Dietrich Rothenbacher

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Adipokines in cord blood and risk of wheezing disorders within the first two years of life
    D Rothenbacher
    Division of Clinical Epidemiology and Aging Research, The German Cancer Research Center, Heidelberg, Germany
    Clin Exp Allergy 37:1143-9. 2007
  2. ncbi request reprint Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links
    Dietrich Rothenbacher
    Division of Clinical Epidemiology and Aging Research, The German Cancer Research Center, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 14:547-54. 2007
  3. doi request reprint Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers
    Lutz P Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, TP4 INF581, 69120 Heidelberg, Germany
    Pharmacogenomics 12:1099-106. 2011
  4. pmc Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
    Cardiovasc Diabetol 11:88. 2012
  5. doi request reprint Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2: a competing risk analysis in a large population-based cohort of older adults
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 28:267-75. 2013
  6. doi request reprint Epidemiology of chronic kidney disease: results from a population of older adults in Germany
    Qiu Li Zhang
    German Cancer Research Center, Heidelberg, Germany
    Prev Med 48:122-7. 2009
  7. doi request reprint Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population-based study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    J Hypertens 30:1364-72. 2012
  8. doi request reprint Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults
    Lei Gao
    German Cancer Research Center, Heidelberg, Germany
    Ann Epidemiol 20:122-8. 2010
  9. doi request reprint Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2918-22. 2009
  10. doi request reprint Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Hepatology 49:802-8. 2009

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Adipokines in cord blood and risk of wheezing disorders within the first two years of life
    D Rothenbacher
    Division of Clinical Epidemiology and Aging Research, The German Cancer Research Center, Heidelberg, Germany
    Clin Exp Allergy 37:1143-9. 2007
    ..Adipokines are involved in the regulation of many inflammatory processes and are present at very high concentrations in cord blood of term infants...
  2. ncbi request reprint Symptoms of anxiety and depression in patients with stable coronary heart disease: prognostic value and consideration of pathogenetic links
    Dietrich Rothenbacher
    Division of Clinical Epidemiology and Aging Research, The German Cancer Research Center, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 14:547-54. 2007
    ..We evaluated the association of symptoms of anxiety and depression with fatal and non-fatal cardiovascular disease events among patients with coronary heart disease and considered several potential underlying pathogenetic links...
  3. doi request reprint Dopamine-related genes and spontaneous smoking cessation in ever-heavy smokers
    Lutz P Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, TP4 INF581, 69120 Heidelberg, Germany
    Pharmacogenomics 12:1099-106. 2011
    ..Several studies have provided evidence for associations of polymorphisms located in and near dopamine-related genes and nicotine dependence and other smoking-related phenotypes, including pharmacogenetic interactions...
  4. pmc Gender disparities in diabetes and coronary heart disease medication among patients with type 2 diabetes: results from the DIANA study
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120, Heidelberg, Germany
    Cardiovasc Diabetol 11:88. 2012
    ..Coronary heart disease (CHD) is one of the most common long-term complications in people with type 2 diabetes. We analyzed whether or not gender differences exist in diabetes and CHD medication among people with type 2 diabetes...
  5. doi request reprint Serum 25-hydroxyvitamin D levels and incident diabetes mellitus type 2: a competing risk analysis in a large population-based cohort of older adults
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120, Heidelberg, Germany
    Eur J Epidemiol 28:267-75. 2013
    ..In this large cohort study of older adults, serum 25(OH)D levels were inversely associated with incident diabetes in women but not in men. The association was particularly strong in subjects with renal dysfunction...
  6. doi request reprint Epidemiology of chronic kidney disease: results from a population of older adults in Germany
    Qiu Li Zhang
    German Cancer Research Center, Heidelberg, Germany
    Prev Med 48:122-7. 2009
    ..To determine prevalences and stages of chronic kidney disease (CKD), and evaluate association of CKD with related covariables in a large population of older adults...
  7. doi request reprint Longitudinal predictors of health-related quality of life in middle-aged and older adults with hypertension: results of a population-based study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    J Hypertens 30:1364-72. 2012
    ..g. awareness of hypertension, number of types of antihypertensive drugs, comorbidity), and health-related quality of life (HRQOL) in a large cohort of patients with hypertension, over a follow-up period of 5 years...
  8. doi request reprint Alcohol consumption, serum gamma-glutamyltransferase, and helicobacter pylori infection in a population-based study among 9733 older adults
    Lei Gao
    German Cancer Research Center, Heidelberg, Germany
    Ann Epidemiol 20:122-8. 2010
    ..pylori infection in a large population-based study...
