L Langbein

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle
    L Langbein
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 274:19874-84. 1999
  2. pmc The human keratins: biology and pathology
    Roland Moll
    Institute of Pathology, Philipps University, 35033, Marburg, Germany
    Histochem Cell Biol 129:705-33. 2008
  3. ncbi request reprint Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21
    M A Rogers
    Divisions of Biochemistry of Tissue-specific Regulation, Cell Biology, and Resource Center for Human Genome Research, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 276:19440-51. 2001
  4. ncbi request reprint Plakophilin 3--a novel cell-type-specific desmosomal plaque protein
    A Schmidt
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Differentiation 64:291-306. 1999
  5. ncbi request reprint Sequences and differential expression of three novel human type-II hair keratins
    M A Rogers
    Division of Tumor Cell Regulation, German Cancer Research Center, Heidelberg, Germany
    Differentiation 61:187-94. 1997
  6. ncbi request reprint Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain
    M A Rogers
    German Cancer Research Center, Research Programs 1 and 2, Heidelberg, Germany
    J Invest Dermatol 114:464-72. 2000
  7. ncbi request reprint The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratins
    L Langbein
    Divisions of Cell Biology and Tumor Cell Regulation, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 276:35123-32. 2001
  8. ncbi request reprint Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5
    M A Rogers
    Research Program, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 107:633-8. 1996
  9. ncbi request reprint Human type I hair keratin pseudogene phihHaA has functional orthologs in the chimpanzee and gorilla: evidence for recent inactivation of the human gene after the Pan-Homo divergence
    H Winter
    German Cancer Research Center, Heidelberg, Germany
    Hum Genet 108:37-42. 2001
  10. ncbi request reprint A splice site mutation in the gene of the human type I hair keratin hHa1 results in the expression of a tailless keratin isoform
    H Winter
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 272:32345-52. 1997

