C Niehrs

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
    Bingyu Mao
    Molecular Embryology Division, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 417:664-7. 2002
  2. ncbi request reprint Axis formation: redundancy rules
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Curr Biol 15:R391-3. 2005
  3. ncbi request reprint Regionally specific induction by the Spemann-Mangold organizer
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Rev Genet 5:425-34. 2004
  4. doi request reprint On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Development 137:845-57. 2010
  5. doi request reprint Dialectics, systems biology and embryonic induction
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Differentiation 81:209-16. 2011
  6. ncbi request reprint Function and biological roles of the Dickkopf family of Wnt modulators
    C Niehrs
    Department of Molecular Embryology, German Cancer Research Center, Heidelberg, Germany
    Oncogene 25:7469-81. 2006
  7. doi request reprint Active DNA demethylation and DNA repair
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Differentiation 77:1-11. 2009
  8. pmc The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer
    F S de Souza
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 18:6062-72. 1999
  9. ncbi request reprint LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    B Mao
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 411:321-5. 2001
  10. ncbi request reprint Phenotypic effects in Xenopus and zebrafish suggest that one-eyed pinhead functions as antagonist of BMP signalling
    C Kiecker
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mech Dev 94:37-46. 2000

Collaborators

  • Guillermo Barreto
  • Gary Davidson
  • Nicolas Pollet
  • M Vingron
  • Danila Baldessari
  • KEN CHO
  • I W Mattaj
  • Y Li
  • U Strahle
  • F R Bischoff
  • Naoto Ueno
  • Mariann Bienz
  • H G Augustin
  • Georges Rawadi
  • C Hansis
  • F Lyko
  • Corinne Houart
  • ROLAND E BARON
  • Cristina Maria Cruciat
  • Emil Karaulanov
  • Olga Kazanskaya
  • Ivan del Barco Barrantes
  • H Delius
  • Sonia Pinho
  • Wei Wu
  • Ralph T Böttcher
  • A Glinka
  • Bisei Ohkawara
  • W Wu
  • Souichi Ogata
  • Kristina Ellwanger
  • Ya Lin Huang
  • Bingyu Mao
  • Christine Hassler
  • V Gawantka
  • Heiner Westphal
  • Peter Stannek
  • C Kiecker
  • Michael Boutros
  • Tina Buechling
  • Nicole Maltry
  • Philippe Clément-Lacroix
  • Luca Caneparo
  • Roberto Mayor
  • Carlos Carmona-Fontaine
  • Josipa Bilic
  • C Blumenstock
  • Frederic Morvan
  • Corina Guder
  • Emil E Karaulanov
  • D Onichtchouk
  • Rainer König
  • A P Monaghan
  • Andrei Glinka
  • Hajo Delius
  • B Mao
  • Carmen Reinhard
  • Varun Chaudhary
  • Kerstin Bartscherer
  • Kerstin Spirohn
  • Sergio P Acebron
  • Dierk Ingelfinger
  • Marlene Rau
  • Joachim Niedermeyer
  • Hiroaki Saito
  • Melanie Heroult
  • Woon Kyu Lee
  • F S de Souza
  • P Askjaer
  • Junji Morokuma
  • Masasumi Tada
  • Timo Zimmermann
  • Sei Kuriyama
  • Gustavo Acuña
  • Nicole Staudt
  • Gabriel Kolle
  • Tadayoshi Hayata
  • Reiner Ahrendt
  • Martin Hrabe de Angelis
  • Martina Klempt
  • Ana Montero-Pedrazuela
  • Valerie Gailus-Durner
  • Gabriella Morreale de Escobar
  • Thomas W Holstein
  • Patrick Ammann
  • Maria Jesus Obregon
  • Kim Boulukos
  • Birgit Rathkolb
  • Tobias J Franz
  • Wolfgang Wurst

Detail Information

Publications56

  1. ncbi request reprint Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling
    Bingyu Mao
    Molecular Embryology Division, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 417:664-7. 2002
    ..The results indicate that Kremen1 and Kremen2 are components of a membrane complex modulating canonical Wnt signalling through LRP6 in vertebrates...
  2. ncbi request reprint Axis formation: redundancy rules
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Curr Biol 15:R391-3. 2005
    ..The role of BMP antagonists in the Spemann-Mangold organizer of vertebrate embryos is a controversial issue. A study using combined knock down of multiple antagonists finally reveals dramatic effects...
