Kai Schulze

Summary

Affiliation: German Research Centre for Biotechnology
Country: Germany

Publications

  1. pmc The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae
    Roy Gross
    Chair of Microbiology, Biocenter, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    BMC Genomics 9:449. 2008
  2. ncbi request reprint Intranasal vaccination with SfbI or M protein-derived peptides conjugated to diphtheria toxoid confers protective immunity against a lethal challenge with Streptococcus pyogenes
    Kai Schulze
    Department of Vaccinology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Vaccine 24:6088-95. 2006
  3. pmc The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant
    Thomas Ebensen
    Department of Vaccinology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    Clin Vaccine Immunol 14:952-8. 2007
  4. doi request reprint The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant
    Rimma Libanova
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre of Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    Vaccine 28:2249-58. 2010
  5. ncbi request reprint The FAI protein of group C streptococci acts as a mucosal adjuvant by the specific targeting and activation of B cells
    Kai Schulze
    Division of Microbiology, Department of Vaccinology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    Int J Med Microbiol 298:3-10. 2008
  6. ncbi request reprint Identification of the domains of the fibronectin-binding protein I of Streptococcus pyogenes responsible for adjuvanticity
    Kai Schulze
    Vaccine Research Group, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124, Braunschweig, Germany
    FEMS Immunol Med Microbiol 37:173-7. 2003
  7. ncbi request reprint A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties
    Thomas Ebensen
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Immunol 179:2065-73. 2007
  8. ncbi request reprint The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties
    Thomas Ebensen
    Department of Vaccinology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Vaccine 25:1464-9. 2007
  9. ncbi request reprint The FAI protein of group C streptococci targets B-cells and exhibits adjuvant activity
    Kai Schulze
    Vaccine Research Group, Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Vaccine 23:1408-13. 2005
  10. doi request reprint Development and characterization of attenuated metabolic mutants of Bordetella bronchiseptica for applications in vaccinology
    Tetyana Yevsa
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, D 38124 Braunschweig, Germany
    Environ Microbiol 15:64-76. 2013

Collaborators

Detail Information

Publications14

  1. pmc The missing link: Bordetella petrii is endowed with both the metabolic versatility of environmental bacteria and virulence traits of pathogenic Bordetellae
    Roy Gross
    Chair of Microbiology, Biocenter, University of Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    BMC Genomics 9:449. 2008
    ..Recently, clinical isolates associated with bone degenerative disease or cystic fibrosis have also been described...
  2. ncbi request reprint Intranasal vaccination with SfbI or M protein-derived peptides conjugated to diphtheria toxoid confers protective immunity against a lethal challenge with Streptococcus pyogenes
    Kai Schulze
    Department of Vaccinology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Vaccine 24:6088-95. 2006
    ..The obtained results indicate that in our experimental animal model peptide-based conjugate vaccines represent a valid alternative to protect against streptococcal infection...
  3. pmc The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant
    Thomas Ebensen
    Department of Vaccinology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    Clin Vaccine Immunol 14:952-8. 2007
    ..The results obtained indicate that cdiGMP is a promising tool for the development of mucosal vaccines...
  4. doi request reprint The member of the cyclic di-nucleotide family bis-(3', 5')-cyclic dimeric inosine monophosphate exerts potent activity as mucosal adjuvant
    Rimma Libanova
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre of Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    Vaccine 28:2249-58. 2010
    ....
  5. ncbi request reprint The FAI protein of group C streptococci acts as a mucosal adjuvant by the specific targeting and activation of B cells
    Kai Schulze
    Division of Microbiology, Department of Vaccinology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    Int J Med Microbiol 298:3-10. 2008
    ....
  6. ncbi request reprint Identification of the domains of the fibronectin-binding protein I of Streptococcus pyogenes responsible for adjuvanticity
    Kai Schulze
    Vaccine Research Group, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124, Braunschweig, Germany
    FEMS Immunol Med Microbiol 37:173-7. 2003
    ..The obtained results suggest that different sub-domains of the SfbI protein can be used as adjuvants for the development of mucosal vaccines...
  7. ncbi request reprint A pegylated derivative of alpha-galactosylceramide exhibits improved biological properties
    Thomas Ebensen
    Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig, Germany
    J Immunol 179:2065-73. 2007
    ..e., nose, lung, and vagina). The new synthetic derivative alphaGalCerMPEG represents a promising tool for the development of immune interventions against infectious and noninfectious diseases...
  8. ncbi request reprint The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties
    Thomas Ebensen
    Department of Vaccinology, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Vaccine 25:1464-9. 2007
    ..These results suggest that cdiGMP represents a promising adjuvant for vaccine development...
  9. ncbi request reprint The FAI protein of group C streptococci targets B-cells and exhibits adjuvant activity
    Kai Schulze
    Vaccine Research Group, Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Vaccine 23:1408-13. 2005
    ..The obtained results suggest that the FAI protein represents a useful tool to improve the immunogenicity of vaccine antigens...
  10. doi request reprint Development and characterization of attenuated metabolic mutants of Bordetella bronchiseptica for applications in vaccinology
    Tetyana Yevsa
    Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, D 38124 Braunschweig, Germany
    Environ Microbiol 15:64-76. 2013
    ....
  11. ncbi request reprint Stimulation of long-lasting protection against Streptococcus pyogenes after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein
    Kai Schulze
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Vaccine 21:1958-64. 2003
    ..The adjuvant properties exhibited by the fibronectin-binding domain of the SfbI protein strength the potential of this antigen for inclusion in multi-component vaccines against S. pyogenes...
  12. doi request reprint Opacity factor activity and epithelial cell binding by the serum opacity factor protein of Streptococcus pyogenes are functionally discrete
    Christine M Gillen
    School of Biological Sciences, University of Wollongong, New South Wales 2522, Australia
    J Biol Chem 283:6359-66. 2008
    ..We demonstrate that while the N terminus of SOF does not directly mediate intracellular uptake by epithelial cells, this domain enhances epithelial cell uptake mediated by full-length SOF, in comparison to the FnBD alone...
  13. ncbi request reprint Intranasal immunization with serum opacity factor (SOF) of Streptococcus pyogenes fails to protect mice against lethal mucosal challenge with a heterologous strain
    Kai Schulze
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Vaccine 24:1446-50. 2006
    ..These results highlight the importance of developing adequate experimental animal models to evaluate vaccine efficiency, according to the selected antigen...
  14. pmc Identification of B- and T-cell epitopes within the fibronectin-binding domain of the SfbI protein of Streptococcus pyogenes
    Kai Schulze
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Infect Immun 71:7197-201. 2003
    ..All identified epitopes clustered in a 30-amino-acid fragment. These results suggest that this polypeptide may be suitable for incorporation into a polyepitope-based vaccine formulation against S. pyogenes...