E Medina

Summary

Affiliation: German Research Centre for Biotechnology
Country: Germany

Publications

  1. pmc Intracellular survival of Streptococcus pyogenes in polymorphonuclear cells results in increased bacterial virulence
    Eva Medina
    Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Centre for Biotechnology, Braunschweig, Germany
    Infect Immun 71:5376-80. 2003
  2. ncbi request reprint Genetic control of susceptibility to group A streptococcal infection in mice
    E Medina
    Division of Microbiology, Department of Microbial Pathogenesis and Vaccine Research, National Research Centre for Biotechnology, Braunschweig, Germany
    J Infect Dis 184:846-52. 2001
  3. ncbi request reprint Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion
    Eva Medina
    Department of Microbial Pathogenesis and Vaccine Research, German Research Centre for Biotechnology, Braunschweig, Germany
    J Infect Dis 187:597-603. 2003
  4. ncbi request reprint Induction of NF-kappaB nuclear translocation in human respiratory epithelial cells by group A streptococci
    Eva Medina
    Department of Microbial Pathogenesis and Vaccine Research, GBF National Research Centre for Biotechnology, Braunschweig, Germany
    Microb Pathog 33:307-13. 2002
  5. pmc Characterization of the domain of fibronectin-binding protein I of Streptococcus pyogenes responsible for elicitation of a protective immune response
    K Schulze
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Infect Immun 69:622-5. 2001
  6. ncbi request reprint Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI
    C A Guzman
    Department of Microbial Pathogenicity and Vaccine Research, Division of Microbiology, GBF National Research Centre for Biotechnology, 38124 Braunschweig, Germany
    J Infect Dis 179:901-6. 1999
  7. ncbi request reprint Attenuated Listeria monocytogenes carrier strains can deliver an HIV-1 gp120 T helper epitope to MHC class II-restricted human CD4+ T cells
    C A Guzman
    Division of Microbiology, GBF National Research Centre for Biotechnology, Braunschweig, Germany
    Eur J Immunol 28:1807-14. 1998
  8. ncbi request reprint Use of live bacterial vaccine vectors for antigen delivery: potential and limitations
    E Medina
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF-German Research Center for Biotechnology, Mascheroder Weg 1, D-38124, Braunschweig, Germany
    Vaccine 19:1573-80. 2001
  9. ncbi request reprint Role played by the response regulator Ris in Bordetella bronchiseptica resistance to macrophage killing
    K Zimna
    Division of Microbiology, GBF-German Research Centre for Biotechnology, Braumschweig, Germany
    FEMS Microbiol Lett 201:177-80. 2001
  10. ncbi request reprint Upregulation of capsule enables Streptococcus pyogenes to evade immune recognition by antigen-specific antibodies directed to the G-related alpha2-macroglobulin-binding protein GRAB located on the bacterial surface
    Katrin Dinkla
    Department of Microbial Pathogenicity, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Microbes Infect 9:922-31. 2007

