Gunnar Loh

Summary

Affiliation: German Institute of Human Nutrition
Country: Germany

Publications

  1. doi request reprint Enterococcus faecium NCIMB 10415 does not protect interleukin-10 knock-out mice from chronic gut inflammation
    B P Ganesh
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany
    Benef Microbes 3:43-50. 2012
  2. pmc Differences in mucosal gene expression in the colon of two inbred mouse strains after colonization with commensal gut bacteria
    Frances Brodziak
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    PLoS ONE 8:e72317. 2013
  3. pmc Role of commensal gut bacteria in inflammatory bowel diseases
    Gunnar Loh
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany
    Gut Microbes 3:544-55. 2012
  4. ncbi request reprint The Toll-like receptors TLR2 and TLR4 do not affect the intestinal microbiota composition in mice
    Gunnar Loh
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, 14558 Nuthetal, Germany
    Environ Microbiol 10:709-15. 2008
  5. pmc Requirement of purine and pyrimidine synthesis for colonization of the mouse intestine by Escherichia coli
    Jacqueline Vogel-Scheel
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Appl Environ Microbiol 76:5181-7. 2010
  6. doi request reprint Contribution of gut bacteria to the metabolism of cyanidin 3-glucoside in human microbiota-associated rats
    Laura Hanske
    Department of Gastrointestinal Microbiology, Analytics Group, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Br J Nutr 109:1433-41. 2013
  7. pmc Impact of nutritional factors on the proteome of intestinal Escherichia coli: induction of OxyR-dependent proteins AhpF and Dps by a lactose-rich diet
    Monique Rothe
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Appl Environ Microbiol 78:3580-91. 2012
  8. pmc Dextran sodium sulfate-induced inflammation alters the expression of proteins by intestinal Escherichia coli strains in a gnotobiotic mouse model
    Sara Schumann
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Appl Environ Microbiol 78:1513-22. 2012
  9. doi request reprint Adaptation of protein expression by Escherichia coli in the gastrointestinal tract of gnotobiotic mice
    Carl Alpert
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    Environ Microbiol 11:751-61. 2009
  10. doi request reprint Recovery and metabolism of xanthohumol in germ-free and human microbiota-associated rats
    Laura Hanske
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Nutr Food Res 54:1405-13. 2010