  9. doi request reprint Alcohol consumption and chronic atrophic gastritis: population-based study among 9,444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 125:2918-22. 2009
    ..pylori. However, the observed patterns suggest that other mechanisms are likely to contribute to the association as well...
  10. doi request reprint Synergism between smoking and alcohol consumption with respect to serum gamma-glutamyltransferase
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Hepatology 49:802-8. 2009
    ..9 (1.1-7.6) in women and to 3.8 (2.2-6.6) in men (test for interaction between alcohol consumption and smoking: P(females) = 0.12, P(males) = 0.0017)...
  11. doi request reprint Serum parathyroid hormone and risk of adverse outcomes in patients with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Ageing Research C070, German Cancer Research Center, Heidelberg, Germany
    Heart 97:1215-21. 2011
    ..This study presents analyses of the prognostic value of baseline PTH for subsequent cardiovascular events and all-cause mortality in a high-risk population with stable coronary heart disease...
  12. doi request reprint Gender specific temporal and cross-sectional associations between BMI-class and symptoms of depression in the elderly
    Beate Wild
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital, Heidelberg, Germany
    J Psychosom Res 72:376-82. 2012
    ..The aim of the study was the gender specific analysis of cross-sectional and longitudinal associations between body mass index class (BMI-class) and symptoms of depression in a representative sample of elderly German people...
  13. doi request reprint Sibship size, Helicobacter pylori infection and chronic atrophic gastritis: a population-based study among 9444 older adults from Germany
    Lei Gao
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Epidemiol 39:129-34. 2010
    ..We aimed to assess the association of sibship size with H. pylori infection and chronic atrophic gastritis (CAG) in a population-based study from Germany...
  14. ncbi request reprint Genotype combinations of plasminogen activator inhibitor-1 and angiotensin-converting enzyme genes and risk for early onset of coronary heart disease
    Michael Loew
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 13:449-56. 2006
    ....
  15. ncbi request reprint Changes of cardiovascular risk factors and their implications in subsequent birth cohorts of older adults in Germany: a life course approach
    Elke Raum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 14:809-14. 2007
    ....
  16. doi request reprint Type 2 diabetes mellitus and gender-specific risk for colorectal neoplasia
    Heike Ursula Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, INF 581, 69120 Heidelberg, Germany
    Eur J Epidemiol 27:341-7. 2012
    ..01; 95 % CI 0.71-1.43). T2DM might have a stronger impact on CN among women than among men. Further research should examine possible reasons for these differences...
  17. ncbi request reprint Epidemiologic findings on serologically defined chronic atrophic gastritis strongly depend on the choice of the cutoff-value
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 121:2782-6. 2007
    ..The association of age and H. pylori infection with CAG may be strongly underestimated in studies in which CAG is defined by pepsinogen I only...
  18. doi request reprint Low-to-moderate alcohol consumption and smoking cessation rates: retrospective analysis of 4576 elderly ever-smokers
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Drug Alcohol Depend 108:122-9. 2010
    ..We aimed to elucidate the association of concurrent alcohol consumption with the probability of smoking cessation in non-clinical populations...
  19. doi request reprint Asymmetric and symmetric dimethylarginine and risk of secondary cardiovascular disease events and mortality in patients with stable coronary heart disease: the KAROLA follow-up study
    Bob Siegerink
    German Cancer Research Center DKFZ, Division of Clinical Epidemiology and Aging Research C070, Heidelberg, Germany
    Clin Res Cardiol 102:193-202. 2013
    ..This study aimed to determine the associations of both ADMA and SDMA levels with secondary cardiovascular disease events and all-cause mortality in patients with stable coronary heart disease (CHD)...
  20. doi request reprint Medication non-adherence and poor glycaemic control in patients with type 2 diabetes mellitus
    Elke Raum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Diabetes Res Clin Pract 97:377-84. 2012
    ..Our main aim was to analyse gender differences in the association of adherence and poor glycaemic control (PGC) in a cohort of patients with type 2 diabetes mellitus in Germany...
  21. doi request reprint Association of diabetes and body mass index with levels of prostate-specific antigen: implications for correction of prostate-specific antigen cutoff values?
    Heiko Muller
    German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Bergheimer Strasse 20, D 69115 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 18:1350-6. 2009
    ..However, all of the studies were conducted in populations with intensive PSA screening and the role of diabetes severity, duration, and therapy are yet to be explored...
  22. doi request reprint Evaluation of serum and urinary myeloid related protein-14 as a marker for early detection of prostate cancer
    Heiko Muller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    J Urol 180:1309-12; discussion 1312-3. 2008
    ..In diagnostic studies promising results were shown for myeloid related protein-14 in serum and urine. However, confirmation in longitudinal population based studies is needed...
