Min Li-Weber

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 30:661-70. 2000
  2. ncbi request reprint Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells
    Peter Proksch
    Institute of Pharmaceutical Biology, University of Dusseldorf, Germany
    J Immunol 174:7075-84. 2005
  3. ncbi request reprint HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)
    Andreas Krueger
    Tumorimmunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Blood 107:3933-9. 2006
  4. pmc Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells
    Thomas Efferth
    Pharmaceutical Biology of Natural Products, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 2:e693. 2007
  5. pmc Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1
    G Polier
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cell Death Dis 2:e182. 2011
  6. doi request reprint Targeting apoptosis pathways in cancer by Chinese medicine
    Min Li-Weber
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Cancer Lett 332:304-12. 2013
  7. ncbi request reprint Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    J Immunol 158:1194-200. 1997
  8. ncbi request reprint The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells
    M Li-Weber
    Tumorimmunology Program, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Cell Death Differ 9:1256-65. 2002
  9. ncbi request reprint The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T
    Min Li-Weber
    Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
    Eur J Immunol 32:3587-97. 2002
  10. ncbi request reprint Regulation of IL4 gene expression by T cells and therapeutic perspectives
    Min Li-Weber
    Tumour Immunology Programme D030, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nat Rev Immunol 3:534-43. 2003

Collaborators

Detail Information

Publications40

  1. ncbi request reprint T cell activation-induced and HIV tat-enhanced CD95(APO-1/Fas) ligand transcription involves NF-kappaB
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 30:661-70. 2000
    ..Our studies provide evidence that Tat-enhanced CD95L expression is regulated at least in part by the NF-kappaB sites of the promoter...
  2. ncbi request reprint Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells
    Peter Proksch
    Institute of Pharmaceutical Biology, University of Dusseldorf, Germany
    J Immunol 174:7075-84. 2005
    ..Our study suggests that rocaglamide derivatives may serve as a new source of NF-AT-specific inhibitors for the treatment of certain inflammatory diseases...
  3. ncbi request reprint HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP)
    Andreas Krueger
    Tumorimmunology Program, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Blood 107:3933-9. 2006
    ..In conclusion, our data suggest an important mechanism by which expression of HTLV-1 Tax may lead to immune escape of infected T cells and, thus, to persistent infection and transformation...
  4. pmc Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells
    Thomas Efferth
    Pharmaceutical Biology of Natural Products, German Cancer Research Center, Heidelberg, Germany
    PLoS ONE 2:e693. 2007
    ..Another salient feature of these compounds is the lack of severe side effects in malaria patients...
  5. pmc Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1
    G Polier
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, Heidelberg, Germany
    Cell Death Dis 2:e182. 2011
    ..Thus, our study reveals a new mechanism of anti-cancer action of natural flavones and supports CDK9 as a therapeutic target in oncology...
  6. doi request reprint Targeting apoptosis pathways in cancer by Chinese medicine
    Min Li-Weber
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Cancer Lett 332:304-12. 2013
    ..This review also intends to give an overview of the mechanisms of action identified so far. These breakthrough findings may have important implications for targeted-cancer therapy and for modernization of TCM...
  7. ncbi request reprint Differential interaction of nuclear factors with the PRE-I enhancer element of the human IL-4 promoter in different T cell subsets
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    J Immunol 158:1194-200. 1997
    ..In contrast, POS-1 was not found in nuclear extracts of human Th1 clones. These findings suggest that PRE-I may play a role in the differential regulation of IL-4 gene expression levels...
  8. ncbi request reprint The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells
    M Li-Weber
    Tumorimmunology Program, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Cell Death Differ 9:1256-65. 2002
    ..Our study indicates that parthenolide supports T-cell survival by down-regulating the CD95 system, at least in part, and, therefore, may have therapeutic potential as a new anti-apoptotic substance against AICD in T-cells...
  9. ncbi request reprint The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T
    Min Li-Weber
    Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
    Eur J Immunol 32:3587-97. 2002
    ..So far, drugs directed against IL-4 expression have not been described. This finding raises the potential to develop parthenolide to treat IL-4-mediated allergic-like inflammation...
  10. ncbi request reprint Regulation of IL4 gene expression by T cells and therapeutic perspectives
    Min Li-Weber
    Tumour Immunology Programme D030, German Cancer Research Centre DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Nat Rev Immunol 3:534-43. 2003
    ..This review focuses on acute activation of the gene encoding IL-4 in T cells and discusses therapeutic perspectives at the transcriptional level...
  11. ncbi request reprint Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system
    Min Li-Weber
    Tumor Immunology Program G0300, German Cancer Research Center DKFZ, INF 280, D 69120 Heidelberg, Germany
