Markus Schmitt

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Multiple human papillomavirus infections with high viral loads are associated with cervical lesions but do not differentiate grades of cervical abnormalities
    Markus Schmitt
    Department Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center, Heidelberg, Germany
    J Clin Microbiol 51:1458-64. 2013
  2. doi request reprint Viral load of high-risk human papillomaviruses as reliable clinical predictor for the presence of cervical lesions
    Markus Schmitt
    Corresponding Author Markus Schmitt, German Cancer Research Center DKFZ, INF 242, Heidelberg 69120, Germany
    Cancer Epidemiol Biomarkers Prev 22:406-14. 2013
  3. doi request reprint Prevalence and viral load of 51 genital human papillomavirus types and three subtypes
    Markus Schmitt
    Department Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 132:2395-403. 2013
  4. doi request reprint The HPV16 transcriptome in cervical lesions of different grades
    Markus Schmitt
    Department of Genome Modifications and Carcinogenesis, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Mol Cell Probes 25:260-5. 2011
  5. doi request reprint C-terminal deletions of Merkel cell polyomavirus large T-antigen, a highly specific surrogate marker for virally induced malignancy
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Int J Cancer 131:2863-8. 2012
  6. pmc Bead-based multiplex genotyping of human papillomaviruses
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Clin Microbiol 44:504-12. 2006
  7. pmc Evaluation of a novel multiplex human papillomavirus (HPV) genotyping assay for HPV types in skin warts
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Clin Microbiol 49:3262-7. 2011
  8. doi request reprint Human polyomaviruses and other human viruses in neuroendocrine tumors
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 20:1558-61. 2011
  9. doi request reprint The HPV transcriptome in HPV16 positive cell lines
    Markus Schmitt
    Department of Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cell Probes 25:108-13. 2011
  10. pmc High-throughput detection and multiplex identification of cell contaminations
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center, Im Neuenheimer Feld 242, Heidelberg 69120, Germany
    Nucleic Acids Res 37:e119. 2009

