Margot Zoller

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc C4.4A as a candidate marker in the diagnosis of colorectal cancer
    C Paret
    Department of Tumour Progression and Immune Defence, German Cancer Research Centre, Heidelberg, Germany
    Br J Cancer 97:1146-56. 2007
  2. ncbi request reprint Prophylactic tumor vaccination: comparison of effector mechanisms initiated by protein versus DNA vaccination
    M Zoller
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    J Immunol 166:3440-50. 2001
  3. ncbi request reprint Gastrointestinal tumors: metastasis and tetraspanins
    M Zoller
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    Z Gastroenterol 44:573-86. 2006
  4. ncbi request reprint Anti-CD44-mediated blockade of leukocyte migration in skin-associated immune diseases
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    J Leukoc Biol 82:57-71. 2007
  5. ncbi request reprint Thymus repopulation after allogeneic reconstitution in hematological malignancies
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Exp Hematol 35:1891-905. 2007
  6. ncbi request reprint Immunotherapy of cancer for the elderly patient: does allogeneic bone marrow transplantation after nonmyeloablative conditioning provide a new option?
    Margot Zoller
    Department of Applied Genetics, University of Karlsruhe, Germany
    Cancer Immunol Immunother 53:659-76. 2004
  7. pmc Chronic delayed-type hypersensitivity reaction as a means to treat alopecia areata
    M Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Clin Exp Immunol 135:398-408. 2004
  8. ncbi request reprint Tumor vaccination after allogeneic bone marrow cell reconstitution of the nonmyeloablatively conditioned tumor-bearing murine host
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    J Immunol 171:6941-53. 2003
  9. doi request reprint Tetraspanins: push and pull in suppressing and promoting metastasis
    Margot Zoller
    Department of Tumour Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Nat Rev Cancer 9:40-55. 2009
  10. ncbi request reprint Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Autoimmun 23:241-56. 2004

Collaborators

Detail Information

Publications69

  1. pmc C4.4A as a candidate marker in the diagnosis of colorectal cancer
    C Paret
    Department of Tumour Progression and Immune Defence, German Cancer Research Centre, Heidelberg, Germany
    Br J Cancer 97:1146-56. 2007
    ..By de novo expression in colonic cancer tissue, we consider C4.4A as a candidate diagnostic marker in colorectal cancer, which possibly can be detected in body fluids...
  2. ncbi request reprint Prophylactic tumor vaccination: comparison of effector mechanisms initiated by protein versus DNA vaccination
    M Zoller
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    J Immunol 166:3440-50. 2001
    ..The data demonstrate the strength of DNA vaccination, particularly by the oral route, and provide evidence that a combined treatment with protein-loaded DC can significantly increase the therapeutic efficacy...
  3. ncbi request reprint Gastrointestinal tumors: metastasis and tetraspanins
    M Zoller
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    Z Gastroenterol 44:573-86. 2006
    ....
  4. ncbi request reprint Anti-CD44-mediated blockade of leukocyte migration in skin-associated immune diseases
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    J Leukoc Biol 82:57-71. 2007
    ..Thus, allergen treatment of AA likely can be supported by targeting AA T cells selectively via a panCD44-CD49d-bispecific antibody...
  5. ncbi request reprint Thymus repopulation after allogeneic reconstitution in hematological malignancies
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Exp Hematol 35:1891-905. 2007
    ..To create a basis for vaccination in the allogeneically reconstituted, lymphoma-bearing host, we elaborate a reconstitution protocol that supports thymus repopulation and tolerance induction...
  6. ncbi request reprint Immunotherapy of cancer for the elderly patient: does allogeneic bone marrow transplantation after nonmyeloablative conditioning provide a new option?
    Margot Zoller
    Department of Applied Genetics, University of Karlsruhe, Germany
    Cancer Immunol Immunother 53:659-76. 2004
    ..Inevitably, the problem of the aged immune system would be circumvented...
  7. pmc Chronic delayed-type hypersensitivity reaction as a means to treat alopecia areata
    M Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Clin Exp Immunol 135:398-408. 2004
    ..Accordingly, the therapeutic effect of long-term SADBE treatment may rely on impaired leucocyte traffic...
  8. ncbi request reprint Tumor vaccination after allogeneic bone marrow cell reconstitution of the nonmyeloablatively conditioned tumor-bearing murine host
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    J Immunol 171:6941-53. 2003
    ..Thus, the LNC were tolerant toward the host, but not toward the tumor. The finding convincingly demonstrates the feasibility and efficacy of tumor vaccination after allogeneic reconstitution of the nonmyeloablatively conditioned host...
