 6:e21230. 2011
  3. pmc Schizophrenia shows a unique metabolomics signature in plasma
    Y He
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Transl Psychiatry 2:e149. 2012
  4. pmc Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study
    Tao Xu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Ingolstädter Landstraße 1, Neuherberg 85764, Germany
    BMC Med 11:60. 2013
  5. pmc Novel biomarkers for pre-diabetes identified by metabolomics
    Rui Wang-Sattler
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Syst Biol 8:615. 2012
  6. pmc Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study
    Rui Wang-Sattler
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 3:e3863. 2008
  7. pmc Human gene expression sensitivity according to large scale meta-analysis
    Pei Hao
    Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    BMC Bioinformatics 10:S56. 2009
  8. pmc A genome-wide perspective of genetic variation in human metabolism
    Thomas Illig
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 42:137-41. 2010
  9. pmc Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
    Cornelia Huth
    Institute of Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Ann Med 41:128-38. 2009
  10. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012

Detail Information

Publications42

  1. pmc Human serum metabolic profiles are age dependent
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, 85764 Neuherberg, Germany
    Aging Cell 11:960-7. 2012
    ..The use of metabolomics will increase our understanding of aging networks and may lead to discoveries that help enhance healthy aging...
  2. pmc Differences between human plasma and serum metabolite profiles
    Zhonghao Yu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS ONE 6:e21230. 2011
    ..However, different collecting procedures and the coagulation cascade influence concentrations of both proteins and metabolites in these matrices. The effects on metabolite concentration profiles have not been fully characterized...
  3. pmc Schizophrenia shows a unique metabolomics signature in plasma
    Y He
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Transl Psychiatry 2:e149. 2012
    ..This study illustrated that the metabolic deviations detected in plasma may serve as potential biomarkers to aid diagnosis of schizophrenia...
  4. pmc Effects of smoking and smoking cessation on human serum metabolite profile: results from the KORA cohort study
    Tao Xu
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Ingolstädter Landstraße 1, Neuherberg 85764, Germany
    BMC Med 11:60. 2013
    ..Here, we extend our metabolomics study with a large prospective study including female smokers and quitters...
  5. pmc Novel biomarkers for pre-diabetes identified by metabolomics
    Rui Wang-Sattler
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Mol Syst Biol 8:615. 2012
    ..The expression levels of these enzymes correlate with changes in the metabolite concentrations linked to diabetes. Our results may help developing novel strategies to prevent T2D...
  6. pmc Metabolic profiling reveals distinct variations linked to nicotine consumption in humans--first results from the KORA study
    Rui Wang-Sattler
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 3:e3863. 2008
    ..Our findings provide new insight into the pathophysiology of smoking addiction. Activation of the enzyme alkyl-DHAP by small molecules may provide novel routes for therapy...
  7. pmc Human gene expression sensitivity according to large scale meta-analysis
    Pei Hao
    Bioinformatics Center, Key Lab of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China
    BMC Bioinformatics 10:S56. 2009
    ..Systematical study of this concept is required because of its important implications in microarray analysis etc. J.H. Ohn et al. first studied this gene property with yeast transcriptional profiling data...
  8. pmc A genome-wide perspective of genetic variation in human metabolism
    Thomas Illig
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 42:137-41. 2010
    ..5 x 10(-179). These loci explained 5.6%-36.3% of the observed variance in metabolite concentrations. For several loci, associations with clinically relevant parameters have been reported previously...
  9. pmc Joint analysis of individual participants' data from 17 studies on the association of the IL6 variant -174G>C with circulating glucose levels, interleukin-6 levels, and body mass index
    Cornelia Huth
    Institute of Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    Ann Med 41:128-38. 2009
    ..Several studies have investigated associations between the -174G>C single nucleotide polymorphism (rs1800795) of the IL6 gene and phenotypes related to type 2 diabetes mellitus (T2DM) but presented inconsistent results...
  10. doi request reprint PSEA: Phenotype Set Enrichment Analysis--a new method for analysis of multiple phenotypes
    Janina S Ried
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Ingolstädter Landstraße 1, Neuherberg, Germany
    Genet Epidemiol 36:244-52. 2012
    ..Its flexible design enables both the use of prior knowledge and the generation of new knowledge on connection of multiple phenotypes. A software program for PSEA based on GWAS results is available upon request...
  11. pmc Mining the unknown: a systems approach to metabolite identification combining genetic and metabolic information
    Jan Krumsiek
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    PLoS Genet 8:e1003005. 2012
    ..Our approach is generic in nature and can be directly transferred to metabolomics data from different experimental platforms...
