Research Topics
Genomes and Genes | Anne T NiesSummaryAffiliation: German Cancer Research Center Country: Germany Publications
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Publications
ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrierHolger Bronger
Division of Tumor Biochemistry, German Cancer Research Center
Cancer Res 65:11419-28. 2005..Our data provide a basis for the assessment of the role of uptake transporters and efflux pumps in the accessibility of human gliomas for chemotherapeutic agents...- Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinomaA T Nies
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Int J Cancer 94:492-9. 2001..When MRP1 was detected by immunofluorescence microscopy, it was localized on the intracellular membranes of carcinoma cells. Thus, plasma membrane expression of MRP2 and MRP3, but not of MRP1, can contribute to the MDR phenotype of HCC... - Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2)Anne T Nies
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Eur J Biochem 269:1866-76. 2002..Instead, our data indicate that a deletion of at least 15 C-terminal amino acids impairs the localization of MRP2 to the apical membrane of polarized cells... - The role of membrane transporters in drug delivery to brain tumorsAnne T Nies
Division of Tumor Biochemistry, German Cancer Research Center, Heidelberg, Germany
Cancer Lett 254:11-29. 2007..This review focuses on the localization and function of drug-transporting members of both transporter groups in human brain... - Expression and immunolocalization of the multidrug resistance proteins, MRP1-MRP6 (ABCC1-ABCC6), in human brainA T Nies
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Neuroscience 129:349-60. 2004.... - The apical conjugate efflux pump ABCC2 (MRP2)Anne T Nies
Division of Tumor Biochemistry, German Cancer Research Center, Heidelberg, Germany
Pflugers Arch 453:643-59. 2007..A comprehensive list of sequence variants in the human ABCC2 gene summarizes predicted and proven functional consequences, including variants leading to Dubin-Johnson syndrome... - Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinomaJorg Konig
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Int J Cancer 115:359-67. 2005..These data suggest that MRP3 and MRP5 are involved in drug resistance of pancreatic tumors and that quantitative analysis of their expression may contribute to predict the benefit of chemotherapy in patients with pancreatic cancer... - Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinomaYunhai Cui
Deutsches Krebsforschungszentrum, Division of Tumor Biochemistry, Heidelberg, Germany
Lab Invest 83:527-38. 2003..Moreover, both antibodies should be useful in studies on the expression and localization of two important uptake transporters of human hepatocytes under physiologic and pathophysiologic conditions... - A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)Verena Keitel
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
Am J Physiol Gastrointest Liver Physiol 284:G165-74. 2003..Impaired protein maturation followed by proteasomal degradation of inactive MRP2I1173F explain the deficient hepatobiliary elimination observed in this group of Dubin-Johnson syndrome patients... - Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosisHideyuki Kojima
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
J Hepatol 39:693-702. 2003..Expression and localization of human hepatocellular transporters and of radixin, cross-linking actin with some membrane transporters, may change in cholestatic liver diseases... - Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membraneMaria Rius
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Hepatology 38:374-84. 2003..In conclusion, MRP4 can mediate the efflux of GSH from hepatocytes into blood by cotransport with monoanionic bile salts... - Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1)Anne T Nies
Division of Tumor Biochemistry, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Naunyn Schmiedebergs Arch Pharmacol 376:449-61. 2008..The MDCK-OCT1/MDR1 P-gp double transfectants may be useful to identify additional cationic substrates and inhibitors of OCT1 and MDR1 P-gp, including drug candidates... - Identification and functional characterization of the natural variant MRP3-Arg1297His of human multidrug resistance protein 3 (MRP3/ABCC3)Young-Min A Lee
Division of Tumour Biochemistry, Deutsches Krebsforschungszentrum, D-69120 Heidelberg, Germany
Pharmacogenetics 14:213-23. 2004..This experimental setup provides a useful tool to analyse the functional consequences of polymorphic variants of MRP3... - Prostanoid transport by multidrug resistance protein 4 (MRP4/ABCC4) localized in tissues of the human urogenital tractMaria Rius
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
J Urol 174:2409-14. 2005.... - A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporterChristoph Michalski
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, D 69120 Heidelberg, Germany
J Biol Chem 277:43058-63. 2002..Importantly, most of the mutant protein SLC21A6-L193R was retained intracellularly, and this single amino acid exchange abolished transport function... - Immunolocalization of multidrug resistance protein 5 in the human genitourinary systemAnne T Nies
Divisions of Tumor Biochemistry and Cell Biology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
J Urol 167:2271-5. 2002..Thus, MRP5 inhibition represents a new approach for enhancing cGMP levels in smooth muscle cells and developing drugs for erectile dysfunction... - Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugsAnne T Nies
Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart and University of Tübingen, Auerbachstrasse 112, 70376 Stuttgart, Germany
Expert Opin Drug Metab Toxicol 4:545-68. 2008..Hepatobiliary elimination is a vectorial process involving uptake transporters in the basolateral hepatocyte membrane, possibly Phase I and Phase II metabolizing enzymes, and ATP-dependent efflux pumps in the apical hepatocyte membrane...