Thomas Muller

Summary

Affiliation: German Pelvic Floor Center
Country: Germany

Publications

  1. ncbi request reprint Drug treatment of non-motor symptoms in Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Expert Opin Pharmacother 3:381-8. 2002
  2. ncbi request reprint Apomorphine delays simple reaction time in Parkinsonian patients
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Parkinsonism Relat Disord 8:357-60. 2002
  3. ncbi request reprint Chronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's disease
    Siegfried Muhlack
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Neurosci Lett 363:284-7. 2004
  4. ncbi request reprint Levodopa, motor fluctuations and dyskinesia in Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56 44791 Bochum, Germany
    Expert Opin Pharmacother 7:1715-30. 2006
  5. ncbi request reprint Endurance exercise modulates levodopa induced growth hormone release in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Neurosci Lett 422:119-22. 2007
  6. ncbi request reprint Levodopa-related cysteinyl-glycine and cysteine reduction with and without catechol-O-methyltransferase inhibition in Parkinson's disease patients
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Gartenstr 1, 13088, Berlin, Germany
    J Neural Transm 121:643-8. 2014
  7. pmc Levodopa/carbidopa and entacapone in the treatment of Parkinson's disease: efficacy, safety and patient preference
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Patient Prefer Adherence 3:51-9. 2009
  8. doi request reprint Current status of safinamide for the drug portfolio of Parkinson's disease therapy
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weißensee, Gartenstr 1, 13088 Berlin, Germany 49 309 279 0223 49 309 279 0703
    Expert Rev Neurother 13:969-77. 2013
  9. doi request reprint Suitability of the adenosine antagonist istradefylline for the treatment of Parkinson's disease: pharmacokinetic and clinical considerations
    Thomas Muller
    St Joseph Hospital Berlin Weißensee, Department of Neurology, Berlin, Germany
    Expert Opin Drug Metab Toxicol 9:1015-24. 2013
  10. doi request reprint Pharmacokinetic considerations for the use of levodopa in the treatment of Parkinson disease: focus on levodopa/carbidopa/entacapone for treatment of levodopa-associated motor complications
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Clin Neuropharmacol 36:84-91. 2013

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Drug treatment of non-motor symptoms in Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Expert Opin Pharmacother 3:381-8. 2002
    ..Nevertheless, this review tries to provide a survey of possible therapeutic options for the treatment of the symptoms of Parkinson's disease other the dopamine-sensitive motor features...
  2. ncbi request reprint Apomorphine delays simple reaction time in Parkinsonian patients
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Parkinsonism Relat Disord 8:357-60. 2002
    ..Parkinsonian patients have difficulty in the preparation and execution of movements, which translate into delayed performance of simple reaction time (SRT) paradigms...
  3. ncbi request reprint Chronic levodopa intake increases levodopa plasma bioavailability in patients with Parkinson's disease
    Siegfried Muhlack
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Neurosci Lett 363:284-7. 2004
    ..The maximum plasma levodopa concentration did not differ (ANCOVA: F(1.19) = 1.17, P = 0.29). Long-term levodopa administration results in an increased levodopa plasma bioavailability in PD patients...
  4. ncbi request reprint Levodopa, motor fluctuations and dyskinesia in Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56 44791 Bochum, Germany
    Expert Opin Pharmacother 7:1715-30. 2006
    ..It also gives an overview of existing and potential future treatment-strategies for the management of these troublesome treatment complications that affect motor behaviour in PD patients...
  5. ncbi request reprint Endurance exercise modulates levodopa induced growth hormone release in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Neurosci Lett 422:119-22. 2007
    ..This might additionally have caused the significant faster GH release during exercise...
  6. ncbi request reprint Levodopa-related cysteinyl-glycine and cysteine reduction with and without catechol-O-methyltransferase inhibition in Parkinson's disease patients
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Gartenstr 1, 13088, Berlin, Germany
    J Neural Transm 121:643-8. 2014
    ..Cysteinyl-glycine decrease results from the alternative glutathione transformation to its oxidized form glutathione dissulfide after free radical scavenging. ..