Collaborators

Detail Information

Publications26

  1. pmc Multiple human papillomavirus infections with high viral loads are associated with cervical lesions but do not differentiate grades of cervical abnormalities
    Markus Schmitt
    Department Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center, Heidelberg, Germany
    J Clin Microbiol 51:1458-64. 2013
    ..However, the presence of multiple infections did not distinguish low-grade from high-grade cytological lesions...
  2. doi request reprint Viral load of high-risk human papillomaviruses as reliable clinical predictor for the presence of cervical lesions
    Markus Schmitt
    Corresponding Author Markus Schmitt, German Cancer Research Center DKFZ, INF 242, Heidelberg 69120, Germany
    Cancer Epidemiol Biomarkers Prev 22:406-14. 2013
    ..HPV DNA tests generally are very sensitive to detect cervical neoplastic lesions but also identify transient HPV infections. As a consequence, the specificity and positive predictive value are low...
  3. doi request reprint Prevalence and viral load of 51 genital human papillomavirus types and three subtypes
    Markus Schmitt
    Department Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 132:2395-403. 2013
    ..Our study provides quantitative data for the whole spectrum of genital HPV in a Belgian screening population and in a representative set of women with cervical abnormalities...
  4. doi request reprint The HPV16 transcriptome in cervical lesions of different grades
    Markus Schmitt
    Department of Genome Modifications and Carcinogenesis, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    Mol Cell Probes 25:260-5. 2011
    ..In conclusion, quantitative expression changes of HPV16 transcript markers may be involved in tumour progression. This study provides a basis for selection of candidate RNA markers for diagnostics of HPV16-related disease...
  5. doi request reprint C-terminal deletions of Merkel cell polyomavirus large T-antigen, a highly specific surrogate marker for virally induced malignancy
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Int J Cancer 131:2863-8. 2012
    ..The study further supports the notion that MCPyV does not play a role in cutaneous lymphoma pathogenesis...
  6. pmc Bead-based multiplex genotyping of human papillomaviruses
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Clin Microbiol 44:504-12. 2006
    ..922) but also indicated a higher sensitivity of MPG. In conclusion, MPG appears to be highly suitable for large-scale epidemiological studies and vaccination trials as well as for routine diagnostic purposes...
  7. pmc Evaluation of a novel multiplex human papillomavirus (HPV) genotyping assay for HPV types in skin warts
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Clin Microbiol 49:3262-7. 2011
    ..They would be advantageous to monitor the efficacy of future skin HPV vaccines and to identify novel HPV vaccine candidates...
  8. doi request reprint Human polyomaviruses and other human viruses in neuroendocrine tumors
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 20:1558-61. 2011
    ....
  9. doi request reprint The HPV transcriptome in HPV16 positive cell lines
    Markus Schmitt
    Department of Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cell Probes 25:108-13. 2011
    ..Very little is known about the quantitative expression of the various HPV16 transcripts in frequently used cervical cancer cell lines...
  10. pmc High-throughput detection and multiplex identification of cell contaminations
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center, Im Neuenheimer Feld 242, Heidelberg 69120, Germany
    Nucleic Acids Res 37:e119. 2009
    ..McCT proved to be highly specific, sensitive and robust, and allows to analyze more than 1000 cell lysates per week. In conclusion, the novel McCT assay is a powerful high-throughput tool in assessing cell line purity...
  11. doi request reprint Genotyping of AAV plasmid stocks: quality control in adeno-associated virus vector production
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Mol Microbiol Biotechnol 19:204-12. 2010
    ..In conclusion, MAG is a powerful high-throughput tool in assessing the purity and identity of AAV DNA plasmids and other starting materials used for AAV vector production...
  12. doi request reprint Prevalence of BPV genotypes in a German cowshed determined by a novel multiplex BPV genotyping assay
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, Heidelberg, Germany
    J Virol Methods 170:67-72. 2010
    ..In conclusion, BSBP-PCR/MBG is a powerful high-throughput method suitable for the study of the natural history of BPV and could be useful to veterinarians for the monitoring of the efficacy of future BPV vaccines...
  13. doi request reprint Diagnosing cervical cancer and high-grade precursors by HPV16 transcription patterns
    Markus Schmitt
    Research Program Infection and Cancer, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cancer Res 70:249-56. 2010
    ..In conclusion, we identified a novel HPV16 RNA pattern for grading of cervical lesions with a potentially high diagnostic value for the primary screening of CxCa precursors and the triage of cervical lesions...
  14. pmc Homogeneous amplification of genital human alpha papillomaviruses by PCR using novel broad-spectrum GP5+ and GP6+ primers
    Markus Schmitt
    German Cancer Research Center, Infection and Cancer, Im Neuenheimer Feld 280, Heidelberg D 69120, Germany