  23. doi request reprint For the majority of patients with diabetes blood pressure and lipid management is not in line with recommendations. Results from a large population-based cohort in Germany
    Elke Raum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Pharmacoepidemiol Drug Saf 17:485-94. 2008
    ..To evaluate the management of cardiovascular risk factors in a population-based cohort of adults with diabetes mellitus in Germany...
  24. ncbi request reprint Mutant-enriched PCR and allele-specific hybridization reaction to detect K-ras mutations in stool DNA: high prevalence in a large sample of older adults
    Ulrike Haug
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Chem 53:787-90. 2007
    ..We investigated the prevalence and potential determinants of mutant K-ras in stool in a large sample of unselected older adults and assessed the association with colonoscopic findings...
  25. doi request reprint Association between the prevalence of depression and age in a large representative German sample of people aged 53 to 80 years
    Beate Wild
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital, Heidelberg, Germany
    Int J Geriatr Psychiatry 27:375-81. 2012
    ..The aim of the study was to determine the association between the prevalence of clinically significant depression and age in a large representative sample of elderly German people...
  26. ncbi request reprint The mother as source of Helicobacter pylori infection
    Maria Weyermann
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Epidemiology 17:332-4. 2006
    ..To further elucidate the intrafamilial transmission of Helicobacter pylori infection, we investigated the occurrence of infection by parental infection status in a large community-based birth cohort of children from Germany...
  27. ncbi request reprint Helicobacter pylori and hepatitis A virus infections and the cardiovascular risk profile in patients with diabetes mellitus: results of a population-based study
    Mercy Ongey
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 11:471-6. 2004
    ....
  28. ncbi request reprint Comparison of N-terminal pro-B-natriuretic peptide, C-reactive protein, and creatinine clearance for prognosis in patients with known coronary heart disease
    Dietrich Rothenbacher
    Department of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Arch Intern Med 166:2455-60. 2006
    ....
  29. ncbi request reprint Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in Germany
    Natalia Zumkeller
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur J Cancer 43:1283-9. 2007
    ..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk...
  30. doi request reprint Prognostic value of haemoglobin A1c and fasting plasma glucose for incident diabetes and implications for screening
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Eur J Epidemiol 26:779-87. 2011
    ..FPG and HbA(1c) have comparable (yet insufficient) abilities in identifying individuals at high risk for diabetes. Effectiveness of a diabetes screening program could be improved by a risk score including FPG and HbA(1c)...
  31. ncbi request reprint Prevalence and determinants of exocrine pancreatic insufficiency among older adults: results of a population-based study
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Scand J Gastroenterol 40:697-704. 2005
    ..The prevalence and main determinants of exocrine pancreatic insufficiency were investigated in a large population-based sample of older adults by measuring pancreatic elastase-1 in stool...
  32. doi request reprint Prognostic value of chronic kidney disease in patients with coronary heart disease: role of estimating equations
    Qiu Li Zhang
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Atherosclerosis 211:342-7. 2010
    ....
  33. doi request reprint Variants in COMT and spontaneous smoking cessation: retrospective cohort analysis of 925 cessation events
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Pharmacogenet Genomics 19:657-9. 2009
    ....
  34. pmc Proinflammatory cytokines, adiponectin, and increased risk of primary cardiovascular events in diabetic patients with or without renal dysfunction: results from the ESTHER study
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Diabetes Care 36:1703-11. 2013
    ..We wanted to investigate whether circulating concentrations of proinflammatory immune mediators and adiponectin in diabetic patients are associated with incident cardiovascular events...
  35. ncbi request reprint Gender differences in healthcare utilization of patients with diabetes
    Heike U Krämer
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Manag Care 18:362-9. 2012
    ..To examine gender differences in healthcare utilization including outpatient and inpatient medical care for patients with type 2 diabetes mellitus (T2DM), despite participation in T2DM-specific disease management programs (DMP-DM)...
  36. pmc Temporal predictors of health-related quality of life in elderly people with diabetes: results of a German cohort study
    Imad Maatouk
    Department of General Internal Medicine and Psychosomatics, Medical University Hospital Heidelberg, Heidelberg, Germany
    PLoS ONE 7:e31088. 2012
    ..The aim of the study was to determine predictors that influence health-related quality of life (HRQOL) in a large cohort of elderly diabetes patients from primary care over a follow-up period of five years...
  37. pmc Clinical utility of creatinine- and cystatin C-based definition of renal function for risk prediction of primary cardiovascular events in patients with diabetes
    Ben Schöttker
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Diabetes Care 35:879-86. 2012
    ....
