D Schadendorf

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Primary staging and follow-up in melanoma patients--monocenter evaluation of methods, costs and patient survival
    U Hofmann
    Skin Cancer Unit German Cancer Research Centre, University Hospital Mannheim, Theodor Kutzer Ufer 1, Mannheim 68167, Germany
    Br J Cancer 87:151-7. 2002
  2. ncbi request reprint Is there a standard for the palliative treatment of melanoma?
    D Schadendorf
    Skin Cancer Unit of the German Cancer Research Center at the Department of Dermatology, University Hospital Mannheim
    Onkologie 25:74-6. 2002
  3. ncbi request reprint Dose-intensified bi-weekly temozolomide in patients with asymptomatic brain metastases from malignant melanoma: a phase II DeCOG/ADO study
    D Schadendorf
    Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Department of Dermatology, Mannheim, Germany
    Ann Oncol 17:1592-7. 2006
  4. ncbi request reprint Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG
    D Schadendorf
    Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Mannheim
    Ann Oncol 17:563-70. 2006
  5. doi request reprint Temozolomide plus pegylated interferon alfa-2b as first-line treatment for stage IV melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group (DeCOG)
    K Spieth
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Ann Oncol 19:801-6. 2008
  6. pmc Lack of clinical efficacy of imatinib in metastatic melanoma
    S Ugurel
    German Cancer Research Center Heidelberg, Department of Dermatology, University Hospital of Mannheim, Theodor Kutzer Ufer 1, D 68167 Mannheim, Germany
    Br J Cancer 92:1398-405. 2005
  7. doi request reprint Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma: a multicenter phase II DeCOG trial
    F Egberts
    Department of Dermatology, University of Kiel, Kiel, Germany
    Ann Oncol 22:1667-74. 2011
  8. doi request reprint Radio-guided surgery: advantages of a new portable γ-camera (Sentinella) for intraoperative real time imaging and detection of sentinel lymph nodes in cutaneous malignancies
    I Stoffels
    Department of Dermatology, Venerology and Allergology, University of Essen Duisburg, Essen, Germany
    J Eur Acad Dermatol Venereol 26:308-13. 2012
  9. pmc Metastatic potential of human melanoma cells in nude mice--characterisation of phenotype, cytokine secretion and tumour-associated antigens
    D Schadendorf
    Virchow Clinic, Department of Dermatology, Humboldt University of Berlin, Germany
    Br J Cancer 74:194-9. 1996
  10. doi request reprint Advantages of preoperative ultrasound in conjunction with lymphoscintigraphy in detecting malignant melanoma metastases in sentinel lymph nodes: a retrospective analysis in 221 patients with malignant melanoma AJCC Stages I and II
    I Stoffels
    Department of Dermatology, Venerology and Allergology, University of Essen Duisburg, Essen, Germany
    J Eur Acad Dermatol Venereol 26:79-85. 2012

Detail Information

Publications61

  1. pmc Primary staging and follow-up in melanoma patients--monocenter evaluation of methods, costs and patient survival
    U Hofmann
    Skin Cancer Unit German Cancer Research Centre, University Hospital Mannheim, Theodor Kutzer Ufer 1, Mannheim 68167, Germany
    Br J Cancer 87:151-7. 2002
    ..Taken together, imaging procedures for routine follow-up in stage I/II and stage III melanoma patients were inefficient and not cost-efficient...
  2. ncbi request reprint Is there a standard for the palliative treatment of melanoma?
    D Schadendorf
    Skin Cancer Unit of the German Cancer Research Center at the Department of Dermatology, University Hospital Mannheim
    Onkologie 25:74-6. 2002
  3. ncbi request reprint Dose-intensified bi-weekly temozolomide in patients with asymptomatic brain metastases from malignant melanoma: a phase II DeCOG/ADO study
    D Schadendorf
    Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Department of Dermatology, Mannheim, Germany
    Ann Oncol 17:1592-7. 2006
    ..The purpose of this study was to test a dose-intensified regimen of temozolomide in melanoma patients with brain metastases in a prospective, open-label, multicentre phase II trial...
