Research Topics
Genomes and Genes
| S WiemannSummaryAffiliation: German Cancer Research Center Country: Germany Publications
| Collaborators
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Detail Information
Publications
RNAi-based validation of antibodies for reverse phase protein arraysHeiko A Mannsperger
German Cancer Research Center, Division of Molecular Genome Analysis, Heidelberg, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Proteome Sci 8:69. 2010..abstract:..- Statistical methods and software for the analysis of highthroughput reverse genetic assays using flow cytometry readoutsFlorian Hahne
Division of Molecular Genome Analysis, German Cancer Research Center, INF 580, 69120 Heidelberg, Germany
Genome Biol 7:R77. 2006..The software is freely available in the Bioconductor package prada. The method permits analysis of large screens to detect the effects of molecular interventions in cellular systems... - The full-ORF clone resource of the German cDNA ConsortiumStephanie Bechtel
Department of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
BMC Genomics 8:399. 2007..In combination with a unique and versatile cloning system, these will provide the tools for genome-wide systematic functional analyses, to achieve a deeper insight into complex biological processes... - The systematic functional characterisation of Xq28 genes prioritises candidate disease genesAnja Kolb-Kokocinski
Division of Molecular Genome Analysis, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
BMC Genomics 7:29. 2006..To expedite disease gene identification, we have initiated the functional characterisation of all known Xq28 genes... - SMART amplification combined with cDNA size fractionation in order to obtain large full-length clonesRuth Wellenreuther
Department of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
BMC Genomics 5:36. 2004..The SMART technique for full-length enrichment is robust but results in limited cDNA insert size of the library... - Extending pathways based on gene lists using InterPro domain signaturesFlorian Hahne
German Cancer Research Center, Molecular Genome Analysis, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
BMC Bioinformatics 9:3. 2008..This works by comparing InterPro domain signatures of the candidate gene lists with domain signatures of gene sets derived from known classifications, e.g. KEGG pathways... - The 3of5 web application for complex and comprehensive pattern matching in protein sequencesMarkus Seiler
Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
BMC Bioinformatics 7:144. 2006..This is especially true for patterns containing ambiguous characters and positions and/or length ambiguities... - CAFTAN: a tool for fast mapping, and quality assessment of cDNAsCoral Del Val
DKFZ, German Cancer Research Center, Division Molecular Biophysics, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
BMC Bioinformatics 7:473. 2006..To this end we have developed a new high-throughput analysis tool, CAFTAN, which simplifies these efforts and thus fills the gap between large-scale cDNA collections and their systematic annotation and application in functional genomics... - Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAsS Wiemann
Molecular Genome Analysis, German Cancer Research Center, 69120 Heidelberg, Germany
Genome Res 11:422-35. 2001..We thus substantially contribute to the generation of a gene catalog, consisting of both full-coding cDNA sequences and clones, which should be made freely available and will become an invaluable tool for detailed functional studies... 