  38. doi request reprint Serum vitamin D and risk of secondary cardiovascular disease events in patients with stable coronary heart disease
    Norma Christine Grandi
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am Heart J 159:1044-51. 2010
    ..Because the prognostic value of vitamin D for the occurrence of secondary cardiovascular events remains unclear, we examined the association of baseline 25-OH-D levels with prognosis in patients with stable coronary heart disease (CHD)...
  39. ncbi request reprint Adipokines in human milk and risk of overweight in early childhood: a prospective cohort study
    Maria Weyermann
    Division of Clinical Epidemiology and Aging Research, The German Cancer Research Center, Heidelberg, Germany
    Epidemiology 18:722-9. 2007
    ..We assessed the role of adiponectin and leptin in human milk in childhood overweight...
  40. ncbi request reprint Clustering of Helicobacter pylori infection in couples: differences between high- and low-prevalence population groups
    Hermann Brenner
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Ann Epidemiol 16:516-20. 2006
    ..We assessed clustering of H pylori infections in a large community-based study from Germany that included both high-prevalence and low-prevalence population subgroups...
  41. ncbi request reprint Relationship between lifetime alcohol consumption and Helicobacter pylori infection
    Jutta Kuepper-Nybelen
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Ann Epidemiol 15:607-13. 2005
    ..The aim of this study was to further explore this hypothesis by taking lifetime alcohol consumption, which may be a better marker of the relevant exposure than current alcohol consumption, into account...
  42. doi request reprint Gastric parietal cell antibodies, Helicobacter pylori infection, and chronic atrophic gastritis: evidence from a large population-based study in Germany
    Yan Zhang
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cancer Epidemiol Biomarkers Prev 22:821-6. 2013
    ..pylori)-associated gastritis have suggested a potential link between these two pathologic conditions in the progression of chronic atrophic gastritis (CAG); however, evidence has remained conflicting...
  43. pmc Effectiveness of a supportive telephone counseling intervention in type 2 diabetes patients: randomized controlled study
    Ute Mons
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 8:e77954. 2013
    ..5%) in a primary care setting...
  44. pmc Chlamydia pneumoniae, heat shock proteins 60 and risk of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes: a prospective study
    Mercy Guech-Ongey
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    BMC Cardiovasc Disord 6:17. 2006
    ....
  45. ncbi request reprint Relationship between infectious burden, systemic inflammatory response, and risk of stable coronary artery disease: role of confounding and reference group
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing at the University of Heidelberg, Heidelberg, Germany
    Atherosclerosis 170:339-45. 2003
    ..We also investigated whether the choice of a larger reference group might affect the results, and whether or not seropositivity to multiple agents was associated with a systemic inflammatory response...
  46. doi request reprint Acquisition of Helicobacter pylori infection in early childhood: independent contributions of infected mothers, fathers, and siblings
    Maria Weyermann
    Department of Clinical Epidemiology and Aging Research, The German Cancer Research Center, Heidelberg, Germany
    Am J Gastroenterol 104:182-9. 2009
    ..Infected siblings, mothers, and fathers have all been suggested to be major sources for Helicobacter pylori acquisition among children, but few studies have addressed the potential role of various family members simultaneously...
  47. ncbi request reprint Smoking, apolipoprotein E genotype, and early onset of coronary heart disease
    Michael Loew
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Eur J Cardiovasc Prev Rehabil 12:268-70. 2005
    ..We examined the association between smoking, apolipoprotein E (ApoE) genotype, and early onset of coronary heart disease (CHD)...
  48. pmc Type II secretory phospholipase A2 and prognosis in patients with stable coronary heart disease: mendelian randomization study
    Lutz P Breitling
    Division C070 Clinical Epidemiology and Aging Research, German Cancer Research Center DKFZ, Heidelberg, Germany
    PLoS ONE 6:e22318. 2011
    ..This study investigated if an association of sPLA(2)-IIa with secondary cardiovascular disease (CVD) events may be of causal nature or mainly a matter of confounding by correlated cardiovascular risk markers...
  49. ncbi request reprint Relationship of adiponectin with markers of systemic inflammation, atherogenic dyslipidemia, and heart failure in patients with coronary heart disease
    Maximilian von Eynatten
    Department of Medicine I Endocrinology and Metabolism, Ruprecht Karls University of Heidelberg, Heidelberg, Germany
    Clin Chem 52:853-9. 2006
    ..We examined the associations between serum adiponectin and several biomarkers related to cardiovascular disease and heart failure in a large high-risk population comprising patients with prevalent CHD...