  4. ncbi request reprint Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG
    D Schadendorf
    Skin Cancer Unit, German Cancer Research Center and University Hospital Mannheim, Mannheim
    Ann Oncol 17:563-70. 2006
    ..This randomized phase III trial was designed to demonstrate the superiority of autologous peptide-loaded dendritic cell (DC) vaccination over standard dacarbazine (DTIC) chemotherapy in stage IV melanoma patients...
  5. doi request reprint Temozolomide plus pegylated interferon alfa-2b as first-line treatment for stage IV melanoma: a multicenter phase II trial of the Dermatologic Cooperative Oncology Group (DeCOG)
    K Spieth
    Department of Dermatology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Ann Oncol 19:801-6. 2008
    ....
  6. pmc Lack of clinical efficacy of imatinib in metastatic melanoma
    S Ugurel
    German Cancer Research Center Heidelberg, Department of Dermatology, University Hospital of Mannheim, Theodor Kutzer Ufer 1, D 68167 Mannheim, Germany
    Br J Cancer 92:1398-405. 2005
    ..In conclusion, this study did not reveal an efficacy of imatinib in advanced metastatic melanoma, regardless of the expression pattern of the imatinib target molecules c-kit and PDGF-R...
  7. doi request reprint Sorafenib and pegylated interferon-α2b in advanced metastatic melanoma: a multicenter phase II DeCOG trial
    F Egberts
    Department of Dermatology, University of Kiel, Kiel, Germany
    Ann Oncol 22:1667-74. 2011
    ..Previously, combinations of interferon and sorafenib have been used in renal cell cancer...
  8. doi request reprint Radio-guided surgery: advantages of a new portable γ-camera (Sentinella) for intraoperative real time imaging and detection of sentinel lymph nodes in cutaneous malignancies
    I Stoffels
    Department of Dermatology, Venerology and Allergology, University of Essen Duisburg, Essen, Germany
    J Eur Acad Dermatol Venereol 26:308-13. 2012
    ..The histological status of the sentinel lymph node (SLN) is one of the most relevant prognostic factors for the overall survival of patients with cutaneous malignancies, independent of tumour depth of the primary tumour...
  9. pmc Metastatic potential of human melanoma cells in nude mice--characterisation of phenotype, cytokine secretion and tumour-associated antigens
    D Schadendorf
    Virchow Clinic, Department of Dermatology, Humboldt University of Berlin, Germany
    Br J Cancer 74:194-9. 1996
    ....
  10. doi request reprint Advantages of preoperative ultrasound in conjunction with lymphoscintigraphy in detecting malignant melanoma metastases in sentinel lymph nodes: a retrospective analysis in 221 patients with malignant melanoma AJCC Stages I and II
    I Stoffels
    Department of Dermatology, Venerology and Allergology, University of Essen Duisburg, Essen, Germany
    J Eur Acad Dermatol Venereol 26:79-85. 2012
    ..Sentinel lymph node excision (SLNE) for the detection of regional nodal metastases and staging of malignant melanoma has resulted in some controversies in international discussions as it is a surgical intervention with potential morbidity...
  11. doi request reprint Advantages of preoperative hybrid SPECT/CT in detection of sentinel lymph nodes in cutaneous head and neck malignancies
    J Klode
    Department of Dermatology, University of Essen Duisburg, Essen, Germany
    J Eur Acad Dermatol Venereol 25:1213-21. 2011
    ..Our study seeks to identify the potential medical and economic advantages of preoperative SPECT/CT in direct comparison to standard SLNE without SPECT/CT in patients with cutaneous head and neck malignancies...
  12. ncbi request reprint Clinical phase II study of pegylated liposomal doxorubicin as second-line treatment in disseminated melanoma
    W Fink
    Skin Cancer Unit German Cancer Research Center at the Department of Dermatology, University Hospital Mannheim, Germany
    Onkologie 27:540-4. 2004
    ..Response rates in first-line regimens range around 15-20%. Non-responders have a median survival around 6 months. Currently, no second-line treatment in advanced melanoma has been established...