  7. pmc Levodopa/carbidopa and entacapone in the treatment of Parkinson's disease: efficacy, safety and patient preference
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Patient Prefer Adherence 3:51-9. 2009
    ..The introduction of LD/CD/EN in one tablet supported patients' preference of COMT inhibition as an essential component of LD/DDI therapy, as this combination reduced number and size of tablets...
  8. doi request reprint Current status of safinamide for the drug portfolio of Parkinson's disease therapy
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weißensee, Gartenstr 1, 13088 Berlin, Germany 49 309 279 0223 49 309 279 0703
    Expert Rev Neurother 13:969-77. 2013
    ....
  9. doi request reprint Suitability of the adenosine antagonist istradefylline for the treatment of Parkinson's disease: pharmacokinetic and clinical considerations
    Thomas Muller
    St Joseph Hospital Berlin Weißensee, Department of Neurology, Berlin, Germany
    Expert Opin Drug Metab Toxicol 9:1015-24. 2013
    ....
  10. doi request reprint Pharmacokinetic considerations for the use of levodopa in the treatment of Parkinson disease: focus on levodopa/carbidopa/entacapone for treatment of levodopa-associated motor complications
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Clin Neuropharmacol 36:84-91. 2013
    ....
  11. doi request reprint Detoxification and antioxidative therapy for levodopa-induced neurodegeneration in Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weißensee, Gartenstr 1, 13088, Berlin, Germany
    Expert Rev Neurother 13:707-18. 2013
    ..To counteract these metabolic long-term levodopa-associated effects, chronic levodopa therapy should be combined with supplemental application of free radical scavengers and methyl group donating vitamins...
  12. doi request reprint Switch from selegiline to rasagiline is beneficial in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital, Gartenstr 1, 13088 Berlin, Germany
    J Neural Transm 120:761-5. 2013
    ..Motor behavior and motor complications probably became better due to the additional glutamate receptor antagonizing properties of rasagiline in this open label study...
  13. doi request reprint Methyl group-donating vitamins elevate 3-O-methyldopa in patients with Parkinson disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Clin Neuropharmacol 36:52-4. 2013
    ..This accompanying reaction is partially reversible by methyl group-donating vitamins...
  14. doi request reprint Comparison of gait training versus cranial osteopathy in patients with Parkinson's disease: a pilot study
    Thomas Muller
    Department of Neurology, St Joseph Hospital, 13088 Berlin Weissensee, Germany
    NeuroRehabilitation 32:135-40. 2013
    ..Osteopathy in the cranial field (OCF) is a gentle manual method to treat dysfunctions of the central nervous system. Therapists may employ GT and OCF to bypass deficient basal ganglia dysfunction, which causes gait disturbances in PD...
  15. doi request reprint Peripheral neuropathy in Parkinson's disease: levodopa exposure and implications for duodenal delivery
    Thomas Muller
    Department of Neurology, St Joseph Krankenhaus Berlin Weißensee, Gartenstr 1, 13088 Berlin, Germany
    Parkinsonism Relat Disord 19:501-7 ; discussion 501. 2013
    ....
  16. doi request reprint Levodopa increases speed of alternating movements in Parkinson's disease patients
    Thomas Muller
    Department of Neurology, St Josef Hospital Bochum, Gudrunstr 56, 44791 Bochum, Germany
    J Neural Transm 120:309-13. 2013
    ..The amplitude of motions did not differ between both assessment moments. Closer correlations between rating- and diadochokinesimeter outcomes appeared before levodopa intake...
  17. pmc Drug therapy in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St, Joseph Hospital Berlin Weissensee, Gartenstr, 1, 13088, Berlin, Germany
    Transl Neurodegener 1:10. 2012
    ..This complicates the differentiation from the disease process itself and influences therapeutic options, which are often limited because of additional morbidity with necessary concomitant drug therapy...
  18. doi request reprint Cysteine decrease following acute Levodopa intake in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Gartenstr 1, 13088 Berlin, Germany
    Neurosci Lett 521:37-9. 2012
    ..Cysteine decrease may result from an up regulation of GSH synthesis to encounter augmented appearance of free radicals associated with LD turnover via mitochondrial monoaminooxidase...
