Joachim Spranger

Summary

Affiliation: German Institute of Human Nutrition
Country: Germany

Publications

  1. ncbi request reprint Adiponectin and protection against type 2 diabetes mellitus
    Joachim Spranger
    Department of Nutrition, Endocrinology, and Metabolism, Benjamin Franklin Medical Centre, Free University Berlin, Germany
    Lancet 361:226-8. 2003
  2. ncbi request reprint Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells
    Joachim Spranger
    Dept of Clinical Nutrition, German Institute of Human Nutrition Potsdam, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Diabetes 55:141-7. 2006
  3. ncbi request reprint Post-prandial decrease of human plasma ghrelin in the absence of insulin
    J Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbrucke, Bergholz Rehbrücke, Germany
    J Endocrinol Invest 26:RC19-22. 2003
  4. ncbi request reprint Predictors of abnormal glucose metabolism in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Germany
    Eur J Endocrinol 154:295-301. 2006
  5. doi request reprint Effect of meglitinides on postprandial ghrelin secretion pattern in type 2 diabetes mellitus
    Natalia Rudovich
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbrucke, 14558 Nuthetal, Germany
    Diabetes Technol Ther 12:57-64. 2010
  6. ncbi request reprint Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    J Clin Endocrinol Metab 89:1885-90. 2004
  7. ncbi request reprint Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
  8. ncbi request reprint Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome
    Joachim Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 61:738-46. 2004
  9. ncbi request reprint KCNJ11 E23K affects diabetes risk and is associated with the disposition index: results of two independent German cohorts
    Antje Fischer
    Department of Clinical Nutrition, German Institute of Human Nutrition, Nuthetal, Germany
    Diabetes Care 31:87-9. 2008
  10. ncbi request reprint Comparison of relative and attributable risk of myocardial infarction and stroke according to C-reactive protein and low-density lipoprotein cholesterol levels
    Tobias Pischon
    Department of Epidemiology, German Institute of Human Nutrition DIfE, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Eur J Epidemiol 22:429-38. 2007

