Gislene Pereira

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Elm1 kinase activates the spindle position checkpoint kinase Kin4
    Ayse Koca Caydasi
    German Cancer Research Center, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia, 69120 Heidelberg, Germany
    J Cell Biol 190:975-89. 2010
  2. pmc A dynamical model of the spindle position checkpoint
    Ayse Koca Caydasi
    Molecular Biology of Centrosomes and Cilia, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    Mol Syst Biol 8:582. 2012
  3. pmc Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
    Kerstin N Schmidt
    DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
    J Cell Biol 199:1083-101. 2012
  4. pmc A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity
    Franz Meitinger
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    PLoS Biol 11:e1001495. 2013
  5. pmc The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4
    Daniela Trinca Bertazzi
    DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
    J Cell Biol 193:1033-48. 2011
  6. pmc Monitoring spindle orientation: Spindle position checkpoint in charge
    Ayse K Caydasi
    German Cancer Research Centre, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Cell Div 5:28. 2010
  7. pmc Fly meets yeast: checking the correct orientation of cell division
    Gislene Pereira
    Deutsches Krebsforschungszentrum DKFZ Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH Alliance, German Cancer Research Center, Molecular Biology of Centrosomes and Cilia, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Trends Cell Biol 21:526-33. 2011
  8. ncbi request reprint Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation
    Saravanan Palani
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Cell Sci 125:3091-6. 2012
  9. pmc Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis
    Franz Meitinger
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
    Genes Dev 25:875-88. 2011
  10. ncbi request reprint Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner
    Ilde Mancini Lombardi
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Curr Biol 23:1736-45. 2013

Collaborators

  • Wolfgang Huber
  • Sabrina Heisel
  • Oliver J Gruss
  • Andrew D Sharrocks
  • Michael Knop
  • Michael Boutros
  • Holger Erfle
  • Ursula Klingmuller
  • Philipp J Keller
  • Peter Dittrich
  • Franz Meitinger
  • Ayse Koca Caydasi
  • Saravanan Palani
  • Birgit Hub
  • Stefanie Kuhns
  • Hanswalter Zentgraf
  • Kerstin N Schmidt
  • Ilde Mancini Lombardi
  • Bahtiyar Kurtulmus
  • Astrid Hofmann
  • Daniela Trinca Bertazzi
  • Bashar Ibrahim
  • Maren Klinger
  • Annett Neuner
  • Anton Khmelinskii
  • Martin E Boehm
  • Wolf D Lehmann
  • Ayse K Caydasi
  • Elmar Schiebel
  • Hiromi Maekawa
  • Stefanie Dräger-Meurer
  • WenBo Wang
  • Yagmur Micoogullari
  • Felix Bärenz
  • Zoulfia Darieva
  • Heidi Richter
  • Philipp Wiedemann
  • Jürgen Reymann
  • Wolfgang Seufert
  • Ricardo Carvalho
  • Daniel F Gilbert
  • Balca R Mardin
  • Malte Wachsmuth
  • Matthias Meurer
  • Anna Bartosik
  • Gerd Grünert
  • Andreas Kaufmann
  • Joseph D Barry
  • Maiko Lohel
  • Susanne Trautmann
  • Maria I L Orrico
  • Boryana Petrova
  • Claire Priest
  • Johannes Lechner

