Florenz Sasse

Summary

Affiliation: German Research Centre for Biotechnology
Country: Germany

Publications

  1. pmc Archazolid and apicularen: novel specific V-ATPase inhibitors
    Markus Huss
    Universitat Osnabruck, Fachbereich Biologie chemie, Abteilung Tierphysiologie, 49069 Osnabruck, Germany
    BMC Biochem 6:13. 2005
  2. ncbi request reprint Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties
    Florenz Sasse
    GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Antibiot (Tokyo) 55:543-51. 2002
  3. ncbi request reprint Archazolids, new cytotoxic macrolactones from Archangium gephyra (Myxobacteria). Production, isolation, physico-chemical and biological properties
    Florenz Sasse
    GBF, German Research Centre for Biotechnology, Department Natural Product Biology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Antibiot (Tokyo) 56:520-5. 2003
  4. ncbi request reprint Cyrmenins, new beta-methoxyacrylate inhibitors of the electron transport. Production, isolation, physico-chemical and biological properties
    Florenz Sasse
    GBF, German Research Centre for Biotechnology, Department of Natural Product Biology, Mascheroder Weg I, D 38124 Braunschweig, Germany
    J Antibiot (Tokyo) 56:827-31. 2003
  5. ncbi request reprint Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria
    Mohamed W Khalil
    Department of Natural Product Biology, GBF, German Research Center for Biotechnology, 38124 Braunschweig, Germany
    Chembiochem 7:678-83. 2006
  6. ncbi request reprint Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria
    Heinrich Steinmetz
    Bereich Naturstoffe, Gesellschaft fur Biotechnologische Forschung mbH, Mascheroder Weg 1, 38124 Braunschweig, Germany
    Angew Chem Int Ed Engl 43:4888-92. 2004
  7. ncbi request reprint Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells
    Yasser A Elnakady
    Department of Natural Product Biology, GBF, German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Biochem Pharmacol 67:927-35. 2004
  8. ncbi request reprint Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity
    Axel Sandmann
    GBF German Research Center for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    Chem Biol 11:1071-9. 2004
  9. ncbi request reprint Sulfur, selenium and tellurium pseudopeptides: Synthesis and biological evaluation
    Saad Shaaban
    Department of Chemistry, Faculty of Science, Mansoura University, El Gomhoria Street, Mansoura 35516, Egypt Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, D 38124 Braunschweig, Germany Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D 66123 Saarbruecken, Germany
    Bioorg Med Chem 22:3610-9. 2014
  10. ncbi request reprint Identification of StiR, the first regulator of secondary metabolite formation in the myxobacterium Cystobacter fuscus Cb f17.1
    Shwan Rachid
    GBF German Research Center for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Biotechnol 121:429-41. 2006

Collaborators

  • Hans Reichenbach
  • Gerhard Hofle
  • Rolf Muller
  • Claus Jacob
  • Jørgen Kjems
  • Rajeshwar P Verma
  • Brigitte Kunze
  • Volker Brinkmann
  • Dirk Menche
  • Jun Li
  • Michael P Manns
  • K Gerth
  • Kira J Weissman
  • Teresa Carlomagno
  • Saad Shaaban
  • Yasser A Elnakady
  • Heinrich Steinmetz
  • Shwan Rachid
  • Randi Diestel
  • Irina Nickeleit
  • Markus Kalesse
  • Ulrike Eggert
  • Viktor V Vintonyak
  • Susanne Schneiker
  • Achim Grube
  • Rolf Jansen
  • Stefan Beyer
  • Mohamed W Khalil
  • Yana Galeyeva
  • Markus Huss
  • Heinrich Lünsdorf
  • Axel Sandmann
  • Mario Köster
  • Torsten Burkholz
  • Yazh Muthukumar
  • Bettina Hinkelmann
  • Frank Lay
  • Nisar P Malek
  • Martin E Maier
  • Marcellino Calà
  • Steffen Zender
  • Robert Geffers
  • Ronald Frank
  • Achim Gossler
  • Stefan Kubicka
  • Inga Sörensen
  • Gudrun Brandes
  • Ines Gütgemann
  • Jan Buer
  • Silke C Wenzel
  • Lars Gaigalat
  • Susanne Wilhelm
  • Sabrina Doss
  • Alfred Pühler
  • Matthias Köck
  • Stephan C Schuster
  • Ellen Lichte
  • Lotte Jelsbak
  • Rosa Martinez-Arias
  • Jose Munoz-Dorado
  • Michelle Merai
  • Christian Ruckert
  • Roy D Welch
  • Jorn Kalinowski
  • Edna Bode
  • Maren Kopp
  • Carsten Kegler
  • Maren Scharfe
  • Garret Suen
  • Jomuna V Choudhuri
  • Gregory J Velicer
  • Carolin Groeger
  • Juana Perez
  • Tina Knauber
  • Frank Gross
  • Frank Rosenau
  • Folker Meyer
  • Olena Perlova
  • Michael Assmann
  • Christoph J Bolten
  • Matthias O Altmeyer
  • Olaf Kaiser
  • Sebastian Konietzny
  • Bettina Frank
  • Joseph R Pawlik
  • Lars Jelsbak
  • Bukhard Linke
  • Thomas Bekel
  • Günter Raddatz
  • Alexander Goesmann

