D Mayer

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. pmc Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation
    Jean Grisouard
    Department of Biomedicine, University Hospital Basel, Basel, CH 4031, Switzerland
    Diabetol Metab Syndr 3:16. 2011
  2. ncbi request reprint Impact of dehydroepiandrosterone on hepatocarcinogenesis in the rat (Review)
    Doris Mayer
    Research Group Hormones and Signal Transduction, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Int J Oncol 25:1021-30. 2004
  3. ncbi request reprint Induction and modulation of hepatic preneoplasia and neoplasia in the rat by dehydroepiandrosterone
    Doris Mayer
    Research Group Hormones and Signal Transduction, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Toxicol Pathol 31:103-12. 2003
  4. ncbi request reprint Dehydroepiandrosterone increases the zone [correction of in zone] of glutamine synthetase-positive hepatocytes in female rat liver: a putative androgenic effect
    D Mayer
    Abteilung für Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Histochem Cell Biol 111:375-80. 1999
  5. ncbi request reprint Differential expression of key enzymes of energy metabolism in preneoplastic and neoplastic rat liver lesions induced by N-nitrosomorpholine and dehydroepiandrosterone
    D Mayer
    Division of Cell Pathology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 79:232-40. 1998
  6. ncbi request reprint Cytochemical and biochemical studies on adenylate cyclase activity in preneoplastic and neoplastic liver tissue and cultured liver cells
    D Mayer
    Abteilung Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Microsc Res Tech 40:463-72. 1998
  7. ncbi request reprint Sequential appearance and ultrastructure of amphophilic cell foci, adenomas, and carcinomas in the liver of male and female rats treated with dehydroepiandrosterone
    C Metzger
    Deutsches Krebsforschungszentrum, Abteilung Cytopathologie, Heidelberg, Germany
    Toxicol Pathol 23:591-605. 1995
  8. ncbi request reprint Activity of glycogen synthase and phosphorylase and glucose 6-phosphate content in renal clear cell carcinomas
    D Mayer
    Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    J Cancer Res Clin Oncol 114:369-72. 1988
  9. ncbi request reprint Re-evaluation of the specificity of adenylyl (beta,gamma-methylene)diphosphonate as a substrate for adenylate cyclase
    D Mayer
    Abteilung Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Histochem J 23:100-6. 1991
  10. pmc Glycogen phosphorylase isoenzymes from hepatoma 3924A and from a non-tumorigenic liver cell line. Comparison with the liver and brain enzymes
    D Mayer
    Abteilung Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    Biochem J 282:665-73. 1992

