Research Topics
Genomes and Genes
| M A RogersSummaryAffiliation: German Cancer Research Center Country: Germany Publications
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Detail Information
Publications
Characterization of human KAP24.1, a cuticular hair keratin-associated protein with unusual amino-acid composition and repeat structureMichael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 127:1197-204. 2007..The structure of the KRTAP24, its proximity to the chromosome 21q22.1 KAP gene domain, the presence of repeat motifs in the protein and its localization in the hair cuticle points to KAP24.1 being a novel human KAP family member...- The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domainMichael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Im Neuenheimer Feld 280, 69210 Heidelberg, Germany
Differentiation 72:527-40. 2004..Together with K18, a type I keratin gene found on the type II keratin domain, this seems to be the entire complement of functional type I keratins in humans... - Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13Michael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 124:536-44. 2005..All 26 human type II keratins found on this domain as well as K18, dtype 1 Keratin, are identified at the genomic and transcriptional level. This appears to be the total complement of functional type II keratins in humans... 
Characterization and expression analysis of the hair keratin associated protein KAP26.1M A Rogers
Division of Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
Br J Dermatol 159:725-9. 2008..Recently, four new KAP family members KAP24.1, KAP25.1, KAP26.1 and KAP27.1 were identified from the genome, but the expression of only one, KAP24.1, was investigated and shown in hair follicles...- The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicleL Langbein
Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Biol Chem 274:19874-84. 1999.... - Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domainM A Rogers
German Cancer Research Center, Research Programs 1 and 2, Heidelberg, Germany
J Invest Dermatol 114:464-72. 2000..We assume that the approximately 200 kbp DNA domain contains the entire complement of human type II hair keratin genes... - Characterization of a 190-kilobase pair domain of human type I hair keratin genesM A Rogers
German Cancer Research Center, Research Program 2, Im Neuenheimerfeld 280, 691200 Heidelberg, Germany
J Biol Chem 273:26683-91. 1998..We suspect that the 190-kbp domain contains the entire complement of human type I hair keratin genes... - Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21M A Rogers
Divisions of Biochemistry of Tissue-specific Regulation, Cell Biology, and Resource Center for Human Genome Research, German Cancer Research Center, 69120 Heidelberg, Germany
J Biol Chem 276:19440-51. 2001..Hair follicle in situ hybridization data for single members of five different KAP multigene families all showed localization of the respective mRNAs to the upper cortex of the hair shaft... - Sequences and differential expression of three novel human type-II hair keratinsM A Rogers
Division of Tumor Cell Regulation, German Cancer Research Center, Heidelberg, Germany
Differentiation 61:187-94. 1997..This early phase of hair differentiation is followed by a late cortical phase of terminal differentiation which comprises at least three type-II hair keratins in the zone of elongation and the keratogenous zone of the hair shaft... - A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrixH Winter
German Cancer Research Center, Research Program 2, Heidelberg, Germany
Hum Genet 101:165-9. 1997..Both hHb1 and hHb6 are largely coexpressed in cortical trichocytes of the hair shaft. This indicates that monilethrix is a disease of the hair cortex... - A novel human type I hair keratin gene: evidence for two keratin hHa3 isoformsM A Rogers
German Cancer Research Center, Research Program 2, Heidelberg
Mol Biol Rep 20:155-61. 1994..Collectively, these data demonstrate that the human type I hair keratin described in this paper represents an isoform of the previously described hHa3 keratin.(ABSTRACT TRUNCATED AT 250 WORDS).. - A variable monilethrix phenotype associated with a novel mutation, Glu402Lys, in the helix termination motif of the type II hair keratin hHb1H Winter
German Cancer Research Center, Research Program 2, Heidelberg
J Invest Dermatol 111:169-72. 1998.... - Human type I hair keratin pseudogene phihHaA has functional orthologs in the chimpanzee and gorilla: evidence for recent inactivation of the human gene after the Pan-Homo divergenceH Winter
German Cancer Research Center, Heidelberg, Germany
Hum Genet 108:37-42. 2001.... - The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratinsL Langbein
Divisions of Cell Biology and Tumor Cell Regulation, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
J Biol Chem 276:35123-32. 2001.... - A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicleH Winter
German Cancer Research Center, Department of Tumor Cell Regulation, Heidelberg
J Invest Dermatol 111:955-62. 1998..Thus, not only morphologically but also biochemically, the companion layer is different from the ORS and can therefore be regarded as an independent histologic compartment of the hair follicle... - Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5M A Rogers
Research Program, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 107:633-8. 1996..Our results confirm the type specific clustering of keratin genes and indicate that the human type I hair keratin subfamily contains more members than previously assumed... - A cDNA encoding the human type I hair keratin hHalP Fink
German Cancer Research Center, Research Program 2 Tumor Cell Regulation, Heidelberg, Germany
Biochim Biophys Acta 1264:12-4. 1995..Based on sequence homology comparisons with the four known mouse type I hair keratins mHal-4 the keratin could be identified as the human hair keratin hHal... - Monilethrix: a novel mutation (Glu402Lys) in the helix termination motif and the first causative mutation (Asn114Asp) in the helix initiation motif of the type II hair keratin hHb6H Winter
German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 113:263-6. 1999..In conclusion, our data strongly suggest that monilethrix is a disease of the hair cortex, whose etiology is interesting in that causative mutations seem to be restricted to type II hair keratins... - Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrixH Winter
Division of Tumour Cell Regulation, German Cancer Research Center, Heidelberg, Germany
Nat Genet 16:372-4. 1997..These mutations provide the first direct evidence for involvement of hair keratins in hair disease... - A splice site mutation in the gene of the human type I hair keratin hHa1 results in the expression of a tailless keratin isoformH Winter
German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Biol Chem 272:32345-52. 1997..This finding confirms the view of a noninvolvement of the keratin tail domain in filament assembly and explains the lack of a pathological hair phenotype in hHa1-t positive individuals... - K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicleLutz Langbein
German Cancer Research Center, Department of Cell Biology, University of Heidelberg, Heidelberg, Germany
J Invest Dermatol 126:2377-86. 2006.... - Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glandsLutz Langbein
Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 125:428-44. 2005..We provide evidence that the cellular and intercellular properties of the peripheral and the luminal layers reflect adaptations to different functions... 
Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epitheliaLutz Langbein
Department of Genetics of Skin Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Biol Chem 285:36909-21. 2010..1, which arose only during mammalian evolution. Remarkably, unlike the widely expressed K80, the expression of K80.1 is restricted to soft and hard keratinizing epithelial structures of the hair follicle and the filiform tongue papilla...
New consensus nomenclature for mammalian keratinsJurgen Schweizer
Section of Normal and Neoplastic Epidermal Differentiation, Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
J Cell Biol 174:169-74. 2006....- Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21Michael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 122:147-58. 2004..Primary among these were binding elements for the ETS, heat shock factor, AML, and HOX families of transcription factors... - A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicleLutz Langbein
German Cancer Research Center, Department of Cell Biology and Tumor Cell Regulation, Heidelberg, Germany
J Invest Dermatol 118:789-99. 2002..This tightly connected companion layer/inner root sheath unit provides an optimal molding and guidance of the growing hair shaft... - Human hair keratin-associated proteins (KAPs)Michael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
Int Rev Cytol 251:209-63. 2006.... - K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicleLutz Langbein
German Cancer Research Center, Department of Cell Biology, Heidelberg, Germany
J Invest Dermatol 120:512-22. 2003..We provide evidence that Flügelzellen penetrate the Henle layer actively and may play a role in conferring plasticity and resilience to the otherwise rigid upper Henle layer... - Hair keratins and hair follicle-specific epithelial keratinsLutz Langbein
Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
Methods Cell Biol 78:413-51. 2004 - Human KAP genes, only the half of it? Extensive size polymorphisms in hair keratin-associated protein genesMichael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 124:vii-ix. 2005 - Sequence data and chromosomal localization of human type I and type II hair keratin genesM A Rogers
Research Program 2 Tumor Cell Regulation, German Cancer Research Center, Heidelberg
Exp Cell Res 220:357-62. 1995..DAPI banding of the chromosomes allowed sublocalization of the hHa2 gene to 17q12-q21 and the hHb1 gene to 12q13, i.e., gene loci that have also been previously determined for human type I and type II epithelial keratins... - Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1Michael A Rogers
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, 69120 Heidelberg, Germany
J Biol Chem 277:48993-9002. 2002..1 region revealed varying degrees and regions of expression of 11 members of the high tyrosine-glycine genes and 6 members of the high sulfur KAP genes in the hair forming compartment... - Hair follicle-specific keratins and their diseasesJurgen Schweizer
Section of Normal and Neoplastic Epidermal, Differentiation A145, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Exp Cell Res 313:2010-20. 2007.... - HOXC13 is involved in the regulation of human hair keratin gene expressionLuis Felipe Jave-Suarez
Divisions of Tumor Cell Regulation and Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
J Biol Chem 277:3718-26. 2002..Collectively, our data speak for a direct involvement of HOXC13 in the control of hair keratin expression during early trichocyte differentiation... - Androgen regulation of the human hair follicle: the type I hair keratin hHa7 is a direct target gene in trichocytesLuis F Jave-Suarez
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 122:555-64. 2004..As such, hHa7 represents a marker for androgen action on hair follicles and might be a suitable tool for investigations of androgen-dependent hair disorders... - An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbaeHermelita Winter
Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
J Invest Dermatol 122:652-7. 2004.... - hKAP1.6 and hKAP1.7, two novel human high sulfur keratin-associated proteins are expressed in the hair follicle cortexYutaka Shimomura
Department of Dermatology, Niigata University School of Medicine, Asahimachi Dori, Niigata, Japan
J Invest Dermatol 118:226-31. 2002..RNA in situ hybridization studies of human anagen hair follicles using a conserved probe for these four keratin-associated protein 1 members demonstrated the expression of this group in the differentiated portions of the hair cortex... - Novel type I hair keratins K39 and K40 are the last to be expressed in differentiation of the hair: completion of the human hair keratin catalogLutz Langbein
J Invest Dermatol 127:1532-5. 2007 - Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene familyYutaka Shimomura
Department of Dermatology, Niigata University School of Medicine, Asahimachi Dori, Japan
J Biol Chem 277:45493-501. 2002..In addition, by means of a pan-hKAP1 antibody, we confirm the previous hKAP1 family mRNA localization data in the middle to upper cortex of the human anagen hair follicle... - Human hair keratin-associated proteins: sequence regularities and structural implicationsDavid A D Parry
Institute of Fundamental Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand
J Struct Biol 155:361-9. 2006..This may give additional conformational flexibility to the chain and hence allow the A pentapeptides greater opportunity to interact appropriately with the IF via disulphide bonds, ionic interactions and/or hydrogen bonding... - Characterization of human keratin-associated protein 1 family membersYutaka Shimomura
Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
J Investig Dermatol Symp Proc 8:96-9. 2003..The sum of the data analyzed suggests that human keratin-associated protein 1 family genes may have arisen mainly through gene duplication of the cysteine-repeat motifs during evolution...