Detail Information

Publications22

  1. pmc Archazolid and apicularen: novel specific V-ATPase inhibitors
    Markus Huss
    Universitat Osnabruck, Fachbereich Biologie chemie, Abteilung Tierphysiologie, 49069 Osnabruck, Germany
    BMC Biochem 6:13. 2005
    ..Since their malfunction is correlated with various diseases in humans, the elucidation of the properties of this enzyme for the development of selective inhibitors and drugs is one of the challenges in V-ATPase research...
  2. ncbi request reprint Argyrins, immunosuppressive cyclic peptides from myxobacteria. I. Production, isolation, physico-chemical and biological properties
    Florenz Sasse
    GBF, Gesellschaft fur Biotechnologische Forschung mbH, Abteilung Naturstoffbiologie, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Antibiot (Tokyo) 55:543-51. 2002
    ..All argyrins had slight antibiotic activity, especially against Pseudomonas sp., and inhibited growth of mammalian cell cultures. The growth inhibition was often incomplete and varied highly with different cell lines...
  3. ncbi request reprint Archazolids, new cytotoxic macrolactones from Archangium gephyra (Myxobacteria). Production, isolation, physico-chemical and biological properties
    Florenz Sasse
    GBF, German Research Centre for Biotechnology, Department Natural Product Biology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Antibiot (Tokyo) 56:520-5. 2003
    ..We therefore assume that archazolid is an inhibitor of the V-ATPase of higher cells...
  4. ncbi request reprint Cyrmenins, new beta-methoxyacrylate inhibitors of the electron transport. Production, isolation, physico-chemical and biological properties
    Florenz Sasse
    GBF, German Research Centre for Biotechnology, Department of Natural Product Biology, Mascheroder Weg I, D 38124 Braunschweig, Germany
    J Antibiot (Tokyo) 56:827-31. 2003
    ..Investigations by difference spectroscopy showed that cyrmenin B1 blocks the electron transport within the cytochrome bc1-segment (complex III) of the respiratory chain...
  5. ncbi request reprint Mechanism of action of tubulysin, an antimitotic peptide from myxobacteria
    Mohamed W Khalil
    Department of Natural Product Biology, GBF, German Research Center for Biotechnology, 38124 Braunschweig, Germany
    Chembiochem 7:678-83. 2006
    ..The mode of action of tubulysin A resembled that of peptide antimitotics dolastatin 10, phomopsin A, and hemiasterlin. Efforts are underway to develop this new group of compounds as anticancer drugs...
  6. ncbi request reprint Isolation, crystal and solution structure determination, and biosynthesis of tubulysins--powerful inhibitors of tubulin polymerization from myxobacteria
    Heinrich Steinmetz
    Bereich Naturstoffe, Gesellschaft fur Biotechnologische Forschung mbH, Mascheroder Weg 1, 38124 Braunschweig, Germany
    Angew Chem Int Ed Engl 43:4888-92. 2004
  7. ncbi request reprint Disorazol A1, a highly effective antimitotic agent acting on tubulin polymerization and inducing apoptosis in mammalian cells
    Yasser A Elnakady
    Department of Natural Product Biology, GBF, German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Biochem Pharmacol 67:927-35. 2004
    ..Formation of defined degradation structures was not observed. Disorazol is a novel, highly effective antimitotic agent. Efforts are going on to develop it as an anticancer drug...
  8. ncbi request reprint Identification and analysis of the core biosynthetic machinery of tubulysin, a potent cytotoxin with potential anticancer activity
    Axel Sandmann
    GBF German Research Center for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    Chem Biol 11:1071-9. 2004
    ..Sequence analysis of more than 80,000 bp reveals an unusual multimodular hybrid polyketide synthase/peptide synthetase assembly line with a variety of unprecedented features...
  9. ncbi request reprint Sulfur, selenium and tellurium pseudopeptides: Synthesis and biological evaluation
    Saad Shaaban
    Department of Chemistry, Faculty of Science, Mansoura University, El Gomhoria Street, Mansoura 35516, Egypt Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, D 38124 Braunschweig, Germany Division of Bioorganic Chemistry, School of Pharmacy, Saarland University, D 66123 Saarbruecken, Germany
    Bioorg Med Chem 22:3610-9. 2014
    ..As most of these peptidomimetic compounds also comply with Lipinski's Rule of Five, they promise good bioavailability, which needs to be studied as part of future investigations. ..
  10. ncbi request reprint Identification of StiR, the first regulator of secondary metabolite formation in the myxobacterium Cystobacter fuscus Cb f17.1
    Shwan Rachid
    GBF German Research Center for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    J Biotechnol 121:429-41. 2006
    ..This strain was shown to be equally effected in natural product biosynthesis...
