Affiliation: German Cancer Research Center
Langbein L, Cribier B, Schirmacher P, Praetzel Wunder S, Peltre B, Schweizer J. New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma. Br J Dermatol. 2008;159:633-45 pubmed publisher
..Instead, poroid cells consist only of keratinocytes of the lowermost acrosyringium and the sweat duct ridge and poromas tend to differentiate towards the cells of the upper acrosyringium. ..
Langbein L, Yoshida H, Praetzel Wunder S, Parry D, Schweizer J. The keratins of the human beard hair medulla: the riddle in the middle. J Invest Dermatol. 2010;130:55-73 pubmed publisher
..In both keratin expression profile and keratin number, medulla cells are distinct from all other cells of the hair follicle or from any other epithelium. ..
Langbein L, Rogers M, Praetzel S, Aoki N, Winter H, Schweizer J. A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle. J Invest Dermatol. 2002;118:789-99 pubmed
..This tightly connected companion layer/inner root sheath unit provides an optimal molding and guidance of the growing hair shaft. ..
Langbein L, Rogers M, Praetzel S, Cribier B, Peltre B, Gassler N, et al
. Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands. J Invest Dermatol. 2005;125:428-44 pubmed
..We provide evidence that the cellular and intercellular properties of the peripheral and the luminal layers reflect adaptations to different functions. ..
Langbein L, Rogers M, Praetzel Wunder S, Helmke B, Schirmacher P, Schweizer J. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. J Invest Dermatol. 2006;126:2377-86 pubmed
Langbein L, Eckhart L, Rogers M, Praetzel Wunder S, Schweizer J. Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia. J Biol Chem. 2010;285:36909-21 pubmed publisher
..1, which arose only during mammalian evolution. Remarkably, unlike the widely expressed K80, the expression of K80.1 is restricted to soft and hard keratinizing epithelial structures of the hair follicle and the filiform tongue papilla...
Langbein L, Eckhart L, Fischer H, Rogers M, Praetzel Wunder S, Parry D, et al
. Localisation of keratin K78 in the basal layer and first suprabasal layers of stratified epithelia completes expression catalogue of type II keratins and provides new insights into sequential keratin expression. Cell Tissue Res. 2016;363:735-50 pubmed publisher
..Moreover, the K78 expression pattern and the decoupled K1/K10 and K4/K13 expression define the existence of a hitherto unperceived early differentiation stage in the parabasal layer characterized by K78/K10 or K78/K13 expression. ..