Collaborators

Detail Information

Publications18

  1. pmc Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation
    Jean Grisouard
    Department of Biomedicine, University Hospital Basel, Basel, CH 4031, Switzerland
    Diabetol Metab Syndr 3:16. 2011
    ..abstract:..
  2. ncbi request reprint Impact of dehydroepiandrosterone on hepatocarcinogenesis in the rat (Review)
    Doris Mayer
    Research Group Hormones and Signal Transduction, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Int J Oncol 25:1021-30. 2004
    ..This review summarizes the current knowledge on DHEA effects on the liver and discusses molecular and functional aspects that may explain the paradoxical effects of DHEA regarding hepatocarcinogenesis...
  3. ncbi request reprint Induction and modulation of hepatic preneoplasia and neoplasia in the rat by dehydroepiandrosterone
    Doris Mayer
    Research Group Hormones and Signal Transduction, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Toxicol Pathol 31:103-12. 2003
    ..This might be explained by a DHEA related cellular metabolism, which results in significant energy consumption. Additionally, a DHEA-induced alteration of cytokine levels might contribute to this growth inhibition as well...
  4. ncbi request reprint Dehydroepiandrosterone increases the zone [correction of in zone] of glutamine synthetase-positive hepatocytes in female rat liver: a putative androgenic effect
    D Mayer
    Abteilung für Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Histochem Cell Biol 111:375-80. 1999
    ..Furthermore, preneoplastic and neoplastic liver lesions induced by DHEA were all negative for GS, indicating that they do not derive from the perivenular cells which show the most pronounced peroxisomal proliferation...
  5. ncbi request reprint Differential expression of key enzymes of energy metabolism in preneoplastic and neoplastic rat liver lesions induced by N-nitrosomorpholine and dehydroepiandrosterone
    D Mayer
    Division of Cell Pathology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 79:232-40. 1998
    ....
  6. ncbi request reprint Cytochemical and biochemical studies on adenylate cyclase activity in preneoplastic and neoplastic liver tissue and cultured liver cells
    D Mayer
    Abteilung Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Microsc Res Tech 40:463-72. 1998
    ..It is concluded that alterations in cellular signal transduction caused by alterations in AC activity play an important role in hepatocarcinogenesis...
  7. ncbi request reprint Sequential appearance and ultrastructure of amphophilic cell foci, adenomas, and carcinomas in the liver of male and female rats treated with dehydroepiandrosterone
    C Metzger
    Deutsches Krebsforschungszentrum, Abteilung Cytopathologie, Heidelberg, Germany
    Toxicol Pathol 23:591-605. 1995
    ..Mitochondrial proliferation as the most prominent feature in all stages of this model of hepatocarcinogenesis may offer a new approach for analysis of hepatocarcinogenesis induced by DHEA and possibly other peroxisomal proliferators...
  8. ncbi request reprint Activity of glycogen synthase and phosphorylase and glucose 6-phosphate content in renal clear cell carcinomas
    D Mayer
    Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    J Cancer Res Clin Oncol 114:369-72. 1988
    ..These findings agree with those in some other glycogenotic tissues and support the concept that an accumulation of G6P is associated with excessive storage of glycogen in preneoplastic and neoplastic lesions...
  9. ncbi request reprint Re-evaluation of the specificity of adenylyl (beta,gamma-methylene)diphosphonate as a substrate for adenylate cyclase
    D Mayer
    Abteilung Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Histochem J 23:100-6. 1991
    ....
  10. pmc Glycogen phosphorylase isoenzymes from hepatoma 3924A and from a non-tumorigenic liver cell line. Comparison with the liver and brain enzymes
    D Mayer
    Abteilung Cytopathologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    Biochem J 282:665-73. 1992
    ....
  11. ncbi request reprint Inhibition of leukotriene omega-oxidation by omega-trifluoro analogs of leukotrienes
    G Jedlitschky
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany
    Arch Biochem Biophys 282:333-9. 1990
    ..omega-Trifluoro analogs of leukotrienes provide a new tool for interfering with the inactivation of leukotrienes in the omega-oxidation pathway...
  12. ncbi request reprint Detection and quantification of protein phosphatase inhibitor-1 gene expression in total rat liver and isolated hepatocytes
    E A Aleem
    Division of Cellular and Molecular Pathology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Mol Cell Biochem 217:1-12. 2001
    ..It is concluded that mRNA expression of inhibitor-1 may have implications for the regulation of protein phosphatase-1 (PP1) in rat liver...
  13. ncbi request reprint Immunocytochemical demonstration of cytochrome c oxidase as a marker for renal oncocytes and oncocytomas
    D Mayer
    , Deutsches Krebsforschungszentrum, Heidelberg, FRG
    Toxicol Pathol 17:46-9. 1989
    ..Thus, this antibody may be used for detection as well as for investigation of the development of oncocytic lesions in various species...
  14. ncbi request reprint Dehydroepiandrosterone stimulates proliferation and gene expression in MCF-7 cells after conversion to estradiol
    M Schmitt
    Research Group 'Hormones and Signal Transduction, Division of Signal Transduction and Growth Control, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Mol Cell Endocrinol 173:1-13. 2001
    ..An androgenic effect of DHEA on proliferation and gene expression of MCF-7 cells was not observed. We conclude that conversion of DHEA to estrogens, particularly estradiol, is required to exert a mitogenic response...
  15. ncbi request reprint The nucleotide sequence of rat liver glycogen phosphorylase cDNA
    K Schiebel
    Deutsches Krebsforschungszentrum, Abteilung Cytopathologie, Heidelberg, Germany
    Biochim Biophys Acta 1130:349-51. 1992
    ..Human and rat liver glycogen phosphorylase showed 86% homology at the DNA level whereas the deduced amino acid sequence has 93.5% identity...
  16. ncbi request reprint Increase in NAD but not ATP and GTP concentrations in rat liver by dehydroepiandrosterone feeding
    J Swierczynski
    Department of Biochemistry, Medical University of Gdansk, Poland
    Pol J Pharmacol 53:125-30. 2001
    ..The findings indicate that an increase in liver NAD pool and/or altered redox status, but no changes in adenine or guanine nucleotide content, may be involved in the pleiotropic effects of DHEA...
  17. ncbi request reprint Gender-specific expression of liver organic anion transporters in rat
    D Rost
    Department of Gastroenterology, University of Heidelberg, Germany
    Eur J Clin Invest 35:635-43. 2005
    ..The aim of this study was to investigate the effect of gender on the expression of hepatocellular transport proteins involved in uptake and secretion of organic anions in rat...
  18. ncbi request reprint Sex differences in dehydroepiandrosterone metabolism in the rat: different plasma levels following ingestion of DHEA-supplemented diet and different metabolite patterns in plasma, bile and urine
    G Hobe
    , Jena, Germany
    Horm Metab Res 26:326-9. 1994
    ..In female rats, DHEA is present predominantly as the sulfate conjugate in considerable amounts in all materials investigated, whereas in male rats polar metabolites dominate in the patterns...