  9. doi request reprint Tetraspanins: push and pull in suppressing and promoting metastasis
    Margot Zoller
    Department of Tumour Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Nat Rev Cancer 9:40-55. 2009
    ..It is reasonable to assume that differences in the membrane and vesicular web components that associate with individual tetraspanins account for their differing abilities to promote and suppress metastasis...
  10. ncbi request reprint Apoptosis resistance in peripheral blood lymphocytes of alopecia areata patients
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Autoimmun 23:241-56. 2004
    ..Thus, survival of activated T cells in progressive AA patients' PBMC is apparently sustained by downregulation of CD95L and upregulation of CD44v7 which is known to be associated with anti-apoptotic gene expression...
  11. ncbi request reprint Costimulatory molecules and their ligands as therapeutic targets in autoimmune disease
    M Zoller
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    Eur J Dermatol 11:335-42. 2001
    ..Due to the regulated and restricted expression of these molecules, treatment should not be burdened by severe side effects...
  12. ncbi request reprint Tumor vaccination by Salmonella typhimurium after transformation with a eukaryotic expression vector in mice: impact of a Salmonella typhimurium gene interfering with MHC class I presentation
    Susanne Hummel
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    J Immunother 28:467-79. 2005
    ..Thus, the immunosuppressive yej operon affects innate and adaptive immunity. However, when ST are carriers for eukaryotic-expressed tumor antigens, yej does not severely hamper induction of an immune response...
  13. ncbi request reprint Transient CD44 variant isoform expression and reduction in CD4(+)/CD25(+) regulatory T cells in C3H/HeJ mice with alopecia areata
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 118:983-92. 2002
    ....
  14. ncbi request reprint Unexpected induction of unresponsiveness by vaccination with transformed Salmonella typhimurium
    Margot Zoller
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg
    J Immunother 25:162-75. 2002
    ....
  15. ncbi request reprint Immunotherapy of cancer by active vaccination: does allogeneic bone marrow transplantation after non-myeloablative conditioning provide a new option?
    Margot Zoller
    Dept of Tumor Progression and Immune Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Technol Cancer Res Treat 2:237-60. 2003
    ....
  16. ncbi request reprint Active vaccination after allogeneic bone marrow cell transplantation: a new option in the immunotherapy of cancer?
    Margot Zoller
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Arch Immunol Ther Exp (Warsz) 50:197-224. 2002
    ....
  17. ncbi request reprint A chronic contact eczema impedes migration of antigen-presenting cells in alopecia areata
    Pooja Gupta
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 126:1559-73. 2006
    ....
  18. ncbi request reprint A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression
    Sebastian Kuhn
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Im Neuenheimer Feld, 280 D 69120 Heidelberg, Germany
    Mol Cancer Res 5:553-67. 2007
    ..However, claudin-7-associated EpCAM is recruited into TEM and forms a complex with CO-029 and CD44v6 that facilitates metastasis formation...
  19. ncbi request reprint CD44v6 promotes proliferation by persisting activation of MAP kinases
    Rachid Marhaba
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg
    Cell Signal 17:961-73. 2005
    ..Thus, CD44v6, distinct to CD44s, stimulates autonomously growth and IL-2 secretion of a thymoma line and rescues cells from apoptosis...
  20. pmc Tumorigenicity of IL-1alpha- and IL-1beta-deficient fibrosarcoma cells
    Irina Nazarenko
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Neoplasia 10:549-62. 2008
    ..Both sarcoma cell-derived IL-1alpha and IL-1beta promote tumor growth. However, IL-1alpha exerts regulatory activity on the tumor cell-matrix cross-talk, and only IL-1beta initiates systemic inflammation...
  21. doi request reprint Concomitant tumor and autoantigen vaccination supports renal cell carcinoma rejection
    Nicolás Herbert
    Department of Tumor Cell Biology, University Hospital of Surgery, University of Heidelberg, Germany
    J Immunol 185:902-16. 2010
    ..Activation of autoantigen-specific Th cells strongly supports tumor-specific Th cells and thereby CTL activation...
  22. ncbi request reprint In vivo CD44-CD49d complex formation in autoimmune disease has consequences on T cell activation and apoptosis resistance
    Rachid Marhaba
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    Eur J Immunol 36:3017-32. 2006
    ..This strongly influences the lymphocytes' activation state and function...
  23. doi request reprint Claudin-7 regulates EpCAM-mediated functions in tumor progression
    Tobias Nubel
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Mol Cancer Res 7:285-99. 2009
    ....
  24. doi request reprint CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance
    Pamela Klingbeil
    Department of Tumor Progression and Immune Defense, University Hospital of Surgery, University of Heidelberg, Heidelberg, Germany
    Mol Cancer Res 7:168-79. 2009
    ....
  25. ncbi request reprint Allogeneic reconstitution after nonmyeloablative conditioning: mitigation of graft-versus-host and host-versus-graft reactivity by anti-CD44v6
    Oliver Christ
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    J Leukoc Biol 71:33-46. 2002
    ....
  26. ncbi request reprint Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: impact on cell motility
    Sabine Gesierich
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, University of Heidelberg, Heidelberg, Germany
    Clin Cancer Res 11:2840-52. 2005
    ..The finding led us to explore whether and which integrin-tetraspanin complexes influence the motility of human pancreatic tumors...
  27. ncbi request reprint Donor T cell and host NK depletion improve the therapeutic efficacy of allogeneic bone marrow cell reconstitution in the nonmyeloablatively conditioned tumor-bearing host
    Susanne Hummel
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg
    J Leukoc Biol 72:898-912. 2002
    ..Thus, concomitant depletion of host NK and donor T cells is advantageous when approaching therapeutic treatment of solid tumors by allogeneic reconstitution of the nonmyeloablatively conditioned host...
  28. pmc CD44v6 dependence of premetastatic niche preparation by exosomes
    Thorsten Jung
    Department of Tumor Cell Biology, University Hospital of Surgery and German Cancer Research Center, D 69120 Heidelberg, Germany
    Neoplasia 11:1093-105. 2009
    ..Instead, CD44v suffices for assembling a soluble matrix, which allows exosomes, independent of their origin from poorly or highly metastatic cells, to modulate (pre) metastatic organ cells for tumor cell embedding and growth...
  29. doi request reprint Cooperativity of CD44 and CD49d in leukemia cell homing, migration, and survival offers a means for therapeutic attack
    Vibuthi Singh
    Department of Tumor Cell Biology, University Hospital of Surgery, 69120 Heidelberg, Germany
    J Immunol 191:5304-16. 2013
    ..Thus, mostly owing to a blockade of joint signaling, anti-CD44 and anti-CD49d hamper leukemic cell settlement and break apoptosis resistance, which strongly supports low-dose chemotherapy. ..
  30. doi request reprint CD44 promotes progenitor homing into the thymus and T cell maturation
    Mohini Rajasagi
    Tumor Cell Biology, Department of Surgery, University of Heidelberg, German Cancer Research Center, Heidelberg, Germany
    J Leukoc Biol 85:251-61. 2009
    ..In addition, CD44v6 is important for survival and expansion of early thymocytes. These findings suggest that strengthening CD44v6 expression on lymphoid progenitors could well contribute to accelerated regain of immunocompetence...
  31. doi request reprint Thymocyte expansion and maturation: crosstalk of CD44v6 on thymocytes and panCD44 on stroma cells
    Mohini Rajasagi
    Department of Tumor Cell Biology, University Hospital of Surgery and German Cancer Research Center, Heidelberg, Germany
    Immunol Cell Biol 88:136-47. 2010
    ....
  32. pmc Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the α(6)β(4) integrin and MT1-MMP
    Honoré Ngora
    Department of Tumor Cell Biology, University of Heidelberg, Heidelberg, Germany
    Neoplasia 14:95-107. 2012
    ..4A, MT1-MMP, and TACE allows for a shift from adhesion to motility, which is supported by laminin degradation. These findings provide the first explanation for the C4.4A contribution to wound healing and metastasis...
  33. doi request reprint Tspan8 and CD151 promote metastasis by distinct mechanisms
    Shijing Yue
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Eur J Cancer 49:2934-48. 2013
    ..To define whether Tspan8 and CD151 fulfil redundant or additive activities, Tspan8 and CD151 were stably knocked-down in highly metastatic rat pancreatic adenocarcinoma BSp73ASML cells (ASML(wt), ASML-Tspan8(kd), ASML-CD151(kd))...
  34. ncbi request reprint CD44 variant isoforms associate with tetraspanins and EpCAM
    Dirk Steffen Schmidt
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Exp Cell Res 297:329-47. 2004
    ..Because CD44v4-v7-EpCAM complex-specific functions strictly depended on the GEM localization, linker or signal-transducing molecules associating with the complex are likely located in GEMs...
  35. ncbi request reprint Anti-CD44 induces apoptosis in T lymphoma via mitochondrial depolarization
    Mohini Rajasagi
    Department of Tumor Cell Biology, University Hospital of Surgery and German Cancer Research Center, Heidelberg, Germany
    J Cell Mol Med 14:1453-67. 2010
    ..Uncovering this new pathway of CD44-induced leukemic cell death provides new options of therapeutic interference...
  36. doi request reprint Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation
    Irina Nazarenko
    Department of Tumor Cell Biology, University Hospital of Surgery, D 69120 Heidelberg, Germany
    Cancer Res 70:1668-78. 2010
    ..Unraveling these new pathways of exosome-initiated EC regulation could provide new options for therapeutic interference with tumor-induced angiogenesis...
  37. ncbi request reprint The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7
    Markus Ladwein
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Exp Cell Res 309:345-57. 2005
    ..This is the first report on an association between EpCAM and claudins in both non-transformed tissues and metastasizing tumor cell lines...
  38. doi request reprint Opposing effects of fibrosarcoma cell-derived IL-1 alpha and IL-1 beta on immune response induction
    Rachid Marhaba
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 123:134-45. 2008
    ..Induction of a strong immune response by IL-1 alpha demands therapeutic exploitation, which may become more efficient if systemic induction of immunosuppression by IL-1 beta can also be circumvented...
  39. ncbi request reprint The importance of myeloid-derived suppressor cells in the regulation of autoimmune effector cells by a chronic contact eczema
    Rachid Marhaba
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    J Immunol 179:5071-81. 2007
    ..Thus, a chronic eczema supports the expansion and activation of myeloid suppressor cells that, via zeta-chain down-regulation, contribute to autoreactive T cell silencing in vitro and in vivo...
  40. doi request reprint Delayed type hypersensitivity-induced myeloid-derived suppressor cells regulate autoreactive T cells
    Vibhuti Singh
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Eur J Immunol 41:2871-82. 2011
    ....
  41. pmc Host matrix modulation by tumor exosomes promotes motility and invasiveness
    Wei Mu
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Neoplasia 15:875-87. 2013
    ..Reorganization of the ECM by exosomes likely also contributes to organogenesis, physiological and pathologic angiogenesis, wound healing, and clotting after vessel disruption...
  42. doi request reprint Differential survival of AML subpopulations in NOD/SCID mice
    Mario Schubert
    Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany
    Exp Hematol 39:250-263.e4. 2011
    ..The latter still being discussed for acute myeloid leukemia (AML), nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice were used to evaluate long-time reconstitution and expansion of AML subpopulations...
  43. ncbi request reprint Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migration
    Claudia Paret
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 115:724-33. 2005
    ..Our findings that LN1 and LN5 are C4.4A ligands, that galectin-3 associates with C4.4A and that C4.4A ligand binding confers a migratory phenotype are well in line with the supposed metastasis association...
  44. doi request reprint EpCAM-associated claudin-7 supports lymphatic spread and drug resistance in rat pancreatic cancer
    Florian Thuma
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Int J Cancer 133:855-66. 2013
    ..On the other hand, only cld7 is directly engaged in motility and apoptosis resistance. Thus, at least in concern of migrating CIC, it is cld7 that acts as a CIC biomarker...
  45. doi request reprint Tspan8, CD44v6 and alpha6beta4 are biomarkers of migrating pancreatic cancer-initiating cells
    Haobin Wang
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Int J Cancer 133:416-26. 2013
    ..The stability of the percentage of PaCIC in long-term and freshly established lines after a roughly 8-fold enrichment by cloning indicates PaCIC, though required for long-term survival, concomitantly depending on support by non-CIC...
  46. ncbi request reprint The progressive state, in contrast to the stable or regressive state of alopecia areata, is reflected in peripheral blood mononuclear cells
    Margot Zoller
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Exp Dermatol 13:435-44. 2004
    ..Furthermore, an increase in CD16(+)- and TNF-alpha-expressing cells may contribute to AA susceptibility...
  47. doi request reprint The metastasis-associated molecule C4.4A promotes tissue invasion and anchorage independence by associating with the alpha6beta4 integrin
    Florian Thuma
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg D 69120, Germany
    Mol Oncol 7:917-28. 2013
    ..Thereby C4.4A acts as a linker to facilitate several steps in the metastatic cascade. Taking the restricted C4.4A expression in non-transformed tissue, this knowledge should pave the way toward the use of C4.4A as a therapeutic target. ..
  48. doi request reprint Tolerance induction by hair-specific keratins in murine alopecia areata
    Ulrike Erb
    1 University Hospital of Surgery, Im Neuenheimer Feld 365, D 69120 Heidelberg, Germany
    J Leukoc Biol 94:845-57. 2013
    ..Thus, keratins K71 and K31 contribute to AA induction, and peptide application in a nonimmunogenic form serves as an efficient therapeutic. ..
  49. ncbi request reprint Antitumoral activity of non-platinum xanthate complexes
    Wolfgang Friebolin
    German Cancer Research Centre, Department D060, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Med Chem 48:7925-31. 2005
    ..A pH of 6.8 and lower has been frequently found in solid tumors. Drugs with such pH dependent activity are supposed to have an improved therapeutic index as compared to drugs that are active irrespective of pH...
  50. pmc The tetraspanin D6.1A and its molecular partners on rat carcinoma cells
    Christoph Claas
    Department of Tumor Progression and Immune Defense, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Biochem J 389:99-110. 2005
    ..The characterization of the D6.1A core complex and additional more indirect interactions will help to elucidate the role in tumour progression and metastasis attributed to D6.1A...
  51. ncbi request reprint Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics
    Vanessa Rausch
    Molecular OncoSurgery, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany
    Cancer Res 70:5004-13. 2010
    ..Our data suggest that SF may be suited to increase targeting of CSCs by SO...
  52. ncbi request reprint Systemic induction of the angiogenesis switch by the tetraspanin D6.1A/CO-029
    Sabine Gesierich
    Department of Tumor Progression and Immune Defence, German Cancer Research Centre, Heidelberg, Germany
    Cancer Res 66:7083-94. 2006
    ..1A, promotes tumor growth by its capacity to induce systemic angiogenesis that can effectively, and with high selectivity for sprouting endothelium, be blocked by a D6.1A-specific antibody...
  53. ncbi request reprint Serological analysis of human renal cell carcinoma
    Gerard Devitt
    Department of Tumor Progression and Immune Defence, German Cancer Research Center, 69120 Heidelberg, Germany
    Int J Cancer 118:2210-9. 2006
    ..Sera from patients with non-malignant renal diseases or an autoimmune disease did not react with these 10 antigens...
  54. pmc Exosomal tumor microRNA modulates premetastatic organ cells
    Sanyukta Rana
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Neoplasia 15:281-95. 2013
    ..The demonstration of function-competent exosomal miRNA in host target cells encourages exploiting exosomes as a therapeutic gene delivery system...
  55. ncbi request reprint CEBPbeta, JunD and c-Jun contribute to the transcriptional activation of the metastasis-associated C4.4A gene
    Frank Fries
    Departments of Tumor Progression and Immune Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Int J Cancer 120:2135-47. 2007
    ..4A-negative tumor cell line after cotransfection with C/EBPbeta plus JunD or c-Jun. Thus, upregulation of C/EBPbeta during tumor progression and wound repair may well provide a sufficient trigger for transcription of the C4.4A gene...
  56. ncbi request reprint The association of the tetraspanin D6.1A with the alpha6beta4 integrin supports cell motility and liver metastasis formation
    Mikael Herlevsen
    Department of Tumor Progression and Immune Defense, German Cancer Research Center, Heidelberg, Germany
    J Cell Sci 116:4373-90. 2003
    ..The findings provide a convincing experimental explanation for the repeatedly described involvement of alpha6beta4 in tumor progression...
  57. doi request reprint Improved T and B cell recovery by the transfer of slowly dividing human hematopoietic stem cells
    Mario Vitacolonna
    Department of Tumor Cell Biology, University Hospital of Surgery and German Cancer Research Centre, University of Heidelberg, Heidelberg, Germany
    Leuk Res 34:622-30. 2010
    ..The capacity of the SDF to differentiate and mature in the patients' thymus could provide an advantage in immunocompetence recovery...
  58. ncbi request reprint Stimulation of CD95-induced apoptosis in T-cells by a subtype specific neutral sphingomyelinase inhibitor
    Eberhard Amtmann
    German Cancer Research Center, Abteilung Immunregulation und Tumorabwehr, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Biochem Pharmacol 69:1141-8. 2005
    ..Accordingly, C11AG displayed curative effects on experimental arthritis: swelling and inflammation were found to be significantly alleviated...
  59. ncbi request reprint GSK-3 mediates differentiation and activation of proinflammatory dendritic cells
    Elena Rodionova
    Department of Molecular Oncology Hematology, German Cancer Research Center, Heidelberg, Germany
    Blood 109:1584-92. 2007
    ..GSK-3 may therefore act as a key integrator of activating and inhibitory pathways involved in proinflammatory DC differentiation and activation...
  60. ncbi request reprint The efficacy of an IL-1alpha vaccine depends on IL-1RI availability and concomitant myeloid-derived suppressor cell reduction
    Tobias Weiss
    Department of Tumor Cell Biology, University Hospital of Surgery and German Cancer Research Center, Heidelberg, Germany
    J Immunother 32:552-64. 2009
    ..However, care should be taken to interfere with MDSC expansion/activation not through a blockade of the IL-1RI, which is the preferential target of IL-1alpha...
  61. ncbi request reprint CD44v7 interferes with activation-induced cell death by up-regulation of anti-apoptotic gene expression
    Rachid Marhaba
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    J Leukoc Biol 74:135-48. 2003
    ..Thus, as opposed to the CD44 standard isoform, CD44v7 does not function as an accessory molecule; instead, it supports survival of activated T cells by interfering with activation-induced cell death...
  62. ncbi request reprint Synthesis and structure-activity relationship of novel antitumoral platinum xanthate complexes
    Wolfgang Friebolin
    Department D060, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Med Chem 47:2256-63. 2004
    ..Drugs with such pH-dependent antitumoral activity have an improved therapeutic index compared to drugs that are active irrespective of pH...
  63. pmc CD44v6 coordinates tumor matrix-triggered motility and apoptosis resistance
    Thorsten Jung
    Department of Tumor Cell Biology, University Hospital of Surgery, University of Heidelberg, Heidelberg, Germany
    J Biol Chem 286:15862-74. 2011
    ....
  64. ncbi request reprint Generation of RAGE-1 and MAGE-9 peptide-specific cytotoxic T-lymphocyte lines for transfer in patients with renal cell carcinoma
    Nicole Oehlrich
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 117:256-64. 2005
    ..Thus, B cells are well suited as APCs for the generation of large numbers of tumor peptide-specific CTLs for adoptive transfer. MAGE-9 as well as RAGE-1 may well provide suitable targets for immunotherapy of RCC...
  65. doi request reprint Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection
    Sanyukta Rana
    Department of Tumor Cell Biology, University Hospital of Surgery, Heidelberg, Germany
    Int J Biochem Cell Biol 44:1574-84. 2012
    ..This is the first report on the exosomal tetraspanin web contributing to target cell selection such that predictions can be made on potential targets, which will facilitate tailoring exosomes for drug delivery...
  66. pmc Tumor-exosomes and leukocyte activation: an ambivalent crosstalk
    Daniela Zech
    Department of Tumor Cell Biology, University Hospital of Surgery, Im Neuenheimer Feld 365, D 69120, Heidelberg, Germany
    Cell Commun Signal 10:37. 2012
    ..abstract:..
  67. doi request reprint Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis
    Sanyukta Rana
    Department of Tumor Cell Biology, University Hospital of Surgery, Im Neuenheimer Feld 365, D 69120 Heidelberg, Germany
    Biochem Soc Trans 39:559-62. 2011
    ..Exosomes herald an unanticipated powerful path of cell-cell communication. An answer to how exosomes collect and transfer information will allow the use of Nature's concept to cope with malfunctions...
  68. doi request reprint CD44: can a cancer-initiating cell profit from an abundantly expressed molecule?
    Margot Zoller
    Department of Tumour Cell Biology, University Hospital of Surgery and German Cancer Research Centre, D69120 Heidelberg, Germany
    Nat Rev Cancer 11:254-67. 2011
    ..expression of the molecule or is CD44 expression advantageous as it fulfils some of the special properties that are displayed by CICs, such as self-renewal, niche preparation, epithelial-mesenchymal transition and resistance to apoptosis?..
  69. doi request reprint Prognostic value of melanoma-associated antigen A9 in renal cell carcinoma
    Gencay Hatiboglu
    Department of Urology, University of Heidelberg, Heidelberg, Germany
    Scand J Urol 47:311-22. 2013
    ..The aim of this study was to evaluate the prognostic relevance of melanoma-associated antigen (MAGE) A9 in renal cell carcinoma (RCC)...