V Umansky

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. doi request reprint Melanoma-induced immunosuppression and its neutralization
    Viktor Umansky
    Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Heidelberg, Germany
    Semin Cancer Biol 22:319-26. 2012
  2. doi request reprint Overcoming immunosuppression in the melanoma microenvironment induced by chronic inflammation
    Viktor Umansky
    Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cancer Immunol Immunother 61:275-82. 2012
  3. ncbi request reprint Nitric oxide-induced apoptosis in tumor cells
    V Umansky
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, D 69120 Heidelberg, Germany
    Adv Cancer Res 82:107-31. 2001
  4. ncbi request reprint Glutathione is a factor of resistance of Jurkat leukemia cells to nitric oxide-mediated apoptosis
    V Umansky
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Cell Biochem 78:578-87. 2000
  5. ncbi request reprint Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow
    M Feuerer
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Nat Med 7:452-8. 2001
  6. ncbi request reprint Breaking tolerance to a tumor-associated viral superantigen as a basis for graft-versus-leukemia reactivity
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Tumor Immunology Program, Heidelberg, Germany
    Int J Cancer 87:695-706. 2000
  7. ncbi request reprint Loss of endogenous mouse mammary tumor virus superantigen increases tumor resistance
    V Schirrmacher
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg
    J Immunol 161:563-70. 1998
  8. ncbi request reprint Functional and in situ evidence for nitric oxide production driven by CD40-CD40L interactions in graft-versus-leukemia reactivity
    S Müerköster
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg
    Clin Cancer Res 6:1988-96. 2000
  9. ncbi request reprint Inhibition of nitric-oxide-mediated apoptosis in Jurkat leukemia cells despite cytochrome c release
    V Umansky
    Division of Cellular Immunology, German Cancer Research Center, D 69120, Heidelberg, Germany
    Exp Cell Res 265:274-82. 2001
  10. ncbi request reprint Enrichment of memory T cells and other profound immunological changes in the bone marrow from untreated breast cancer patients
    M Feuerer
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 92:96-105. 2001

Collaborators

Detail Information

Publications15

  1. doi request reprint Melanoma-induced immunosuppression and its neutralization
    Viktor Umansky
    Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Heidelberg, Germany
    Semin Cancer Biol 22:319-26. 2012
    ....
  2. doi request reprint Overcoming immunosuppression in the melanoma microenvironment induced by chronic inflammation
    Viktor Umansky
    Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cancer Immunol Immunother 61:275-82. 2012
    ..Our data imply that inhibition of chronic inflammation in the tumor microenvironment should be applied in conjunction with melanoma immunotherapies to increase their efficacy...
  3. ncbi request reprint Nitric oxide-induced apoptosis in tumor cells
    V Umansky
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, D 69120 Heidelberg, Germany
    Adv Cancer Res 82:107-31. 2001
    ..In this review, we will concentrate on the current knowledge about the role of NO as an effector of apoptosis in tumor cells and discuss the mechanisms of NO-mediated apoptosis...
  4. ncbi request reprint Glutathione is a factor of resistance of Jurkat leukemia cells to nitric oxide-mediated apoptosis
    V Umansky
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Cell Biochem 78:578-87. 2000
    ..Our data suggest a complex mechanism of the resistence to NO-induced apoptosis in Jurkat human leukemia cells in which glutathione plays an important role...
  5. ncbi request reprint Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow
    M Feuerer
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Nat Med 7:452-8. 2001
    ..Our findings reveal an innate, specific recognition of breast cancer antigens and point to a possible novel cancer therapy using patients' bone-marrow-derived memory T cells...
  6. ncbi request reprint Breaking tolerance to a tumor-associated viral superantigen as a basis for graft-versus-leukemia reactivity
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Tumor Immunology Program, Heidelberg, Germany
    Int J Cancer 87:695-706. 2000
    ..These findings suggest that immune responses to SAg can be exploited to break tolerance and augment immune responses to tumors...
  7. ncbi request reprint Loss of endogenous mouse mammary tumor virus superantigen increases tumor resistance
    V Schirrmacher
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg
    J Immunol 161:563-70. 1998
    ..Mls-1a, the mice became again more tumor susceptible. Finally, we demonstrate the ability to transfer immunoresistance and graft-vs-leukemia reactivity from tumor-resistant to tumor-susceptible mice...
  8. ncbi request reprint Functional and in situ evidence for nitric oxide production driven by CD40-CD40L interactions in graft-versus-leukemia reactivity
    S Müerköster
    Division of Cellular Immunology, Tumor Immunology Program, German Cancer Research Center, Heidelberg
    Clin Cancer Res 6:1988-96. 2000
    ..These data provide functional and in situ evidence that the increased CD40 and iNOS expression observed during ADI contribute to the eradication of liver metastases and to the clearance of donor lymphocytes from the liver...
  9. ncbi request reprint Inhibition of nitric-oxide-mediated apoptosis in Jurkat leukemia cells despite cytochrome c release
    V Umansky
    Division of Cellular Immunology, German Cancer Research Center, D 69120, Heidelberg, Germany
    Exp Cell Res 265:274-82. 2001
    ....
  10. ncbi request reprint Enrichment of memory T cells and other profound immunological changes in the bone marrow from untreated breast cancer patients
    M Feuerer
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 92:96-105. 2001
    ..The overall results reveal that BM is a valuable additional compartment for immune diagnosis in pathological conditions and possibly for follow-up treatment strategies...
  11. pmc Dissection of tumour and host cells from target organs of metastasis for testing gene expression directly ex vivo
    M Rocha
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 74:1216-22. 1996
    ..The possibility of direct analysis of tumour and host cell properties also provides a new method for the evaluation of the effects of immunisation with tumour vaccines or of gene therapy...
  12. doi request reprint Second International Conference on Cancer Vaccines/Adjuvants/Delivery for the Next Decade (CVADD): Heidelberg, Germany, 10-12 October 2007
    V Schirrmacher
    Division of Cellular Immunology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Immunol Immunother 57:1421-7. 2008
  13. ncbi request reprint Antagonistic effects of systemic interleukin 2 on immune Tcell-mediated graft-versus-leukemia reactivity
    V Schirrmacher
    German Cancer Research Center, Division of Cellular Immunology, Heidelberg
    Clin Cancer Res 4:2635-45. 1998
    ..The results emphasize the importance of a better understanding of IL-2 function in vivo and of its interaction with immune cell function to improve protocols for optimal application in the clinic to achieve maximal GvL effects...
  14. pmc Superantigen reactive Vbeta6+ T cells induce perforin/granzyme B mediated caspase-independent apoptosis in tumour cells
    S Müerköster
    Division of Cellular Immunology, G0100, Tumorimmunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Br J Cancer 86:828-36. 2002
    ....
  15. ncbi request reprint Generation of dendritic cells from human bone marrow mononuclear cells: advantages for clinical application in comparison to peripheral blood monocyte derived cells
    L Bai
    German Cancer Research Center, Division of Cellular Immunology, D 69120 Heidelberg, Germany
    Int J Oncol 20:247-53. 2002
    ..These results suggest that BM-DC as produced here may be a very economic and useful source of professional antigen-presenting cells for anti-tumor immunotherapeutic protocols...