H Ponstingl

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Human RanBP3, a group of nuclear RanGTP binding proteins
    L Mueller
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    FEBS Lett 427:330-6. 1998
  2. pmc Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    EMBO J 14:705-15. 1995
  3. ncbi request reprint Localization of the gene encoding the Ran-binding protein RanBP2 to human chromosome 2q11-q13 by fluorescence in situ hybridization
    H Krebber
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    Genomics 43:247-8. 1997
  4. pmc RanGAP1 induces GTPase activity of nuclear Ras-related Ran
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 91:2587-91. 1994
  5. ncbi request reprint DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness
    J Uhlmann
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    FEBS Lett 460:153-60. 1999
  6. ncbi request reprint Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization
    H Bastians
    Division of Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Germany
    Genomics 42:181-2. 1997
  7. ncbi request reprint Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1
    H Krebber
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Germany
    Gene 180:7-11. 1996
  8. ncbi request reprint Human Supt5h protein, a putative modulator of chromatin structure, is reversibly phosphorylated in mitosis
    A A Stachora
    Deutsches Krebsforschungszentrum, Division for Molecular Biology of Mitosis, Heidelberg, Germany
    FEBS Lett 409:74-8. 1997
  9. ncbi request reprint Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3
    H Bastians
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Germany
    Genomics 41:296-7. 1997
  10. ncbi request reprint The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation
    H Bastians
    Deutsches Krebsforschungszentrum, Division for Molecular Biology of Mitosis, Heidelberg, Germany
    J Cell Sci 109:2865-74. 1996

Collaborators

  • F R Bischoff
  • S Joos
  • P Lichter
  • S Wiemann
  • V C Cordes
  • U Kutay
  • U Eichenlaub-Ritter
  • D Gorlich
  • H Bastians
  • H Krebber
  • L Mueller
  • R Deane
  • J Hoheisel
  • J Uhlmann
  • G Schlenstedt
  • A A Stachora
  • I Sobek-Klocke
  • F Aslund
  • J Becker
  • M J Macias
  • M Ronsiek
  • H P Zimmermann
  • J Solsbacher
  • H Jockusch
  • S Ohl
  • D Vetrie
  • G Maier
  • A Breuning
  • M Pohlmeier
  • R E Schäfer
  • E Smirnova
  • W Schafer
  • C Disqué-Kochem
  • S Prehn
  • R Klocke
  • J Overhauser
  • K Rojas
  • T Bergman
  • A Holmgren
  • G Otting
  • K D Berndt
  • K Nordstrand
  • H Jornvall
  • M Nikkola
  • F Melchior
  • V Gerke
  • A Wittinghofer
  • A Musacchio
  • H Oschkinat
  • M Saraste
  • M Nilges

