Andreas Trumpp

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment
    Daniel Klimmeck
    Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum DKFZ, 69120 Heidelberg, Germany Heidelberg Institute for Stem Cell Technology and Experimental Medicine HI STEM gGmbH, 69120 Heidelberg, Germany European Molecular Biology Laboratory EMBL, Genome Biology Unit, 69120 Heidelberg, Germany German Cancer Consortium DKTK
    Stem Cell Reports 3:858-75. 2014
  2. pmc Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients
    Markus Wallwiener
    National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany
    BMC Cancer 14:512. 2014
  3. pmc The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
    Armin Ehninger
    Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Exp Med 208:421-8. 2011
  4. pmc The evolving concept of cancer and metastasis stem cells
    Irène Baccelli
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine, D 69120 Heidelberg, Germany
    J Cell Biol 198:281-93. 2012
  5. pmc c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland
    Tina Stoelzle
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    BMC Biol 7:63. 2009
  6. ncbi request reprint Awakening dormant haematopoietic stem cells
    Andreas Trumpp
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany
    Nat Rev Immunol 10:201-9. 2010
  7. ncbi request reprint Targeting leukemic stem cells by breaking their dormancy
    Marieke Alida Gertruda Essers
    HI STEM Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Division of Stem Cells and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany
    Mol Oncol 4:443-50. 2010
  8. pmc Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B
    Larissa S Carnevalli
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine HI STEM gGmbH, D 69120 Heidelberg, Germany
    J Exp Med 211:769-79. 2014
  9. pmc Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization
    Melania Tesio
    Deutsches Krebsforschungszentrum DKFZ, D 69120 Heidelberg, Germany
    J Exp Med 210:2337-49. 2013
  10. pmc Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells
    Daniel Klimmeck
    Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum DKFZ, INF 280, DE 69120 Heidelberg, Germany
    Mol Cell Proteomics 11:286-302. 2012

Collaborators

  • Jeroen Krijgsveld
  • Marieke Alida Gertruda Essers
  • Jenny Hansson
  • Daniel Klimmeck
  • Irène Baccelli
  • Melania Tesio
  • Markus Wallwiener
  • Nina Cabezas-Wallscheid
  • Larissa S Carnevalli
  • Armin Ehninger
  • Tina Stoelzle
  • Klaus Pantel
  • Andreas Daniel Hartkopf
  • Martin Ronald Sprick
  • Andrea Kück
  • Barbara Burwinkel
  • Susann Rahmig
  • Stefanie Sujer
  • Alejandro Reyes
  • Christof Sohn
  • Elisa Laurenti
  • Christoph Domschke
  • Dharanija Madhavan
  • Birgitt Schönfisch
  • Sabine Riethdorf
  • Kohei Masuda
  • Andreas Schneeweiss
  • Roberta Scognamiglio
  • Wolfgang Huber
  • Frederik Marme
  • Miriam Erlacher
  • Manolis Pasparakis
  • Simon Renders
  • Caroline Modugno
  • Apostolos Polykratis
  • Lisa von Paleske
  • Juliane Nees
  • Sarah Schott
  • Lars Jöckel
  • Jörg Heil
  • Gabriela M Oser
  • William Blanco-Bose
  • Joachim R Gothert
  • Scott C Kogan
  • Hong Wu
  • Simon Raffel
  • Sergey Y Vakhrushev
  • Patrick Schwarb
  • Nancy E Hynes

Detail Information

Publications12

  1. ncbi request reprint Transcriptome-wide profiling and posttranscriptional analysis of hematopoietic stem/progenitor cell differentiation toward myeloid commitment
    Daniel Klimmeck
    Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum DKFZ, 69120 Heidelberg, Germany Heidelberg Institute for Stem Cell Technology and Experimental Medicine HI STEM gGmbH, 69120 Heidelberg, Germany European Molecular Biology Laboratory EMBL, Genome Biology Unit, 69120 Heidelberg, Germany German Cancer Consortium DKTK
    Stem Cell Reports 3:858-75. 2014
    ..This in-depth molecular analysis outlines the enormous complexity of expressed coding and noncoding RNAs and posttranscriptional regulation during the early differentiation steps of hematopoietic stem cells toward the myeloid lineage. ..
  2. pmc Serial enumeration of circulating tumor cells predicts treatment response and prognosis in metastatic breast cancer: a prospective study in 393 patients
    Markus Wallwiener
    National Center for Tumor Diseases, Im Neuenheimer Feld 460, 69120 Heidelberg, Germany
    BMC Cancer 14:512. 2014
    ....
  3. pmc The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in
    Armin Ehninger
    Division of Stem Cells and Cancer, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Exp Med 208:421-8. 2011
    ....
  4. pmc The evolving concept of cancer and metastasis stem cells
    Irène Baccelli
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine, D 69120 Heidelberg, Germany
    J Cell Biol 198:281-93. 2012
    ..The CSC concept has therefore evolved to better model the complex and highly dynamic processes of tumorigenesis, tumor relapse, and metastasis...
  5. pmc c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland
    Tina Stoelzle
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    BMC Biol 7:63. 2009
    ..Here we investigated functions of c-Myc during mouse mammary gland development using a conditional knockout approach...
  6. ncbi request reprint Awakening dormant haematopoietic stem cells
    Andreas Trumpp
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine, German Cancer Research Center, Germany
    Nat Rev Immunol 10:201-9. 2010
    ..Thus, we propose that two-step strategies could target resistant leukaemic stem cells by priming tumours with activators of dormancy followed by chemotherapy or targeted therapies...
  7. ncbi request reprint Targeting leukemic stem cells by breaking their dormancy
    Marieke Alida Gertruda Essers
    HI STEM Heidelberg Institute for Stem Cell Technology and Experimental Medicine, Division of Stem Cells and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, Heidelberg, Germany
    Mol Oncol 4:443-50. 2010
    ....
  8. pmc Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B
    Larissa S Carnevalli
    Heidelberg Institute for Stem Cell Technology and Experimental Medicine HI STEM gGmbH, D 69120 Heidelberg, Germany
    J Exp Med 211:769-79. 2014
    ..Blockade of GzmB production may help to improve hematopoiesis in various situations of BM stress. ..
  9. pmc Pten loss in the bone marrow leads to G-CSF-mediated HSC mobilization
    Melania Tesio
    Deutsches Krebsforschungszentrum DKFZ, D 69120 Heidelberg, Germany
    J Exp Med 210:2337-49. 2013
    ....
  10. pmc Proteomic cornerstones of hematopoietic stem cell differentiation: distinct signatures of multipotent progenitors and myeloid committed cells
    Daniel Klimmeck
    Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum DKFZ, INF 280, DE 69120 Heidelberg, Germany
    Mol Cell Proteomics 11:286-302. 2012
    ....
  11. ncbi request reprint Breaking the cell cycle of HSCs by p57 and friends
    Melania Tesio
    Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cell Stem Cell 9:187-92. 2011
    ..Two new Cell Stem Cell articles in this issue (Matsumoto et al., 2011; Zou et al., 2011) now show that the CDK inhibitor p57 is a crucial brake for cycling HSCs, and links self-renewal activity to cell cycle quiescence...
  12. ncbi request reprint IFNalpha activates dormant haematopoietic stem cells in vivo
    Marieke A G Essers
    Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum DKFZ, DKFZ ZMBH Alliance, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 458:904-8. 2009
    ..These data may help to clarify the so far unexplained clinical effects of IFNalpha on leukaemic cells, and raise the possibility for new applications of type I interferons to target cancer stem cells...