    Semin Immunol 15:145-57. 2003
    ..It should also be evident from this review that a profound insight into the molecular mechanisms of CD95L activation should allow to explore potential therapeutic means to treat CD95/CD95L-dependent diseases...
  12. ncbi request reprint NF-kappa B synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells
    Min Li-Weber
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 34:1111-8. 2004
    ..Inhibition of NF-kappa B nuclear translocation in living cells blocked binding of NF-kappa B to the IL-4 promoter. The data provide first evidence that NF-kappa B is directly involved in IL-4 transcription...
  13. doi request reprint New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin
    Min Li-Weber
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Cancer Treat Rev 35:57-68. 2009
    ..This review is aimed to summarize the research results obtained since the last 20 years and to highlight the recently discovered molecular mechanisms...
  14. ncbi request reprint Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-kappa B signaling pathways
    Min Li-Weber
    Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
    J Immunol 175:2132-43. 2005
    ..Thus, our data provide an additional mechanism by which UV irradiation directly suppresses immune responses...
  15. ncbi request reprint Vitamin E inhibits IL-4 gene expression in peripheral blood T cells
    Min Li-Weber
    Tumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
    Eur J Immunol 32:2401-8. 2002
    ..Our data provide molecular evidence supporting the beneficial effect of dietary vitamin E on atopic disorders...
  16. ncbi request reprint Characterization of constitutive and inducible transcription factors binding to the P2 NF-AT site in the human interleukin-4 promoter
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center, Heidelberg
    Gene 188:253-60. 1997
    ..Therefore, the DNA sequence at -173 to -150 of the IL-4 promoter is a binding site for NF-ATp/c and AP-1. Octamer proteins are unlikely to cooperate with NF-ATp/c at this site...
  17. ncbi request reprint Th2-specific protein/DNA interactions at the proximal nuclear factor-AT site contribute to the functional activity of the human IL-4 promoter
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center, Heidelberg
    J Immunol 161:1380-9. 1998
    ..These findings suggest that besides c-Maf, another Th2-specific factor(s) may be involved in tissue-specific expression of the IL-4 gene...
  18. ncbi request reprint A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center, Heidelberg
    Eur J Immunol 28:2373-83. 1998
    ..Our data also show that the immunosuppressive agent cyclosporin A down-regulates CD95L transcription by inhibiting the function of this positive regulatory element...
  19. ncbi request reprint Involvement of Jun and Rel proteins in up-regulation of interleukin-4 gene activity by the T cell accessory molecule CD28
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center, D 69126 Heidelberg, Germany
    J Biol Chem 273:32460-6. 1998
    ..The data provide the first mapping of the CD28-responsive site in a Th2 cytokine gene, the IL-4 gene. They also show that the CD28 signal can directly activate a gene (e.g. IL-4) at the transcriptional level...
  20. ncbi request reprint Novel Egr/NF-AT composite sites mediate activation of the CD95 (APO-1/Fas) ligand promoter in response to T cell stimulation
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 29:3017-27. 1999
    ..These findings provide further insight into the mechanisms involved in the regulation of the CD95L expression in response to T cell activation...
  21. ncbi request reprint Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    Eur J Immunol 31:2623-32. 2001
    ..Our studies provide the first evidence of the functional involvement of Tax in IL-4 gene regulation...
  22. ncbi request reprint Roles of CCAAT/enhancer-binding protein in transcriptional regulation of the human IL-5 gene
    M Li-Weber
    Tumor Immunology Program, German Cancer Research Center DKFZ, Heidelberg, Germany
    Eur J Immunol 31:3694-703. 2001
    ..Thus, the C/EBP site may be also involved in HTLV-I Tax-mediated up-regulation of IL-5 gene expression. Our data suggest that C/EBP proteins may regulate IL-5 gene expression in response to different stimulation signals...
  23. pmc Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death
    Min Li-Weber
    Tumor Immunology G0300, German Cancer Research Center, Heidelberg, Germany
    J Clin Invest 110:681-90. 2002
    ..This evidence that vitamin E can affect T cell survival may merit further clinical investigation...
  24. ncbi request reprint IFN-gamma represses IL-4 expression via IRF-1 and IRF-2
    Bernd Elser
    Tumorimmunology Program, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Immunity 17:703-12. 2002
    ..Our data demonstrate a direct negative feedback of IFN-gamma on expression of the Th2 cytokine gene IL-4 and, thus, provide evidence for another important mechanism by which IFNgamma assists Th1 and attenuates Th2 responses...
  25. ncbi request reprint The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints
    Jennifer Neumann
    Tumorimmunology Program D030, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 134:1991-2002. 2014
    ..In particular, Roc-A selectively stimulates a set of genes responsive to DNA replication stress in leukemic but not in normal T lymphocytes. These findings further support the development of Rocaglamide for antitumor therapy. ..
  26. ncbi request reprint Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter
    Sabine Kirchhoff
    Tumor Immunology Program, Tumorvirus Immunology, German Cancer Research Center, D 16920 Heidelberg, Germany
    J Immunol 168:1226-34. 2002