  19. doi request reprint Efficacy of parecoxib, sumatriptan, and rizatriptan in the treatment of acute migraine attacks
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Clin Neuropharmacol 34:206-9. 2011
    ..This trial demonstrates the effectiveness of a parecoxib infusion in the treatment of acute migraine and that the circumvention of the first pass effect of the liver by rizatriptan may be beneficial for fast pain relief...
  20. doi request reprint Cysteine elevation in levodopa-treated patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Gartenstrasse 1, Berlin, Germany or
    Mov Disord 24:929-32. 2009
    ..The correlation outcomes support the view that LD/DCI intake may also increase cysteine...
  21. doi request reprint Impact of endurance exercise on levodopa-associated cortisol release and force increase in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital, Ruhr University Bochum, Bochum, Germany
    J Neural Transm 115:851-5. 2008
    ..Since cortisol improves muscle function, the lack of increase in maximal grip strength following LD administration during exercise may contribute to reduced exercise capacity, which is reported by PD patients...
  22. doi request reprint Pain perception, pain drug therapy and health status in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Neuroepidemiology 37:183-7. 2011
    ..We performed a survey to analyze the relations between health status, pain perception and gender in 4,086 PD patients. Moreover, the participants should tick whether they took pain medications or not...
  23. doi request reprint Caries and periodontal disease in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Spec Care Dentist 31:178-81. 2011
    ..Individuals with PD, their caregivers, and their physicians need to focus more on their oral health and quality of oral hygiene...
  24. doi request reprint New small molecules for the treatment of Parkinson's disease
    Thomas Muller
    St Joseph Hospital Berlin Weissensee, Department of Neurology, Gartenstrasse 1, 13088 Berlin, Germany
    Expert Opin Investig Drugs 19:1077-86. 2010
    ..Until now, therapy approaches have predominantly focused on motor behavior associated with dopamine substitution...
  25. doi request reprint Effect of exercise on reactivity and motor behaviour in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Gartenstr 1, 13 088 Berlin, Germany
    J Neurol Neurosurg Psychiatry 81:747-53. 2010
    ..This may result from an exercise induced increase in endogenous dopamine synthesis. As a result, beneficial effects on movement and reactivity may occur...
  26. doi request reprint Quality of life, caregiver burden and insurance in patients with Parkinson's disease in Germany
    T Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse, Bochum, Germany
    Eur J Neurol 17:1365-9. 2010
    ..Patient organizations i.e. the Deutsche Parkinson Vereinigung for patients with Parkinson's disease (PD), physicians, patients themselves and their carers controversially discuss this opinion making by politicians...
  27. doi request reprint Diadochokinetic movements differ between patients with Parkinson's disease and controls
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin, Weissensee, Gartenstr 1, 13088 Berlin, Germany
    J Neural Transm 117:189-95. 2010
    ..This altered performance of diadochokinetic movements corresponds to the clinical motor symptoms of PD patients and differs from healthy controls...
  28. doi request reprint Peripheral COMT inhibition prevents levodopa associated homocysteine increase
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Gartenstr 1, 13088, Berlin, Germany
    J Neural Transm 116:1253-6. 2009
    ..Therefore, peripheral COMT inhibition may have a beneficial effect on putative, controversially debated components of homocysteine-related progression of PD...
  29. doi request reprint Homocysteine levels after acute levodopa intake in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Germany
    Mov Disord 24:1339-43. 2009
    ..91; P = 0.44), accordingly L-dopa accumulation was better in Group I than in Group II. Thus, in conclusion, L-dopa metabolism is an important component for homocysteine elevation after one time L-dopa/DDI administration in PD patients...
  30. doi request reprint Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Gartenstr 1, 13088 Berlin, Germany
    Naunyn Schmiedebergs Arch Pharmacol 383:627-33. 2011
    ..Measurements of homocysteine should consider acute repeated levodopa/DDI applications, as homocysteine and metabolically related 3-O-methyldopa accumulate due to their long plasma half-life in contrast to short-living levodopa...
  31. doi request reprint Levodopa induces synthesis of nerve growth factor and growth hormone in patients with Parkinson disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Clin Neuropharmacol 34:101-3. 2011
    ..Levodopa may experimentally exert supportive effects on nerve growth factor synthesis and on growth hormone production, a hormonal compound with regenerative potential...