Detail Information

Publications36

  1. ncbi request reprint Adiponectin and protection against type 2 diabetes mellitus
    Joachim Spranger
    Department of Nutrition, Endocrinology, and Metabolism, Benjamin Franklin Medical Centre, Free University Berlin, Germany
    Lancet 361:226-8. 2003
    ..3 [95% CI 0.2-0.7], p=0.0051). We conclude that adiponectin is independently associated with a reduced risk of type 2 diabetes in apparently healthy individuals...
  2. ncbi request reprint Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells
    Joachim Spranger
    Dept of Clinical Nutrition, German Institute of Human Nutrition Potsdam, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Diabetes 55:141-7. 2006
    ....
  3. ncbi request reprint Post-prandial decrease of human plasma ghrelin in the absence of insulin
    J Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbrucke, Bergholz Rehbrücke, Germany
    J Endocrinol Invest 26:RC19-22. 2003
    ..These data tentatively suggest that post-prandial secretion of ghrelin is not exclusively regulated by plasma insulin or plasma glucose but may depend on other metabolic factors yet to be identified...
  4. ncbi request reprint Predictors of abnormal glucose metabolism in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Germany
    Eur J Endocrinol 154:295-301. 2006
    ..This procedure is time-consuming and inconvenient, limiting its general use. Therefore, an easy method is wanted to separate PCOS women with normal from those with potentially abnormal glucose metabolism...
  5. doi request reprint Effect of meglitinides on postprandial ghrelin secretion pattern in type 2 diabetes mellitus
    Natalia Rudovich
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbrucke, 14558 Nuthetal, Germany
    Diabetes Technol Ther 12:57-64. 2010
    ..Based on evidence that functional ATP-sensitive channels are present in ghrelin-producing cells, we hypothesized that meglitinides may affect circulating ghrelin levels in subjects with type 2 diabetes...
  6. ncbi request reprint Body mass index and C-174G interleukin-6 promoter polymorphism interact in predicting type 2 diabetes
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    J Clin Endocrinol Metab 89:1885-90. 2004
    ....
  7. ncbi request reprint Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study
    Joachim Spranger
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Free University Berlin, Berlin, Germany
    Diabetes 52:812-7. 2003
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes...
  8. ncbi request reprint Adiponectin is independently associated with insulin sensitivity in women with polycystic ovary syndrome
    Joachim Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany
    Clin Endocrinol (Oxf) 61:738-46. 2004
    ..The aim of the study was to elucidate determinants of circulating adiponectin levels and to investigate the potential role of adiponectin in insulin resistance in PCOS women...
  9. ncbi request reprint KCNJ11 E23K affects diabetes risk and is associated with the disposition index: results of two independent German cohorts
    Antje Fischer
    Department of Clinical Nutrition, German Institute of Human Nutrition, Nuthetal, Germany
    Diabetes Care 31:87-9. 2008
  10. ncbi request reprint Comparison of relative and attributable risk of myocardial infarction and stroke according to C-reactive protein and low-density lipoprotein cholesterol levels
    Tobias Pischon
    Department of Epidemiology, German Institute of Human Nutrition DIfE, Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Eur J Epidemiol 22:429-38. 2007
    ..Consideration of LDL-C beyond smoking, diabetes and hypertension may increase the PAF of MI slightly more than CRP. In contrast, consideration of CRP but not of LDL-C may increase the PAF of stroke beyond these factors...
  11. ncbi request reprint Cereal fiber improves whole-body insulin sensitivity in overweight and obese women
    Martin O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal 14558, Germany
    Diabetes Care 29:775-80. 2006
    ..The pathogenic background of this phenomenon is unknown. Based on recent findings, we hypothesized that intake of purified insoluble oat fiber may improve whole-body insulin sensitivity...
  12. ncbi request reprint Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men
    Matthias Mohlig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Clinical Nutrition, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Clin Endocrinol Metab 91:964-7. 2006
    ..We therefore investigated whether salicylates reduce lipid-induced insulin resistance in humans by affecting inflammatory pathways as reflected by serum adipocytokines...
  13. doi request reprint Plasma resistin levels and risk of myocardial infarction and ischemic stroke
    Cornelia Weikert
    Department of Epidemiology, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    J Clin Endocrinol Metab 93:2647-53. 2008
    ....
  14. ncbi request reprint The polycystic ovary syndrome per se is not associated with increased chronic inflammation
