W Meyerhof

Summary

Affiliation: German Institute of Human Nutrition
Country: Germany

Publications

  1. ncbi The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    Bernd Bufe
    Department of Molecular Genetics, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Potsdam Rehbrücke, Germany
    Nat Genet 32:397-401. 2002
  2. ncbi Human bitter taste perception
    Wolfgang Meyerhof
    German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Molecular Genetics, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany
    Chem Senses 30:i14-5. 2005
  3. ncbi Independent evolution of bitter-taste sensitivity in humans and chimpanzees
    Stephen Wooding
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Nature 440:930-4. 2006
  4. ncbi Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor
    Marcel Winnig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    BMC Neurosci 6:22. 2005
  5. ncbi Signaling in chemosensory systems
    W Meyerhof
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany
    Cell Mol Life Sci 63:1461-4. 2006
  6. ncbi Elucidation of mammalian bitter taste
    Wolfgang Meyerhof
    German Institute of Human Nutrition Potsdam Rehbrucke, Department of Molecular Genetics, Arthur Scheunert Allee 114 1 16, 14558 Nuthetal, Germany
    Rev Physiol Biochem Pharmacol 154:37-72. 2005
  7. ncbi Oligomerization of TAS2R bitter taste receptors
    Christina Kuhn
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal 14558, Germany
    Chem Senses 35:395-406. 2010
  8. ncbi Bitter taste receptors for saccharin and acesulfame K
    Christina Kuhn
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, 14558 Nuthetal, Germany
    J Neurosci 24:10260-5. 2004
  9. ncbi Mammalian bitter taste perception
    M Behrens
    German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, 14558, Germany
    Results Probl Cell Differ 47:203-20. 2009
  10. ncbi Involvement of a Pit-1 binding site in the regulation of the rat somatostatin receptor 1 gene expression
    H Baumeister
    Department of Molecular Genetics, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Ann N Y Acad Sci 865:390-2. 1998