Detail Information

Publications21

  1. ncbi request reprint Human RanBP3, a group of nuclear RanGTP binding proteins
    L Mueller
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    FEBS Lett 427:330-6. 1998
    ..These proteins are localized in the nucleus, preferentially bind RanGTP and may be nuclear effectors of the Ran pathway...
  2. pmc Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    EMBO J 14:705-15. 1995
    ..RanBP1 is the first member of a new class of proteins regulating the binding and hydrolysis of GTP by Ras-related proteins...
  3. ncbi request reprint Localization of the gene encoding the Ran-binding protein RanBP2 to human chromosome 2q11-q13 by fluorescence in situ hybridization
    H Krebber
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    Genomics 43:247-8. 1997
  4. pmc RanGAP1 induces GTPase activity of nuclear Ras-related Ran
    F R Bischoff
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 91:2587-91. 1994
    ..It was purified from HeLa cell lysates and induces GTPase activity of Ran, but not Ras, by more than 3 orders of magnitude. The Ran mutant Q69L, modeled after RasQ61L, which is unable to hydrolyze bound GTP, is insensitive to RanGAP1...
  5. ncbi request reprint DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness
    J Uhlmann
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    FEBS Lett 460:153-60. 1999
    ..In addition, we have identified a murine homologue, mDelGEF. The ubiquitously expressed soluble protein hDelGEF1 is found both in the cyytoplasm and in the nucleus. Overexpressed hDelGEF2 colocalizes with mitochondria...
  6. ncbi request reprint Assignment of the human serine/threonine protein phosphatase 4 gene (PPP4C) to chromosome 16p11-p12 by fluorescence in situ hybridization
    H Bastians
    Division of Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Germany
    Genomics 42:181-2. 1997
  7. ncbi request reprint Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1
    H Krebber
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Germany
    Gene 180:7-11. 1996
    ..Taking the 3' UTR of RanGAP1, which lies downstream of the first polyadenylation signal, as a probe in Northern blot analysis, we confirmed that this second transcript found in testis results from a distinct 3' UTR...
  8. ncbi request reprint Human Supt5h protein, a putative modulator of chromatin structure, is reversibly phosphorylated in mitosis
    A A Stachora
    Deutsches Krebsforschungszentrum, Division for Molecular Biology of Mitosis, Heidelberg, Germany
    FEBS Lett 409:74-8. 1997
    ..One of them, with the consensus sequence P-T/S-P-S-P-Q/A-S/G-Y, is similar to the C-terminal domain in the largest subunit of RNA polymerase II...
  9. ncbi request reprint Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3
    H Bastians
    Division for Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg, Germany
    Genomics 41:296-7. 1997
  10. ncbi request reprint The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation
    H Bastians
    Deutsches Krebsforschungszentrum, Division for Molecular Biology of Mitosis, Heidelberg, Germany
    J Cell Sci 109:2865-74. 1996
    ..These data indicate that human PP6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, implying a function of PP6 in cell cycle regulation...
  11. pmc Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport
    F R Bischoff
    Division of Molecular Biology of Mitosis, German Cancer Research Center, Heidelberg
    Proc Natl Acad Sci U S A 92:1749-53. 1995
    ..Thus, a defect in either of the two antagonistic regulators of Ran would result in a shutdown of Ran-dependent transport processes, in agreement with the almost identical phenotypes described for such defects in budding yeast...
  12. ncbi request reprint Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1
    F R Bischoff
    Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 354:80-2. 1991
    ..Here we show that RCC1 specifically catalyses the exchange of guanine nucleotides on the Ran protein but not on the protein c-Ha-ras p21 (p21ras)...
  13. pmc Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide
    F R Bischoff
    Project Molecular Biology of Mitosis, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:10830-4. 1991
    ..We designate this polypeptide Ran, for ras-related nuclear protein...
  14. pmc Yrb4p, a yeast ran-GTP-binding protein involved in import of ribosomal protein L25 into the nucleus
    G Schlenstedt
    Medizinische Biochemie, Universit at des Saarlandes, D 66421 Homburg, Germany
    EMBO J 16:6237-49. 1997
    ..L25 binds to Yrb4p and Pse1p and is released by Gsp1p-GTP. Consistent with its putative role as an import receptor for L25-like proteins, Yrb4p localizes to the cytoplasm, the nucleoplasm and the NPC...
  15. pmc Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1
    R Deane
    Abteilung Molekulare Biologie der Mitose, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mol Cell Biol 17:5087-96. 1997
    ..We propose that RanBP5 is a mediator of a nucleocytoplasmic transport pathway that is distinct from the importin-alpha-dependent import of proteins with a classical NLS...
  16. pmc A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensation
    F R Bischoff
    Institute of Cell and Tumor Biology, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 87:8617-21. 1990
    ..This sequence is highly homologous with the translated reading frame of RCC1, a gene reportedly involved in regulating onset of mammalian chromosome condensation...
  17. ncbi request reprint The human gene ZFP161 on 18p11.21-pter encodes a putative c-myc repressor and is homologous to murine Zfp161 (Chr 17) and Zfp161-rs1 (X Chr)
    I Sobek-Klocke
    Faculty of Biology, Genetechnology Microbiology Unit, University of Bielefeld, Germany
    Genomics 43:156-64. 1997
    ..Mapping of Zfp161 confirms and extends a region of homology between distal mouse chromosome 17 and human 18p...
  18. ncbi request reprint RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae
    J Becker
    Max Planck Institut fur molekulare Physiologie, Abteilung Strukturelle Biologie, Dortmund, Germany
    J Biol Chem 270:11860-5. 1995
    ..The GTP hydrolysis of Ran is induced by RanGAP1 and rna1p but not by Rna1p. Implications for the suggested functions of Ran/TC4/Gsp1p in nuclear transport and mitotic control are discussed...
  19. ncbi request reprint Structure of the pleckstrin homology domain from beta-spectrin
    M J Macias
    European Molecular Biology Laboratory, Heidelberg, Germany
    Nature 369:675-7. 1994
    ..There is a distant relationship to the peptidyl-prolyl-cis-trans-isomerase FKBP in which this pocket is involved in the binding of the macrocyclic compound FK506 (refs 8-11)...
  20. ncbi request reprint NMR assignments, secondary structure and hydration of oxidized Escherichia coli flavodoxin
    H Ponstingl
    Karolinska Institute, Department of Medical Biochemistry and Biophysics, Stockholm, Sweden
    Eur J Biochem 244:384-99. 1997
    ..One of these water molecules mediates hydrogen bonds between the protein backbone and the ribityl chain of the FMN cofactor...
  21. ncbi request reprint Glutaredoxin-3 from Escherichia coli. Amino acid sequence, 1H AND 15N NMR assignments, and structural analysis
    F Aslund
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Biol Chem 271:6736-45. 1996
    ..Thus, despite an identical active site disulfide motif and a similar secondary structure and tertiary fold, Grx3 and Grx1 display large functional differences in in vitro protein disulfide oxido-reduction reactions...