  13. ncbi request reprint Chemoimmunotherapy for cutaneous melanoma with dacarbazine and epifocal contact sensitizers: results of a nationwide survey of the German Dermatologic Co-operative Oncology Group
    P Terheyden
    Department of Dermatology, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    J Cancer Res Clin Oncol 133:437-44. 2007
    ..This therapy merges the effects of an allergic contact dermatitis elicited at the site of a cutaneous metastasis, and systemic chemotherapy...
  14. pmc The chemokine RANTES is secreted by human melanoma cells and is associated with enhanced tumour formation in nude mice
    U Mrowietz
    Department of Dermatology, Univeristy of Kiel, Germany
    Br J Cancer 79:1025-31. 1999
    ..However, transplantation experiments in nude mice suggest that effects of RANTES may also benefit tumour progression. Further studies are needed to dissect the underlying mechanisms...
  15. pmc Lysis of allogeneic and autologous melanoma cells by IL-7-induced lymphokine-activated killer cells
    M Bohm
    University Hospital Rudolf Virchow, Department of Dermatology, Free University of Berlin, Germany
    Br J Cancer 70:54-9. 1994
    ..These results suggest that IL-7 is a potential alternative to immunotherapy with IL-2 in terms of efficacy and possible side-effects and encourages pilot studies with IL-7 in melanoma patients...
  16. ncbi request reprint Autologous, allogeneic tumor cells or genetically engineered cells as cancer vaccine against melanoma
    D Schadendorf
    Department of Dermatology, Clinical Cooperation Unit for Dermato Oncology DKFZ, Clinics Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1, 68135, Mannheim, Germany
    Immunol Lett 74:67-74. 2000
    ..Also other novel vaccine approaches such as dendritic cell-based therapy hold promise for the treatment of melanoma. But the clinical value of all these new approaches has to be analysed in prospectively randomized clinical studies...
  17. pmc Expression of SCF splice variants in human melanocytes and melanoma cell lines: potential prognostic implications
    P Welker
    Department of Dermatology, , Humboldt University, Berlin, Germany
    Br J Cancer 82:1453-8. 2000
    ....
  18. ncbi request reprint Alterations of DNA repair in melanoma cell lines resistant to cisplatin, fotemustine, or etoposide
    T M Rünger
    Department of Dermatology, Georg August University, Gottingen, Germany
    J Invest Dermatol 114:34-9. 2000
    ....
  19. ncbi request reprint Expression of the c-kit receptor in hypomelanosis: a comparative study between piebaldism, naevus depigmentosus and vitiligo
    E Dippel
    Department of Dermatology, University Hospital R Virchow, , Germany
    Br J Dermatol 132:182-9. 1995
    ....
  20. ncbi request reprint Panniculitis in a patient with chronic myelogenous leukaemia treated with imatinib
    S Ugurel
    Institute of Pathology and Department of Dermatology, Medical Centre Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1, 68167 Mannheim, Germany
    Br J Dermatol 149:678-9. 2003
  21. pmc TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours
    K G Griewank
    Department of Dermatology, University Hospital, University Duisburg Essen, Hufelandstrasse 55, Essen, Germany
    Br J Cancer 109:497-501. 2013
    ..Recently, activating mutations in the TERT promoter were identified in cutaneous melanoma. We tested a cohort of ocular melanoma samples for similar mutations...
  22. pmc MGMT gene promoter methylation correlates with tolerance of temozolomide treatment in melanoma but not with clinical outcome
    J C Hassel
    Skin Cancer Unit, German Cancer Research Center, University Hospital Mannheim, Mannheim, Germany
    Br J Cancer 103:820-6. 2010
    ..For melanoma, data are limited and controversial...