Collaborators

Detail Information

Publications30

  1. pmc Intracellular survival of Streptococcus pyogenes in polymorphonuclear cells results in increased bacterial virulence
    Eva Medina
    Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Centre for Biotechnology, Braunschweig, Germany
    Infect Immun 71:5376-80. 2003
    ..Here we provide evidence that S. pyogenes can escape from the phagosome into the cytoplasm of phagocytic cells. Furthermore, intracellular bacteria seem to undergo phenotypic switching that results in much more virulent microorganisms...
  2. ncbi request reprint Genetic control of susceptibility to group A streptococcal infection in mice
    E Medina
    Division of Microbiology, Department of Microbial Pathogenesis and Vaccine Research, National Research Centre for Biotechnology, Braunschweig, Germany
    J Infect Dis 184:846-52. 2001
    ..The use of this mouse model of group A streptococcal infection will allow for a better definition of parameters involved in the outcome of the disease...
  3. ncbi request reprint Survival of Streptococcus pyogenes within host phagocytic cells: a pathogenic mechanism for persistence and systemic invasion
    Eva Medina
    Department of Microbial Pathogenesis and Vaccine Research, German Research Centre for Biotechnology, Braunschweig, Germany
    J Infect Dis 187:597-603. 2003
    ..The ability of S. pyogenes to exploit the inflammatory response of the host by surviving inside phagocytic cells may constitute an additional virulence mechanism of this pathogen...
  4. ncbi request reprint Induction of NF-kappaB nuclear translocation in human respiratory epithelial cells by group A streptococci
    Eva Medina
    Department of Microbial Pathogenesis and Vaccine Research, GBF National Research Centre for Biotechnology, Braunschweig, Germany
    Microb Pathog 33:307-13. 2002
    ..pyogenes alone might be sufficient to stimulate nuclear translocation of NF-kappaB, however, bacterial internalization is required for a sustained nuclear translocation of this transcriptional factor...
  5. pmc Characterization of the domain of fibronectin-binding protein I of Streptococcus pyogenes responsible for elicitation of a protective immune response
    K Schulze
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Infect Immun 69:622-5. 2001
    ..These results demonstrate that the fibronectin-binding region of SfbI is a promising candidate antigen for developing anti-S. pyogenes vaccines...
  6. ncbi request reprint Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI
    C A Guzman
    Department of Microbial Pathogenicity and Vaccine Research, Division of Microbiology, GBF National Research Centre for Biotechnology, 38124 Braunschweig, Germany
    J Infect Dis 179:901-6. 1999
    ..These results suggest that SfbI is a promising candidate for inclusion in acellular vaccines against S. pyogenes...
  7. ncbi request reprint Attenuated Listeria monocytogenes carrier strains can deliver an HIV-1 gp120 T helper epitope to MHC class II-restricted human CD4+ T cells
    C A Guzman
    Division of Microbiology, GBF National Research Centre for Biotechnology, Braunschweig, Germany
    Eur J Immunol 28:1807-14. 1998
    ..The eukaryotic cell compartment in which the antigen is synthesized, and the mode of display seem to play a minor role in the overall efficiency of epitope processing and presentation...
  8. ncbi request reprint Use of live bacterial vaccine vectors for antigen delivery: potential and limitations
    E Medina
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF-German Research Center for Biotechnology, Mascheroder Weg 1, D-38124, Braunschweig, Germany
    Vaccine 19:1573-80. 2001
    ..The potential and limitations of the most extensively studied bacterial carrier systems will be discussed...
  9. ncbi request reprint Role played by the response regulator Ris in Bordetella bronchiseptica resistance to macrophage killing
    K Zimna
    Division of Microbiology, GBF-German Research Centre for Biotechnology, Braumschweig, Germany
    FEMS Microbiol Lett 201:177-80. 2001
    ..In this study we demonstrate that ris-regulated products play a role in B. bronchiseptica resistance against both phagosomal acidification and reactive oxygen intermediates...
  10. ncbi request reprint Upregulation of capsule enables Streptococcus pyogenes to evade immune recognition by antigen-specific antibodies directed to the G-related alpha2-macroglobulin-binding protein GRAB located on the bacterial surface
    Katrin Dinkla
    Department of Microbial Pathogenicity, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Microbes Infect 9:922-31. 2007
    ..Thus, masking of surface immunogenic determinants by the hyaluronic acid capsule may constitute a novel mechanism of S. pyogenes for evasion of antigen-specific antibodies...
  11. pmc Role of macrophages in host resistance to group A streptococci
    Oliver Goldmann
    Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Centre for Biotechnology, Braunschweig, Germany
    Infect Immun 72:2956-63. 2004
    ..These results emphasize the important contribution of macrophages to the early control of S. pyogenes infection...
  12. pmc Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program
    Oliver Goldmann
    Infection Immunology Research Group, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Infect Immun 75:4148-57. 2007
    ..An understanding of how macrophages respond to S. pyogenes at the molecular level may facilitate the development of new therapeutic paradigms...
  13. ncbi request reprint Contribution of protein G-related alpha2-macroglobulin-binding protein to bacterial virulence in a mouse skin model of group A streptococcal infection
    Antonia W Toppel
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Center for Biotechnology, Braunschweig, Germany
    J Infect Dis 187:1694-703. 2003
    ..Thus, mice infected with MR4 survived longer, developed smaller skin lesions, and exhibited lower levels of bacterial dissemination than did those infected with KTL3. These results emphasize the role of GRAB as a virulence factor of GAS...
  14. ncbi request reprint Stimulation of long-lasting protection against Streptococcus pyogenes after intranasal vaccination with non adjuvanted fibronectin-binding domain of the SfbI protein
    Kai Schulze
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    Vaccine 21:1958-64. 2003
    ..The adjuvant properties exhibited by the fibronectin-binding domain of the SfbI protein strength the potential of this antigen for inclusion in multi-component vaccines against S. pyogenes...
  15. ncbi request reprint Immune mechanisms underlying host susceptibility to infection with group A streptococci
    Oliver Goldmann
    Division of Microbiology, Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Centre for Biotechnology, Mascheroder Weg 1, D 38124 Braunschweig, Germany