  50. ncbi request reprint Genotype and plasma concentration of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events
    Michael Loew
    Department of Epidemiology, German Centre for Research on Ageing at the University of Heidelberg, Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 25:1470-4. 2005
    ..The aim of the study was to investigate the impact of cystatin C polymorphisms on cystatin C plasma levels and on prognosis of patients with CHD...
  51. ncbi request reprint Body mass index and premature mortality in physically heavily working men--a ten-year follow-up of 20,000 construction workers
    Volker Arndt
    German Cancer Research Center, Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany
    J Occup Environ Med 49:913-21. 2007
    ..Although obesity is clearly associated with diabetes and cardiovascular disease, health consequences of being mildly or moderately overweight are less clear in physically heavily working men...
  52. doi request reprint Epidemiology of stomach cancer
    Hermann Brenner
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Methods Mol Biol 472:467-77. 2009
    ..Future epidemiologic research should pay particular attention to differentiation of stomach cancer epidemiology by subsite, and to exploration of potential interactions between H. pylori infection, genetic, and environmental factors...
  53. ncbi request reprint Is Helicobacter pylori infection a necessary condition for noncardia gastric cancer?
    Hermann Brenner
    Department of Epidemiology, German Center for Research on Aging, Heidelberg, Germany
    Am J Epidemiol 159:252-8. 2004
    ..The H. pylori-gastric cancer relation may be much stronger than previously thought, and H. pylori infection may even be a (close to) necessary condition for development of noncardia gastric cancer...
  54. doi request reprint Prognostic usefulness of free fatty acids in patients with stable coronary heart disease
    Lutz P Breitling
    Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Center, Heidelberg, Germany
    Am J Cardiol 108:508-13. 2011
    ..02, for 95th percentile vs first quartile). In conclusion, FFAs are closely correlated with cardiovascular risk markers, and in particular, very high FFA might identify patients with stable coronary heart disease with worse prognoses...
  55. ncbi request reprint Adiponectin and leptin in maternal serum, cord blood, and breast milk
    Maria Weyermann
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Chem 52:2095-102. 2006
    ..The presence of the adipokines adiponectin and leptin in cord blood and placental and fetal tissues suggests a possible role in fetal development...
  56. doi request reprint Incidence and risk factors for the development of chronic atrophic gastritis: five year follow-up of a population-based cohort study
    Mariam Abdullahi Adamu
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 128:1652-8. 2011
    ..Incidence of CAG is rather low in the German population. Older age and infection with H. pylori are key risk factors for the development of CAG...
  57. doi request reprint Smoking, F2RL3 methylation, and prognosis in stable coronary heart disease
    Lutz Philipp Breitling
    Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur Heart J 33:2841-8. 2012
    ..We aimed to determine the clinical importance of methylation at the F2RL3 locus...
  58. ncbi request reprint Helicobacter pylori infection and colorectal cancer risk: a meta-analysis
    Natalia Zumkeller
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Helicobacter 11:75-80. 2006
    ..We carried out a systematic review and meta-analysis of published studies investigating this association and paid special attention to the possibility of publication bias and sources of heterogeneity between studies. Materials and..
  59. ncbi request reprint Heavy physical activity: risk or protective factor for cardiovascular disease? A life course perspective
    Elke Raum
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Ann Epidemiol 17:417-24. 2007
    ..The objective of this analysis was to examine the impact of lifetime physical activity (PA) on major cardiovascular disease...
  60. ncbi request reprint Physical activity, coronary heart disease, and inflammatory response
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Heidelberg, Germany
    Arch Intern Med 163:1200-5. 2003
    ....
  61. pmc Prognostic value of physicians' assessment of compliance regarding all-cause mortality in patients with type 2 diabetes: primary care follow-up study
    Dietrich Rothenbacher
    Dept of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    BMC Fam Pract 7:42. 2006
    ..The objective of this prospective cohort study was to investigate the prognostic value of the physicians' assessment of patient compliance and other factors with respect to all-cause mortality during a one year follow-up period...
  62. ncbi request reprint The effect of thiazolidinediones on adiponectin serum level: a meta-analysis
    N Riera-Guardia
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Diabetes Obes Metab 10:367-75. 2008
    ..The aim of this study is to systematically review the current state of evidence of the effect of TZD on adiponectin serum level with special attention to avoid publication bias...
  63. doi request reprint Gamma-glutamyltransferase and prognosis in patients with stable coronary heart disease followed over 8 years
    L P Breitling
    Division of Clinical Epidemiology and Aging Research C070, German Cancer Research Center, Bergheimer Str 20, 69115 Heidelberg, Germany
    Atherosclerosis 210:649-55. 2010
    ..Serum gamma-glutamyltransferase (gamma-GT) predicts incident cardiovascular disease and mortality. The present study examined whether gamma-GT also is associated with prognosis in patients with stable coronary heart disease...