  23. doi request reprint Reliability and cost-effectiveness of complete lymph node dissection under tumescent local anaesthesia vs. general anaesthesia: a retrospective analysis in patients with malignant melanoma AJCC stage III
    I Stoffels
    Department of Dermatology, Venerology and Allergology, University of Essen Duisburg, Essen, Germany
    J Eur Acad Dermatol Venereol 26:200-6. 2012
    ..Complete lymph node dissection (CLND) in melanoma patients with a positive sentinel lymph node (SLN) is currently being debated, as it is a cost-intensive surgical intervention with potentially high morbidity...
  24. doi request reprint β-Blocker use and all-cause mortality of melanoma patients: results from a population-based Dutch cohort study
    E Livingstone
    Department of Dermatology, University Hospital Duisburg Essen, Essen, Germany
    Eur J Cancer 49:3863-71. 2013
    ..Results from preclinical and observational studies suggest that β-adrenoreceptor inhibition might influence disease progression of melanoma...
  25. doi request reprint Reliability and cost-effectiveness of sentinel lymph node excision under local anaesthesia versus general anaesthesia for malignant melanoma: a retrospective analysis in 300 patients with malignant melanoma AJCC Stages I and II
    I Stoffels
    Department of Dermatology, Venerology and Allergology, University of Essen Duisburg, Essen, Germany
    J Eur Acad Dermatol Venereol 25:306-10. 2011
    ....
  26. pmc Immunotherapy of distant metastatic disease
    D Schadendorf
    Department of Dermatology, University Hospital Essen, Essen, Germany
    Ann Oncol 20:vi41-50. 2009
    ..Recent advances of intratumour gene transfer technologies and adoptive immunotherapy, which represents a promising although technically challenging direction, are also discussed...
  27. doi request reprint Investigation of adhesion of modern wound dressings: a comparative analysis of 56 different wound dressings
    J Klode
    Department of Dermatology, Venerology and Allergology, University School of Medicine Essen Duisburg, Essen, Germany
    J Eur Acad Dermatol Venereol 25:933-9. 2011
    ..At present, no standardized test procedures are available for the investigation of adhesion of wound dressings. Therefore, our study aimed to test the adhesion of different wound dressings on steel as well as on healthy skin...
  28. doi request reprint Polidocanol foam sclerotherapy is a new and effective treatment for post-operative lymphorrhea and lymphocele
    J Klode
    Department of Dermatology, University of Essen, Essen, Germany
    J Eur Acad Dermatol Venereol 24:904-9. 2010
    ..Therefore, the aim of our clinical trial was to compare the use of polidocanol foam sclerotherapy with compression therapy to wound drainage, in the treatment of post-operative lymphoceles...
  29. ncbi request reprint Tumour progression and metastatic behaviour in vivo correlates with integrin expression on melanocytic tumours
    D Schadendorf
    Department of Dermatology, University Hospital Rudolf Virchow, FU Berlin, Germany
    J Pathol 170:429-34. 1993
    ....
  30. pmc Treatment of disseminated ocular melanoma with sequential fotemustine, interferon alpha, and interleukin 2
    J C Becker
    Department of Dermatology, University of Wurzburg, Germany
    Br J Cancer 87:840-5. 2002
    ..Of note, this overall survival is much longer than that repeatedly reported for stage IV uveal melanoma not treated with fotemustine, suggesting a therapeutic activity of this cytostatic drug even after systemic administration...
  31. ncbi request reprint Advances and perspectives in immunotherapy of melanoma
    D Schadendorf
    Department of Dermatology, Skin Cancer Centre, University Hospital Essen, Essen, Germany
    Ann Oncol 23:x104-8. 2012
    ..Based on this major step in treating metastatic melanoma, novel adjuvant strategies in stage III and combination therapies with targeted agents in stage IV are currently being explored...
  32. ncbi request reprint Reduced serum 25-hydroxyvitamin D levels in stage IV melanoma patients
    B Nurnberg
    Department of Dermatology, The Saarland University Hospital, Homburg, Germany
    Anticancer Res 29:3669-74. 2009
    ..However, the influence of serum 25(OH)D on the incidence and outcome of patients with malignant melanoma is unknown...