  32. doi request reprint Cysteinyl-glycine reduction as marker for levodopa-induced oxidative stress in Parkinson's disease patients
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Mov Disord 26:543-6. 2011
    ..Cys-Gly decay may result from the alternative transformation of glutathione to its oxidized form glutathione dissulfide as consequence of free radical scavenging...
  33. doi request reprint Motor complications, levodopa metabolism and progression of Parkinson's disease
    Thomas Muller
    St Joseph Hospital Berlin Weissensee, Department of Neurology, Gartenstr 1, 13088 Berlin, Germany
    Expert Opin Drug Metab Toxicol 7:847-55. 2011
    ..Clinically, progression of PD is also characterised by onset of motor complications (MC). MC results from the peripheral and central degree of fluctuations of levodopa (LD) and of dopamine...
  34. doi request reprint Elevation of total homocysteine levels in patients with Parkinson's disease treated with duodenal levodopa/carbidopa gel
    Thomas Muller
    Department of Neurology, St Joseph Hospital, Berlin Weissensee, Gartenstr 1, 13088, Berlin, Germany
    J Neural Transm 118:1329-33. 2011
    ..7) correlation between LD and 3-OMD. thcys ascent was observed in relation with the onset of atherosclerosis, non-motor symptoms and polyneuropathy in PD patients in the long term...
  35. doi request reprint Entacapone improves absorption of a coadministered salt in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital Berlin Weissensee, Berlin, Germany
    Mov Disord 23:1458-61. 2008
    ..This improves dissolution and absorption of acids and salts. Thus it may enhance absorption of LD itself...
  36. ncbi request reprint Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q(10) in Parkinson disease
    Alexander Storch
    Department of Neurology, Technical University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Arch Neurol 64:938-44. 2007
    ..Coenzyme Q(10) (CoQ(10)) is an electron acceptor bridging mitochondrial complexes I and II/III and a potent antioxidant that consistently partially recovers the function of dopaminergic neurons...
  37. ncbi request reprint Efficacy and safety of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients
    Volker Hoffmann
    Department of Neurology, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Neurol Sci 211:81-4. 2003
    ..No serious side effects occurred. We conclude that repeated intrathecal TCA injection provides substantial benefit for progressive MS patients with predominantly spinal symptoms...
  38. ncbi request reprint Entacapone improves complex movement performance in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Clin Neurosci 14:424-8. 2007
    ..A possible strategy to prolong plasma metabolism of Levodopa/Carbidopa (LD/CD) is Entacapone addition (EN), which improves impaired motor behaviour in patients with Parkinson's disease (PD)...
  39. doi request reprint Catechol-O-methyltransferase inhibition improves levodopa-associated strength increase in patients with Parkinson disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Clin Neuropharmacol 31:134-40. 2008
    ..This antiacid scenario may support a better muscle function with a positive impact on muscle excitability and contractibility...
  40. ncbi request reprint Inhibition of catechol-O-methyltransferase contributes to more stable levodopa plasma levels
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Mov Disord 21:332-6. 2006
    ..Our study shows a more stable LD plasma behavior during LCE intake and accordingly a better effect on motor symptoms according to rating outcomes and motor test results to a lesser extent...
  41. ncbi request reprint Levodopa availability improves with progression of Parkinson's disease
    Dirk Woitalla
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    J Neurol 253:1221-6. 2006
    ..Previous pharmacokinetic trials with standard levodopa formulations showed a different behaviour of levodopa degradation in plasma of patients with Parkinson's disease (PD) in various stages...
  42. ncbi request reprint Impact of gastric emptying on levodopa pharmacokinetics in Parkinson disease patients
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Clin Neuropharmacol 29:61-7. 2006
    ....
  43. ncbi request reprint Treatment benefit and daily drug costs associated with treating Parkinson's disease in a Parkinson's disease clinic
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    CNS Drugs 18:105-11. 2004
    ..This study was conducted to determine the effect of an inpatient setting (a specialised Parkinson's disease clinic) on drug therapy costs and patient symptoms...
  44. ncbi request reprint Repeat intrathecal triamcinolone acetonide application reduces acute occurring painful dysesthesia in patients with relapsing remitting multiple sclerosis
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    ScientificWorldJournal 6:460-5. 2006
    ..Repeated intrathecal TCA injection may provide a substantial benefit in RRMS patients with acute onset of pain due to an inflammatory lesion within the spinal cord...