The German cDNA network: cDNAs, functional genomics and proteomicsStefan Wiemann
Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
J Struct Funct Genomics 4:87-96. 2003....- CDNAs for functional genomics and proteomics: the German ConsortiumStefan Wiemann
Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
C R Biol 326:1003-9. 2003..The resulting information is integrated with functional genomics and proteomics data for further understanding of protein functions in the cellular context... - From ORFeome to biology: a functional genomics pipelineStefan Wiemann
Molecular Genome Analysis, German Cancer Research Center, 69120 Heidelberg, Germany
Genome Res 14:2136-44. 2004..All information is presented in a Web database (http://www.dkfz.de/LIFEdb). It is exploited for the identification of disease-relevant genes and proteins for diagnosis and therapy... - Alternative pre-mRNA processing regulates cell-type specific expression of the IL4l1 and NUP62 genesStefan Wiemann
Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, 69120, Germany
BMC Biol 3:16. 2005..Tissue specific regulation of expression and splicing are major factors enhancing the number of the encoded products. Commonly these mechanisms are intragenic and affect only one gene... - DMBT1 encodes a protein involved in the immune defense and in epithelial differentiation and is highly unstable in cancerJ Mollenhauer
Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Cancer Res 60:1704-10. 2000..Thus, DMBT1 is a gene that is highly unstable in cancer and encodes for a protein with at least two different functions, one in the immune defense and a second one in epithelial differentiation... - The genomic structure of the DMBT1 gene: evidence for a region with susceptibility to genomic instabilityJ Mollenhauer
Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Oncogene 18:6233-40. 1999..The major part of the gene harbours locus specific repeats. These repeats may point to the DMBT1 locus as a region susceptible to chromosomal instability... - DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafnessJ Uhlmann
Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
FEBS Lett 460:153-60. 1999..In addition, we have identified a murine homologue, mDelGEF. The ubiquitously expressed soluble protein hDelGEF1 is found both in the cyytoplasm and in the nucleus. Overexpressed hDelGEF2 colocalizes with mitochondria... - Transcription mapping in a medulloblastoma breakpoint interval and Smith-Magenis syndrome candidate region: identification of 53 transcriptional units and new candidate genesP Seranski
Abt Molekulare Genomanalyse, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
Genomics 56:1-11. 1999..Based on their homologies to known genes or proteins, some of the novel genes are considered candidate genes either for malignant diseases or for the Smith-Magenis syndrome... - Deleted in Malignant Brain Tumors 1 is a versatile mucin-like molecule likely to play a differential role in digestive tract cancerJ Mollenhauer
Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany
Cancer Res 61:8880-6. 2001..However, although DMBT1 originally has divergent functions in monolayered and multilayered epithelia, carcinogenesis possibly converges in a common pathway that requires an inactivation of its functions in the ECM... - Dyskerin localizes to the nucleolus and its mislocalization is unlikely to play a role in the pathogenesis of dyskeratosis congenitaN S Heiss
Deutsches Krebsforschungszentrum DKFZ, Department of Molecular Genome Analysis, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Hum Mol Genet 8:2515-24. 1999..Further, examination of dyskerin-EGFP fusions mimicking mutations detected in patients indicated that the intracellular mislocalization of dyskerin is unlikely to cause DKC... - X-linked dyskeratosis congenita is caused by mutations in a highly conserved gene with putative nucleolar functionsN S Heiss
Deutsches Krebsforschungszentrum, Department of Molecular Genome Analysis, Heidelberg, Germany
Nat Genet 19:32-8. 1998..By analogy to the function of the known dyskerin orthologues, involvement in the cell cycle and nucleolar function is predicted for the protein... - Frequent downregulation of DMBT1 and galectin-3 in epithelial skin cancerJan Mollenhauer
Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Int J Cancer 105:149-57. 2003..This would support the view that galectin-3 can exert tumor-suppressive effects in certain scenarios, and DMBT1/galectin-3-mediated differentiation represents a candidate mechanism for this effect... - Genomic organization of a 225-kb region in Xq28 containing the gene for X-linked myotubular myopathy (MTM1) and a related gene (MTMR1)P Kioschis
Deutsches Krebsforschungszentrum, Molekulare Genomanalyse, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
Genomics 54:256-66. 1998..Knowledge of the genomic sequence will facilitate mutation analyses of the coding and noncoding sequences of MTM1 and MTMR1... - Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoformsJohannes F Coy
German Cancer Research Center, Division of Molecular Genomeanalysis, Im Neuenheimer Feld 280, Heidelberg, Germany
Gene 290:73-94. 2002.... - DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumoursJ Mollenhauer
Division of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Nat Genet 17:32-9. 1997..Lack of DMBT1 expression has been demonstrated in 4/5 brain-tumour cell lines. We suggest that DMBT1 is a putative tumour-suppressor gene implicated in the carcinogenesis of medulloblastoma and glibolastoma multiforme... 
miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancerS Uhlmann
Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
Oncogene 29:4297-306. 2010..Our results suggest that the miR-200 family has a tumor-suppressor function by negatively regulating EGF-driven cell invasion, viability and cell cycle progression in breast cancer...- Primer design for large scale sequencingS Haas
Department of Molecular Genome Analysis and Department of Theoretical Bioinformatics, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Nucleic Acids Res 26:3006-12. 1998..The high performance of PRIDE, combined with its minimal requirement of user interaction and its fast algorithm, make this program useful for the large scale design of primers, especially in large sequencing projects... - Construction of a physical map of an autism susceptibility region in 7q32.3-q33K S Beyer
Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Gene 272:85-91. 2001..As this map contains a putative autistic disorder locus this integrated physical and transcript map provides a valuable resource for identification of candidate gene(s)... - Isolation of human and mouse HMG2a cDNAs: evidence for an HMG2a-specific 3' untranslated regionK Wilke
Deutsches Krebsforschungszentrum, Abteilung Molekulare Genomanalyse, Heidelberg, Germany
Gene 198:269-74. 1997..Whereas expression of the chicken HMG2a gene has previously been demonstrated in liver of newly hatched chicken, the human HMG2a gene is transcribed mainly in placenta... - Reduced expression of vacuole membrane protein 1 affects the invasion capacity of tumor cellsM Sauermann
Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
Oncogene 27:1320-6. 2008..In conclusion, our findings establish Vmp1 to be a novel cell-cell adhesion protein and that its expression level determines the invasion and metastatic potential of cancer cells... - The LIFEdb database in 2006Alexander Mehrle
Division Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
Nucleic Acids Res 34:D415-8. 2006..LIFEdb enables researchers to systematically select and characterize genes and proteins of interest, and presents data and information via its user-friendly web-based interface... - Increasing the sensitivity of reverse phase protein arrays by antibody-mediated signal amplificationJan C Brase
Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
Proteome Sci 8:36. 2010..Increasing the sensitivity of RPPA approaches is important since many signaling proteins or posttranslational modifications are present at a low level... - The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancerJan Mollenhauer
Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Genes Chromosomes Cancer 35:242-55. 2002..DMBT1 thus compares to mucins rather than to conventional tumor suppressors... - Dynamic deterministic effects propagation networks: learning signalling pathways from longitudinal protein array dataChristian Bender
Department of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
Bioinformatics 26:i596-602. 2010.... - Sequential changes of the DMBT1 expression and location in normal lung tissue and lung carcinomasJan Mollenhauer
Department of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Genes Chromosomes Cancer 35:164-9. 2002..We hypothesize that the changes of the DMBT1 expression and location do reflect a time course that may point to possible mechanisms for its role in epithelial cancer... - High-throughput protein analysis integrating bioinformatics and experimental assaysCoral Del Val
Division of Molecular Biophysics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
Nucleic Acids Res 32:742-8. 2004.... - Functional genomics and proteomics approaches to study the ERBB network in cancerOzgur Sahin
Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
FEBS Lett 583:1766-71. 2009..Here, we describe the potential of applying functional genomics and proteomics, taking the ERBB family of growth-factor receptors as an example to study the signaling network and its impact on cancer... - Large-scale protein expression for proteome researchUlrike Korf
Molecular Genome Analysis, DKFZ, Heidelberg, Germany
Proteomics 5:3571-80. 2005..Affinity-purified fusion proteins were confirmed by MALDI-TOF MS... - Protein microarrays as a discovery tool for studying protein-protein interactionsUlrike Korf
Division of Molecular Genome Analysis B050, DKFZ Heidelberg, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Expert Rev Proteomics 2:13-26. 2005..This review provides an overview on the basic principles of protein microarrays and their potential to multiplex protein-protein interaction studies... - An integrative model on the role of DMBT1 in epithelial cancerJan Mollenhauer