  3. ncbi request reprint Regionally specific induction by the Spemann-Mangold organizer
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Nat Rev Genet 5:425-34. 2004
  4. doi request reprint On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Development 137:845-57. 2010
    ....
  5. doi request reprint Dialectics, systems biology and embryonic induction
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Differentiation 81:209-16. 2011
    ..The example highlights that despite its shortcomings, dialectics can be of heuristic value as a theory of systems biology...
  6. ncbi request reprint Function and biological roles of the Dickkopf family of Wnt modulators
    C Niehrs
    Department of Molecular Embryology, German Cancer Research Center, Heidelberg, Germany
    Oncogene 25:7469-81. 2006
    ..In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease...
  7. doi request reprint Active DNA demethylation and DNA repair
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Differentiation 77:1-11. 2009
    ..Far from merely protecting genomic integrity from environmental insult, DNA repair is therefore at the heart of an epigenetic activation process...
  8. pmc The zinc finger gene Xblimp1 controls anterior endomesodermal cell fate in Spemann's organizer
    F S de Souza
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    EMBO J 18:6062-72. 1999
    ..Our results indicate that Xblimp1 is required for anterior endomesodermal cell fate and head induction...
  9. ncbi request reprint LDL-receptor-related protein 6 is a receptor for Dickkopf proteins
    B Mao
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 411:321-5. 2001
    ..Thus, DKKs inhibit Wnt co-receptor function, exemplifying the modulation of LRP signalling by antagonists...
  10. ncbi request reprint Phenotypic effects in Xenopus and zebrafish suggest that one-eyed pinhead functions as antagonist of BMP signalling
    C Kiecker
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mech Dev 94:37-46. 2000
    ....
  11. ncbi request reprint A morphogen gradient of Wnt/beta-catenin signalling regulates anteroposterior neural patterning in Xenopus
    C Kiecker
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Development 128:4189-201. 2001
    ..Our results indicate that an activity gradient of Wnt/beta-catenin signalling acts as transforming morphogen to pattern the Xenopus central nervous system...
  12. ncbi request reprint Dickkopf1 and the Spemann-Mangold head organizer
    C Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Dev Biol 45:237-40. 2001
    ..Injection of inhibitory antibodies leads to microcephaly and cyclopia. Dkk1 thus is an essential mediator of the vertebrate head organizer...
  13. ncbi request reprint Silencing of TGF-beta signalling by the pseudoreceptor BAMBI
    D Onichtchouk
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 401:480-5. 1999
    ..The results indicate that BAMBI negatively regulates TGF-beta-family signalling by a regulatory mechanism involving the interaction of signalling receptors with a pseudoreceptor...
  14. ncbi request reprint The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesoderm
    D Onichtchouk
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Development 122:3045-53. 1996
    ..5) Microinjection of Xvent-2 mRNA can rescue dorsalization by a dominant-negative BMP-4 receptor. The results suggest that Xvent-2 functions in the BMP-4 signalling pathway that antagonizes the Spemann organizer...
  15. ncbi request reprint Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling
    W Wu
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Curr Biol 10:1611-4. 2000
    ..The study identifies Dkk2 as a secreted molecule that is able to activate Wnt/beta-catenin signalling. The results suggest that a coordinated interplay between inhibiting dkk1 and activating dkk2 can modulate Fz signalling...
  16. ncbi request reprint Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
    A Glinka
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Nature 391:357-62. 1998
    ..Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 s a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors...
  17. ncbi request reprint Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning
    V Gawantka
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Mech Dev 77:95-141. 1998
    ..In conclusion, this study describes a semi-functional approach to investigate genes expressed during early development and provides global insight into embryonic patterning...
  18. ncbi request reprint Dickkopf genes are co-ordinately expressed in mesodermal lineages
    A P Monaghan
    Division of Molecular Biology of the Cell I, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Mech Dev 87:45-56. 1999
    ..Our observations indicate that dkk genes constitute a new family of secreted proteins that may mediate inductive interactions between epithelial and mesenchymal cells...
  19. ncbi request reprint Combinatorial signalling by Xwnt-11 and Xnr3 in the organizer epithelium
    A Glinka
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mech Dev 60:221-31. 1996
    ..The results indicate that induction by the organizer epithelium may result from the combinatorial action of instructive Xnr3 and permissive Xwnt-11 signalling...