  45. ncbi request reprint Recovery of glucocorticoid-related loss of synaptic density in the fetal sheep brain at 0.75 of gestation
    Claudia Colberg
    Department of Neurology, Friedrich Schiller University, D 07740 Jena, Germany
    Neurosci Lett 364:130-4. 2004
    ..It was not accompanied by neuronal damage and was reversible within 24h. In conclusion, fetal betamethasone exposure induces a gestational age-dependent decrease of synaptic density that is transient and more severe in younger fetuses...
  46. ncbi request reprint Hyperhomocysteinaemia in treated patients with Huntington's disease homocysteine in HD
    Jürgen Andrich
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Mov Disord 19:226-8. 2004
    ..Because the protein Huntingtin interacts with the homocysteine metabolism modulating enzyme cystathionine beta-synthase, we hypothesize that homocysteine promotes neurodegeneration in HD...
  47. doi request reprint Entacapone
    Thomas Muller
    St Joseph Hospital Berlin Weissensee, Department of Neurology, Berlin, Germany
    Expert Opin Drug Metab Toxicol 6:983-93. 2010
    ..These plasma fluctuations support alternating stimulation of striatal postsynaptic dopamine receptors and thus onset of motor complications. They are significant components for the quality of treatment of PD patients...
  48. ncbi request reprint Assessment of complex movements reflects dysfunction in Huntington's disease
    Carsten Saft
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    J Neurol 250:1469-74. 2003
    ..Therefore peg insertion particularly reflects executive dysfunction in early HD and additionally motor impairment in advanced HD...
  49. ncbi request reprint Glucose transporter proteins GLUT1 and GLUT3 like immunoreactivities in the fetal sheep brain are not reduced by maternal betamethasone treatment
    Iwa Antonow-Schlorke
    Department of Neurology, Friedrich Schiller University, D 07740 Jena, Germany
    Neurosci Lett 403:261-5. 2006
    ..These data indicate that alteration of GLUT expression is unlikely to explain the cerebral functional effects of antenatal glucocorticoids...
  50. ncbi request reprint Tolcapone decreases plasma levels of S-adenosyl-L-homocysteine and homocysteine in treated Parkinson's disease patients
    Thomas Muller
    Department of Neurology, St Josef Hospital, University of Bochum, Gudrunstr 56, 44791, Bochum, Germany
    Eur J Clin Pharmacol 62:447-50. 2006
    ..A further therapeutic alternative is inhibition of catechol-O-methyltransfrase (COMT) on a regular basis, when levodopa/DDI treatment is performed...
  51. ncbi request reprint Acute levodopa intake and associated cortisol decrease in patients with Parkinson disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Clin Neuropharmacol 30:101-6. 2007
    ..These lower 5-HT levels reduce the hypothalamic function and, via the corticotropin axis, the subsequent peripheral cortisol release. Thus, levodopa-induced cortisol decrease may be related to PD progression...
  52. doi request reprint A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord
    Dominique Bröhl
    Department of Neuroscience, Max Delbrück Centrum for Molecular Medicine, Berlin, Germany
    Dev Biol 322:381-93. 2008
    ..We conclude that a transcriptional network operates in maturing dorsal horn neurons that coordinately determines transmitter and peptidergic fate...
  53. ncbi request reprint Dopaminergic substitution in Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Expert Opin Pharmacother 3:1393-403. 2002
    ....
  54. ncbi request reprint Assessment of simple movements reflects impairment in Huntington's disease
    Carsten Saft
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Mov Disord 21:1208-12. 2006
    ..Results of our applied instrumental tool measure impaired movement performance, which is not specific for HD, but reflects the various methods assessed and the slowly evolving symptoms of the degenerative process in HD...
  55. ncbi request reprint Impact of levodopa on reduced nerve growth factor levels in patients with Parkinson disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Clin Neuropharmacol 28:238-40. 2005
    ....
  56. ncbi request reprint Exercise improves efficacy of levodopa in patients with Parkinson's disease
    Siegfried Muhlack
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Bochum 44791, Germany
    Mov Disord 22:427-30. 2007
    ..Moderate exercise increases clinical efficacy of LD...