Detail Information

Publications20

  1. pmc Elm1 kinase activates the spindle position checkpoint kinase Kin4
    Ayse Koca Caydasi
    German Cancer Research Center, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia, 69120 Heidelberg, Germany
    J Cell Biol 190:975-89. 2010
    ..These findings establish a novel function for Elm1 in the coordination of spindle positioning with cell cycle progression via its control of Kin4...
  2. pmc A dynamical model of the spindle position checkpoint
    Ayse Koca Caydasi
    Molecular Biology of Centrosomes and Cilia, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    Mol Syst Biol 8:582. 2012
    ..Our model suggests that Bfa1 interacts with Tem1 in the cytoplasm as well as at the SPBs to provide efficient Tem1 inhibition...
  3. pmc Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesis
    Kerstin N Schmidt
    DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
    J Cell Biol 199:1083-101. 2012
    ..We propose that Cep164 is targeted to the apical domain of the mother centriole to provide the molecular link between the mother centriole and the membrane biogenesis machinery that initiates cilia formation...
  4. pmc A safeguard mechanism regulates Rho GTPases to coordinate cytokinesis with the establishment of cell polarity
    Franz Meitinger
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    PLoS Biol 11:e1001495. 2013
    ..Our findings provide unexpected insights into the temporal control of cytokinesis and describe the importance of a Gps1-dependent mechanism for highly accurate polarity switching between two closely connected locations...
  5. pmc The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4
    Daniela Trinca Bertazzi
    DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
    J Cell Biol 193:1033-48. 2011
    ..This Lte1-mediated exclusion of Kin4 from the dSPB is essential for proper mitotic exit of cells with a correctly aligned spindle. Therefore, Lte1 promotes mitotic exit by inhibiting Kin4 activity at the dSPB...
  6. pmc Monitoring spindle orientation: Spindle position checkpoint in charge
    Ayse K Caydasi
    German Cancer Research Centre, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Cell Div 5:28. 2010
    ..Here, we review the current model of SPOC activation and highlight the importance of protein localization and phosphorylation for SPOC function...
  7. pmc Fly meets yeast: checking the correct orientation of cell division
    Gislene Pereira
    Deutsches Krebsforschungszentrum DKFZ Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH Alliance, German Cancer Research Center, Molecular Biology of Centrosomes and Cilia, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Trends Cell Biol 21:526-33. 2011
    ..In this review we highlight similarities in the mechanisms of asymmetric cell division in yeast and Drosophila male germline stem cells (GSCs) in the hope of extracting common themes underlying several systems...
  8. ncbi request reprint Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation
    Saravanan Palani
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Heidelberg, Germany
    J Cell Sci 125:3091-6. 2012
    ..We propose that Cdc14 counteracts Cdk1 phosphorylation of Inn1 to facilitate Inn1-Cyk3 complex formation and so promote cytokinesis...
  9. pmc Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis
    Franz Meitinger
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
    Genes Dev 25:875-88. 2011
    ..Genetic and functional data support a model in which Dbf2-Mob1 regulates Hof1 by inducing domain rearrangements, leading to the exposure of the Hof1 RLS domain during telophase...
  10. ncbi request reprint Lre1 directly inhibits the NDR/Lats kinase Cbk1 at the cell division site in a phosphorylation-dependent manner
    Ilde Mancini Lombardi
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Curr Biol 23:1736-45. 2013
    ..Whereas the activators of Cbk1-Mob2 have been more extensively described, the mechanisms that restrict or inhibit Cbk1-Mob2 catalytic activity remain largely unknown...
  11. pmc Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis
    Franz Meitinger
    Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, 69120 Heidelberg, Germany
    Mol Biol Cell 24:1290-304. 2013
    ..Thus our data show that Dbf2 coordinates septin and AMR functions during cytokinesis through the regulation/control of Hof1...
  12. pmc The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signal
    Hiromi Maekawa
    Zentrum für Molekulare Biologie and 2Biochemie Zentrum, Universitat Heidelberg, 69120 Heidelberg, Germany
    J Cell Biol 179:423-36. 2007
    ..Moreover, we present evidence that Spc72 has an additional function in SPOC regulation that is independent of the recruitment of Kin4. Thus, Spc72 provides a missing link between cytoplasmic MT function and components of the SPOC...
  13. doi request reprint Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast
    Franz Meitinger
    German Cancer Research Centre, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia Unit, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    J Cell Sci 123:1851-61. 2010
    ..This defect was partially suppressed by increased levels of Cyk3. We therefore propose that the MEN directly controls cytokinesis via targeting of Inn1, Cyk3 and Chs2 to the bud neck...
  14. doi request reprint Spindle alignment regulates the dynamic association of checkpoint proteins with yeast spindle pole bodies
    Ayse Koca Caydasi
    DKFZ ZMBH Alliance, German Cancer Research Centre DKFZ, Heidelberg, Germany
    Dev Cell 16:146-56. 2009
    ..In addition, we established that the SPOC kinase Kin4 is the major regulator of Bfa1 residence time at SPBs. We suggest that upon SPOC activation Bfa1-Bub2 spreads throughout the cytoplasm, thereby inhibiting mitotic exit...
  15. pmc The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesis
    Stefanie Kuhns
    Molecular Biology of Centrosomes and Cilia group, Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    J Cell Biol 200:505-22. 2013
    ..We propose that MARK4 is a critical positive regulator of early steps in ciliogenesis...
  16. doi request reprint The power of MEN in cytokinesis
    Franz Meitinger
    German Cancer Research Center, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia Unit, Heidelberg, Germany
    Cell Cycle 11:219-28. 2012
    ..In this review, we discuss the current view on the role of MEN kinases and Cdc14 in cytokinesis and comment on the cytokinesis-related function of MEN and Cdc14 orthologs in higher eukaryotes...
  17. doi request reprint SPOC alert--when chromosomes get the wrong direction
    Ayse Koca Caydasi
    Molecular Biology of Centrosomes and Cilia, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
    Exp Cell Res 318:1421-7. 2012
    ..In addition, we summarize the recent advances in the molecular understanding of SPOC regulation and discuss whether similar checkpoints may exist in higher eukaryotic cells that undergo asymmetric divisions...
  18. pmc The 14-3-3 protein Bmh1 functions in the spindle position checkpoint by breaking Bfa1 asymmetry at yeast centrosomes
    Ayse Koca Caydasi
    Molecular Biology of Centrosomes and Cilia, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg 69120, Germany
    Mol Biol Cell 25:2143-51. 2014
    ..Consistently, BMH1-null cells are SPOC deficient. Our work thus identifies Bmh1 as a new SPOC component and refines the molecular mechanism that breaks Bfa1 centrosome asymmetry upon SPOC activation. ..
  19. pmc The novel centriolar satellite protein SSX2IP targets Cep290 to the ciliary transition zone
    Maren Klinger
    Zentrum fur Molekulare Biologie der Universitat Heidelberg, 69120 Heidelberg, Germany Molecular Biology of Centrosomes and Cilia Group, Deutsches Krebsforschungszentrum Zentrum für Molekulare Biologie der Universität Heidelberg Alliance, 69120 Heidelberg, Germany
    Mol Biol Cell 25:495-507. 2014
    ..Our data establish SSX2IP as a novel targeting factor for ciliary membrane proteins cooperating with Cep290, the BBSome, and Rab8. ..
  20. ncbi request reprint Tandem fluorescent protein timers for in vivo analysis of protein dynamics
    Anton Khmelinskii
    Center for Molecular Biology of the University of Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany
    Nat Biotechnol 30:708-14. 2012
    ..Our experiments reveal the stable nature and asymmetric inheritance of nuclear pore complexes and identify regulators of N-end rule–mediated protein degradation...