Cancer Detect Prev 26:266-74. 2002..The expression patterns in carcinomas arising from the respective structures support this view. Accepting this functional dualism gives rise to an initial model on the role of DMBT1 in epithelial cancer... - KEGGgraph: a graph approach to KEGG PATHWAY in R and bioconductorJitao David Zhang
Division of Molecular Genome Analysis, German Cancer Research Center DKFZ, INF 580, Heidelberg, Germany
Bioinformatics 25:1470-1. 2009..While valuable graph tools have been implemented in R/Bioconductor, to our knowledge there is currently no software package to parse and analyze KEGG pathways with graph theory... - LIFEdb: a database for functional genomics experiments integrating information from external sources, and serving as a sample tracking systemDetlev Bannasch
German Cancer Research Center DKFZ, Division of Molecular Genome Analysis, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
Nucleic Acids Res 32:D505-8. 2004..A web interface enables the scientific community to explore and visualize features of the annotated cDNAs and ORFs combined with experimental results, and thus helps to unravel new features of proteins with as yet unknown functions... - QuantProReloaded: quantitative analysis of microspot immunoassaysAnika Jöcker
Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
Bioinformatics 26:2480-1. 2010..Availability and implementation: QuantProReloaded is written in R and Java and is open for download under the BSB license at http://code.google.com/p/quantproreloaded/... - Modeling breast cell cycle regulation--overcoming drug resistanceDorit Arlt
Div. of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
Conf Proc IEEE Eng Med Biol Soc 1:40-3. 2006 - Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancerA Ward
Division of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
Oncogene 32:1173-82. 2013..As most cancer-related deaths occur because of resistance to standard therapies and metastasis, re-expression of miR-375 or targeting MTDH might serve as potential therapeutic approaches for the treatment of TamR breast cancer... - MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathwaysI Keklikoglou
Division of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
Oncogene 31:4150-63. 2012.... - Functional profiling: from microarrays via cell-based assays to novel tumor relevant modulators of the cell cycleDorit Arlt
Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
Cancer Res 65:7733-42. 2005..We have established a novel functional profiling strategy that links genomics to cell biology and showed its potential for discerning cancer relevant modulators of the cell cycle in the candidate lists from microarray studies... - Contact spotting of protein microarrays coupled with spike-in of normalizer protein permits time-resolved analysis of ERBB receptor signalingChristian Löbke
Division of Molecular Genome Analysis, German Cancer Research Center Heidelberg, Heidelberg, Germany
Proteomics 8:1586-94. 2008.... - Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistanceOzgur Sahin
German Cancer Research Center, Heidelberg, Germany
BMC Syst Biol 3:1. 2009.... - Combinatorial RNAi for quantitative protein network analysisOzgur Sahin
Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 104:6579-84. 2007..This experimental approach combines multiple gene knockdown with a subsequent quantitative validation of reduced protein expression and is a major advancement toward the analysis of signaling pathways in systems biology... - Nucleotide sequence and analysis of the centromeric region of yeast chromosome IXH Voss
Biological Structures and Biocomputing Programmes, European Molecular Biology Laboratory, Heidelberg, Germany
Yeast 11:61-78. 1995..A surprisingly large fraction of the ORFs (at least six out of 17) in the centromeric region are apparently involved in RNA or DNA binding... - Gamma-BAR, a novel AP-1-interacting protein involved in post-Golgi traffickingVeronika E Neubrand
Cell Biology and Cell Biophysics Programme, European Molecular Biology Laboratory EMBL, Heidelberg, Germany
EMBO J 24:1122-33. 2005..This suggests that the direct interaction of 2c18 and gamma1-adaptin is crucial for membrane association and thus the function of the AP-1 complex in living cells. We propose to name this protein gamma-BAR... - Infrared-based protein detection arrays for quantitative proteomicsChristian Loebke
Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
Proteomics 7:558-64. 2007..Employing the IPAQ approach, a detailed analysis of activated signaling networks in biopsy samples and of crosstalk between signaling modules as required in drug discovery strategies can easily be performed... - Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28U C Rogner
Deutsches Krebsforschungszentrum, Abteilung Molekulare Genomanalyse, Heidelberg, Germany