  12. pmc Body fat free mass is associated with the serum metabolite profile in a population-based study
    Carolin Jourdan
    Institute of Epidemiology I, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 7:e40009. 2012
    ..To characterise the influence of the fat free mass on the metabolite profile in serum samples from participants of the population-based KORA (Cooperative Health Research in the Region of Augsburg) S4 study...
  13. pmc Discovery of sexual dimorphisms in metabolic and genetic biomarkers
    Kirstin Mittelstrass
    Unit of Molecular Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 7:e1002215. 2011
    ..Our study provides new important insights into sex-specific differences of cell regulatory processes and underscores that studies should consider sex-specific effects in design and interpretation...
  14. pmc Blood cis-eQTL analysis fails to identify novel association signals among sub-threshold candidates from genome-wide association studies in restless legs syndrome
    Eva C Schulte
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 9:e98092. 2014
    ..42). Although a similar approach has been used successfully with regard to other complex diseases, we were unable to identify new genetic susceptibility factor for RLS by adding this novel level of functional assessment to RLS GWAS data...
  15. pmc Tobacco smoking leads to extensive genome-wide changes in DNA methylation
    Sonja Zeilinger
    Research Unit of Molecular Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 8:e63812. 2013
    ..The results of our study confirm the broad effect of tobacco smoking on the human organism, but also show that quitting tobacco smoking presumably allows regaining the DNA methylation state of never smokers...
  16. doi request reprint Genome-wide association analysis of high-density lipoprotein cholesterol in the population-based KORA study sheds new light on intergenic regions
    Iris M Heid
    Institute of Epidemiology, Helmholtz Center, Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Circ Cardiovasc Genet 1:10-20. 2008
    ..We aimed to identify gene regions that influence HDLC levels by a genome-wide association analysis in the population-based KORA (Cooperative Health Research in the Region of Augsburg) study...
  17. doi request reprint Rare sequence variants in ANO3 and GNAL in a primary torsion dystonia series and controls
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    Mov Disord 29:143-7. 2014
    ..Rare autosomal-dominant mutations in ANO3 and GNAL have been recently shown to represent novel genetic factors underlying primary torsion dystonia (PTD) with predominantly craniocervical involvement...
  18. pmc Metabolomics approach reveals effects of antihypertensives and lipid-lowering drugs on the human metabolism
    Elisabeth Altmaier
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764, Neuherberg, Germany
    Eur J Epidemiol 29:325-36. 2014
    ..Taken together, our results provide a basis for a deeper functional understanding of the action and side-effects of antihypertensive and lipid-lowering drugs in the general population. ..
  19. pmc A genome-wide association study identifies three loci associated with mean platelet volume
    Christa Meisinger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Am J Hum Genet 84:66-71. 2009
    ..These findings may not only enhance our understanding of platelet activation and function, but may also provide a focus for several novel research avenues...
  20. pmc Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 5:e13953. 2010
    ....
  21. pmc Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
    Christian Gieger
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 4:e1000282. 2008
    ..These genetically determined metabotypes may subscribe the risk for a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental challenge...
  22. doi request reprint Genetic associations with lipoprotein subfractions provide information on their biological nature
    Ann Kristin Petersen
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg 85764, Germany
    Hum Mol Genet 21:1433-43. 2012
    ..Future clinical studies are now needed to investigate their biomedical relevance...
  23. pmc On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies
    Ann Kristin Petersen
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany
    BMC Bioinformatics 13:120. 2012
    ..So far, only a rule of thumb was applied to determine the significance of the p-gain...
  24. pmc Targeted Resequencing and Systematic In Vivo Functional Testing Identifies Rare Variants in MEIS1 as Significant Contributors to Restless Legs Syndrome
    Eva C Schulte
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, 81675 Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, 85764 Munich, Germany
    Am J Hum Genet 95:85-95. 2014
    ....
  25. pmc Mapping the genetic architecture of gene regulation in whole blood
    Katharina Schramm
    Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany Institute of Human Genetics, Technical University Munich, Munchen, Germany
    PLoS ONE 9:e93844. 2014
    ..We aimed to assess whether whole blood expression quantitative trait loci (eQTLs) with effects in cis and trans are robust and can be used to identify regulatory pathways affecting disease susceptibility...
  26. pmc Metabolomic markers reveal novel pathways of ageing and early development in human populations
    Cristina Menni
    Department of Twin Research and Genetic Epidemiology, King s College London, London, UK, Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, Neuherberg, Germany, Institute of Epidemiology I, Helmholtz Zentrum Munchen, Neuherberg, Germany, Pfizer Research Laboratories, Groton, CT, USA, Worldwide R and D, Pfizer Inc, Cambridge, MA, USA, School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia, Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, Australia, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK, Metabolon Inc, 617 Davis Drive, Durham, NC 27713, USA Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, Doha, National University of Singapore
    Int J Epidemiol 42:1111-9. 2013
    ..Human ageing is a complex, multifactorial process and early developmental factors affect health outcomes in old age...