  64. ncbi request reprint Role of Helicobacter pylori infection in iron deficiency during pregnancy
    Maria Weyermann
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Am J Obstet Gynecol 192:548-53. 2005
    ..We investigated the possible role of Helicobacter pylori infection in iron deficiency during pregnancy in a large group of mothers in Germany after the birth of their baby under special consideration of iron supplementation...
  65. ncbi request reprint Age, alcohol consumption, and all-cause mortality
    Volker Arndt
    German Centre for Research on Ageing, Department of Epidemiology, Heidelberg, Germany
    Ann Epidemiol 14:750-3. 2004
    ..Numerous epidemiological studies on middle aged men suggest that moderate alcohol consumption lowers all-cause mortality. Uncertainty exists whether this finding also applies to younger adults...
  66. pmc Prevalence of chronic kidney disease in population-based studies: systematic review
    Qiu Li Zhang
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    BMC Public Health 8:117. 2008
    ..We provide a summary of available data about the burden of CKD in various populations...
  67. ncbi request reprint Drug interactions in primary care: impact of a new algorithm on risk determination
    Verena Bergk
    Department of Internal Medicine VI, Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
    Clin Pharmacol Ther 76:85-96. 2004
    ..Earlier studies may have overestimated the risk arising from drug interactions because they usually reported interaction frequencies and the severity of potential outcomes irrespective of their manageability...
  68. ncbi request reprint History of breastfeeding and Helicobacter pylori infection in pre-school children: results of a population-based study from Germany
    Dietrich Rothenbacher
    Department of Epidemiology, German Centre for Research on Ageing, Heidelberg, Germany
    Int J Epidemiol 31:632-7. 2002
    ..However, there are few current data from developed countries to elucidate this association. We investigated the relation between history of breastfeeding and H. pylori infection in a large population-based sample...
  69. pmc Long term adherence to dietary recommendations after inpatient rehabilitation: prospective follow up study of patients with coronary heart disease
    D Twardella
    Department of Epidemiology, The German Centre for Research on Aging, Heidelberg, Germany
    Heart 92:635-40. 2006
    ..To evaluate the adherence to nutritional recommendations in inpatient rehabilitation and the long term maintenance of dietary changes among patients with coronary heart disease...
  70. doi request reprint Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program
    C Y Vossen
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Clin Pharmacol Ther 84:222-7. 2008
    ..We therefore found no evidence that APOE genotyping will be useful in guiding dietary or pharmacological lipid-lowering treatment decisions...
  71. ncbi request reprint Homocysteine and methylenetetrahydrofolate reductase genotype: association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters
    D Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Atherosclerosis 162:193-200. 2002
    ..We performed a case-control study to investigate whether tHcy levels and MTHFR genotype (677 C-->T mutation and 1298 A-->C mutation) are associated with CHD under special consideration of the possibility for confounding...
  72. ncbi request reprint Breastfeeding, soluble CD14 concentration in breast milk and risk of atopic dermatitis and asthma in early childhood: birth cohort study
    D Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Clin Exp Allergy 35:1014-21. 2005
    ..Breast milk contains a variety of bioactive substances, among them, soluble CD14 (sCD14), which plays an important role in innate immunity...
  73. ncbi request reprint Duration of breastfeeding and risk of overweight in childhood: a prospective birth cohort study from Germany
    M Weyermann
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany
    Int J Obes (Lond) 30:1281-7. 2006
    ....
  74. ncbi request reprint Lifetime prevalence of self-reported atopic diseases in a population-based sample of elderly subjects: results of the ESTHER study
    M Wolkewitz
    Department of Clinical Social Medicine, Ruprecht Karls University Heidelberg, Heidelberg, Germany
    Br J Dermatol 156:693-7. 2007
    ..Prevalence studies of atopic diseases such as atopic dermatitis (AD), hay fever and allergic asthma have mostly been performed in children. Studies in the adult population are still rare...
  75. ncbi request reprint Helicobacter pylori-specific immune response in maternal serum, cord blood, and human milk among mothers with and without current Helicobacter pylori infection
    Maria Weyermann
    Department of Epidemiology, The German Center for Research on Aging, D 69115 Heidelberg, Germany
    Pediatr Res 58:897-902. 2005
    ..Breast-fed neonates are additionally provided with specific IgA antibodies in human milk. Notably, the latter may also be activated if exposure of the mother to H. pylori might have been long time ago and been cleared in the meantime...