  57. pmc Neuropathy in Parkinson's disease patients with intestinal levodopa infusion versus oral drugs
    Constanze Jugel
    Department of Neurology, Charite University Medicine, Campus Benjamin Franklin, Berlin, Germany
    PLoS ONE 8:e66639. 2013
    ..Severe polyneuropathy has been observed in a number of patients treated for Parkinson's disease with Levodopa/Carbidopa intestinal gel infusion. This may reflect a rare individual complication or a systematic side effect...
  58. pmc Efficacy of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients with spinal symptoms
    Kerstin Hellwig
    Department of Neurology, St, Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    BMC Neurol 4:18. 2004
    ..There are controversial results on the efficacy of the abandoned, intrathecal predominant methylprednisolone application in multiple sclerosis (MS) in contrast to the proven effectiveness in intractable postherpetic neuralgia...
  59. ncbi request reprint Is levodopa toxic?
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    J Neurol 251:VI/44-6. 2004
    ..e. folic acid administration in the case of levodopa-associated homocysteine elevation...
  60. ncbi request reprint Apomorphine reduces BOLD signal in fMRI during voluntary movement in Parkinsonian patients
    Sören Peters
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Neuroreport 14:809-12. 2003
    ..These findings warrant future consideration and further investigation of possible central inhibitory effects of dopaminergic therapy in functional imaging studies in PD...
  61. ncbi request reprint Rapid switch from oral antiparkinsonian combination drug therapy to duodenal levodopa infusion
    Birgit Meiler
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, 44791 Bochum, Germany
    Mov Disord 23:145-6. 2008
    ..We have shown that a prior change to an oral levodopa monotherapy and a slow titration of duodenal levodopa infusion may be skipped and a direct switch to duodenal levodopa is a safe option...
  62. ncbi request reprint Mutation analysis of the neurofilament M gene in Parkinson's disease
    Rejko Kruger
    Department of Neurology, Neurodegeneration Laboratory, University of Tubingen, Hoppe Seyler Strasse 3, D 72076, Tubingen, Germany
    Neurosci Lett 351:125-9. 2003
    ..However, rare variants of the NF-M gene may act as susceptibility factors for PD and functional analyses of the identified variations are warranted to decipher possible mechanisms in neurodegeneration...
  63. ncbi request reprint Complex movement behaviour and progression of Huntington's disease
    Jürgen Andrich
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Neurosci Lett 416:272-4. 2007
    ..We conclude, that instrumental assessment of complex movement sequences is an additional simple method to follow impairment in HD patients in addition to clinical rating...
  64. pmc Assessment of simple movements and progression of Huntington's disease
    Jürgen Andrich
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, D 44791 Bochum, Germany
    J Neurol Neurosurg Psychiatry 78:405-7. 2007
    ..Instrumental test results significantly correlated with both UHDRS scores at each assessment. Assessment of simple movement sequences is an additional simple method to follow impairment in patients with HD in addition to clinical rating...
  65. ncbi request reprint Intravenous amantadine sulphate application improves the performance of complex but not simple motor tasks in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    Neurosci Lett 339:25-8. 2003
    ..Since peg insertion depends on more complex movements and thus more dopamine dependent cognitive processes, it improved after application of the indirect dopaminomimetic substance amantadine...
  66. ncbi request reprint Levodopa-associated increase of homocysteine levels and sural axonal neurodegeneration
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Arch Neurol 61:657-60. 2004
    ..Levodopa metabolism via catechol O-methyltransferase increases levels of the neurotoxin homocysteine, which induces an axonal-accentuated degeneration in sensory peripheral nerves in vitro...
  67. doi request reprint Selegiline reduces cisplatin-induced neuronal death in neuroblastoma cells
    Thomas Muller
    Department of Neurology, St Josef Hospital, University of Bochum, Gudrunstr 56, 44791 Bochum, Germany
    Neurol Res 30:417-9. 2008
    ..Clinically, our findings support an early start of long-term treatment with selegiline in view of the various neurotoxin hypotheses and mechanisms of neuronal death in chronic neurodegenerative disorders...
