Britta Mersch

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc SERpredict: detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements
    Britta Mersch
    Department of Molecular Biophysics, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Genet 8:78. 2007
  2. ncbi request reprint Evolutionary optimization of sequence kernels for detection of bacterial gene starts
    Britta Mersch
    Abteilung Molekulare Biophysik, German Cancer Research Center, 69120 Heidelberg, Germany
    Int J Neural Syst 17:369-81. 2007
  3. pmc Automatic detection of exonic splicing enhancers (ESEs) using SVMs
    Britta Mersch
    Department of Molecular Biophysics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, Germany
    BMC Bioinformatics 9:369. 2008
  4. pmc Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome
    Noa Sela
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Genome Biol 8:R127. 2007
  5. ncbi request reprint Gradient-based optimization of kernel-target alignment for sequence kernels applied to bacterial gene start detection
    Christian Igel
    Institut fur Neuroinformatik, Ruhr Universitat Bochum, Bochum, Germany
    IEEE/ACM Trans Comput Biol Bioinform 4:216-26. 2007

Detail Information

Publications5

  1. pmc SERpredict: detection of tissue- or tumor-specific isoforms generated through exonization of transposable elements
    Britta Mersch
    Department of Molecular Biophysics, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Genet 8:78. 2007
    ..Thus, exonizations can have negative effects for the transcriptome of an organism...
  2. ncbi request reprint Evolutionary optimization of sequence kernels for detection of bacterial gene starts
    Britta Mersch
    Abteilung Molekulare Biophysik, German Cancer Research Center, 69120 Heidelberg, Germany
    Int J Neural Syst 17:369-81. 2007
    ..The resulting kernels lead to higher classification rates, and the adapted parameters reveal the importance of particular triplets for classification, for example of those occurring in the Shine-Dalgarno Sequence...
  3. pmc Automatic detection of exonic splicing enhancers (ESEs) using SVMs
    Britta Mersch
    Department of Molecular Biophysics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, Heidelberg, Germany
    BMC Bioinformatics 9:369. 2008
    ..Identifying SR protein-binding sites in human DNA sequences by machine learning techniques is a formidable task, since the exon sequences are also constrained by their functional role in coding for proteins...
  4. pmc Comparative analysis of transposed element insertion within human and mouse genomes reveals Alu's unique role in shaping the human transcriptome
    Noa Sela
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel
    Genome Biol 8:R127. 2007
    ..Transposed elements (TEs) have a substantial impact on mammalian evolution and are involved in numerous genetic diseases. We compared the impact of TEs on the human transcriptome and the mouse transcriptome...
  5. ncbi request reprint Gradient-based optimization of kernel-target alignment for sequence kernels applied to bacterial gene start detection
    Christian Igel
    Institut fur Neuroinformatik, Ruhr Universitat Bochum, Bochum, Germany
    IEEE/ACM Trans Comput Biol Bioinform 4:216-26. 2007
    ..The power of this new, general model selection procedure and the benefits of fitting kernels to problem classes are demonstrated by adapting oligo kernels for bacterial gene start detection...