Reinhard Schwartz-Albiez

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc The glycome of normal and malignant plasma cells
    Thomas M Moehler
    Medizinische Klinik V, Universitatsklinikum Heidelberg, Heidelberg, Germany Translationale Immunologie, Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany
    PLoS ONE 8:e83719. 2013
  2. pmc Understanding the specificity of human Galectin-8C domain interactions with its glycan ligands based on molecular dynamics simulations
    Sonu Kumar
    D015, Translational Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    PLoS ONE 8:e59761. 2013
  3. doi request reprint Naturally occurring antibodies directed against carbohydrate tumor antigens
    Reinhard Schwartz-Albiez
    Department of Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Adv Exp Med Biol 750:27-43. 2012
  4. pmc Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation
    R Schwartz-Albiez
    German Cancer Research Center, D015, Heidelberg, Germany
    Clin Exp Immunol 158:43-50. 2009
  5. doi request reprint Cytotoxic natural antibodies against human tumours: an option for anti-cancer immunotherapy?
    Reinhard Schwartz-Albiez
    German Cancer Research Center, Tumor Immunology Programme, Heidelberg, Germany
    Autoimmun Rev 7:491-5. 2008
  6. ncbi request reprint Regioselectively modified sulfated cellulose as prospective drug for treatment of malaria tropica
    Reinhard Schwartz-Albiez
    German Cancer Research Center, Tumor Immunology, D010, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Glycoconj J 24:57-65. 2007
  7. ncbi request reprint Cell surface sialylation and ecto-sialyltransferase activity of human CD34 progenitors from peripheral blood and bone marrow
    Reinhard Schwartz-Albiez
    German Cancer Research Center, Tumor Immunology Program, Heidelberg, Germany
    Glycoconj J 21:451-9. 2004
  8. ncbi request reprint Perspectives for establishment and reorganization of carbohydrate-directed CD antibodies. Report of the carbohydrate section
    Reinhard Schwartz-Albiez
    German Cancer Research Center, Heidelberg, Germany
    Cell Immunol 236:48-50. 2005
  9. doi request reprint Differentially regulated expression of 9-O-acetyl GD3 (CD60b) and 7-O-acetyl-GD3 (CD60c) during differentiation and maturation of human T and B lymphocytes
    Dirk Wipfler
    German Cancer Research Center, D015 Translational Immunology, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Glycobiology 21:1161-72. 2011
  10. ncbi request reprint Effect of cytokine treatment on the in vitro expression of the P. falciparum adhesion receptor chondroitin-4-sulphate on the surface of human choriocarcinoma (BeWo) cells
    Yvonne Adams
    Hygiene Institut, Abteilung Parasitologie, Universitat Heidelberg, Im Neuenheimer Feld 324, Heidelberg, 69120, Germany
    Parasitol Res 101:479-83. 2007

