Astrid M Westendorf

Summary

Affiliation: German Research Centre for Biotechnology
Country: Germany

Publications

  1. ncbi request reprint Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model
    Astrid M Westendorf
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Ann N Y Acad Sci 1072:401-6. 2006
  2. ncbi request reprint Autoimmune-mediated intestinal inflammation-impact and regulation of antigen-specific CD8+ T cells
    Astrid Maria Westendorf
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Braunschweig, Germany
    Gastroenterology 131:510-24. 2006
  3. ncbi request reprint CD83 expression in CD4+ T cells modulates inflammation and autoimmunity
    Simone Reinwald
    Department of Mucosal Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Immunol 180:5890-7. 2008
  4. ncbi request reprint Intestinal immunity of Escherichia coli NISSLE 1917: a safe carrier for therapeutic molecules
    Astrid M Westendorf
    Arbeitsgruppe Mukosale Immunit├Ąt, Gesellschaft fur Biotechnologische Forschung, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    FEMS Immunol Med Microbiol 43:373-84. 2005
  5. ncbi request reprint On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes
    Dunja Bruder
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Diabetes 54:3395-401. 2005
  6. pmc Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
    Sya N Ukena
    Department of Mucosal Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 2:e1308. 2007
  7. pmc Signatures of human regulatory T cells: an encounter with old friends and new players
    Susanne Pfoertner
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Braunschweig, Germany
    Genome Biol 7:R54. 2006
  8. ncbi request reprint G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo
    Wiebke Hansen
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Immunol 177:209-15. 2006
  9. pmc The host response to the probiotic Escherichia coli strain Nissle 1917: specific up-regulation of the proinflammatory chemokine MCP-1
    Sya N Ukena
    German Research Centre for Biotechnology, Mucosal Immunity Group, Mascheroder Weg 1, 38124 Braunschweig, Germany
    BMC Med Genet 6:43. 2005
  10. ncbi request reprint CD4 T Lymphocyte-mediated lung disease: steady state between pathological and tolerogenic immune reactions
    Dunja Bruder
    Department of Cell Biology and Immunology, German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Am J Respir Crit Care Med 170:1145-52. 2004

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Intestinal epithelial antigen induces CD4+ T cells with regulatory phenotype in a transgenic autoimmune mouse model
    Astrid M Westendorf
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Ann N Y Acad Sci 1072:401-6. 2006
    ..Functional and molecular characterization of IECs from VILLIN-HA and VILLIN-HA x TCR-HA transgenic mice revealed a direct role in the induction of CD4(+) T cells with a regulatory phenotype that maintain intestinal homeostasis...
  2. ncbi request reprint Autoimmune-mediated intestinal inflammation-impact and regulation of antigen-specific CD8+ T cells
    Astrid Maria Westendorf
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Braunschweig, Germany
    Gastroenterology 131:510-24. 2006
    ..In addition, antigen-specific regulatory CD4+ T cells induced in vivo were tested to control these autoreactive CD8+ T cells...
  3. ncbi request reprint CD83 expression in CD4+ T cells modulates inflammation and autoimmunity
    Simone Reinwald
    Department of Mucosal Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Immunol 180:5890-7. 2008
    ..Taken together, our data provide the first evidence that CD83 expression can contribute to the immunosuppressive function of CD4(+) T cells in vivo...
  4. ncbi request reprint Intestinal immunity of Escherichia coli NISSLE 1917: a safe carrier for therapeutic molecules
    Astrid M Westendorf
    Arbeitsgruppe Mukosale Immunit├Ąt, Gesellschaft fur Biotechnologische Forschung, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    FEMS Immunol Med Microbiol 43:373-84. 2005
    ..The excellent colonization properties of E. coli NISSLE 1917 render this strain an ideal candidate as carrier organism for gut-focused in situ synthesis of therapeutic molecules...
  5. ncbi request reprint On the edge of autoimmunity: T-cell stimulation by steady-state dendritic cells prevents autoimmune diabetes
    Dunja Bruder
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Diabetes 54:3395-401. 2005
    ..Our results provide a basis for the development of novel strategies focusing on prevention rather than treatment of autoimmune diseases...
  6. pmc Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
    Sya N Ukena
    Department of Mucosal Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany
    PLoS ONE 2:e1308. 2007
    ..Disruption of this border alters paracellular permeability and is a key mechanism for the development of enteric infections and inflammatory bowel diseases (IBDs)...
  7. pmc Signatures of human regulatory T cells: an encounter with old friends and new players
    Susanne Pfoertner
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Braunschweig, Germany
    Genome Biol 7:R54. 2006
    ..Thus far, genomic studies on TReg cells were restricted to murine systems, and requirements for their development, maintenance, and mode of action in humans are poorly defined...
  8. ncbi request reprint G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo
    Wiebke Hansen
    Department of Mucosal Immunity, German Research Centre for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Immunol 177:209-15. 2006
    ..Our results suggest that GPR83 might be critically involved in the peripheral generation of Foxp3+ Treg cells in vivo...
  9. pmc The host response to the probiotic Escherichia coli strain Nissle 1917: specific up-regulation of the proinflammatory chemokine MCP-1
    Sya N Ukena
    German Research Centre for Biotechnology, Mucosal Immunity Group, Mascheroder Weg 1, 38124 Braunschweig, Germany
    BMC Med Genet 6:43. 2005
    ..The aim of this study was to improve our understanding of the E. coli Nissle 1917-host interaction by analyzing the gene expression pattern initiated by this probiotic in human intestinal epithelial cells...
  10. ncbi request reprint CD4 T Lymphocyte-mediated lung disease: steady state between pathological and tolerogenic immune reactions
    Dunja Bruder
    Department of Cell Biology and Immunology, German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Am J Respir Crit Care Med 170:1145-52. 2004
    ..Together our data provide important insights into functional and molecular alterations being associated with the induction and/or regulation of T cell-mediated pulmonary inflammation...
  11. ncbi request reprint Genomic peculiarity of coding sequences and metabolic potential of probiotic Escherichia coli strain Nissle 1917 inferred from raw genome data
    Jibin Sun
    GBF German Research Centre for Biotechnology, Experimental Bioinformatics, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Biotechnol 117:147-61. 2005
    ..coli strain Nissle 1917 and is helpful for designing further functional studies long before the sequencing project is completely finished...