Collaborators

Detail Information

Publications19

  1. ncbi request reprint The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle
    L Langbein
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 274:19874-84. 1999
    ....
  2. pmc The human keratins: biology and pathology
    Roland Moll
    Institute of Pathology, Philipps University, 35033, Marburg, Germany
    Histochem Cell Biol 129:705-33. 2008
    ..Future research might open further fields of clinical application for this remarkable protein family...
  3. ncbi request reprint Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21
    M A Rogers
    Divisions of Biochemistry of Tissue-specific Regulation, Cell Biology, and Resource Center for Human Genome Research, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 276:19440-51. 2001
    ..Hair follicle in situ hybridization data for single members of five different KAP multigene families all showed localization of the respective mRNAs to the upper cortex of the hair shaft...
  4. ncbi request reprint Plakophilin 3--a novel cell-type-specific desmosomal plaque protein
    A Schmidt
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Differentiation 64:291-306. 1999
    ..The similarities and differences of the diverse plakophilins are discussed...
  5. ncbi request reprint Sequences and differential expression of three novel human type-II hair keratins
    M A Rogers
    Division of Tumor Cell Regulation, German Cancer Research Center, Heidelberg, Germany
    Differentiation 61:187-94. 1997
    ..This early phase of hair differentiation is followed by a late cortical phase of terminal differentiation which comprises at least three type-II hair keratins in the zone of elongation and the keratogenous zone of the hair shaft...
  6. ncbi request reprint Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain
    M A Rogers
    German Cancer Research Center, Research Programs 1 and 2, Heidelberg, Germany
    J Invest Dermatol 114:464-72. 2000
    ..We assume that the approximately 200 kbp DNA domain contains the entire complement of human type II hair keratin genes...
  7. ncbi request reprint The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratins
    L Langbein
    Divisions of Cell Biology and Tumor Cell Regulation, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 276:35123-32. 2001
    ....
  8. ncbi request reprint Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5
    M A Rogers
    Research Program, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 107:633-8. 1996
    ..Our results confirm the type specific clustering of keratin genes and indicate that the human type I hair keratin subfamily contains more members than previously assumed...
  9. ncbi request reprint Human type I hair keratin pseudogene phihHaA has functional orthologs in the chimpanzee and gorilla: evidence for recent inactivation of the human gene after the Pan-Homo divergence
    H Winter
    German Cancer Research Center, Heidelberg, Germany
    Hum Genet 108:37-42. 2001
    ....
  10. ncbi request reprint A splice site mutation in the gene of the human type I hair keratin hHa1 results in the expression of a tailless keratin isoform
    H Winter
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 272:32345-52. 1997
    ..This finding confirms the view of a noninvolvement of the keratin tail domain in filament assembly and explains the lack of a pathological hair phenotype in hHa1-t positive individuals...
  11. ncbi request reprint Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix
    H Winter
    Division of Tumour Cell Regulation, German Cancer Research Center, Heidelberg, Germany
    Nat Genet 16:372-4. 1997
    ..These mutations provide the first direct evidence for involvement of hair keratins in hair disease...
  12. ncbi request reprint Drebrin particles: components in the ensemble of proteins regulating actin dynamics of lamellipodia and filopodia
    W K Peitsch
    Division of Cell Biology, German Cancer Research Center, Heidelberg
    Eur J Cell Biol 80:567-79. 2001
    ....
  13. doi request reprint Characterization and expression analysis of the hair keratin associated protein KAP26.1
    M A Rogers
    Division of Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Br J Dermatol 159:725-9. 2008
    ..Recently, four new KAP family members KAP24.1, KAP25.1, KAP26.1 and KAP27.1 were identified from the genome, but the expression of only one, KAP24.1, was investigated and shown in hair follicles...
  14. ncbi request reprint Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components
    A Schmidt
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cell Tissue Res 290:481-99. 1997
    ..Possible functions of plakophilins are discussed in relation to recent reports of the involvement of other members of the armadillo/plakoglobin multigene family of proteins in cell surface-gene regulation signalling pathways...
  15. ncbi request reprint A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle
    H Winter
    German Cancer Research Center, Department of Tumor Cell Regulation, Heidelberg
    J Invest Dermatol 111:955-62. 1998
    ..Thus, not only morphologically but also biochemically, the companion layer is different from the ORS and can therefore be regarded as an independent histologic compartment of the hair follicle...
  16. ncbi request reprint Molecular characterization of the body site-specific human epidermal cytokeratin 9: cDNA cloning, amino acid sequence, and tissue specificity of gene expression
    L Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg
    Differentiation 55:57-71. 1993
    ..We discuss the molecular properties of CK 9 and its cell type- and body site-specific expression in relation to the special differentiation of palmar/plantar epidermis and to diseases specific for this body site...
  17. ncbi request reprint Cytokeratins as markers of follicular differentiation: an immunohistochemical study of trichoblastoma and basal cell carcinoma
    H Kurzen
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Am J Dermatopathol 23:501-9. 2001
    ..This indicates a differentiation toward the outer root sheath epithelium or the companion layer and not toward the inner root sheath, matrix, or cortex...
  18. ncbi request reprint Hair keratin pattern in human hair follicles grown in vitro
    S Thibaut
    L Oreal Recherche, Clichy, France
    Exp Dermatol 12:160-4. 2003
    ..It also shows that hair follicle integrity was maintained in vitro, both in terms of gross morphology and molecular organization despite the complexity of the keratin expression pattern...
  19. ncbi request reprint Expression of hair keratins in the adult nail unit: an immunohistochemical analysis of the onychogenesis in the proximal nail fold, matrix and nail bed
    C Perrin
    Hôpital L Pasteur, Laboratoire d Anatomie Pathologique, 30 Av voie Romaine, B P 69, 06002 Nice, Cedex 1, France
    Br J Dermatol 151:362-71. 2004
    ..Recently, the expression profiles of the members of the complex hair keratin family have been determined in the human anagen hair follicle. In contrast, the details of hair keratin expression in the human nail unit are poorly known...