  11. doi request reprint Novel peptidomimetic compounds containing redox active chalcogens and quinones as potential anticancer agents
    Saad Shaaban
    Department of Chemical Biology, Helmholtz Centre for Infection Research, Inhoffenstraße 7, D 38124 Braunschweig, Germany
    Eur J Med Chem 58:192-205. 2012
    ..The cause was obviously OS, which was reflected by significant decrease in reduced glutathione, subsequently cell cycle arrest and induction of apoptosis...
  12. ncbi request reprint Ratjadones inhibit nuclear export by blocking CRM1/exportin 1
    Mario Köster
    Department of Gene Regulation and Differentiation, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Exp Cell Res 286:321-31. 2003
    ..Thus, the ratjadones represent a new class of natural compounds which inhibit proliferation in eukaryotes by blocking nuclear export...
  13. ncbi request reprint Bioactive metabolites from the Caribbean sponge Aka coralliphagum
    Achim Grube
    Alfred Wegener Institut für Polar und Meeresforschung in der Helmholtz Gemeinschaft, Am Handelshafen 12, D 27570 Bremerhaven, Germany
    J Nat Prod 70:504-9. 2007
    ..The biological activity was linked to the presence of the ortho-hydroquinone moiety...
  14. ncbi request reprint The first hydroxylated archazolid from the myxobacterium Cystobacter violaceus: isolation, structural elucidation and V-ATPase inhibition
    Dirk Menche
    Helmholtz Zentrum für Infektionsforschung GmbH, Medicinal Chemistry and Chemical Biology, Braunschweig, Germany
    J Antibiot (Tokyo) 60:328-31. 2007
    ..This novel metabolite was evaluated for growth inhibition of murine connective tissue cells and V-ATPase inhibition in comparison to other known archazolids...
  15. doi request reprint Chondramide C: synthesis, configurational assignment, and structure-activity relationship studies
    Ulrike Eggert
    Zentrum für Biomolekulare Wirkstoffe BMWZ, Leibniz Universitat Hannover, Schneiderberg 1B, 30167 Hannover, Germany
    Angew Chem Int Ed Engl 47:6478-82. 2008
  16. doi request reprint Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition
    Irina Nickeleit
    Institute for Molecular Biology, Hannover Medical School, 30625 Hannover, Germany
    Cancer Cell 14:23-35. 2008
    ..By comparing the cellular responses exerted by argyrin A with siRNA-mediated knockdown of proteasomal subunits, we find that the biological effects of proteasome inhibition per se depend on the expression of p27(kip1)...
  17. doi request reprint Synthesis and biological evaluation of cruentaren A analogues
    Viktor V Vintonyak
    Institut fur Organische Chemie, Universitat Tubingen, Auf der Morgenstelle 18, 72076 Tubingen, Germany
    Chemistry 14:3709-20. 2008
    ..Under the conditions for cleavage of the C3 aromatic methyl ether, the enamide function was transformed to the corresponding oxazinanone, resulting in analogues 25 and 52...
  18. ncbi request reprint Complete genome sequence of the myxobacterium Sorangium cellulosum
    Susanne Schneiker
    Department of Genetics, Bielefeld University, PO Box 100131, D 33501 Bielefeld, Germany
    Nat Biotechnol 25:1281-9. 2007
    ..Seventeen secondary metabolite loci are encoded in the genome, as well as many enzymes with potential utility in industry...
  19. ncbi request reprint Efficient one-pot synthesis of biologically active polysubstituted aromatic amines
    Dirk Menche
    Helmholtz Zentrum für Infektionsforschung GmbH, Medizinische Chemie, Inhoffenstr 7, 38124 Braunschweig, Germany
    Bioorg Med Chem 15:7311-7. 2007
    ....
  20. ncbi request reprint Cruentaren A, a highly cytotoxic benzolactone from Myxobacteria is a novel selective inhibitor of mitochondrial F1-ATPases
    Brigitte Kunze
    Arbeitsgruppe Mikrobielle Kommunikation, Helmholtz Zentrum für Infektionsforschung, 38124 Braunschweig, Germany
    FEBS Lett 581:3523-7. 2007
    ..Since mitochondrial ATPases play a crucial role in the pathophysiology of several human disorders including cancer, cruentaren or synthetic derivatives thereof could form the basis of future therapeutic strategies...
  21. ncbi request reprint Total synthesis and biological evaluation of (-)-pectinatone employing a methyl-branched wax ester as key building block
    Yana Galeyeva
    Institut fur Organische Chemie, Universitat Stuttgart, Pfaffenwaldring 55, D 70569 Stuttgart
    Chem Biodivers 3:935-41. 2006
    ..Both (-)-3 and the amides 8b and 8c, which were isolated as by-products in the reaction sequence, displayed antimicrobial activity and cytotoxicity...
  22. ncbi request reprint Design, synthesis, and biological evaluation of novel analogues of archazolid: a highly potent simplified V-ATPase inhibitor
    Dirk Menche
    Helmholtz Zentrum für Infektionsforschung GmbH, Medizinische Chemie, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Bioorg Med Chem Lett 17:1732-5. 2007
    ....