  20. pmc Axeldb: a Xenopus laevis database focusing on gene expression
    N Pollet
    Department of Molecular Embryology, Deutsches Krebsforschungszentrum, lm Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nucleic Acids Res 28:139-40. 2000
    ..Axeldb is implemented using an ACEDB database system, and available through the web at http://www.dkfz-heidelberg.de/abt0135/axeldb.htm..
  21. ncbi request reprint Kremen2 modulates Dickkopf2 activity during Wnt/LRP6 signaling
    Bingyu Mao
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120, Heidelberg, Germany
    Gene 302:179-83. 2003
    ..Finally, we show that interaction with Krm2 is mediated by the second cysteine-rich domain of Dkks. These results suggest that Krm2 can function as a switch that turns Dkk2 from an activator into an inhibitor of Wnt/lRP6 signaling...
  22. doi request reprint Requirement of prorenin receptor and vacuolar H+-ATPase-mediated acidification for Wnt signaling
    Cristina Maria Cruciat
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 327:459-63. 2010
    ..The results reveal an unsuspected role for the prorenin receptor, V-ATPase activity, and acidification during Wnt/beta-catenin signaling...
  23. ncbi request reprint Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning
    Gary Davidson
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Development 129:5587-96. 2002
    ..The results indicate that Krm proteins function in a Wnt inhibition pathway regulating early AP patterning of the CNS...
  24. pmc RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase
    P Askjaer
    Department of Gene Expression, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mol Cell Biol 19:6276-85. 1999
    ..In addition, we identify the Xenopus homologue of the nucleoporin CAN/Nup214 as a RanGTP- and NES cargo-specific binding site for CRM1, suggesting that this nucleoporin plays a role in export complex disassembly and/or CRM1 recycling...
  25. ncbi request reprint Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction
    Gary Davidson
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 438:867-72. 2005
    ..Our results reveal an evolutionarily conserved mechanism that couples Wnt receptor activation to the cytoplasmic signal transduction apparatus...
  26. ncbi request reprint Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation
    Josipa Bilic
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Science 316:1619-22. 2007
    ..We propose that Wnts induce coclustering of receptors and Dvl in LRP6-signalosomes, which in turn triggers LRP6 phosphorylation to promote Axin recruitment and beta-catenin stabilization...
  27. pmc Unc5B interacts with FLRT3 and Rnd1 to modulate cell adhesion in Xenopus embryos
    Emil Karaulanov
    Division of Molecular Embryology, DKFZ ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 4:e5742. 2009
    ..The results suggest that FLRT3, Unc5B and Rnd1 proteins interact to modulate cell adhesion in early Xenopus development...
  28. ncbi request reprint Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation
    Guillermo Barreto
    Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nature 445:671-5. 2007
    ..Active demethylation occurs by DNA repair and Gadd45a interacts with and requires the DNA repair endonuclease XPG. We conclude that Gadd45a relieves epigenetic gene silencing by promoting DNA repair, which erases methylation marks...
  29. pmc Transcriptional regulation of BMP4 synexpression in transgenic Xenopus
    Emil Karaulanov
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg, Germany
    EMBO J 23:844-56. 2004
    ..The results highlight that in vivo analysis is required to reveal the physiological, spatio-temporal regulation of BMP-responsive genes...
  30. ncbi request reprint An atlas of differential gene expression during early Xenopus embryogenesis
    Nicolas Pollet
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mech Dev 122:365-439. 2005
    ..In conclusion, this study represents an atlas of gene expression patterns, which reveals embryonic regionalization, provides novel marker genes, and makes predictions about the functional role of unknown genes...
  31. ncbi request reprint The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition
    Cristina Maria Cruciat
    Department of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 281:12986-93. 2006
    ..The results indicate that Erlectin functions in N-glycan recognition in the endoplasmic reticulum, suggesting that it may regulate glycoprotein traffic...
  32. ncbi request reprint Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling
    Christine Hassler
    Department of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Development 134:4255-63. 2007
    ..Furthermore, Krm2 knockdown specifically reduces LRP6 protein levels in NC explants. The results indicate that in the absence of Dkks, Kremens activate Wnt/beta-catenin signaling through LRP6...
  33. ncbi request reprint Dkk3 is required for TGF-beta signaling during Xenopus mesoderm induction
    Sonia Pinho
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany
    Differentiation 75:957-67. 2007
    ..Furthermore, depletion of Dkk3 up-regulates FGF signaling, while Dkk3 overexpression reduces it. These results indicate that Dkk3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development...