  68. doi request reprint Allergic and nonallergic delayed infusion reactions during natalizumab therapy
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Arch Neurol 65:656-8. 2008
    ..Delayed infusion reactions resembling serum sickness-type reactions (type III reaction) are commonly reported in other monoclonal antibody therapies (eg, infliximab and rituximab), but are not described yet for natalizumab...
  69. ncbi request reprint Efficacy of mitoxantrone and intrathecal triamcinolone acetonide treatment in chronic progressive multiple sclerosis patients
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Clin Neuropharmacol 29:286-91. 2006
    ..Future trials will show the efficacy of combination of both treatment approaches in chronic progressive patients with MS...
  70. doi request reprint Refractory epileptic seizures due to vitamin B6 deficiency in a patient with Parkinson's disease under duodopa® therapy
    Sabine Skodda
    Department of Neurology, Knappschaftskrankenhaus, Hospital of the Ruhr University Bochum, Bochum, Germany
    J Neural Transm 120:315-8. 2013
    ..We describe a PD patient under LCIG therapy developing refractory epileptic seizures obviously promoted by vitamin B6 deficiency...
  71. pmc Time processing in Huntington's disease: a group-control study
    Christian Beste
    Department of Neurology, Huntington Centre NRW, St Josef Hospital, Ruhr University, Bochum, Germany
    PLoS ONE 2:e1263. 2007
    ..It may be hypothesized that timing functions may be deteriorated to a different extent in motor and non-motor timing, because in motor timing the underlying brain structures may be more demanding than in non-motor timing...
  72. ncbi request reprint Levodopa intake increases plasma levels of S-adenosylmethionine in treated patients with Parkinson disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University of Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Clin Neuropharmacol 28:274-6. 2005
    ....
  73. doi request reprint Deep brain stimulation improves performance of complex instrumental paradigms
    Gisa Ellrichmann
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Eur Neurol 60:32-6. 2008
    ....
  74. doi request reprint Role of homocysteine in the treatment of Parkinson's disease
    Thomas Muller
    Department of Neurology, St Joseph Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    Expert Rev Neurother 8:957-67. 2008
    ..They have a structure similar to 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine or its ion 1-methyl-4-phenylpyridinium, both of which are known to induce PD-like motor symptoms...
  75. doi request reprint Increase in relapse rate during assisted reproduction technique in patients with multiple sclerosis
    Kerstin Hellwig
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    Eur Neurol 61:65-8. 2009
    ..These results suggest that female MS patients who wish to have children should be informed that the RR may be increasing if ART is necessary...
  76. ncbi request reprint Diagnostic aspects of early Parkinson's disease
    Thomas Muller
    Dept of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791, Bochum, Germany
    J Neurol 253:IV29-31. 2006
    ..It will also support the concept of a clinically effective pharmacological intervention on a disease process, which is also more and more demanded by the health authorities for drug approval...
  77. ncbi request reprint Budipine provides additional benefit in patients with Parkinson disease receiving a stable optimum dopaminergic drug regimen
    Horst Przuntek
    Department of Neurology, Ruhr University of Bochum, Gudrunstrass 56, 44791 Bochum, Germany
    Arch Neurol 59:803-6. 2002
    ..Previous studies have demonstrated the therapeutic efficacy of budipine on motor symptoms in insufficiently treated patients with Parkinson disease...
  78. ncbi request reprint Tapping and peg insertion after levodopa intake in treated and de novo parkinsonian patients
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Germany
    Can J Neurol Sci 29:73-7. 2002
    ..To date, such studies on treated parkinsonian patients have not addressed acute and long-term effects of dopaminergic drugs...
  79. ncbi request reprint Coenzyme Q10 supplementation provides mild symptomatic benefit in patients with Parkinson's disease
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Germany
    Neurosci Lett 341:201-4. 2003
    ..48, P=0.008) better improvement of FMT performance compared with placebo. Our results indicate a moderate beneficial effect of oral CoQ(10) supplementation in PD patients...
  80. ncbi request reprint Treatment benefit correlates with increase of daily drug costs in Parkinson's disease clinics
    Thomas Muller
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, 44791 Bochum, Germany
    NeuroRehabilitation 18:271-5. 2003
    ..There is a move towards treatment of Parkinson's disease (PD) patients in specialized units, however, data on the outcome and on daily antiparkinsonian drug costs are rare...