Collaborators

Detail Information

Publications37

  1. ncbi The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides
    Bernd Bufe
    Department of Molecular Genetics, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Potsdam Rehbrücke, Germany
    Nat Genet 32:397-401. 2002
    ..If the ability of TAS2R16 to detect substances with common molecular properties is typical of the bitter receptor family, it may explain how a few receptors permit the perception of numerous bitter substances...
  2. ncbi Human bitter taste perception
    Wolfgang Meyerhof
    German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Molecular Genetics, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany
    Chem Senses 30:i14-5. 2005
  3. ncbi Independent evolution of bitter-taste sensitivity in humans and chimpanzees
    Stephen Wooding
    Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112 5330, USA
    Nature 440:930-4. 2006
    ..Humans and chimpanzees share variable taste sensitivity to bitter compounds mediated by PTC receptor variants, but the molecular basis of this variation has arisen twice, independently, in the two species...
  4. ncbi Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor
    Marcel Winnig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    BMC Neurosci 6:22. 2005
    ..Using mutational analysis we investigated which amino acid residues distinguish lactisole insensitive rat from sensitive human T1R3 receptors...
  5. ncbi Signaling in chemosensory systems
    W Meyerhof
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany
    Cell Mol Life Sci 63:1461-4. 2006
  6. ncbi Elucidation of mammalian bitter taste
    Wolfgang Meyerhof
    German Institute of Human Nutrition Potsdam Rehbrucke, Department of Molecular Genetics, Arthur Scheunert Allee 114 1 16, 14558 Nuthetal, Germany
    Rev Physiol Biochem Pharmacol 154:37-72. 2005
    ..Thus, dedicated taste receptor cells appear to function as broadly tuned detectors for bitter substances and are wired to elicit aversive behavior...
  7. ncbi Oligomerization of TAS2R bitter taste receptors
    Christina Kuhn
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal 14558, Germany
    Chem Senses 35:395-406. 2010
    ..Thus, our results show that receptor oligomerization occurs between TAS2R bitter taste receptors; however, functional consequences of hetero-oligomerization were not obvious...
  8. ncbi Bitter taste receptors for saccharin and acesulfame K
    Christina Kuhn
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, 14558 Nuthetal, Germany
    J Neurosci 24:10260-5. 2004
    ..Consistent with the in vitro data, cross-adaptation studies in human subjects also support the existence of common receptors for both sulfonyl amide sweeteners...
  9. ncbi Mammalian bitter taste perception
    M Behrens
    German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, 14558, Germany
    Results Probl Cell Differ 47:203-20. 2009
    ....
  10. ncbi Involvement of a Pit-1 binding site in the regulation of the rat somatostatin receptor 1 gene expression
    H Baumeister
    Department of Molecular Genetics, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Ann N Y Acad Sci 865:390-2. 1998
    ....
  11. ncbi Molecular cloning and characterisation of DESC4, a new transmembrane serine protease
    M Behrens
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Cell Mol Life Sci 61:2866-77. 2004
    ..Our results suggest that we have identified a protease that is an important constituent of sensory systems and other organs...
  12. ncbi The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception
    Bernd Bufe
    German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany
    Curr Biol 15:322-7. 2005
    ..The molecular mechanisms of perceived bitterness variability have therapeutic implications, such as helping patients to consume beneficial bitter-tasting compounds-for example, pharmaceuticals and selected phytochemicals...
  13. ncbi The molecular receptive ranges of human TAS2R bitter taste receptors
    Wolfgang Meyerhof
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Chem Senses 35:157-70. 2010
    ..Conversely, though 63 bitter substances activated only 1-3 receptors, 19 compounds stimulated up to 15 hTAS2Rs. Our data suggest that the detection of the numerous bitter chemicals is related to the molecular receptive ranges of hTAS2Rs...
  14. ncbi Bitter taste receptors and their cells
    Maik Behrens
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Ann N Y Acad Sci 1170:111-5. 2009
    ..The article presented here addresses biosynthesis, functional analyses of TAS2Rs and TAS2R variants, as well as gustatory expression of hTAS2R genes...
  15. ncbi Substrate specificity of rat DESC4, a type II transmembrane serine protease
    Maik Behrens
    German Institute of Human Nutrition Potsdam Rehbruecke, Dept Molecular Genetics, 14558 Nuthetal, Germany
    Protein Pept Lett 16:1-6. 2009
    ..For further analyses a homology-based model of the DESC4 catalytic domain was generated enabling us to investigate protease-substrate interaction in more detail...
  16. ncbi Sour taste cells functionally identified
    Wolfgang Meyerhof
    German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Molecular Genetics, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany
    J Physiol 586:2819. 2008
  17. ncbi Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells
    Maik Behrens
    German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    J Neurosci 27:12630-40. 2007
    ..From the data, we conclude that human bitter taste receptor cells are tuned to detect a limited subset of bitter stimuli...
  18. ncbi Oral and extraoral bitter taste receptors
    Maik Behrens
    Department Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Results Probl Cell Differ 52:87-99. 2010
    ....
  19. ncbi Leptin-target neurones of the rat hypothalamus express somatostatin receptors
    Z Stepanyan
    Department of Molecular Genetics, German Institute of Human Nutrition, , Germany
    J Neuroendocrinol 15:822-30. 2003
    ..These results provide strong anatomical evidence for the direct interaction of leptin and the somatostatin systems in neuroendocrine control loops such as the energy homeostasis, growth or stress response...
  20. ncbi Functions of human bitter taste receptors depend on N-glycosylation
    Claudia Reichling
    Department Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Neurochem 106:1138-48. 2008