  76. ncbi request reprint Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum
    Hao Wang
    Department of Clinical Social Medicine, University of Heidelberg, and Unit of Health Monitoring, Saarland Cancer Registry, Saarbrucken, Germany
    Int J Cancer 119:695-701. 2006
    ..The effect on cancer risk by atopy, defined by IgE reactivity, may differ from the effect by atopy-related clinically defined diseases such as asthma, hay fever and atopic dermatitis...
  77. ncbi request reprint Role of infected parents in transmission of helicobacter pylori to their children
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg
    Pediatr Infect Dis J 21:674-9. 2002
    ..The aim of this population-based study was to determine the role of parental infection status in transmission of H. pylori to the child by taking into consideration the infection status of both parents simultaneously...
  78. ncbi request reprint Plasma lipoprotein Lp(a), markers of haemostasis and inflammation, and risk and severity of coronary heart disease
    Armin Imhof
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Eur J Cardiovasc Prev Rehabil 10:362-70. 2003
    ..Little is known about potential atherothrombogenic mechanisms of Lp(a)...
  79. ncbi request reprint Burden of Helicobacter pylori and H. pylori-related diseases in developed countries: recent developments and future implications
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Bergheimer Strasse 20, 69115 Heidelberg, Germany
    Microbes Infect 5:693-703. 2003
    ..pylori infection and H. pylori-associated diseases in the developed world, mainly Europe, and it discusses very recent developments with regard to the prevalence and its future implications for H. pylori-associated diseases...
  80. ncbi request reprint Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stress
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 26:1586-93. 2006
    ..We sought to evaluate whether lipoprotein-associated phospholipase A2 (Lp-PLA2), an emerging marker of cardiovascular risk, is associated with prognosis in patients with coronary heart disease (CHD)...
  81. pmc Helicobacter pylori-specific immune responses of children: implications for future vaccination strategy
    Günter Bode
    Department of Epidemiology, University of Ulm, Germany
    Clin Diagn Lab Immunol 9:1126-8. 2002
    ..0012 and P < 0.0001, respectively)...
  82. ncbi request reprint The diagnosis of a smoking-related disease is a prominent trigger for smoking cessation in a retrospective cohort study
    Dorothee Twardella
    German Center for Research on Ageing, Bergheimer Str 20, D 69115 Heidelberg, Germany
    J Clin Epidemiol 59:82-9. 2006
    ....
  83. ncbi request reprint trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: results of a large birth cohort study
    Eva Szabo
    Department of Paediatrics, University of Pecs, Pecs, Hungary
    Am J Clin Nutr 85:1320-6. 2007
    ..Several observational studies indicate that trans isomeric fatty acids may interfere with the metabolism of essential fatty acids in the human organism...
  84. ncbi request reprint Periodontal infections and coronary heart disease: role of periodontal bacteria and importance of total pathogen burden in the Coronary Event and Periodontal Disease (CORODONT) study
    Axel Spahr
    Department of Operative Dentistry and Periodontology, University of Ulm Medical Center, Ulm, Germany
    Arch Intern Med 166:554-9. 2006
    ..Periodontitis is a possible trigger of chronic inflammation. We investigated the possible association between periodontitis and coronary heart disease (CHD), focusing on microbiological aspects...
  85. ncbi request reprint Role of cytomegalovirus sero-status in the development of secondary cardiovascular events in patients with coronary heart disease under special consideration of diabetes
    Mercy Guech-Ongey
    Department of Epidemiology, German Centre for Research on Ageing, University of Heidelberg, Bergheimer Str 20 69115 Heidelberg, Germany
    Int J Cardiol 111:98-103. 2006
    ..We investigated prospectively the role of cytomegalovirus (CMV) sero-status in the development of secondary cardiovascular disease (CVD) events in patients with coronary heart disease (CHD) under special consideration of diabetes mellitus...
  86. ncbi request reprint Short-term benefit of smoking cessation in patients with coronary heart disease: estimates based on self-reported smoking data and serum cotinine measurements
    Dorothee Twardella
    Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Str 20, D 69115 Heidelberg, Germany
    Eur Heart J 25:2101-8. 2004
    ..To assess the short-term impact of smoking and smoking cessation measured by self-report and by serum cotinine on the risk of secondary cardiovascular disease events (CVD events)...
  87. ncbi request reprint Plasma concentrations of cystatin C in patients with coronary heart disease and risk for secondary cardiovascular events: more than simply a marker of glomerular filtration rate
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    Clin Chem 51:321-7. 2005
    ..We evaluated the impact of cystatin C and other markers of RI on prognosis in a large cohort of patients with coronary heart disease (CHD)...