  34. ncbi request reprint An ancient Wnt-Dickkopf antagonism in Hydra
    Corina Guder
    Molecular Evolution and Genomics, Heidelberg University, Im Neuenheimer Feld 230, 69120 Heidelberg, Germany
    Development 133:901-11. 2006
    ..Based on the corresponding expression patterns of hydkk1/2/4 and neuronal genes, we suggest that the body column of Hydra is a neurogenic environment suppressing Wnt signalling and facilitating neurogenesis...
  35. ncbi request reprint The transmembrane protein XFLRT3 forms a complex with FGF receptors and promotes FGF signalling
    Ralph T Böttcher
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nat Cell Biol 6:38-44. 2004
    ..The results indicate that XFLRT3 is a transmembrane modulator of FGF-MAP kinase signalling in vertebrates...
  36. ncbi request reprint Norrin and frizzled; a new vein for the eye
    Christof Niehrs
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Dev Cell 6:453-4. 2004
    ..Though we become accustomed to novel components, the discovery of an unexpected Wnt receptor ligand, Norrin, is surprising even to the connoisseur...
  37. pmc Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1
    V Gawantka
    Division of Molecular Embryology, German Cancer Research Center, Heidelberg, Germany
    EMBO J 14:6268-79. 1995
    ..Third, microinjection of Xvent-1 mRNA ventralizes dorsal mesoderm. The results suggest that Xvent-1 functions in a ventral signaling pathway that maintains the ventral mesodermal state and antagonizes the Spemann organizer...
  38. doi request reprint Regulation of Lrp6 phosphorylation
    Christof Niehrs
    Division of Molecular Embryology, DKFZ ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 581, Heidelberg, Germany
    Cell Mol Life Sci 67:2551-62. 2010
    ....
  39. ncbi request reprint Cyclic expression of esr9 gene in Xenopus presomitic mesoderm
    Yan Li
    Division of Molecular Embryology, Deutches Krebsforschungszentrum, Heidelberg, Germany
    Differentiation 71:83-9. 2003
    ..Thus, expression of esr9 and esr10 is an indicator of the segmentation clock in the amphibian embryo. This confirms the evolutionary conservation of a molecular pathway involved in vertebrate segmentation clock...
  40. doi request reprint Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor
    Tina Buechling
    Division of Signaling and Functional Genomics, German Cancer Research Center DKFZ, and Department of Cell and Molecular Biology, Faculty of Medicine Mannheim, University of Heidelberg, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Curr Biol 20:1263-8. 2010
    ..Furthermore, dPRR binds to Fz and Fz2 receptors. In summary, our data suggest that dPRR has an evolutionarily conserved role at the receptor level for activation of canonical and noncanonical Wnt/Fz signaling pathways...
  41. pmc Dkk1 and noggin cooperate in mammalian head induction
    Ivan del Barco Barrantes
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Genes Dev 17:2239-44. 2003
    ..The results provide genetic evidence for the dual inhibition model and indicate that dkk1 and noggin functionally cooperate in the head organizer...
  42. ncbi request reprint R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis
    Olga Kazanskaya
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Dev Cell 7:525-34. 2004
    ..In Xenopus embryos depleted of Rspo2, the muscle markers myoD and myf5 fail to be activated and later muscle development is impaired. Thus, Rspo2 functions in a positive feedback loop to stimulate the Wnt/beta-catenin cascade...
  43. doi request reprint The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular development
    Olga Kazanskaya
    Division of Molecular Embryology, German Cancer Research Center, Im Neuenheimer Feld 581, D 69120 Heidelberg, Germany
    Development 135:3655-64. 2008
    ..We show that vascular endothelial growth factor is an immediate early response gene and a mediator of R-spondin signaling. The results identify Rspo3 as a novel, evolutionarily conserved angiogenic factor in embryogenesis...
  44. pmc Targeted disruption of the Wnt regulator Kremen induces limb defects and high bone density
    Kristina Ellwanger
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mol Cell Biol 28:4875-82. 2008
    ..Our study provides the first genetic evidence for a functional interaction of Kremen proteins with Dkk1 as negative regulators of Wnt/beta-catenin signaling and reveals that Kremen proteins are not universally required for Dkk1 function...