  33. ncbi request reprint Primary extracutaneous malignant melanoma: a comprehensive review with emphasis on treatment
    A Thoelke
    Skin Cancer Unit German Cancer Research Center and Department of Dermatology, University Hospital, Mannheim, Germany
    Onkologie 27:492-9. 2004
    ..For this reason, this review focuses primarily on the literature pertaining to therapeutic strategies as well as epidemiologic, biological, and diagnostic aspects of this disease...
  34. pmc Dose-dependent severe cutaneous reactions to imatinib
    S Ugurel
    Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 88:1157-9. 2003
    ..We here report on two out of four melanoma patients treated with high-dose imatinib presenting with severe and strongly dose-dependent skin eruptions, suggesting a cutaneous reactivity pattern different from allergic hypersensitivity...
  35. ncbi request reprint Systemic treatment in advanced melanoma: innovative perspectives
    S Ugurel
    Klinische Kooperationseinheit Dermato Onkologie, Deutsches Krebsforschungszentrum Heidelberg Universitäts Hautklinik Mannheim, Germany
    Onkologie 26:234-8. 2003
    ....
  36. ncbi request reprint Drug resistance in human melanoma: mechanisms and therapeutic opportunities
    H Röckmann
    Skin Cancer Unit at the German Cancer Research Center, University of Heidelberg, Germany
    Onkologie 26:581-7. 2003
    ..However, identification of drug resistance mechanisms provides new therapeutic targets to overcome chemoresistance in this and other malignancies...
  37. doi request reprint Functional and symptom impact of trametinib versus chemotherapy in BRAF V600E advanced or metastatic melanoma: quality-of-life analyses of the METRIC study
    D Schadendorf
    Department of Dermatology, University Hospital Essen, Essen, Germany
    Ann Oncol 25:700-6. 2014
    ..In a randomized phase III study, trametinib prolonged progression-free survival and improved overall survival versus chemotherapy in patients with BRAF V600 mutation-positive melanoma...
  38. doi request reprint Bacterial colonization of chronic leg ulcers: current results compared with data 5 years ago in a specialized dermatology department
    A Korber
    Department of Dermatology, University of Essen, Essen, Germany
    J Eur Acad Dermatol Venereol 24:1017-25. 2010
    ....
  39. ncbi request reprint Expression and functional activity of the IL-8 receptor type CXCR1 and CXCR2 on human mast cells
    U Lippert
    Department of Dermatology, Charite, Campus Virchow Klinikum, Humboldt Universitat, Berlin, Germany
    J Immunol 161:2600-8. 1998
    ..These findings demonstrate for the first time the functional expression of both types of IL-8 receptors on human mast cells, suggesting a role for their ligands during mast cell activation and recruitment...
  40. ncbi request reprint Seroreactivity against MAGE-A and LAGE-1 proteins in melanoma patients
    D Usener
    Skin Cancer Unit, D070, German Cancer Research Centre, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Br J Dermatol 149:282-8. 2003
    ..Cancer-testis antigens exemplify a growing number of tumour antigens which are expressed in a variety of malignancies, but not in normal tissues other than germ cells, primarily those of the testis...
  41. doi request reprint Adjuvant treatment with vindesine in comparison to observation alone in patients with metastasized melanoma after complete metastasectomy: a randomized multicenter trial of the German Dermatologic Cooperative Oncology Group
    Thomas K Eigentler
    Department of Dermatology, Skin Cancer Program, Eberhard Karls University, Tuebingen, Germany
    Melanoma Res 18:353-8. 2008
    ..Thus, this randomized trial did not confirm earlier reports of beneficial effects of adjuvant vindesine and can therefore not be recommended...
  42. doi request reprint Treatment of severe psoriasis with etanercept in a pancreas-kidney transplant recipient
    E I Brokalaki
    Department of Dermatology, University Hospital Essen, University of Duisburg Essen, Germany
    Transplant Proc 44:2776-7. 2012
    ..In both cases the treatment was well tolerated and effective. Psoriasis therapy in organ transplant recipients represents a major challenge. Biological agents such as etanercept may provide an effective option for refractory cases...
