Research Topics
Genomes and Genes | Gislene PereiraSummaryAffiliation: German Cancer Research Center Country: Germany Publications
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Detail Information
Publications
Fly meets yeast: checking the correct orientation of cell divisionGislene Pereira
Deutsches Krebsforschungszentrum DKFZ Zentrum für Molekulare Biologie der Universität Heidelberg ZMBH Alliance, German Cancer Research Center, Molecular Biology of Centrosomes and Cilia, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
Trends Cell Biol 21:526-33. 2011..In this review we highlight similarities in the mechanisms of asymmetric cell division in yeast and Drosophila male germline stem cells (GSCs) in the hope of extracting common themes underlying several systems...- Monitoring spindle orientation: Spindle position checkpoint in chargeAyse K Caydasi
German Cancer Research Centre, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
Cell Div 5:28. 2010..Here, we review the current model of SPOC activation and highlight the importance of protein localization and phosphorylation for SPOC function... 
Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formationSaravanan Palani
Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center DKFZ, Heidelberg, Germany
J Cell Sci 125:3091-6. 2012..We propose that Cdc14 counteracts Cdk1 phosphorylation of Inn1 to facilitate Inn1-Cyk3 complex formation and so promote cytokinesis...- Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesisFranz Meitinger
Molecular Biology of Centrosomes and Cilia Unit, DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
Genes Dev 25:875-88. 2011..Genetic and functional data support a model in which Dbf2-Mob1 regulates Hof1 by inducing domain rearrangements, leading to the exposure of the Hof1 RLS domain during telophase... - The cortical protein Lte1 promotes mitotic exit by inhibiting the spindle position checkpoint kinase Kin4Daniela Trinca Bertazzi
DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
J Cell Biol 193:1033-48. 2011..This Lte1-mediated exclusion of Kin4 from the dSPB is essential for proper mitotic exit of cells with a correctly aligned spindle. Therefore, Lte1 promotes mitotic exit by inhibiting Kin4 activity at the dSPB... - Elm1 kinase activates the spindle position checkpoint kinase Kin4Ayse Koca Caydasi
German Cancer Research Center, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia, 69120 Heidelberg, Germany
J Cell Biol 190:975-89. 2010..These findings establish a novel function for Elm1 in the coordination of spindle positioning with cell cycle progression via its control of Kin4... - A dynamical model of the spindle position checkpointAyse Koca Caydasi
Molecular Biology of Centrosomes and Cilia, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
Mol Syst Biol 8:582. 2012..Our model suggests that Bfa1 interacts with Tem1 in the cytoplasm as well as at the SPBs to provide efficient Tem1 inhibition... - Cep164 mediates vesicular docking to the mother centriole during early steps of ciliogenesisKerstin N Schmidt
DKFZ ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany
J Cell Biol 199:1083-101. 2012..We propose that Cep164 is targeted to the apical domain of the mother centriole to provide the molecular link between the mother centriole and the membrane biogenesis machinery that initiates cilia formation... - Spindle alignment regulates the dynamic association of checkpoint proteins with yeast spindle pole bodiesAyse Koca Caydasi
DKFZ ZMBH Alliance, German Cancer Research Centre DKFZ, Heidelberg, Germany
Dev Cell 16:146-56. 2009..In addition, we established that the SPOC kinase Kin4 is the major regulator of Bfa1 residence time at SPBs. We suggest that upon SPOC activation Bfa1-Bub2 spreads throughout the cytoplasm, thereby inhibiting mitotic exit... - The power of MEN in cytokinesisFranz Meitinger
German Cancer Research Center, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia Unit, Heidelberg, Germany
Cell Cycle 11:219-28. 2012..In this review, we discuss the current view on the role of MEN kinases and Cdc14 in cytokinesis and comment on the cytokinesis-related function of MEN and Cdc14 orthologs in higher eukaryotes... - SPOC alert--when chromosomes get the wrong directionAyse Koca Caydasi
Molecular Biology of Centrosomes and Cilia, German Cancer Research Center, DKFZ ZMBH Alliance, Heidelberg, Germany
Exp Cell Res 318:1421-7. 2012..In addition, we summarize the recent advances in the molecular understanding of SPOC regulation and discuss whether similar checkpoints may exist in higher eukaryotic cells that undergo asymmetric divisions... - The microtubule affinity regulating kinase MARK4 promotes axoneme extension during early ciliogenesisStefanie Kuhns
Molecular Biology of Centrosomes and Cilia group, Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
J Cell Biol 200:505-22. 2013..We propose that MARK4 is a critical positive regulator of early steps in ciliogenesis... - Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeastFranz Meitinger
German Cancer Research Centre, DKFZ ZMBH Alliance, Molecular Biology of Centrosomes and Cilia Unit, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
J Cell Sci 123:1851-61. 2010..This defect was partially suppressed by increased levels of Cyk3. We therefore propose that the MEN directly controls cytokinesis via targeting of Inn1, Cyk3 and Chs2 to the bud neck... - The yeast centrosome translates the positional information of the anaphase spindle into a cell cycle signalHiromi Maekawa
Zentrum für Molekulare Biologie and 2Biochemie Zentrum, Universitat Heidelberg, 69120 Heidelberg, Germany
J Cell Biol 179:423-36. 2007..Moreover, we present evidence that Spc72 has an additional function in SPOC regulation that is independent of the recruitment of Kin4. Thus, Spc72 provides a missing link between cytoplasmic MT function and components of the SPOC... - Tandem fluorescent protein timers for in vivo analysis of protein dynamicsAnton Khmelinskii
Center for Molecular Biology of the University of Heidelberg ZMBH, DKFZ ZMBH Alliance, Heidelberg, Germany
Nat Biotechnol 30:708-14. 2012..Our experiments reveal the stable nature and asymmetric inheritance of nuclear pore complexes and identify regulators of N-end rule–mediated protein degradation...