    J Clin Microbiol 46:1050-9. 2008
    ..BSGP5+/6+-MPG, therefore, is suitable for epidemiologic and also diagnostic applications...
  15. pmc Abundance of multiple high-risk human papillomavirus (HPV) infections found in cervical cells analyzed by use of an ultrasensitive HPV genotyping assay
    Markus Schmitt
    Department of Genome Modifications and Carcinogenesis F020, Research Program Infection and Cancer, German Cancer Research Center DKFZ, Im Neuenheimer Feld 242, Heidelberg 69120, Germany
    J Clin Microbiol 48:143-9. 2010
    ..As a consequence, PCR-TS-MPG appears to be highly suited for analysis of the significance of multiple infections in the development of cervical cancer and for the study the natural history and the latency of HPV...
  16. doi request reprint Biological activity of probable/possible high-risk human papillomavirus types in cervical cancer
    Gordana Halec
    Research Program Infection and Cancer, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Cancer 132:63-71. 2013
    ....
  17. doi request reprint Dried blood spot samples for seroepidemiology of infections with human papillomaviruses, Helicobacter pylori, Hepatitis C Virus, and JC Virus
    Tim Waterboer
    Department of Genome Modifications and Carcinogenesis, Infection and Cancer Program F020, Deutsches Krebsforschungszentrum DKFZ, Im Neuenheimer Feld 242, Heidelberg 69120, Germany
    Cancer Epidemiol Biomarkers Prev 21:287-93. 2012
    ..To establish antibody analysis from dried blood spots (DBS) on filter paper for seroepidemiologic infection and cancer association studies, we analyzed data from a population-based study in Mongolia...
  18. pmc Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility
    Felipe A Castro
    Division of Genome Modifications and Carcinogenesis, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 130:349-55. 2012
    ..The present data support the involvement of the TMC6/8 region in CxCa susceptibility but further analyses are needed to replicate our findings, fully characterize the region and understand the function of the genetic variants involved...
  19. doi request reprint Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach
    Felipe A Castro
    Division Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Int J Cancer 125:1851-8. 2009
    ..In conclusion, our study provides evidence for genetic susceptibility to CxCa due to variations in genes involved in the immune system and in cell cycle...
  20. doi request reprint Identification of oropharyngeal squamous cell carcinomas with active HPV16 involvement by immunohistochemical analysis of the retinoblastoma protein pathway
    Dana Holzinger
    Department of Otolaryngology, Experimental Head and Neck Oncology, Head and Neck Surgery, Heidelberg University, Germany
    Int J Cancer 133:1389-99. 2013
    ....
  21. doi request reprint Viral RNA patterns and high viral load reliably define oropharynx carcinomas with active HPV16 involvement
    Dana Holzinger
    Molecular Biology Laboratory, Department of Otolaryngology, Head and Neck Surgery, Heidelberg University, Heidelberg, Germany
    Cancer Res 72:4993-5003. 2012
    ..55, 95% CI, 0.29-1.08). In summary, our findings argued that viral load or RNA pattern analysis is better suited than p16(INK4a) expression to identify HPV16-driven tumors in OPSCC patient populations...
  22. ncbi request reprint Bead-based multiplex sexually transmitted infection profiling
    Markus Schmitt
    German Cancer Research Center DKFZ, Research Program Infection and Cancer, Im Neuenheimer Feld 242, 69120 Heidelberg, Germany
    J Infect 69:123-33. 2014
    ....
  23. ncbi request reprint A bead-based multiplex assay for the detection of DNA viruses infecting laboratory rodents
    Daniela Höfler
    Research Program Infection and Cancer, German Cancer Research Center, Heidelberg, Baden Wurttemberg, Germany
    PLoS ONE 9:e97525. 2014
    ..In conclusion, rDVF may have the potential to replace conventional testing and may simplify and improve routine detection of DNA viruses infecting rodents. ..
  24. pmc High-throughput SNP-based authentication of human cell lines
    Felipe Castro
    Department of Genome Modifications and Carcinogenesis, F020, Research Program Infection and Cancer, German Cancer Research Center, DKFZ, Heidelberg, Germany
    Int J Cancer 132:308-14. 2013
    ..In conclusion, MCA could complement routine cell line authentication and replace the standard authentication STR technique in case of MSI cell lines...
  25. pmc Bead-based multiplex genotyping of 58 cutaneous human papillomavirus types
    K M Michael
    Department of Genome Modifications and Carcinogenesis, Infection and Cancer Program, German Cancer Research Center, 69120 Heidelberg, Germany
    J Clin Microbiol 49:3560-7. 2011
    ..7 HPV types with nested FAP-PCR). In conclusion, McPG is a powerful tool for genotyping multiple cutaneous HPVs in a high-throughput format and is thus suitable for large-scale epidemiological studies...
  26. pmc Evaluation of different techniques for identification of human papillomavirus types of low prevalence
    Ivan Sabol
    Division of Molecular Medicine, Rudjer Boskovic Institute, Bijenicka cesta 54, P O Box 180, Zagreb HR 10002, Croatia
    J Clin Microbiol 46:1606-13. 2008
    ..Therefore, a universally evaluated and agreed upon HPV typing assay or a combination of current assays is needed for possible clinical applications, and knowledge of their limitations is advised...