  43. ncbi request reprint Cutaneous large B-cell lymphoma of the leg masquerading as a chronic venous ulcer
    A Garbea
    Department of Dermatology, Venereology, and Allergology, University Medical Center Mannheim, Ruprecht Karls University of Heidelberg, Theodor Kutzer Ufer 1 3, 68135 Mannheim, Germany
    Br J Dermatol 146:144-7. 2002
    ..Local radiotherapy was started and combined photon and electron beam irradiation induced complete remission of the B-cell lymphoma...
  44. ncbi request reprint Analysis of mast cell subpopulations (MCT, MCTC) in cutaneous inflammation using novel enzyme-histochemical staining techniques
    B Algermissen
    Department of Dermatology, University Clinics Rudolf Virchow, FU Berlin, Germany
    Exp Dermatol 3:290-7. 1994
    ..These data suggest that disease-dependent mast cell dynamics involve only MCT in cutaneous inflammation and that MCT numbers are controlled by distinct, disease-specific local tissue factors...
  45. ncbi request reprint Segregation of effector mechanisms in a tumour-specific CD8+ T-cell clone correlates with CD30 expression
    Y Sun
    Skin Cancer Unit (D0900) of German Cancer Research Center, University Hospital Mannheim, D-68135 Mannheim, Germany
    Scand J Immunol 54:314-20. 2001
    ..These results suggest that CD30 antigen can be inducible on a subset of tumour-directed CD8+ CTL, and that this subset of cells may have profound effector functions, such as cytokine secretion, proliferation, and cytotoxicity...
  46. ncbi request reprint Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus
    N Haas
    Department of Dermatology, Medical Faculty Charité, Humboldt University Berlin, Schumannstrasse 20 21, Germany
    Br J Dermatol 147:793-6. 2002
    ..These findings suggest an HPV-independent aetiology of this rare type of multiple KA...
  47. ncbi request reprint Drug-resistance in human melanoma
    H Helmbach
    Skin Cancer Unit, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 93:617-22. 2001
    ..Thus, apoptosis and apoptotic deficiency should be analyzed to better clarify the mechanisms of melanoma resistance...
  48. ncbi request reprint Interleukin-7. Biology and implications for dermatology
    P Moller
    Department of Dermatology, Virchow Clinic, Humboldt University, Berlin, Germany
    Exp Dermatol 5:129-37. 1996
    ..This review summarizes our present knowledge about the molecular and immunological properties of IL7 with emphasis on the effects of that cytokine within the cutaneous compartment and the potential clinical utility in dermatology...
  49. ncbi request reprint Deficient IL-12p70 secretion by dendritic cells based on IL12B promoter genotype
    J Muller-Berghaus
    Skin Cancer Unit, German Cancer Research Center Heidelberg and University Hospital Mannheim, Germany
    Genes Immun 5:431-4. 2004
    ..These findings are important for the understanding of the highly complex regulation of IL-12 secretion, and its consequent impact on disease susceptibility, in humans...
  50. doi request reprint Adjuvant therapy with pegylated interferon alfa-2b versus observation alone in resected stage III melanoma: final results of EORTC 18991, a randomised phase III trial
    Alexander M M Eggermont
    Erasmus University Medical Center, Rotterdam, Netherlands
    Lancet 372:117-26. 2008
    ..Any benefit of adjuvant interferon alfa-2b for melanoma could depend on dose and duration of treatment. Our aim was to determine whether pegylated interferon alfa-2b can facilitate prolonged exposure while maintaining tolerability...
  51. ncbi request reprint Surveillance and follow-up examinations in cutaneous melanoma
    C Garbe
    Section Dermatological Oncology, Dermatology Department, University Hospital Tubingen, Germany
    Onkologie 26:241-6. 2003
    ..Consequently, costs can be reduced considerably without additional risk to the patient...
