Research Topics
Genomes and Genes
| Jurgen SchweizerSummaryAffiliation: German Cancer Research Center Country: Germany Publications
| Collaborators
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Detail Information
Publications
New consensus nomenclature for mammalian keratinsJurgen Schweizer
Section of Normal and Neoplastic Epidermal Differentiation, Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
J Cell Biol 174:169-74. 2006....
Human hair keratin-associated proteins (KAPs)Michael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
Int Rev Cytol 251:209-63. 2006....- The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domainMichael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Im Neuenheimer Feld 280, 69210 Heidelberg, Germany
Differentiation 72:527-40. 2004..Together with K18, a type I keratin gene found on the type II keratin domain, this seems to be the entire complement of functional type I keratins in humans... - K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicleLutz Langbein
German Cancer Research Center, Department of Cell Biology, Heidelberg, Germany
J Invest Dermatol 120:512-22. 2003..We provide evidence that Flügelzellen penetrate the Henle layer actively and may play a role in conferring plasticity and resilience to the otherwise rigid upper Henle layer... - Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13Michael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 124:536-44. 2005..All 26 human type II keratins found on this domain as well as K18, dtype 1 Keratin, are identified at the genomic and transcriptional level. This appears to be the total complement of functional type II keratins in humans... - Hair follicle-specific keratins and their diseasesJurgen Schweizer
Section of Normal and Neoplastic Epidermal, Differentiation A145, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Exp Cell Res 313:2010-20. 2007.... - Characterization of human KAP24.1, a cuticular hair keratin-associated protein with unusual amino-acid composition and repeat structureMichael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 127:1197-204. 2007..The structure of the KRTAP24, its proximity to the chromosome 21q22.1 KAP gene domain, the presence of repeat motifs in the protein and its localization in the hair cuticle points to KAP24.1 being a novel human KAP family member... - Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21Michael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 122:147-58. 2004..Primary among these were binding elements for the ETS, heat shock factor, AML, and HOX families of transcription factors... - Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glandsLutz Langbein
Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 125:428-44. 2005..We provide evidence that the cellular and intercellular properties of the peripheral and the luminal layers reflect adaptations to different functions... - K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicleLutz Langbein
German Cancer Research Center, Department of Cell Biology, University of Heidelberg, Heidelberg, Germany
J Invest Dermatol 126:2377-86. 2006.... - Human KAP genes, only the half of it? Extensive size polymorphisms in hair keratin-associated protein genesMichael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 124:vii-ix. 2005 - The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactorsLuis Felipe Jave-Suarez
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, A145, Im Neuenheimerfeld 280, 69120 Heidelberg, Germany
Arch Dermatol Res 297:372-6. 2006.... - Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1Michael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, 69120 Heidelberg, Germany
J Biol Chem 277:48993-9002. 2002..1 region revealed varying degrees and regions of expression of 11 members of the high tyrosine-glycine genes and 6 members of the high sulfur KAP genes in the hair forming compartment... - Keratins of the human hair follicleLutz Langbein
Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
Int Rev Cytol 243:1-78. 2005..A closing outlook highlights issues that need to be explored further to deepen our insight into the biology and genetics of the hair follicle... - A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicleLutz Langbein
German Cancer Research Center, Department of Cell Biology and Tumor Cell Regulation, Heidelberg, Germany
J Invest Dermatol 118:789-99. 2002..This tightly connected companion layer/inner root sheath unit provides an optimal molding and guidance of the growing hair shaft... - Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpressionKarin Muller-Decker
Section of Eicosanoids and Epithelial Tumor Development, Deutsches Krebsforschungszentrum, Heidelberg, Germany
J Invest Dermatol 121:661-8. 2003..Inhibition of transgenic COX-2 activity by feeding the specific COX-2 inhibitor valdecoxib suppressed the development of alopecia, indicating that COX-2-mediated prostaglandin synthesis is involved in hair follicle biology... - An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbaeHermelita Winter
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 122:652-7. 2004.... - More than one gene involved in monilethrix: intracellular but also extracellular playersJurgen Schweizer
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 126:1216-9. 2006..The underlying gene, desmoglein 4 (DSG4), belongs to the desmosomal cadherin superfamily and is also expressed in the cortex of the hair follicle... - HOXC13 is involved in the regulation of human hair keratin gene expressionLuis Felipe Jave-Suarez
Divisions of Tumor Cell Regulation and Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
J Biol Chem 277:3718-26. 2002..Collectively, our data speak for a direct involvement of HOXC13 in the control of hair keratin expression during early trichocyte differentiation...