Harald zur Hausen

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc A synthetic E7 gene of human papillomavirus type 16 that yields enhanced expression of the protein in mammalian cells and is useful for DNA immunization studies
    Angel Cid-Arregui
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Virol 77:4928-37. 2003
  2. ncbi Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis
    H zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Natl Cancer Inst 92:690-8. 2000
  3. ncbi Perspectives of contemporary papillomavirus research
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    Vaccine 24:S3/iii-iv. 2006
  4. ncbi Novel human polyomaviruses--re-emergence of a well known virus family as possible human carcinogens
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    Int J Cancer 123:247-50. 2008
  5. ncbi Papillomaviruses--to vaccination and beyond
    H zur Hausen
    Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280, Heidelberg 69120, Germany
    Biochemistry (Mosc) 73:498-503. 2008
  6. pmc A specific signature of Merkel cell polyomavirus persistence in human cancer cells
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 105:16063-4. 2008
  7. doi Papillomaviruses in the causation of human cancers - a brief historical account
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Virology 384:260-5. 2009
  8. ncbi TT viruses: oncogenic or tumor-suppressive properties?
    H zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Top Microbiol Immunol 331:109-16. 2009
  9. ncbi Childhood leukemias and other hematopoietic malignancies: interdependence between an infectious event and chromosomal modifications
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Angewandte Tumorvirologie, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Int J Cancer 125:1764-70. 2009
  10. ncbi Papillomaviruses and cancer: from basic studies to clinical application
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nat Rev Cancer 2:342-50. 2002