  81. ncbi request reprint Betamethasone-related acute alterations of microtubule-associated proteins in the fetal sheep brain are reversible and independent of age during the last one-third of gestation
    Iwa Antonow-Schlorke
    Department of Neurology, Friedrich Schiller University, Jena, Germany
    Am J Obstet Gynecol 196:553.e1-6. 2007
    ..The purpose of this study was to examine whether glucocorticoid effects on neuronal cytoskeleton, which we have shown previously at 0.87 gestation when the hypothalamo-pituitary-adrenal axis matures, are age-dependent and reversible...
  82. doi request reprint Catechol-O-methyltransferase enzyme: cofactor S-adenosyl-L-methionine and related mechanisms
    Thomas Muller
    Department of Neurology, St Joseph Hospital, Berlin, Germany
    Int Rev Neurobiol 95:49-71. 2010
    ..These substrates may also accumulate in the nervous system, since homocysteine formation is associated with O-methylation which has a broad detoxification potential...
  83. doi request reprint Heart rate variability analysis allows early asphyxia detection in ovine fetus
    Martin G Frasch
    Department of Neurology, Friedrich Schiller University, D 07740 Jena, Germany
    Reprod Sci 16:509-17. 2009
    ..05). Our results suggest that an increase of RMSSD in association with FHR decelerations reflects initial vagal activation during fetal asphyxia. RMSSD may accurately identify asphyxic fetuses early. Clinical validation is needed...
  84. ncbi request reprint Motor impairment influences Farnsworth-Munsell 100 Hue test error scores in Parkinson's disease patients
    Thomas Muller
    Department of Neurology, Ruhr University of Bochum, St Josef Hospital, Gudrunstrasse 56, Bochum 44791, Germany
    J Neurol Sci 213:61-5. 2003
    ..016) lower in patients with better peg insertion outcome. A significant (Spearman R=0.47, p=0.012) correlation between peg insertion results and the FMT error scores appeared. Motor impairment influences FMT error scores in PD patients...
  85. doi request reprint Malnutritional neuropathy under intestinal levodopa infusion
    Fabian Klostermann
    Deptartment of Neurology, CBF, Charite University Medicine Berlin, Hindenburdamm 30, 12203 Berlin, Germany
    J Neural Transm 119:369-72. 2012
    ..We assume that LCIG can provoke PNP most likely of malnutritional origin. To avoid this side effect, the assessment of predisposing factors before treatment as well as neurophysiological and laboratory screenings appear necessary...
  86. ncbi request reprint Polymorphisms in the interleukin-1 alpha and beta genes and the risk for Parkinson's disease
    Thorsten Schulte
    Department of Neurology, Ruhr University Bochum, St Josef Hospital, Bochum, Germany
    Neurosci Lett 326:70-2. 2002
    ..We found T in position -511 in the IL-1 beta gene more frequent in patients compared to controls (chi(2)=4.44, P=0.034). For the IL-1 alpha-889 polymorphism no significant difference between patients and controls was observed...
  87. ncbi request reprint Treatment of somatoform disorders with St. John's wort: a randomized, double-blind and placebo-controlled trial
    Thomas Muller
    Department of Neurology, St Josef Hospital Bochum, Ruhr University Bochum, Germany
    Psychosom Med 66:538-47. 2004
    ..To investigate efficacy and safety of St. John's wort (SJW) LI 160 in somatoform disorders...
  88. doi request reprint Role of intraspinal steroid application in patients with multiple sclerosis
    Thomas Muller
    Department of Neurology, St Joseph Hospital, Berlin Weissensee, Gartenstrasse 1, 13088 Berlin, Germany
    Expert Rev Neurother 9:1279-87. 2009
    ....
  89. ncbi request reprint Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain
    Martin A Sieber
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    J Neurosci 27:4902-9. 2007
    ..In Lbx1 mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons...
  90. ncbi request reprint Neuroleptic malignant-like syndrome after rapid switch from bromocriptine to pergolide
    Jens Reimer
    Department of Neurology, St Josef Hospital, Ruhr University Bochum, Gudrunstrasse 56, Germany
    Parkinsonism Relat Disord 9:115-6. 2002
    ....