Genome Res 6:922-34. 1996.... - An anthropoid-specific segmental duplication on human chromosome 1q22Vladimir Yu Kuryshev
Department of Molecular Genome Analysis, DKFZ German Cancer Research Center, INF 580, D 69120 Heidelberg, Germany
Genomics 88:143-51. 2006..Moreover, we provide detailed information regarding structure and evolution of the SD1q22 region that is a prerequisite for future studies of its anthropoid-specific functions and possible linkage to human genetic disorders... - Cloning of the C alpha catalytic subunit of the bovine cAMP-dependent protein kinaseS Wiemann
Biochemical Instrumentation, European Molecular Biology Laboratory, Heidelberg, Germany
Biochim Biophys Acta 1171:93-6. 1992..The C alpha mRNA was found to be expressed differentially in various bovine tissues... - Systematic comparison of surface coatings for protein microarraysBirgit Guilleaume
Department of Molecular Genome Analysis, German Cancer Research Center, 69120 Heidelberg, Germany
Proteomics 5:4705-12. 2005..In summary, we demonstrate that only suitable combinations of surface and fluorescent dyes allow the generation of highly reproducible data... - A microscope-based screening platform for large-scale functional protein analysis in intact cellsUrban Liebel
Cell Biology and Cell Biophysics Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
FEBS Lett 554:394-8. 2003..Two automated functional assays addressing protein secretion and the integrity of the Golgi complex were developed and tested. This shows the potential of the system in large-scale, cell-based functional proteomic projects... - Integrative annotation of 21,037 human genes validated by full-length cDNA clonesTadashi Imanishi
Integrated Database Group, Biological Information Research Center, National Institute of Advanced Industrial Science and Technology, Tokyo, Japan
PLoS Biol 2:e162. 2004..The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology... - Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAsJun-ichi Takeda
Integrated Database Group, Japan Biological Information Research Center, Japan Biological Informatics Consortium, AIST Bio-IT Research, Building Aomi 2-42, Koto-ku, Tokyo 135-0064, Japan
Nucleic Acids Res 34:3917-28. 2006.... - Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI projectChris F Taylor
European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK
Nat Biotechnol 26:889-96. 2008 - The first RSBI (ISA-TAB) workshop: "can a simple format work for complex studies?"Susanna Assunta Sansone
EMBL EBI The European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom
OMICS 12:143-9. 2008..This article is part of the special issue of OMICS on the activities of the Genomics Standards Consortium (GSC)... - Human Proteinpedia enables sharing of human protein dataSuresh Mathivanan
Nat Biotechnol 26:164-7. 2008 - High-content microscopy identifies new neurite outgrowth regulatorsVibor Laketa
Cell Biology and Biophysics Unit, European Molecular Biology Laboratory Heidelberg, 69117 Heidelberg, Germany
Mol Biol Cell 18:242-52. 2007..Altogether, we demonstrate the potential of the systematic microscope-based screening approaches described here to tackle the complex biological process of neurite outgrowth regulation... - Proteomics and Beyond: a report on the 3rd Annual Spring Workshop of the HUPO-PSI 21-23 April 2006, San Francisco, CA, USASandra Orchard
EMBL Outstation European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK
Proteomics 6:4439-43. 2006.... - The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcriptsChisato Yamasaki
Japan Biological Information Research Center, Japan Biological Informatics Consortium, Japan
Nucleic Acids Res 36:D793-9. 2008.... - High-content screening microscopy identifies novel proteins with a putative role in secretory membrane trafficVytaute Starkuviene
Cell Biology and Biophysics Programme, European Molecular Biology Laboratory EMBL, 69117 Heidelberg, Germany
Genome Res 14:1948-56. 2004..It will also serve as an example for similar microscope-based screens addressing different biological questions... - Integrating systems biology with clinical researchRainer Pepperkok
Cell Biology and Cell Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Genome Biol 9:314. 2008..A report on the conference 'Systems Genomics 2008', Heidelberg, Germany, 2-3 May 2008... - PML-associated repressor of transcription (PAROT), a novel KRAB-zinc finger repressor, is regulated through association with PML nuclear bodiesSandra Fleischer
Heinrich Pette Institut für Experimentelle Virologie und Immunologie, Martinistrasse 52, 20251 Hamburg, Germany
Exp Cell Res 312:901-12. 2006..Taken together, our data identify a novel transcriptional repressor and provide evidence for its regulation through association with PML-NBs...