Collaborators

Detail Information

Publications32

  1. pmc A synthetic E7 gene of human papillomavirus type 16 that yields enhanced expression of the protein in mammalian cells and is useful for DNA immunization studies
    Angel Cid-Arregui
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Virol 77:4928-37. 2003
    ..Thus, the nonhuman codon bias may have been conserved by HPVs to prevent compromising viability of the host cells by excessive viral early protein expression, as well as to evade the immune system...
  2. ncbi Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis
    H zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Natl Cancer Inst 92:690-8. 2000
    ..Modifications in host-cell genes, most likely engaged in the control of HPV gene expression in proliferating cells, emerge as important events in HPV-mediated carcinogenesis...
  3. ncbi Perspectives of contemporary papillomavirus research
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    Vaccine 24:S3/iii-iv. 2006
  4. ncbi Novel human polyomaviruses--re-emergence of a well known virus family as possible human carcinogens
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    Int J Cancer 123:247-50. 2008
    ..It also makes reference to observations of polyomavirus-like particles in other conditions, particularly in hair-follicle cell-related proliferations...
  5. ncbi Papillomaviruses--to vaccination and beyond
    H zur Hausen
    Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280, Heidelberg 69120, Germany
    Biochemistry (Mosc) 73:498-503. 2008
    ..Some of the mechanistic aspects are discussed in this review...
  6. pmc A specific signature of Merkel cell polyomavirus persistence in human cancer cells
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 105:16063-4. 2008
  7. doi Papillomaviruses in the causation of human cancers - a brief historical account
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Virology 384:260-5. 2009
    ..This review will cover some of the historical aspects of papillomavirus research; it tries briefly to analyze the present state of linking HPV to human cancers and will discuss some emerging developments...
  8. ncbi TT viruses: oncogenic or tumor-suppressive properties?
    H zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Top Microbiol Immunol 331:109-16. 2009
    ..Significant oncolytic functions, potentially mediated by the inhibition of nuclear factor (NF)-kappaB transcription factor or by apoptin-like gene activities, are emerging to be less likely...
  9. ncbi Childhood leukemias and other hematopoietic malignancies: interdependence between an infectious event and chromosomal modifications
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Angewandte Tumorvirologie, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Int J Cancer 125:1764-70. 2009
    ..Existing data on polyoma-like virus types seem to render members of this or structurally related virus families as putative candidates for these malignancies...
  10. ncbi Papillomaviruses and cancer: from basic studies to clinical application
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nat Rev Cancer 2:342-50. 2002
    ..Epidemiological studies have underlined that HPVs are the main aetiological factor for cervical cancer. But how has this knowledge been translated into the clinic to allow the prevention, screening and treatment of cervical cancer?..
  11. ncbi The search for infectious causes of human cancers: where and why (Nobel lecture)
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 60120 Heidelberg, Germany
    Angew Chem Int Ed Engl 48:5798-808. 2009
    ..Emphasis is placed on hematopoietic malignancies, breast and colorectal cancers, as well as basal cell carcinomas of the skin and lung cancers in nonsmokers...
  12. ncbi The search for infectious causes of human cancers: where and why
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Virology 392:1-10. 2009
    ..Emphasis is placed on hematopoietic malignancies, breast and colorectal cancers, but also basal cell carcinomas of the skin and lung cancers in non-smokers...
  13. ncbi HPV vaccines: what remains to be done? Interview by Lauren Constable
    Harald zur Hausen
    Expert Rev Vaccines 10:1505-7. 2011
  14. ncbi Proliferation-inducing viruses in non-permissive systems as possible causes of human cancers
    H zur Hausen
    Deutsches Krebsforschungzentrum, Heidelberg, Germany
    Lancet 357:381-4. 2001
    ..Human tumours should be systematically assessed for proliferation-inducing viruses in non-permissive systems...
  15. pmc Low-dose adenovirus vaccine encoding chimeric hepatitis B virus surface antigen-human papillomavirus type 16 E7 proteins induces enhanced E7-specific antibody and cytotoxic T-cell responses
    Andrés Báez-Astúa
    Gentherapie von Tumoren, Deutsches Krebsforschungszentum DKFZ, Heidelberg, Germany
    J Virol 79:12807-17. 2005
    ..Thus, fusion to HBsAg is a convenient strategy for developing cervical cancer therapeutic vaccines, since it enhances the immunogenicity of E7 while turning it into an innocuous secreted fusion protein...
  16. ncbi Virus target cell conditioning model to explain some epidemiologic characteristics of childhood leukemias and lymphomas
    Harald zur Hausen
    Deutsche Krebsforschungszentrum, Angewandte Tumorvirologie, Heidelberg, Germany
    Int J Cancer 115:1-5. 2005
    ..Interferon induction by intermittent infections should reduce the viral load and thus decrease the risk for chromosomal modifications. Some virologic observations in support of this model are presented...