  88. ncbi request reprint Adiponectin, risk of coronary heart disease and correlations with cardiovascular risk markers
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    Eur Heart J 26:1640-6. 2005
    ..In addition, we investigated the association between adiponectin levels and established sociodemographic and laboratory risk markers for CHD...
  89. ncbi request reprint CD14 C(-260)-->T polymorphism, plasma levels of the soluble endotoxin receptor CD14, their association with chronic infections and risk of stable coronary artery disease
    Wolfgang Koenig
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Ulm, Germany
    J Am Coll Cardiol 40:34-42. 2002
    ..We sought to investigate the association of CD14 genotype and plasma levels of soluble (s)CD14 with risk of stable coronary artery disease (CAD), chronic infections and sensitive markers of systemic inflammation...
  90. ncbi request reprint Evidence of a rapid decrease in prevalence of Helicobacter pylori infection in children of a high risk group living in Germany
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, Bergheimer Strasse 20, 69115 Heidelberg, Germany
    Eur J Pediatr 163:339-40. 2004
  91. ncbi request reprint Role of Lewis A and Lewis B blood group antigens in Helicobacter pylori infection
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg
    Helicobacter 9:324-9. 2004
    ..We investigated the prevalence of Helicobacter pylori infection in a large group of women to determine whether there was an association of current infection status with Lewis blood group antigen A and B phenotype...
  92. ncbi request reprint Recurrent abdominal pain in children: evidence from a population-based study that social and familial factors play a major role but not Helicobacter pylori infection
    Günter Bode
    Department of Epidemiology, University of Ulm, Ulm, Germany
    J Psychosom Res 54:417-21. 2003
    ..To analyze the relationship between social and familial factors, Helicobacter pylori infection and recurrent abdominal pain (RAP) in children in a population-based cross-sectional study among 1221 preschool children aged 5-8 years...
  93. ncbi request reprint Plasminogen levels and risk of coronary artery disease
    Albrecht Hoffmeister
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Am J Cardiol 90:1168-70. 2002
  94. ncbi request reprint The underestimated impact of smoking and smoking cessation on the risk of secondary cardiovascular disease events in patients with stable coronary heart disease: prospective cohort study
    Dorothee Twardella
    J Am Coll Cardiol 47:887-9. 2006
  95. ncbi request reprint Determination of C-reactive protein: comparison of three high-sensitivity immunoassays
    Natalie Khuseyinova
    Department of Internal Medicine II Cardiology, University of Ulm Medical Center, Robert Koch Strasse 8, D 89081 Ulm, Germany
    Clin Chem 49:1691-5. 2003
  96. ncbi request reprint Helicobacter pylori infection and the occurrence and severity of gastrointestinal symptoms during pregnancy
    Maria Weyermann
    Department of Epidemiology, German Centre for Research on Aging, University of Ulm, Germany
    Am J Obstet Gynecol 189:526-31. 2003
    ..We investigated the possible role of Helicobacter pylori infection in the occurrence and severity of gastrointestinal symptoms during pregnancy in a large group of mothers after delivery...
  97. ncbi request reprint Differential expression of chemokines, risk of stable coronary heart disease, and correlation with established cardiovascular risk markers
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    Arterioscler Thromb Vasc Biol 26:194-9. 2006
    ..Furthermore, we analyzed their correlation with various acute-phase proteins, inflammation-associated cytokines, and an adhesion molecule...
  98. pmc Prognostic value of interleukin-1 receptor antagonist gene polymorphism and cytomegalovirus seroprevalence in patients with coronary artery disease
    Dietrich Rothenbacher
    Department of Epidemiology, The German Centre for Research on Ageing, University of Heidelberg, Germany
    BMC Cardiovasc Disord 5:10. 2005
    ....
  99. ncbi request reprint [The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies]
    Erik von Elm
    Institute of Social and Preventive Medicine ISPM, University of Bern, Berna, Suiza
    Rev Esp Salud Publica 82:251-9. 2008
    ..We hope that the STROBE statement will contribute to improving the quality of reporting of observational studies...
  100. ncbi request reprint Tumor M2 pyruvate kinase as a stool marker for colorectal cancer: stability at room temperature and implications for application in the screening setting
    Ulrike Haug
    Clin Chem 52:782-4. 2006
  101. ncbi request reprint Epidemiology of Helicobacter pylori infection
    Guillermo I Perez-Perez
    Departments of Medicine and Microbiology, New York University School of Medicine, USA
    Helicobacter 9:1-6. 2004
    ....