Collaborators

Detail Information

Publications19

  1. pmc The glycome of normal and malignant plasma cells
    Thomas M Moehler
    Medizinische Klinik V, Universitatsklinikum Heidelberg, Heidelberg, Germany Translationale Immunologie, Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany
    PLoS ONE 8:e83719. 2013
    ..The prognostically relevant glycome deviation in malignant cells invites novel strategies of therapy for multiple myeloma. ..
  2. pmc Understanding the specificity of human Galectin-8C domain interactions with its glycan ligands based on molecular dynamics simulations
    Sonu Kumar
    D015, Translational Immunology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    PLoS ONE 8:e59761. 2013
    ..Our results derived from molecular dynamics simulations are able to explain the glycan binding specificities of the Gal-8C-CRD in comparison to those of the Gal-8N -CRD...
  3. doi request reprint Naturally occurring antibodies directed against carbohydrate tumor antigens
    Reinhard Schwartz-Albiez
    Department of Translational Immunology, German Cancer Research Center, Heidelberg, Germany
    Adv Exp Med Biol 750:27-43. 2012
    ..The cytotoxic capacity of these antibodies inspired several research groups and pharmaceutical companies to design novel strategies of immunoglobulin-based anti-tumor immunotherapy...
  4. pmc Natural antibodies, intravenous immunoglobulin and their role in autoimmunity, cancer and inflammation
    R Schwartz-Albiez
    German Cancer Research Center, D015, Heidelberg, Germany
    Clin Exp Immunol 158:43-50. 2009
    ..By recognizing these epitopes, natural antibodies neutralize proinflammatory responses and mediate atheroprotection...
  5. doi request reprint Cytotoxic natural antibodies against human tumours: an option for anti-cancer immunotherapy?
    Reinhard Schwartz-Albiez
    German Cancer Research Center, Tumor Immunology Programme, Heidelberg, Germany
    Autoimmun Rev 7:491-5. 2008
    ..Further studies are needed to elucidate molecular mechanisms leading to either tumour destruction induced by natural antibodies or to overcome the protective strategies of the tumour against antibody attack...
  6. ncbi request reprint Regioselectively modified sulfated cellulose as prospective drug for treatment of malaria tropica
    Reinhard Schwartz-Albiez
    German Cancer Research Center, Tumor Immunology, D010, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Glycoconj J 24:57-65. 2007
    ..The significance of CS10 interactions with the complement system as well as its anti-malarial effect for prospective drug application are discussed...
  7. ncbi request reprint Cell surface sialylation and ecto-sialyltransferase activity of human CD34 progenitors from peripheral blood and bone marrow
    Reinhard Schwartz-Albiez
    German Cancer Research Center, Tumor Immunology Program, Heidelberg, Germany
    Glycoconj J 21:451-9. 2004
    ..The ecto-sialyltransferase may serve to maintain or increase surface sialylation rapidly without de novo synthesis...
  8. ncbi request reprint Perspectives for establishment and reorganization of carbohydrate-directed CD antibodies. Report of the carbohydrate section
    Reinhard Schwartz-Albiez
    German Cancer Research Center, Heidelberg, Germany
    Cell Immunol 236:48-50. 2005
    ....
  9. doi request reprint Differentially regulated expression of 9-O-acetyl GD3 (CD60b) and 7-O-acetyl-GD3 (CD60c) during differentiation and maturation of human T and B lymphocytes
    Dirk Wipfler
    German Cancer Research Center, D015 Translational Immunology, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Glycobiology 21:1161-72. 2011
    ..Our data point to regulatory functions of these anabolic and catabolic key enzymes for the expression of GD3 and its O-acetylated variants in lymphocytes at a given differentiation stage...
  10. ncbi request reprint Effect of cytokine treatment on the in vitro expression of the P. falciparum adhesion receptor chondroitin-4-sulphate on the surface of human choriocarcinoma (BeWo) cells
    Yvonne Adams
    Hygiene Institut, Abteilung Parasitologie, Universitat Heidelberg, Im Neuenheimer Feld 324, Heidelberg, 69120, Germany
    Parasitol Res 101:479-83. 2007
    ..These data demonstrate that in vitro cultured BeWo cells mimic the P. falciparum adhesion receptor expression profile of ex vivo placental cytotrophoblast cells...
  11. doi request reprint Involvement of alpha 1-2-fucosyltransferase I (FUT1) and surface-expressed Lewis(y) (CD174) in first endothelial cell-cell contacts during angiogenesis
    Thomas M Moehler
    Department of Medicine V, University of Heidelberg, Heidelberg, Germany
    J Cell Physiol 215:27-36. 2008
    ..Together, our observations point to a tumor induced transcription of endothelial FUT1 and consequently an enhanced expression of CD174 which is involved in migration and early cell-cell contacts during tumor associated angiogenesis...
  12. doi request reprint Expression of CD175 (Tn), CD175s (sialosyl-Tn) and CD176 (Thomsen-Friedenreich antigen) on malignant human hematopoietic cells
    Yi Cao
    Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 123:89-99. 2008
    ....
  13. ncbi request reprint Differential surface expression and possible function of 9-O- and 7-O-acetylated GD3 (CD60 b and c) during activation and apoptosis of human tonsillar B and T lymphocytes
    Michael Erdmann
    Tumor Immunology Program, German Cancer Research Center, D 69120, Heidelberg, Germany
    Glycoconj J 23:627-38. 2006
    ..Together, surface-expressed CD60 b and c are differently expressed on tonsillar B and T cells and may be involved in the regulation of activation and apoptosis of lymphocytes in secondary lymphatic tissue...
  14. ncbi request reprint GlycoCD: a repository for carbohydrate-related CD antigens
    Sonu Kumar
    D015, Translational Immunology, German Cancer Research Center, INF 280, D 69120 Heidelberg, Germany
    Bioinformatics 28:2553-5. 2012
    ..It allows easy access through a user-friendly web interface to all carbohydrate-defined CDs and those that interact with carbohydrates along with other relevant information...
  15. pmc An easily accessible sulfated saccharide mimetic inhibits in vitro human tumor cell adhesion and angiogenesis of vascular endothelial cells
    Grazia Marano
    German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany Calvatis GmbH, Dr Albert Reimann Str 16a, 68526 Ladenburg, Germany
    Beilstein J Org Chem 8:787-803. 2012
    ....
  16. pmc Modulation of the CD95-induced apoptosis: the role of CD95 N-glycosylation
    Olga M Shatnyeva
    Division of Immunogenetics, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 6:e19927. 2011
    ..These findings are important for the better understanding of CD95 apoptosis regulation and reveal differences between apoptotic signaling pathways of the TRAIL and CD95 systems...
  17. doi request reprint Expression of Mucin-1 in multiple myeloma and its precursors: correlation with glycosylation and subcellular localization
    Mindaugas Andrulis
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    Histopathology 64:799-806. 2014
    ..We aimed at performing a comprehensive expression analysis of the MUC1 subunits in plasma cell dyscrasias...
  18. ncbi request reprint Differential expression of beta-galactoside alpha2,6 sialyltransferase and sialoglycans in normal and cirrhotic liver and hepatocellular carcinoma
    Yi Cao
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Lab Invest 82:1515-24. 2002
    ..Our results describe the expression patterns of ST6Gal I and sialoglycans in various liver tissues and demonstrate an altered expression of these structures between benign and malignant hepatocellular lesions...
  19. pmc Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1
    Frank Götschel
    Division of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e65403. 2013
    ..This suggests that there are more wide-spread, yet context-dependent interactions, between HH/GLI and growth factor receptor signaling in human malignancies...