Alexander Mehrle

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc The LIFEdb database in 2006
    Alexander Mehrle
    Division Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Nucleic Acids Res 34:D415-8. 2006
  2. pmc The full-ORF clone resource of the German cDNA Consortium
    Stephanie Bechtel
    Department of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Genomics 8:399. 2007
  3. pmc High-throughput protein analysis integrating bioinformatics and experimental assays
    Coral Del Val
    Division of Molecular Biophysics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Nucleic Acids Res 32:742-8. 2004
  4. pmc From ORFeome to biology: a functional genomics pipeline
    Stefan Wiemann
    Molecular Genome Analysis, German Cancer Research Center, 69120 Heidelberg, Germany
    Genome Res 14:2136-44. 2004
  5. ncbi Functional profiling: from microarrays via cell-based assays to novel tumor relevant modulators of the cell cycle
    Dorit Arlt
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 65:7733-42. 2005
  6. pmc The systematic functional characterisation of Xq28 genes prioritises candidate disease genes
    Anja Kolb-Kokocinski
    Division of Molecular Genome Analysis, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    BMC Genomics 7:29. 2006
  7. pmc Extending pathways based on gene lists using InterPro domain signatures
    Florian Hahne
    German Cancer Research Center, Molecular Genome Analysis, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    BMC Bioinformatics 9:3. 2008
  8. ncbi CDNAs for functional genomics and proteomics: the German Consortium
    Stefan Wiemann
    Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    C R Biol 326:1003-9. 2003
  9. pmc The 3of5 web application for complex and comprehensive pattern matching in protein sequences
    Markus Seiler
    Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    BMC Bioinformatics 7:144. 2006
  10. pmc LIFEdb: a database for functional genomics experiments integrating information from external sources, and serving as a sample tracking system
    Detlev Bannasch
    German Cancer Research Center DKFZ, Division of Molecular Genome Analysis, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Nucleic Acids Res 32:D505-8. 2004

Collaborators

Detail Information

Publications10

  1. pmc The LIFEdb database in 2006
    Alexander Mehrle
    Division Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Nucleic Acids Res 34:D415-8. 2006
    ..LIFEdb enables researchers to systematically select and characterize genes and proteins of interest, and presents data and information via its user-friendly web-based interface...
  2. pmc The full-ORF clone resource of the German cDNA Consortium
    Stephanie Bechtel
    Department of Molecular Genome Analysis, German Cancer Research Center DKFZ, Heidelberg, Germany
    BMC Genomics 8:399. 2007
    ..In combination with a unique and versatile cloning system, these will provide the tools for genome-wide systematic functional analyses, to achieve a deeper insight into complex biological processes...
  3. pmc High-throughput protein analysis integrating bioinformatics and experimental assays
    Coral Del Val
    Division of Molecular Biophysics, German Cancer Research Center DKFZ, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Nucleic Acids Res 32:742-8. 2004
    ....
  4. pmc From ORFeome to biology: a functional genomics pipeline
    Stefan Wiemann
    Molecular Genome Analysis, German Cancer Research Center, 69120 Heidelberg, Germany
    Genome Res 14:2136-44. 2004
    ..All information is presented in a Web database (http://www.dkfz.de/LIFEdb). It is exploited for the identification of disease-relevant genes and proteins for diagnosis and therapy...
  5. ncbi Functional profiling: from microarrays via cell-based assays to novel tumor relevant modulators of the cell cycle
    Dorit Arlt
    Division of Molecular Genome Analysis, German Cancer Research Center, Heidelberg, Germany
    Cancer Res 65:7733-42. 2005
    ..We have established a novel functional profiling strategy that links genomics to cell biology and showed its potential for discerning cancer relevant modulators of the cell cycle in the candidate lists from microarray studies...
  6. pmc The systematic functional characterisation of Xq28 genes prioritises candidate disease genes
    Anja Kolb-Kokocinski
    Division of Molecular Genome Analysis, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    BMC Genomics 7:29. 2006
    ..To expedite disease gene identification, we have initiated the functional characterisation of all known Xq28 genes...
  7. pmc Extending pathways based on gene lists using InterPro domain signatures
    Florian Hahne
    German Cancer Research Center, Molecular Genome Analysis, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    BMC Bioinformatics 9:3. 2008
    ..This works by comparing InterPro domain signatures of the candidate gene lists with domain signatures of gene sets derived from known classifications, e.g. KEGG pathways...
  8. ncbi CDNAs for functional genomics and proteomics: the German Consortium
    Stefan Wiemann
    Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    C R Biol 326:1003-9. 2003
    ..The resulting information is integrated with functional genomics and proteomics data for further understanding of protein functions in the cellular context...
  9. pmc The 3of5 web application for complex and comprehensive pattern matching in protein sequences
    Markus Seiler
    Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    BMC Bioinformatics 7:144. 2006
    ..This is especially true for patterns containing ambiguous characters and positions and/or length ambiguities...
  10. pmc LIFEdb: a database for functional genomics experiments integrating information from external sources, and serving as a sample tracking system
    Detlev Bannasch
    German Cancer Research Center DKFZ, Division of Molecular Genome Analysis, Im Neuenheimer Feld 580, D 69120 Heidelberg, Germany
    Nucleic Acids Res 32:D505-8. 2004
    ..A web interface enables the scientific community to explore and visualize features of the annotated cDNAs and ORFs combined with experimental results, and thus helps to unravel new features of proteins with as yet unknown functions...