  27. pmc Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood
    Divya Mehta
    Institute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Eur J Hum Genet 21:48-54. 2013
    ..Our data demonstrate that eQTLs in whole blood are highly robust and reproducible across studies and highlight the relevance of whole-blood eQTL mapping in prioritization of GWAS candidate genes in humans...
  28. pmc Niemann-pick C disease gene mutations and age-related neurodegenerative disorders
    Michael Zech
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 8:e82879. 2013
    ..Misdiagnosed NPC patients were not present in our samples. However, further assessment of NPC disease genes in age-related neurodegeneration is warranted. ..
  29. pmc Rare variants in PLXNA4 and Parkinson's disease
    Eva C Schulte
    Neurologische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat, Munchen, Munich, Germany Institut für Humangenetik, Helmholtz Zentrum Munchen, Munich, Germany
    PLoS ONE 8:e79145. 2013
    ....
  30. doi request reprint Genetic variation in metabolic phenotypes: study designs and applications
    Karsten Suhre
    Department of Physiology and Biophysics, Weill Cornell Medical College in Qatar, Education City, Qatar Foundation, PO Box 24144, Doha, Qatar
    Nat Rev Genet 13:759-69. 2012
    ..We discuss such design considerations and applications in this Review...
  31. pmc Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study
    Karl Heinz Ladwig
    Institute of Epidemiology II, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    PLoS ONE 8:e64762. 2013
    ..We analysed the impact of Posttraumatic Stress Disorder (PTSD) on TL in the general population and postulated a dose-dependent TL association in subjects suffering from partial PTSD compared to full PTSD...
  32. doi request reprint A genome-wide association study of metabolic traits in human urine
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Nat Genet 43:565-9. 2011
    ..Moreover, we identify rs37369 in AGXT2 as the genetic basis of hyper-β-aminoisobutyric aciduria...
  33. doi request reprint SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
    Angela Doring
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Nat Genet 40:430-6. 2008
    ..The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women...
  34. pmc Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A
    Carola Marzi
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    PLoS Genet 6:e1001213. 2010
    ..5-p13 region in the regulation of baseline A-SAA levels and provide confirmative evidence of the importance of the 1p31 region for inflammatory processes and the close interplay between A-SAA, leptin, and other acute-phase proteins...
  35. doi request reprint Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function
    Rajesh Rawal
    Institute of Genetic Epidemiology, Helmholtz Zentrum Mu nchen, 85764 Neuherberg, Germany
    Hum Mol Genet 21:3275-82. 2012
    ..Together, these four quantitative trait loci accounted for ∼3.3% of the variance in TSH serum levels. These results contribute to our understanding of genetic factors and physiological mechanisms mediating thyroid function...
  36. doi request reprint The role of SCARB2 as susceptibility factor in Parkinson's disease
    Franziska Hopfner
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany
    Mov Disord 28:538-40. 2013
    ..An association between the common SNP rs6812193, upstream of SCARB2, and PD has been reported previously. The role of exonic variants in the SCARB2 gene in PD has not been examined...
  37. pmc New gene functions in megakaryopoiesis and platelet formation
    Christian Gieger
    Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstadter Landstr 1, 85764 Neuherberg, Germany
    Nature 480:201-8. 2011
    ..Taken together, our findings advance understanding of novel gene functions controlling fate-determining events during megakaryopoiesis and platelet formation, providing a new example of successful translation of GWAS to function...
  38. pmc Human metabolic individuality in biomedical and pharmaceutical research
    Karsten Suhre
    Institute of Bioinformatics and Systems Biology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Nature 477:54-60. 2011
    ..The study advances our knowledge of the genetic basis of metabolic individuality in humans and generates many new hypotheses for biomedical and pharmaceutical research...
  39. pmc Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
    Melanie Kolz
    Institute of Epidemiology, Helmholtz Zentrum Munchen, National Research Center for Environment and Health, Neuherberg, Germany
    PLoS Genet 5:e1000504. 2009
    ..In addition, these findings strongly support the hypothesis that transport proteins are key in regulating serum uric acid levels...
  40. pmc Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon
    Derek Spieler
    Institute of Human Genetics, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Genome Res 24:592-603. 2014
    ..Thus, in vivo and in vitro analysis of a common SNP with small effect size showed allele-dependent function in the prospective basal ganglia representing the first neurodevelopmental region implicated in RLS. ..
  41. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  42. pmc Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies
    Harald Grallert
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Eur Heart J 33:238-51. 2012
    ..We searched for genetic loci related to Lp-PLA2 mass or activity by a genome-wide association study as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium...