Affiliation: German Cancer Research Center
Witt O, Deubzer H, Lodrini M, Milde T, Oehme I. Targeting histone deacetylases in neuroblastoma. Curr Pharm Des. 2009;15:436-47 pubmed
..This review summarizes our current knowledge about classical HDAC family members as novel drug targets for neuroblastoma therapy and discusses the potential role of next generation, selective HDAC inhibitors. ..
Witt O, Hämmerling S, Stockklausner C, Schenk J, Günther P, Behnisch W, et al
. 13-cis retinoic acid treatment of a patient with chemotherapy refractory nephroblastomatosis. J Pediatr Hematol Oncol. 2009;31:296-9 pubmed publisher
..Interestingly, nephroblastomatosis-associated acquired von Willebrand disease also resolved. Retinoic acid maybe a novel nontoxic treatment option for nephroblastomatosis requiring further systematic evaluation. ..
Koeneke E, Witt O, Oehme I. HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities. Cells. 2015;4:135-68 pubmed publisher
..Identification of key HDAC isozymes involved in autophagy and the ability to target specific isozymes yields the potential to cripple and ultimately eliminate malignant cells depending on autophagy as a survival mechanism. ..
Worst B, van Tilburg C, Balasubramanian G, Fiesel P, Witt R, Freitag A, et al
. Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study. Eur J Cancer. 2016;65:91-101 pubmed publisher
Witt O, Deubzer H, Milde T, Oehme I. HDAC family: What are the cancer relevant targets?. Cancer Lett. 2009;277:8-21 pubmed publisher
..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease. ..
Josupeit R, Bender S, Kern S, Leuchs B, Hielscher T, Herold Mende C, et al
. Pediatric and Adult High-Grade Glioma Stem Cell Culture Models Are Permissive to Lytic Infection with Parvovirus H-1. Viruses. 2016;8: pubmed publisher
..Several dysregulated genes encoding receptor proteins, endocytosis factors or regulators innate antiviral responses were identified and represent intriguing candidates for to further study molecular mechanisms of H-1PV resistance. ..