Anne T Nies

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier
    Holger Bronger
    Division of Tumor Biochemistry, German Cancer Research Center
    Cancer Res 65:11419-28. 2005
  2. ncbi Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
    A T Nies
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 94:492-9. 2001
  3. ncbi Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2)
    Anne T Nies
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Eur J Biochem 269:1866-76. 2002
  4. ncbi The role of membrane transporters in drug delivery to brain tumors
    Anne T Nies
    Division of Tumor Biochemistry, German Cancer Research Center, Heidelberg, Germany
    Cancer Lett 254:11-29. 2007
  5. ncbi The apical conjugate efflux pump ABCC2 (MRP2)
    Anne T Nies
    Division of Tumor Biochemistry, German Cancer Research Center, Heidelberg, Germany
    Pflugers Arch 453:643-59. 2007
  6. ncbi Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain
    A T Nies
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Neuroscience 129:349-60. 2004
  7. ncbi A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)
    Verena Keitel
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Am J Physiol Gastrointest Liver Physiol 284:G165-74. 2003
  8. ncbi Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma
    Yunhai Cui
    Deutsches Krebsforschungszentrum, Division of Tumor Biochemistry, Heidelberg, Germany
    Lab Invest 83:527-38. 2003
  9. ncbi Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma
    Jorg Konig
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 115:359-67. 2005
  10. ncbi Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)
    Young Min A Lee
    Division of Tumour Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Pharmacogenetics 14:213-23. 2004

Collaborators

Detail Information

Publications17

  1. ncbi ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier
    Holger Bronger
    Division of Tumor Biochemistry, German Cancer Research Center
    Cancer Res 65:11419-28. 2005
    ..Our data provide a basis for the assessment of the role of uptake transporters and efflux pumps in the accessibility of human gliomas for chemotherapeutic agents...
  2. ncbi Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
    A T Nies
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 94:492-9. 2001
    ..When MRP1 was detected by immunofluorescence microscopy, it was localized on the intracellular membranes of carcinoma cells. Thus, plasma membrane expression of MRP2 and MRP3, but not of MRP1, can contribute to the MDR phenotype of HCC...
  3. ncbi Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2)
    Anne T Nies
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Eur J Biochem 269:1866-76. 2002
    ..Instead, our data indicate that a deletion of at least 15 C-terminal amino acids impairs the localization of MRP2 to the apical membrane of polarized cells...
  4. ncbi The role of membrane transporters in drug delivery to brain tumors
    Anne T Nies
    Division of Tumor Biochemistry, German Cancer Research Center, Heidelberg, Germany
    Cancer Lett 254:11-29. 2007
    ..This review focuses on the localization and function of drug-transporting members of both transporter groups in human brain...
  5. ncbi The apical conjugate efflux pump ABCC2 (MRP2)
    Anne T Nies
    Division of Tumor Biochemistry, German Cancer Research Center, Heidelberg, Germany
    Pflugers Arch 453:643-59. 2007
    ..A comprehensive list of sequence variants in the human ABCC2 gene summarizes predicted and proven functional consequences, including variants leading to Dubin-Johnson syndrome...
  6. ncbi Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brain
    A T Nies
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Neuroscience 129:349-60. 2004
    ....
  7. ncbi A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)
    Verena Keitel
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Am J Physiol Gastrointest Liver Physiol 284:G165-74. 2003
    ..Impaired protein maturation followed by proteasomal degradation of inactive MRP2I1173F explain the deficient hepatobiliary elimination observed in this group of Dubin-Johnson syndrome patients...
  8. ncbi Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma
    Yunhai Cui
    Deutsches Krebsforschungszentrum, Division of Tumor Biochemistry, Heidelberg, Germany
    Lab Invest 83:527-38. 2003
    ..Moreover, both antibodies should be useful in studies on the expression and localization of two important uptake transporters of human hepatocytes under physiologic and pathophysiologic conditions...
  9. ncbi Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma
    Jorg Konig
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 115:359-67. 2005
    ..These data suggest that MRP3 and MRP5 are involved in drug resistance of pancreatic tumors and that quantitative analysis of their expression may contribute to predict the benefit of chemotherapy in patients with pancreatic cancer...
  10. ncbi Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)
    Young Min A Lee
    Division of Tumour Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    Pharmacogenetics 14:213-23. 2004
    ..This experimental setup provides a useful tool to analyse the functional consequences of polymorphic variants of MRP3...
  11. ncbi Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
    Hideyuki Kojima
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Hepatol 39:693-702. 2003
    ..Expression and localization of human hepatocellular transporters and of radixin, cross-linking actin with some membrane transporters, may change in cholestatic liver diseases...
  12. ncbi Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
    Maria Rius
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Hepatology 38:374-84. 2003
    ..In conclusion, MRP4 can mediate the efflux of GSH from hepatocytes into blood by cotransport with monoanionic bile salts...
  13. ncbi Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)
    Anne T Nies
    Division of Tumor Biochemistry, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Naunyn Schmiedebergs Arch Pharmacol 376:449-61. 2008
    ..The MDCK-OCT1/MDR1 P-gp double transfectants may be useful to identify additional cationic substrates and inhibitors of OCT1 and MDR1 P-gp, including drug candidates...
  14. ncbi Prostanoid transport by multidrug resistance protein 4 (MRP4/ABCC4) localized in tissues of the human urogenital tract
    Maria Rius
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Urol 174:2409-14. 2005
    ....
  15. ncbi A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter
    Christoph Michalski
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
    J Biol Chem 277:43058-63. 2002
    ..Importantly, most of the mutant protein SLC21A6-L193R was retained intracellularly, and this single amino acid exchange abolished transport function...
  16. ncbi Immunolocalization of multidrug resistance protein 5 in the human genitourinary system
    Anne T Nies
    Divisions of Tumor Biochemistry and Cell Biology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Urol 167:2271-5. 2002
    ..Therefore, we analyzed whether MRP5 is expressed in tissues of the human genitourinary system and whether MRP5 and phosphodiesterase 5 proteins are localized in the same cell types...
  17. ncbi Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs
    Anne T Nies
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Auerbachstrasse 112, 70376 Stuttgart, Germany
    Expert Opin Drug Metab Toxicol 4:545-68. 2008
    ..Hepatobiliary elimination is a vectorial process involving uptake transporters in the basolateral hepatocyte membrane, possibly Phase I and Phase II metabolizing enzymes, and ATP-dependent efflux pumps in the apical hepatocyte membrane...