    ..As the auxiliary factors receptor transporting proteins 3 and 4 are able to restore the function of non-glycosylated hTAS2R16 partially, we conclude that glycosylation is important for receptor maturation but not for its function per se...
  21. ncbi Members of RTP and REEP gene families influence functional bitter taste receptor expression
    Maik Behrens
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Biol Chem 281:20650-9. 2006
    ..Finally, expression analyses demonstrate RTP and REEP gene expression in human circumvallate papillae and testis, both of which are sites of TAS2R gene expression...
  22. ncbi Bitter taste receptors and human bitter taste perception
    M Behrens
    Dept Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558, Nuthetal, Germany
    Cell Mol Life Sci 63:1501-9. 2006
    ....
  23. ncbi Structural requirements of bitter taste receptor activation
    Anne Brockhoff
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    Proc Natl Acad Sci U S A 107:11110-5. 2010
    ..Detailed structure-function analyses of hTAS2Rs may ultimately pave the way for the development of specific antagonists urgently needed for more sophisticated analyses of human bitter taste perception...
  24. ncbi The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor
    Marcel Winnig
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Molecular Genetics, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    BMC Struct Biol 7:66. 2007
    ..Analysis of interspecies combinations and chimeras of rat and human TAS1R2+TAS1R3 suggested that the heptahelical domain of human TAS1R3 is crucial for the activation of the sweet receptor by neohesperidin dihydrochalcone...
  25. ncbi The human taste receptor hTAS2R14 responds to a variety of different bitter compounds
    Maik Behrens
    Department of Molecular Genetics, German Institute of Human Nutrition, Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany
    Biochem Biophys Res Commun 319:479-85. 2004
    ....
  26. ncbi Somatostatin, a negative-regulator of central leptin action in the rat hypothalamus
    Z Stepanyan
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbrücke Nethetal, Germany
    J Neurochem 100:468-78. 2007
    ..These results suggest that the pleiotropic effector somatostatin also plays a role in the central regulation of energy homeostasis...
  27. ncbi Presence of a plasma membrane targeting sequence in the amino-terminal region of the rat somatostatin receptor 3
    C Ammon
    Department of Molecular Genetics, German Institute of Human Nutrition, Potsdam Rehbrucke, Germany
    Arch Physiol Biochem 110:137-45. 2002
    ..In marked contrast, chimeric receptors that lack this sequence but contain instead the amino-terminus of somatostatin type 1 receptor localize in an intracellular vesicular compartment...
  28. ncbi Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
    Anne Brockhoff
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Agric Food Chem 55:6236-43. 2007
    ....
  29. ncbi The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin
    Maik Behrens
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Agric Food Chem 57:9860-6. 2009
    ..Insights into the general breadth of tuning, functional redundancies, and relationships between pharmacological activation patterns and amino acid homologies for this receptor subfamily are presented...
  30. ncbi Structural properties of orexins for activation of their receptors
    Manja Lang
    Institute of Biochemistry, University of Leipzig, Germany
    J Pept Sci 12:258-66. 2006
    ..Additionally, we showed that no particular secondary structure is required for receptor subtype selectivity...
  31. ncbi Sweet taste receptor interacting protein CIB1 is a general inhibitor of InsP3-dependent Ca2+ release in vivo
    Jan K Hennigs
    Institut für Biochemie und Molekularbiologie II, Molekulare Zellbiologie, Zentrum für Experimentelle Medizin, Hamburg, Germany
    J Neurochem 106:2249-62. 2008
    ..The function of CIB1 on InsP3-evoked Ca2+ release from the ER is most likely mediated by its interaction with the InsP3 receptor. Thus, CIB1 seems to be an inhibitor of InsP3-dependent Ca2+ release in vivo...
  32. ncbi Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence
    Anthony L Hinrichs
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 78:103-11. 2006
    ..6%), whereas 45% of African Americans carry the allele (MAF 26%), which makes it a much more significant risk factor in the African American population...
  33. ncbi A TAS1R receptor-based explanation of sweet 'water-taste'
    Veronica Galindo-Cuspinera
    Monell Chemical Senses Center, 3500 Market Street, Philadelphia, Pennsylvania 19104, USA
    Nature 441:354-7. 2006
    ..This 'rebound' activity occurs when equilibrium forces on the two-state allosteric sweet receptors result in their coordinated shift to the activated state upon being released from inhibition by rinsing...
  34. ncbi Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16
    Nicole Soranzo
    Department of Biology, University College London, United Kingdom
    Curr Biol 15:1257-65. 2005
    ..The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity...
  35. ncbi Early developmental expression of leptin receptor gene and [125I]leptin binding in the rat forebrain
    Anne Sophie Carlo
    Metabolic Health Group, Rowett Research Institute, Greenburn Rd, Bucksburn, Aberdeen, Scotland, UK
    J Chem Neuroanat 33:155-63. 2007
    ..Together these findings demonstrate that the leptin receptor system is differentially regulated during late gestation and early postnatal life in the rat...
  36. ncbi Agonist-induced endocytosis of rat somatostatin receptor 1
    Dirk Roosterman
    Department of Dermatology, and Ludwig Boltzmann Institute for Cell and Immunobiology of the Skin, Von Esmarch Strasse 58, D 48148 Münster, Germany
    Endocrinology 148:1050-8. 2007
    ..Our results show for the first time that sst1 mediates a dynamic process of endocytosis, recycling, and re-endocytosis of its cognate ligand...
  37. ncbi Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2
    Kristin Schmiedeberg
    German Institute of Human Nutrition, Potsdam Rehbruecke, Department of Molecular Genetics, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Struct Biol 159:400-12. 2007
    ..Our results show that the orientation of odorants within a homology modelling-derived binding pocket of olfactory receptor orthologs is defined by evolutionary conserved amino acid positions...