  17. ncbi Ectopic expression of nonliganded retinoic acid receptor beta abrogates AP-1 activity by selective degradation of c-Jun in cervical carcinoma cells
    Johanna De-Castro Arce
    Angewandte Tumorvirologie, Abteilung Virale Transformationsmechanismen, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Biol Chem 279:45408-16. 2004
    ....
  18. pmc Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis
    Silvia S Borkosky
    Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    PLoS ONE 7:e32160. 2012
    ..This suggests a helper effect of EBV infections in the replication of TTV. The present study provides information on a possible interaction of EBV and TTV in the etiology and progression of multiple sclerosis...
  19. pmc Isolation of multiple TT virus genotypes from spleen biopsy tissue from a Hodgkin's disease patient: genome reorganization and diversity in the hypervariable region
    Ilijas Jelcic
    Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Virol 78:7498-507. 2004
    ....
  20. pmc Increased incidence of squamous cell carcinomas in Mastomys natalensis papillomavirus E6 transgenic mice during two-stage skin carcinogenesis
    Iris Helfrich
    Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Virol 78:4797-805. 2004
    ..These results indicate that the development of squamous cell carcinomas in MnPV E6 transgenic mice does not depend on an activated H-ras oncogene...
  21. ncbi Loss of net as repressor leads to constitutive increased c-fos transcription in cervical cancer cells
    Jan van Riggelen
    Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Biol Chem 280:3286-94. 2005
    ..These data indicate that loss of Net and constitutive c-fos expression appear to be a key event in the transformation of cervical cancer cells...
  22. pmc Presence of papillomavirus sequences in condylomatous lesions of the mamillae and in invasive carcinoma of the breast
    Ethel Michele de Villiers
    Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Breast Cancer Res 7:R1-11. 2005
    ..We report the presence of HPV DNA sequences in areolar tissue and tumour tissue samples from female patients with breast carcinoma. The presence of virus in the areolar-nipple complex suggests to us a potential pathogenic mechanism...
  23. doi Red meat consumption and cancer: reasons to suspect involvement of bovine infectious factors in colorectal cancer
    Harald zur Hausen
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Int J Cancer 130:2475-83. 2012
    ..Preceding, concomitant or subsequent exposure to chemical carcinogens arising during cooking procedures should result in increased risk for colorectal cancer synergistic with these infections...
  24. doi Transcription of HERV-E and HERV-E-related sequences in malignant and non-malignant human haematopoietic cells
    Bhupesh K Prusty
    Division for Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Virology 382:37-45. 2008
    ..Our study describes new active HERV-E sequences and new loci throughout the human genome...
  25. ncbi Classification of papillomaviruses
    Ethel Michele de Villiers
    Reference Center for Papillomaviruses, Division for the Characterization of Tumorviruses, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
    Virology 324:17-27. 2004
    ..The taxonomic status of PV types, subtypes, and variants remains unchanged and is based on the traditional criteria that the sequence of their L1 genes should be at least 10%, 2-10%, and maximally 2% dissimilar from one another...
  26. ncbi Heterogeneity of TT virus related sequences isolated from human tumour biopsy specimens
    Ethel Michele de Villiers
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Mol Med (Berl) 80:44-50. 2002
    ..The high variability of these virus types suggests that additional primer combinations within the highly conserved region of the genome would detect a still higher rate of positive tumours...
  27. ncbi Restoration of p53 expression sensitizes human papillomavirus type 16 immortalized human keratinocytes to CD95-mediated apoptosis
    Adriana Aguilar-Lemarroy
    Forschungsschwerpunkt Angewandte Tumorvirologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Oncogene 21:165-75. 2002
    ..These data indicate that the reduced bioavailability of p53 is a key-regulatory event in perturbation of CD95 signaling in HPV16 immortalized keratinocytes...
  28. pmc Disturbance of tumor necrosis factor alpha-mediated beta interferon signaling in cervical carcinoma cells
    Anastasia Bachmann
    Forschungsschwerpunkt Angewandte Tumorvirologie, Abteilung Tumorvirus Immunologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    J Virol 76:280-91. 2002
    ..In contrast, under conditions where tumor suppression was not accomplished upon somatic cell hybridization, neither expression of IRF-1, p48, and IFN-beta nor antiviral activity could be restored...
  29. ncbi Modern criteria to determine the etiology of human carcinogens
    Brooke T Mossman
    Department of Pathology, University of Vermont College of Medicine, 215 HSRF, 89 Beaumont Ave, Burlington, VT 05405, USA
    Semin Cancer Biol 14:449-52. 2004
    ..These approaches should be combined with molecular epidemiology and molecular pathology to identify human carcinogens with more emphasis on evaluating combinations of suspect agents and mechanisms of action of epigenetic carcinogens...
  30. ncbi SV40 in human cancers--an endless tale?
    Harald zur Hausen
    Int J Cancer 107:687. 2003
  31. doi Nobel Prize in Physiology or Medicine. HIV, HPV researchers honored, but one scientist is left out
    Jon Cohen
    Science 322:174-5. 2008
  32. doi Nobel Prize honors HIV, HPV discoveries
    Tracy Hampton
    JAMA 300:2109. 2008