Collaborators

Detail Information

Publications22

  1. doi request reprint Enterococcus faecium NCIMB 10415 does not protect interleukin-10 knock-out mice from chronic gut inflammation
    B P Ganesh
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany
    Benef Microbes 3:43-50. 2012
    ..The exact role of A. muciniphila and of a possible interaction between this bacterium, NCIMB 10415 and the host in gut inflammation requires further investigation...
  2. pmc Differences in mucosal gene expression in the colon of two inbred mouse strains after colonization with commensal gut bacteria
    Frances Brodziak
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    PLoS ONE 8:e72317. 2013
    ..Based on expression differences after colonization with the same bacterial inoculum, we propose that Pla2g2a and interferon-dependent genes may contribute to this phenomenon. ..
  3. pmc Role of commensal gut bacteria in inflammatory bowel diseases
    Gunnar Loh
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany
    Gut Microbes 3:544-55. 2012
    ..This approach may help to identify bacterial functions that can be targeted in future concepts of IBD therapy...
  4. ncbi request reprint The Toll-like receptors TLR2 and TLR4 do not affect the intestinal microbiota composition in mice
    Gunnar Loh
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, 14558 Nuthetal, Germany
    Environ Microbiol 10:709-15. 2008
    ..No differences between the animals were observed in the numbers of bacteria detected by FISH. We conclude that genetic traits but not TLR2 and TLR4 have an impact on the intestinal microbiota composition...
  5. pmc Requirement of purine and pyrimidine synthesis for colonization of the mouse intestine by Escherichia coli
    Jacqueline Vogel-Scheel
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Appl Environ Microbiol 76:5181-7. 2010
    ..These findings indicate that E. coli needs to synthesize purines and pyrimidines to successfully colonize the mouse intestine...
  6. doi request reprint Contribution of gut bacteria to the metabolism of cyanidin 3-glucoside in human microbiota-associated rats
    Laura Hanske
    Department of Gastrointestinal Microbiology, Analytics Group, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Br J Nutr 109:1433-41. 2013
    ..The higher concentrations of phenolic acids observed in the presence of intestinal bacteria may contribute to the proposed beneficial health effects of C3G...
  7. pmc Impact of nutritional factors on the proteome of intestinal Escherichia coli: induction of OxyR-dependent proteins AhpF and Dps by a lactose-rich diet
    Monique Rothe
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Appl Environ Microbiol 78:3580-91. 2012
    ..Mice fed the lactose-rich diet possibly had a higher intestinal osmolality, leading to the upregulation of OxyR-dependent proteins, which enable intestinal E. coli to better cope with diet-induced osmotic stress...
  8. pmc Dextran sodium sulfate-induced inflammation alters the expression of proteins by intestinal Escherichia coli strains in a gnotobiotic mouse model
    Sara Schumann
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    Appl Environ Microbiol 78:1513-22. 2012
    ..coli Nissle. Because of its anti-inflammatory effect, indole is hypothesized to be involved in the extension of the remission phase in ulcerative colitis described for E. coli Nissle...
  9. doi request reprint Adaptation of protein expression by Escherichia coli in the gastrointestinal tract of gnotobiotic mice
    Carl Alpert
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, 14558 Nuthetal, Germany
    Environ Microbiol 11:751-61. 2009
    ....
  10. doi request reprint Recovery and metabolism of xanthohumol in germ-free and human microbiota-associated rats
    Laura Hanske
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Mol Nutr Food Res 54:1405-13. 2010
    ..Thus, the impact of bacteria on the XN metabolism in the gut may affect the in vivo effects of ingested XN...
  11. pmc Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice
    Bhanu Priya Ganesh
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    PLoS ONE 8:e74963. 2013
    ..Typhimurium was 94% in SIHUMI-AS mice but only 2.2% in the SIHUMI-S mice. These results indicate that A. muciniphila exacerbates S. Typhimurium-induced intestinal inflammation by its ability to disturb host mucus homeostasis...
  12. doi request reprint Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer
    Hoda B Mabrok
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, D 14558 Nuthetal, Germany
    Carcinogenesis 33:203-8. 2012
    ..In conclusion, our results show that the bacterial conversion of plant lignans to enterolignans beneficially influences their anticancer effects...
  13. doi request reprint The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats
    Laura Hanske
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, 14558 Nuthetal, Germany
    J Nutr 139:1095-102. 2009
    ..Overall, human intestinal microbiota largely contributed to A7G metabolism, indicating its influence on the bioactivity of flavones...
  14. doi request reprint Human intestinal microbiota: characterization of a simplified and stable gnotobiotic rat model
    Natalie Becker
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany
    Gut Microbes 2:25-33. 2011
    ..The strength of the model communities is their remarkable stability over time and their easy transfer to the offspring...
  15. ncbi request reprint Bacterial transformation of dietary lignans in gnotobiotic rats
    Anni Woting
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke DIfE, Nuthetal, Germany
    FEMS Microbiol Ecol 72:507-14. 2010
    ..Their urine was devoid of lignans. Hence, the presence of enterolignans in the ALB rats, but not in the germ-free rats, demonstrates that this defined microbial community is capable of transforming plant lignans into EL in vivo...
  16. doi request reprint Absence of intestinal microbiota does not protect mice from diet-induced obesity
    Christine K Fleissner
    Group of Physiology of Energy Metabolism, German Institute of Human Nutrition Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    Br J Nutr 104:919-29. 2010
    ....
  17. pmc Novel insights into E. coli's hexuronate metabolism: KduI facilitates the conversion of galacturonate and glucuronate under osmotic stress conditions
    Monique Rothe
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    PLoS ONE 8:e56906. 2013
    ..These results indicate a novel function of KduI and KduD in E. coli and demonstrate the crucial influence of osmotic stress on the gene expression of hexuronate degrading enzymes...
  18. doi request reprint Recent developments and perspectives in the investigation of probiotic effects
    Steffen Wohlgemuth
    German Institute of Human Nutrition Potsdam Rehbrucke, Department of Gastrointestinal Microbiology, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Int J Med Microbiol 300:3-10. 2010
    ..This review covers recent developments and perspectives in the study of probiotic mechanisms...
  19. ncbi request reprint Reduced microbial diversity and high numbers of one single Escherichia coli strain in the intestine of colitic mice
    Steffen Wohlgemuth
    German Institute of Human Nutrition Potsdam Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany
    Environ Microbiol 11:1562-71. 2009
    ..A high number of virulence- and fitness-associated genes were detected in the strain's genome possibly involved in the bacterial adaptation to the murine intestine...
  20. doi request reprint The gastrointestinal microbiota affects the selenium status and selenoprotein expression in mice
    Juliane Hrdina
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Nutr Biochem 20:638-48. 2009
    ..A variable association with different microorganisms might influence the daily requirement of mice for selenium. Whether the microbiota also affects the human selenoprotein status appears worthy of investigation...
  21. doi request reprint Daidzein and genistein are converted to equol and 5-hydroxy-equol by human intestinal Slackia isoflavoniconvertens in gnotobiotic rats
    Anastasia Matthies
    Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Nutr 142:40-6. 2012
    ..The observed activity in the rat model indicates that S. isoflavoniconvertens is capable of contributing in vivo to the bioactivation of daidzein and genistein by formation of equol and 5-hydroxy-equol...
  22. ncbi request reprint Inulin alters the intestinal microbiota and short-chain fatty acid concentrations in growing pigs regardless of their basal diet
    Gunnar Loh
    Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    J Nutr 136:1198-202. 2006
    ..6 +/- 0.6), and was higher due to inulin (CGI, 7.1 +/- 0.1; P < 0.05). In conclusion, inulin affected intestinal SCFA and the number of pigs harboring bifidobacteria; this effect was independent of the basal diet...