    Matthias Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition, 14558 Potsdam Rehbruecke, Germany
    Eur J Endocrinol 150:525-32. 2004
    ....
  15. doi request reprint Circulating vaspin is unrelated to insulin sensitivity in a cohort of nondiabetic humans
    Christian von Loeffelholz
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    Eur J Endocrinol 162:507-13. 2010
    ..To study the association of vaspin with glucose metabolism...
  16. ncbi request reprint L-FABP T94A is associated with fasting triglycerides and LDL-cholesterol in women
    Eva Fisher
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Mol Genet Metab 91:278-84. 2007
    ..These results support previous findings in fenofibrate-treated individuals and thereby provide some additional indication of the functional relevance of the FABP1 T94A SNP in hepatic fatty acid and lipid metabolism in humans...
  17. ncbi request reprint An accurate risk score based on anthropometric, dietary, and lifestyle factors to predict the development of type 2 diabetes
    Matthias B Schulze
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Epidemiology, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Diabetes Care 30:510-5. 2007
    ..We aimed to develop a precise risk score for the screening of large populations for individuals at high risk of developing type 2 diabetes based on noninvasive measurements of major risk factors in German study populations...
  18. doi request reprint Metabolomic linkage reveals functional interaction between glucose-dependent insulinotropic polypeptide and ghrelin in humans
    Natalia N Rudovich
    Department of Clinical Nutrition, German Institute of Human Nutrition, Potsdam, Germany
    Am J Physiol Endocrinol Metab 301:E608-17. 2011
    ..These observations were independent of insulin and offer potential mechanistic underpinnings for the involvement of GIP in systemic control of energy metabolism...
  19. ncbi request reprint B vitamin plasma levels and the risk of ischemic stroke and transient ischemic attack in a German cohort
    Cornelia Weikert
    Department of Epidemiology, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Stroke 38:2912-8. 2007
    ..We investigated the individual and combined effects of plasma folate, vitamin B12, and pyridoxal 5-phosphate (PLP) levels on the risk of ischemic stroke and transient ischemic attack (TIA) in a large, prospective German cohort...
  20. ncbi request reprint Changes of adiponectin oligomer composition by moderate weight reduction
    Thomas Bobbert
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Diabetes 54:2712-9. 2005
    ..In conclusion, weight reduction results in a relative increase of HMW/MMW adiponectin and a reduction of LMW adiponectin. Total adiponectin and especially HMW adiponectin are related to circulating HDL cholesterol...
  21. ncbi request reprint Cell-type specific regulation of the human 11beta-hydroxysteroid dehydrogenase type 1 promoter
    Janin Andres
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Arch Physiol Biochem 113:110-5. 2007
    ..The described promoter constructs will allow subsequent studies about the role of specific hormonal, metabolic and transcription factors to finally characterise the regulation of the human 11beta-HSD1-promoter in more detail...
  22. doi request reprint Plasma gamma-glutamyltransferase, cysteinyl-glycine, and oxidized low-density lipoprotein: a pathway associated with myocardial infarction risk?
    Dagmar Drogan
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Arterioscler Thromb Vasc Biol 30:2053-8. 2010
    ....
  23. doi request reprint Polymorphisms within insulin-degrading enzyme (IDE) gene determine insulin metabolism and risk of type 2 diabetes
    Natalia Rudovich
    Department of Internal Medicine, Division of Endocrinology, Diabetes, and Nutrition, Campus Benjamin Franklin, Charite University Medicine, Berlin, Germany
    J Mol Med (Berl) 87:1145-51. 2009
    ..This study validates and confirms the association of IDE polymorphisms with T2DM risk in the prospective German cohort and provides novel evidence of influences of IDE genetic variants on insulin metabolism...
  24. ncbi request reprint Identification of a functional protein kinase Cbeta promoter polymorphism in humans related to insulin resistance
    Martin A Osterhoff
    German Institute of Human Nutrition, Potsdam Rehbruecke DIfE, Department of Clinical Nutrition KLE, Arthur Scheunert Allee 155, D 14558 Nuthetal, Germany
    Mol Genet Metab 93:210-5. 2008
    ....
  25. ncbi request reprint Wheat-fibre-induced changes of postprandial peptide YY and ghrelin responses are not associated with acute alterations of satiety
    Martin O Weickert
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    Br J Nutr 96:795-8. 2006
    ..Postprandial hunger scores were unaffected by the different test meals (P>0.15). Thus, oat- and wheat-fibre consumption result in different postprandial responses of PYY and ghrelin, but interestingly do not differ in satiety effects...
  26. ncbi request reprint IL6 gene promoter polymorphisms and type 2 diabetes: joint analysis of individual participants' data from 21 studies