  52. ncbi request reprint Prognostic factors for survival and factors associated with long-term remission in patients with advanced melanoma receiving cytokine-based treatments: second analysis of a randomised EORTC Melanoma Group trial comparing interferon-alpha2a (IFNalpha) and
    U Keilholz
    Medizinische Klinik III, UKBF, Free University Berlin, Hindenburgdamm 30, 12200, Berlin, Germany
    Eur J Cancer 38:1501-11. 2002
    ..Site of metastases, the basis for the M-subcategories of the new AJCC staging system, was not informative in this study...
  53. ncbi request reprint SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma
    T B Hartmann
    German Cancer Research Center, Skin Cancer Unit D070, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Br J Dermatol 150:252-8. 2004
    ..Cutaneous T-cell lymphoma (CTCL) is a clonal lymphoproliferative disorder of mainly CD4+ T cells, with primary manifestation in the skin...
  54. ncbi request reprint Final results of the EORTC 18871/DKG 80-1 randomised phase III trial. rIFN-alpha2b versus rIFN-gamma versus ISCADOR M versus observation after surgery in melanoma patients with either high-risk primary (thickness >3 mm) or regional lymph node metastasi
    U R Kleeberg
    Haematologisch Onkologische Praxis Altona HOPA, Max Brauer Allee 52, D 22765 Hamburg, Germany
    Eur J Cancer 40:390-402. 2004
    ..87 (0.69, 1.10) and for Iscador M 1.21 (0.84, 1.75), respectively. The results show no clinical benefit for adjuvant treatment with low dose rIFN-alpha2b or rIFN-gamma or with Iscador M in high-risk melanoma patients...
  55. ncbi request reprint Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT
    M Christmann
    Division of Applied Toxicology, Institute of Toxicology, University of Mainz, Germany
    Int J Cancer 92:123-9. 2001
    ..This is the first report of acquired resistance to a chloroethylating antineoplastic drug of melanoma cells due to gene hypermethylation...
  56. ncbi request reprint Complete remission of multiple satellite and in-transit melanoma metastases after sequential treatment with isolated limb perfusion and topical imiquimod
    J Utikal
    Br J Dermatol 155:488-91. 2006
  57. ncbi request reprint Identification of differentially expressed genes in human melanoma cells with acquired resistance to various antineoplastic drugs
    C Grottke
    Institute of Pathology, Charite, Campus Mitte, Humboldt University Berlin, Berlin, Germany
    Int J Cancer 88:535-46. 2000
    ..Further characterization of these genes may yield inside into the biology and development of drug resistance in malignant melanoma...
  58. pmc Functional HLA-DM on the surface of B cells and immature dendritic cells
    S O Arndt
    Department of Molecular Immunology, German Cancer Research Center, D 69120 Heidelberg, Germany
    EMBO J 19:1241-51. 2000
    ..Thus, this novel concept of functional DM on the surface may be relevant to both protective immune responses and autoimmunity...
  59. ncbi request reprint Patterns of constitutive and IFN-gamma inducible expression of HLA class II molecules in human melanoma cell lines
    T Rodriguez
    Departamento de Analisis Clinicos, Hospital Universitario Virgen de las Nieves, Universidad de Granada, Avda Fuerzas Armadas 2, 18014, Granada, Spain
    Immunogenetics 59:123-33. 2007
    ..This study yielded a panel of melanoma cell lines with different patterns of constitutive and IFN-gamma-induced expression of HLA class II that can be used in future studies of the mechanisms of regulation of HLA class II expression...
  60. pmc Serological detection of cutaneous T-cell lymphoma-associated antigens
    S Eichmuller
    German Cancer Research Center DKFZ, Skin Cancer Unit D0900, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 98:629-34. 2001
    ..The SCP-1-like gene and cTAGE-1 were shown to be immunogenic and immunologically tumor-specific and may therefore be candidates for immunotherapy targeting CTCL...
  61. pmc Expression of cyclins and cyclin dependent kinases in human benign and malignant melanocytic lesions
    J Georgieva
    , , , Germany
    J Clin Pathol 54:229-35. 2001
    ..CONCLUSIONS: Taken together, this study demonstrated a significant increase of cyclin E and CDK2 expression during tumour progression in malignant melanomas...