Jurgen Schweizer

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc New consensus nomenclature for mammalian keratins
    Jurgen Schweizer
    Section of Normal and Neoplastic Epidermal Differentiation, Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
    J Cell Biol 174:169-74. 2006
  2. ncbi request reprint Human hair keratin-associated proteins (KAPs)
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    Int Rev Cytol 251:209-63. 2006
  3. ncbi request reprint The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Im Neuenheimer Feld 280, 69210 Heidelberg, Germany
    Differentiation 72:527-40. 2004
  4. ncbi request reprint K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology, Heidelberg, Germany
    J Invest Dermatol 120:512-22. 2003
  5. ncbi request reprint Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 124:536-44. 2005
  6. ncbi request reprint Hair follicle-specific keratins and their diseases
    Jurgen Schweizer
    Section of Normal and Neoplastic Epidermal, Differentiation A145, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Exp Cell Res 313:2010-20. 2007
  7. ncbi request reprint Characterization of human KAP24.1, a cuticular hair keratin-associated protein with unusual amino-acid composition and repeat structure
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 127:1197-204. 2007
  8. ncbi request reprint Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 122:147-58. 2004
  9. ncbi request reprint Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 125:428-44. 2005
  10. ncbi request reprint K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology, University of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 126:2377-86. 2006

Collaborators

Detail Information

Publications20

  1. pmc New consensus nomenclature for mammalian keratins
    Jurgen Schweizer
    Section of Normal and Neoplastic Epidermal Differentiation, Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
    J Cell Biol 174:169-74. 2006
    ....
  2. ncbi request reprint Human hair keratin-associated proteins (KAPs)
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    Int Rev Cytol 251:209-63. 2006
    ....
  3. ncbi request reprint The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Im Neuenheimer Feld 280, 69210 Heidelberg, Germany
    Differentiation 72:527-40. 2004
    ..Together with K18, a type I keratin gene found on the type II keratin domain, this seems to be the entire complement of functional type I keratins in humans...
  4. ncbi request reprint K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology, Heidelberg, Germany
    J Invest Dermatol 120:512-22. 2003
    ..We provide evidence that Flügelzellen penetrate the Henle layer actively and may play a role in conferring plasticity and resilience to the otherwise rigid upper Henle layer...
  5. ncbi request reprint Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 124:536-44. 2005
    ..All 26 human type II keratins found on this domain as well as K18, dtype 1 Keratin, are identified at the genomic and transcriptional level. This appears to be the total complement of functional type II keratins in humans...
  6. ncbi request reprint Hair follicle-specific keratins and their diseases
    Jurgen Schweizer
    Section of Normal and Neoplastic Epidermal, Differentiation A145, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Exp Cell Res 313:2010-20. 2007
    ....
  7. ncbi request reprint Characterization of human KAP24.1, a cuticular hair keratin-associated protein with unusual amino-acid composition and repeat structure
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 127:1197-204. 2007
    ..The structure of the KRTAP24, its proximity to the chromosome 21q22.1 KAP gene domain, the presence of repeat motifs in the protein and its localization in the hair cuticle points to KAP24.1 being a novel human KAP family member...
  8. ncbi request reprint Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 122:147-58. 2004
    ..Primary among these were binding elements for the ETS, heat shock factor, AML, and HOX families of transcription factors...
  9. ncbi request reprint Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 125:428-44. 2005
    ..We provide evidence that the cellular and intercellular properties of the peripheral and the luminal layers reflect adaptations to different functions...
  10. ncbi request reprint K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology, University of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 126:2377-86. 2006
    ....
  11. ncbi request reprint The HOXC13-controlled expression of early hair keratin genes in the human hair follicle does not involve TALE proteins MEIS and PREP as cofactors
    Luis Felipe Jave-Suarez
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, A145, Im Neuenheimerfeld 280, 69120 Heidelberg, Germany
    Arch Dermatol Res 297:372-6. 2006
    ....
  12. ncbi request reprint Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 277:48993-9002. 2002
    ..1 region revealed varying degrees and regions of expression of 11 members of the high tyrosine-glycine genes and 6 members of the high sulfur KAP genes in the hair forming compartment...
  13. ncbi request reprint The in vitro assembly of hair follicle keratins: comparison of cortex and companion layer keratins
    Ilse Hofmann
    Division of Cell Biology, German Cancer Research Center, Heidelberg
    Biol Chem 383:1373-81. 2002
    ..8 +/- 13.4 nm, comparable to the size distribution of assembly intermediates called 'unit-length' filaments...
  14. ncbi request reprint Human KAP genes, only the half of it? Extensive size polymorphisms in hair keratin-associated protein genes
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 124:vii-ix. 2005
  15. ncbi request reprint Keratins of the human hair follicle
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Int Rev Cytol 243:1-78. 2005
    ..A closing outlook highlights issues that need to be explored further to deepen our insight into the biology and genetics of the hair follicle...
  16. ncbi request reprint A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology and Tumor Cell Regulation, Heidelberg, Germany
    J Invest Dermatol 118:789-99. 2002
    ..This tightly connected companion layer/inner root sheath unit provides an optimal molding and guidance of the growing hair shaft...
  17. ncbi request reprint Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpression
    Karin Muller-Decker
    Section of Eicosanoids and Epithelial Tumor Development, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Invest Dermatol 121:661-8. 2003
    ..Inhibition of transgenic COX-2 activity by feeding the specific COX-2 inhibitor valdecoxib suppressed the development of alopecia, indicating that COX-2-mediated prostaglandin synthesis is involved in hair follicle biology...
  18. ncbi request reprint An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae
    Hermelita Winter
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 122:652-7. 2004
    ....
  19. ncbi request reprint More than one gene involved in monilethrix: intracellular but also extracellular players
    Jurgen Schweizer
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 126:1216-9. 2006
    ..The underlying gene, desmoglein 4 (DSG4), belongs to the desmosomal cadherin superfamily and is also expressed in the cortex of the hair follicle...
  20. ncbi request reprint HOXC13 is involved in the regulation of human hair keratin gene expression
    Luis Felipe Jave-Suarez
    Divisions of Tumor Cell Regulation and Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 277:3718-26. 2002
    ..Collectively, our data speak for a direct involvement of HOXC13 in the control of hair keratin expression during early trichocyte differentiation...