    Cornelia Huth
    GSF Institute of Epidemiology, Neuherberg, Germany
    Diabetes 55:2915-21. 2006
    ....
  27. pmc Frataxin deficiency in pancreatic islets causes diabetes due to loss of beta cell mass
    Michael Ristow
    German Institute of Human Nutrition, Department Klinische Ernährung, 114 Arthur Scheunert Strasse, D 14558 Bergholz Rehbrücke, Germany
    J Clin Invest 112:527-34. 2003
    ..These observations might provide insight into the deterioration of beta cell function observed in different subtypes of diabetes in humans...
  28. ncbi request reprint Effects of pronounced weight loss on adiponectin oligomer composition and metabolic parameters
    Julia Engl
    Department of Internal Medicine, Clinical Division of General Internal Medicine, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Obesity (Silver Spring) 15:1172-8. 2007
    ..The aim of the study was to investigate changes of adiponectin isoforms during profound weight loss and its relation to anthropomorphometric and metabolic parameters...
  29. ncbi request reprint The androgen receptor CAG repeat modifies the impact of testosterone on insulin resistance in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Berlin, Germany
    Eur J Endocrinol 155:127-30. 2006
    ..A polymorphic CAG repeat sequence within the AR gene was reported to modulate its transactivation activity. Therefore, we investigated a putative interaction between testosterone and the CAG repeat length polymorphism with respect to IR...
  30. ncbi request reprint Interleukin-6 g.-174G>C promoter polymorphism is associated with obesity in the EPIC-Potsdam Study
    Kerstin Klipstein-Grobusch
    Department of Epidemiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal
    Obesity (Silver Spring) 14:14-8. 2006
    ..044) and was most pronounced in subjects with the CC genotype, suggesting that the IL-6 g.-174G>C promoter polymorphism is a susceptibility or modifying locus for common obesity and weight gain...
  31. ncbi request reprint Putative association between a new polymorphism in exon 3 (Arg109Cys) of the pancreatic colipase gene and type 2 diabetes mellitus in two independent Caucasian study populations
    Inka Lindner
    Institute for Physiology and Biochemistry of Nutrition, Federal Research Center for Nutrition and Food, Hermann Weigmann Strasse 1, 24103 Kiel, Germany
    Mol Nutr Food Res 49:972-6. 2005
    ..In conclusion, we obtained evidence in two German Caucasian study populations that the variant of the rare CLPS Arg109Cys polymorphism might contribute to increased susceptibility of type 2 diabetes...
  32. doi request reprint Retinol-binding protein 4 is associated with insulin resistance, but appears unsuited for metabolic screening in women with polycystic ovary syndrome
    Matthias Mohlig
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, 12200 Berlin, Germany
    Eur J Endocrinol 158:517-23. 2008
    ..The impact of RBP4 on IR in PCOS and its usability to identify women with metabolic syndrome (MS) or impaired glucose tolerance ((IGT) or diabetes) were investigated...
  33. ncbi request reprint Association of prostaglandin E synthase 2 (PTGES2) Arg298His polymorphism with type 2 diabetes in two German study populations
    Inke Nitz
    Molecular Nutrition, Christian Albrechts University of Kiel, Kiel, Germany
    J Clin Endocrinol Metab 92:3183-8. 2007
    ..On the basis of its chromosomal localization and its role in the synthesis of the antilipolytic compound prostaglandin E(2), the prostaglandin E synthase 2 (PTGES2) is a candidate gene for type 2 diabetes...
  34. ncbi request reprint Plasma pyridoxal-5-phosphate and future risk of myocardial infarction in the European Prospective Investigation into Cancer and Nutrition Potsdam cohort
    Jutta Dierkes
    Institute of Clinical Chemistry and Biochemistry, University Hospital Magdeburg, Magdeburg, Germany
    Am J Clin Nutr 86:214-20. 2007
    ..Retrospective studies indicate that low concentrations of plasma pyridoxal-5-phosphate (PLP) are associated with cardiovascular events; however, few prospective studies of this issue have been conducted...
  35. doi request reprint Growth hormone response during oral glucose tolerance test: the impact of assay method on the estimation of reference values in patients with acromegaly and in healthy controls, and the role of gender, age, and body mass index
    Ayman M Arafat
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 93:1254-62. 2008
    ..However, the development of highly sensitive and specific GH assays necessitates a critical reevaluation of criteria for diagnosis and follow-up of disease activity...
  36. doi request reprint Fatty acids differentially modify the expression of urokinase type plasminogen activator receptor in monocytes
    Anke Assmann
    Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Biochem Biophys Res Commun 376:196-9. 2008
    ..In conclusion we demonstrate that uPAR expression in human monocytes/macrophages is differentially stimulated by FFA. These effects are partially mediated by the p38 MAP-kinase signaling pathway...