    ..Thus, these results demonstrate an important mechanism of HHV8 to modulate the immune response by down-regulation of CD95L expression. Inhibition of CD95-dependent T cell function might contribute to the immune escape of HHV8...
  27. pmc Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4
    Michael Lohoff
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    J Biol Chem 285:1643-52. 2010
    ..Our study provides the first evidence that Egr-1 protein is differentially expressed in Th1 and Th2 cells and is involved in the acute phase of the IL-4 transcription in response to TCR stimulation...
  28. ncbi request reprint HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death
    Karsten Gülow
    Tumor Immunology Program, German Cancer Research Center, Heidelberg, Germany
    J Immunol 174:5249-60. 2005
    ..H(2)O(2) generated by HIV-1 Tat combines with CD4-dependent calcium influx and causes massive T cell apoptosis. Thus, our data provide an explanation for CD4(+) T lymphocyte depletion during progression of AIDS...
  29. pmc Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation
    Christian Kliem
    Technologietransfer T010, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    J Biol Chem 287:10200-9. 2012
    ..Furthermore, because Ca(2+) is also the secondary messenger crucial for the TCR-induced NF-κB signaling pathway, our finding also provides another mechanism by which curcumin suppresses NF-κB activation...
  30. ncbi request reprint Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis
    Stefanie C Fas
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Blood 108:3700-6. 2006
    ..Our data suggest a potential use of wogonin as a TNFalpha or TRAIL adjuvant for cancer treatment. Our data also demonstrate how a herbal compound enhances killing of tumor cells with reduced side effects compared with other treatments...
  31. ncbi request reprint The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2
    Gernot Polier
    Tumorimmunology Program D030, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    Chem Biol 19:1093-104. 2012
    ..Thus, our finding suggests that rocaglamides are a new type of anticancer agent and that they may serve as a small-molecular tool for studying PHB-mediated cellular processes...
  32. ncbi request reprint The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities
    Jia Y Zhu
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 121:1839-46. 2007
    ..Up to now, more than 50 different Roc derivatives have been isolated from Aglaia. Our study suggests that Roc derivatives may be promising candidates for the development of new drugs against hematologic malignancies...
  33. ncbi request reprint Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis
    Sven Baumann
    Tumorimmunology Program D030, German Cancer Research Center, Heidelberg, Germany
    Blood 111:2354-63. 2008
    ..Taken together, our data show a therapeutic potential of Wogonin for the treatment of hematologic malignancies...
  34. pmc Wogonin and related natural flavones overcome tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein resistance of tumors by down-regulation of c-FLIP protein and up-regulation of TRAIL receptor 2 expression
    Jie Ding
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, D 69120 Heidelberg, Germany
    J Biol Chem 287:641-9. 2012
    ..Thus, our study suggests the potential use of these flavones as an adjuvant for TRAIL-mediated anticancer therapy...
  35. ncbi request reprint The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells
    Konstantina Bourkoula
    Tumor Immunology Program D030, German Cancer Research Center DKFZ, Heidelberg, Germany
    Int J Cancer 134:291-300. 2014
    ..Our study provides a new role of WT1 in regulation of CD95L-mediated cell death. ..
  36. doi request reprint Targeting the IL-4/IL-13 signaling pathway sensitizes Hodgkin lymphoma cells to chemotherapeutic drugs
    Antonino Natoli
    Tumorimmunology Program D030, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Int J Cancer 133:1945-54. 2013
    ..This study also suggests that combination of classical chemotherapeutic drugs with the IL-4/IL-13 antagonists may enhance efficacy and reduce risks of toxicity from high dose of drugs in HL treatment. ..
  37. ncbi request reprint Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL
    Tom M Ganten
    Division of Apoptosis Regulation, German Cancer Research Center DKFZ, Heidelberg, Germany
    Hepatology 42:588-97. 2005
    ..Of clinical relevance, proteasome inhibitors sensitize HCC cells but not primary human hepatocytes for TRAIL-induced apoptosis...
  38. doi request reprint Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas
    Marco Giaisi
    German Cancer Research Center, Heidelberg, Germany
    Int J Cancer 131:1003-8. 2012
    ..Synergistic increase in TRAIL-mediated killing of HL cells was only obtained by combination of Rocaglamide and XIAP inhibitors. Our study demonstrates that targeting both c-FLIP and XIAP are necessary for an efficient treatment of HL...
  39. ncbi request reprint Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death
    Bysani Chandrasekar
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 279:20221-33. 2004
    ..Taken together, our results indicate that IL-18 activates both intrinsic and extrinsic proapoptotic signaling pathways, induces endothelial cell death, and thereby may play a role in myocardial inflammation and injury...
  40. pmc LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element
    Daniel Hebenstreit
    Department of Molecular Biology, University of Salzburg, 5020 Salzburg, Austria
    J Biol Chem 283:22490-7. 2008
    ..Furthermore, we found that IL-4 stimulation possesses a negative effect on the expressions of LEF-1 and TCF-1 in primary T cells, suggesting a positive feedback effect of IL-4 on IL4 gene expression...