    J Infect Dis 187:854-61. 2003
    ....
  16. ncbi request reprint Vaccination equally enables both genetically susceptible and resistant mice to control infection with group A streptococci
    Jeannette Siegert
    Infection Immunology Group, Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Center for Biotechnology, Mascheroder Weg 1, 38124 Braunschweig, Germany
    Microbes Infect 8:347-53. 2006
    ....
  17. ncbi request reprint Contribution of interleukin-6/gp 130 signaling in hepatocytes to the inflammatory response in mice infected with Streptococcus pyogenes
    Christian Klein
    Medizinische Klinik III, University Hospital Aachen, Rheinisch Westfalisch Techniche Hochschule Aachen, Aachen, Germany
    J Infect Dis 196:755-62. 2007
    ..Here, we investigated whether blockage of the transducer gp130, a receptor involved in the regulation of the inflammatory response, might be useful in the treatment of experimental gram-positive sepsis...
  18. doi request reprint Phagocytosis-independent antimicrobial activity of mast cells by means of extracellular trap formation
    Maren von Köckritz-Blickwede
    Infection Immunology Research Group, Helmholtz Center for Infection Research, Braunschweig, Germany
    Blood 111:3070-80. 2008
    ..Our study provides the first experimental evidence of antimicrobial extracellular traps formation by an immune cell population other than neutrophils...
  19. ncbi request reprint The contribution of dendritic cells to host defenses against Streptococcus pyogenes
    Torsten G Loof
    Infection Immunology Research Group and Department of Microbial Pathogenesis, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    J Infect Dis 196:1794-803. 2007
    ..Infection with Streptococcus pyogenes remains a significant health care problem. The identification of immune components required for host defenses against S. pyogenes constitutes an important area of research...
  20. ncbi request reprint Genetic regulation of host responses to group A streptococcus in mice
    Eva Medina
    Infection Immunology Research Group Infection Genetics, Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Centre for Biotechnology, 38124 Braunschweig, Germany
    Brief Funct Genomic Proteomic 4:248-57. 2005
    ....
  21. ncbi request reprint Intranasal immunization with serum opacity factor (SOF) of Streptococcus pyogenes fails to protect mice against lethal mucosal challenge with a heterologous strain
    Kai Schulze
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Vaccine 24:1446-50. 2006
    ..These results highlight the importance of developing adequate experimental animal models to evaluate vaccine efficiency, according to the selected antigen...
  22. ncbi request reprint Superior virulence of Mycobacterium bovis over Mycobacterium tuberculosis (Mtb) for Mtb-resistant and Mtb-susceptible mice is manifest as an ability to cause extrapulmonary disease
    Eva Medina
    The Trudeau Institute, 145 Algonquin Ave, Saranac Lake, NY 12983, USA
    Tuberculosis (Edinb) 86:20-7. 2006
    ..It is proposed that disease of the adrenal glands might serve to explain why M. bovis caused mice of both strains to die with the same much shorter MST...
  23. ncbi request reprint The role of the MHC on resistance to group a streptococci in mice
    Oliver Goldmann
    Infection Immunology Group, Gesellschaft fur Biotechnologishe Forschung German Research Center for Biotechnology, Braunschweig, Germany
    J Immunol 175:3862-72. 2005
    ..pyogenes may be associated with an altered transcription of specific genes that may compromise the endogenous regulatory processes controlling the inflammatory cascade and favor the progression to sepsis...
  24. ncbi request reprint Contribution of natural killer cells to the pathogenesis of septic shock induced by Streptococcus pyogenes in mice
    Oliver Goldmann
    Department of Microbial Pathogenesis and Vaccine Research, GBF German Research Center for Biotechnology, Braunschweig, Germany
    J Infect Dis 191:1280-6. 2005
    ..pyogenes than were the corresponding control mice. We conclude that NK cells, by amplifying the inflammatory response, significantly contribute to the progression of S. pyogenes-induced septic shock...
  25. ncbi request reprint Role of host genetic factors in susceptibility to group A streptococcal infections
    Oliver Goldmann
    Division of Microbiology, Department of Microbial Pathogenesis and Vaccine Research, GBF National Research Centre for Biotechnology, Braunschweig, Germany
    Indian J Med Res 119:141-3. 2004
    ..The objective of the present study was to determine the extent to which the genetic background of the mouse strain affected induction and resolution of GAS infection...
  26. pmc Identification of B- and T-cell epitopes within the fibronectin-binding domain of the SfbI protein of Streptococcus pyogenes
    Kai Schulze
    Department of Microbial Pathogenesis and Vaccine Research, Division of Microbiology, GBF German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Infect Immun 71:7197-201. 2003
    ..All identified epitopes clustered in a 30-amino-acid fragment. These results suggest that this polypeptide may be suitable for incorporation into a polyepitope-based vaccine formulation against S. pyogenes...
  27. pmc Phagocytosis of bacille Calmette-Guérin-infected necrotic macrophages induces a maturation phenotype and evokes antigen-presentation functions in dendritic cells
    Oliver Goldmann
    Department of Microbial Pathogenesis and Vaccine Research, GBF National Research Centre for Biotechnology, Braunschweig, Germany
    Immunology 107:500-6. 2002
    ....
  28. pmc Characterization of a novel intracellularly activated gene from Salmonella enterica serovar typhi
    Holger Basso
    Division of Microbiology, GBF German Research Centre for Biotechnology, D 38124 Braunschweig, Germany
    Infect Immun 70:5404-11. 2002
    ..However, gaiA was not required for initial intracellular survival in human cells, indicating that its role in the natural host might be more complex than is suggested by the studies performed in the murine system...
  29. ncbi request reprint The potential for vaccine development against rheumatic fever
    Eva Medina
    Department of Microbial Pathogenesis and Vaccine Research, GBF National Research Centre for Biotechnology, Braunschweig, Germany
    Indian Heart J 54:93-8. 2002
  30. pmc Immune recognition of Streptococcus pyogenes by dendritic cells
    Torsten G Loof
    Infection Immunology Research Group, Department of Microbial Pathogenesis, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Infect Immun 76:2785-92. 2008
    ..pyogenes sensing by DCs and argue for a multimodal recognition in which a combination of several different TLR-mediated signals is essential for a rapid and effective response to the pathogen...