  45. doi request reprint Cell cycle control of wnt receptor activation
    Gary Davidson
    Division of Molecular Embryology, Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Hermann von Helmholtz Platz 1, 76344 Eggenstein Leopoldshafen, Germany
    Dev Cell 17:788-99. 2009
    ..G2/M priming of LRP6 by a Cyclin/CDK complex introduces an unexpected new layer of regulation of Wnt signaling...
  46. ncbi request reprint Global gene expression profiling and cluster analysis in Xenopus laevis
    Danila Baldessari
    Division of Molecular Embryology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mech Dev 122:441-75. 2005
    ..The study provides insights into the higher order of vertebrate gene expression, identifies synexpression groups and marker genes, and makes predictions for the biological role of numerous uncharacterized genes...
  47. pmc Reliability of gene expression ratios for cDNA microarrays in multiconditional experiments with a reference design
    Rainer König
    Division of Theoretical Bioinformatics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Nucleic Acids Res 32:e29. 2004
    ..Finally, we compared microarray-based gene expression profiles with the corresponding expression patterns obtained by whole-mount in situ hybridizations, resulting in a 90% correspondence...
  48. pmc A role for fibronectin-leucine-rich transmembrane cell-surface proteins in homotypic cell adhesion
    Emil E Karaulanov
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    EMBO Rep 7:283-90. 2006
    ..Therefore, FLRT-mediated FGF signal transduction and homotypic cell sorting can be molecularly uncoupled. The results indicate that FLRT proteins have a dual role, promoting FGF signalling and modulating homotypic cell adhesion...
  49. ncbi request reprint Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1
    Christoph Hansis
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Curr Biol 14:1475-80. 2004
    ..Dissection of the molecular machinery using a simplified assay system may aid in achieving complete nuclear reprogramming of somatic cells for regenerative medicine...
  50. ncbi request reprint Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass
    Frederic Morvan
    Department of Cell Biology, Yale University, New Heaven, Connecticut, USA
    J Bone Miner Res 21:934-45. 2006
    ..Unexpectedly, the Wnt antagonist Dkk2 is required for terminal osteoblast differentiation and mineralized matrix formation. We show that Dkk1, unlike Dkk2, negatively regulates osteoblast differentiation and bone formation...
  51. ncbi request reprint Developmental biology: a tale of tails
    Christof Niehrs
    Nature 424:375-6. 2003
  52. pmc Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek
    Luca Caneparo
    Medical Research Council Centre for Developmental Neurobiology, King s College London, SE1 1UL London, UK
    Genes Dev 21:465-80. 2007
    ..Our data therefore indicate that Dkk1 regulates gastrulation movement through interaction with LRP5/6 and Kny and coordinated modulations of Wnt/beta catenin and Wnt/PCP pathways...
  53. pmc TGF-beta signaling-mediated morphogenesis: modulation of cell adhesion via cadherin endocytosis
    Souichi Ogata
    Department of Developmental and Cell Biology, Developmental Biology Center, University of California at Irvine, Irvine, California 92697, USA
    Genes Dev 21:1817-31. 2007
    ....
  54. ncbi request reprint Neural crests are actively precluded from the anterior neural fold by a novel inhibitory mechanism dependent on Dickkopf1 secreted by the prechordal mesoderm
    Carlos Carmona-Fontaine
    Department of Anatomy and Developmental Biology, University College London, UK
    Dev Biol 309:208-21. 2007
    ..These results demonstrate that anterior regions of the embryo lack NC because of a mechanism, conserved from fish to mammals, that suppresses Wnt/beta-catenin signaling via Dkk1...
  55. ncbi request reprint In situ analysis of gene expression in Xenopus embryos
    Nicolas Pollet
    Laboratoire de Transgenèse et Génétique des Amphibiens, CNRS UMR 8080, IBAIC Bat 447, Universite Paris Sud, 91405 Orsay Cedex, France
    C R Biol 326:1011-7. 2003
    ..These sets of co-regulated genes show a striking similarity with operons, and may be a key determinant facilitating evolutionary change leading to animal diversity...
  56. pmc Generation and characterization of dickkopf3 mutant mice
    Ivan del Barco Barrantes
    Division of Molecular Embryology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Mol Cell Biol 26:2317-26. 2006
    ..Altered phenotypes in dkk3 mutant mice were observed in the frequency of NK cells, immunoglobulin M, hemoglobin, and hematocrit levels, as well as lung ventilation. Furthermore, dkk3-deficient mice display hyperactivity...