L Langbein

Summary

Affiliation: German Cancer Research Center
Country: Germany

Publications

  1. ncbi request reprint K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology, University of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 126:2377-86. 2006
  2. pmc Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia
    Lutz Langbein
    Department of Genetics of Skin Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 285:36909-21. 2010
  3. ncbi request reprint Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 125:428-44. 2005
  4. doi request reprint New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma
    L Langbein
    Division of Skin Carcinogenesis, German Cancer Research Centre, Heidelberg, Germany
    Br J Dermatol 159:633-45. 2008
  5. ncbi request reprint A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology and Tumor Cell Regulation, Heidelberg, Germany
    J Invest Dermatol 118:789-99. 2002
  6. doi request reprint The keratins of the human beard hair medulla: the riddle in the middle
    Lutz Langbein
    Genetics of Skin Carcinogenesis, Heidelberg, Germany
    J Invest Dermatol 130:55-73. 2010
  7. ncbi request reprint The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle
    L Langbein
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 274:19874-84. 1999
  8. ncbi request reprint Plakophilin 3--a novel cell-type-specific desmosomal plaque protein
    A Schmidt
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Differentiation 64:291-306. 1999
  9. ncbi request reprint Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21
    M A Rogers
    Divisions of Biochemistry of Tissue-specific Regulation, Cell Biology, and Resource Center for Human Genome Research, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 276:19440-51. 2001
  10. ncbi request reprint Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain
    M A Rogers
    German Cancer Research Center, Research Programs 1 and 2, Heidelberg, Germany
    J Invest Dermatol 114:464-72. 2000

Collaborators

Detail Information

Publications57

  1. ncbi request reprint K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology, University of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 126:2377-86. 2006
    ....
  2. pmc Against the rules: human keratin K80: two functional alternative splice variants, K80 and K80.1, with special cellular localization in a wide range of epithelia
    Lutz Langbein
    Department of Genetics of Skin Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 285:36909-21. 2010
    ..1, which arose only during mammalian evolution. Remarkably, unlike the widely expressed K80, the expression of K80.1 is restricted to soft and hard keratinizing epithelial structures of the hair follicle and the filiform tongue papilla...
  3. ncbi request reprint Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 125:428-44. 2005
    ..We provide evidence that the cellular and intercellular properties of the peripheral and the luminal layers reflect adaptations to different functions...
  4. doi request reprint New concepts on the histogenesis of eccrine neoplasia from keratin expression in the normal eccrine gland, syringoma and poroma
    L Langbein
    Division of Skin Carcinogenesis, German Cancer Research Centre, Heidelberg, Germany
    Br J Dermatol 159:633-45. 2008
    ..Each layer exhibits differential expression of keratins K5/K14 and K6/K16. Keratin K1 occurs only in peripheral cells and the novel keratin K77 is specific for luminal cells...
  5. ncbi request reprint A novel epithelial keratin, hK6irs1, is expressed differentially in all layers of the inner root sheath, including specialized huxley cells (Flügelzellen) of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology and Tumor Cell Regulation, Heidelberg, Germany
    J Invest Dermatol 118:789-99. 2002
    ..This tightly connected companion layer/inner root sheath unit provides an optimal molding and guidance of the growing hair shaft...
  6. doi request reprint The keratins of the human beard hair medulla: the riddle in the middle
    Lutz Langbein
    Genetics of Skin Carcinogenesis, Heidelberg, Germany
    J Invest Dermatol 130:55-73. 2010
    ..In both keratin expression profile and keratin number, medulla cells are distinct from all other cells of the hair follicle or from any other epithelium...
  7. ncbi request reprint The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle
    L Langbein
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 274:19874-84. 1999
    ....
  8. ncbi request reprint Plakophilin 3--a novel cell-type-specific desmosomal plaque protein
    A Schmidt
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Differentiation 64:291-306. 1999
    ..The similarities and differences of the diverse plakophilins are discussed...
  9. ncbi request reprint Characterization of a cluster of human high/ultrahigh sulfur keratin-associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21
    M A Rogers
    Divisions of Biochemistry of Tissue-specific Regulation, Cell Biology, and Resource Center for Human Genome Research, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 276:19440-51. 2001
    ..Hair follicle in situ hybridization data for single members of five different KAP multigene families all showed localization of the respective mRNAs to the upper cortex of the hair shaft...
  10. ncbi request reprint Characterization of a 300 kbp region of human DNA containing the type II hair keratin gene domain
    M A Rogers
    German Cancer Research Center, Research Programs 1 and 2, Heidelberg, Germany
    J Invest Dermatol 114:464-72. 2000
    ..We assume that the approximately 200 kbp DNA domain contains the entire complement of human type II hair keratin genes...
  11. ncbi request reprint Sequences and differential expression of three novel human type-II hair keratins
    M A Rogers
    Division of Tumor Cell Regulation, German Cancer Research Center, Heidelberg, Germany
    Differentiation 61:187-94. 1997
    ..This early phase of hair differentiation is followed by a late cortical phase of terminal differentiation which comprises at least three type-II hair keratins in the zone of elongation and the keratogenous zone of the hair shaft...
  12. ncbi request reprint A novel human type II cytokeratin, K6hf, specifically expressed in the companion layer of the hair follicle
    H Winter
    German Cancer Research Center, Department of Tumor Cell Regulation, Heidelberg
    J Invest Dermatol 111:955-62. 1998
    ..Thus, not only morphologically but also biochemically, the companion layer is different from the ORS and can therefore be regarded as an independent histologic compartment of the hair follicle...
  13. ncbi request reprint Human type I hair keratin pseudogene phihHaA has functional orthologs in the chimpanzee and gorilla: evidence for recent inactivation of the human gene after the Pan-Homo divergence
    H Winter
    German Cancer Research Center, Heidelberg, Germany
    Hum Genet 108:37-42. 2001
    ....
  14. ncbi request reprint The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratins
    L Langbein
    Divisions of Cell Biology and Tumor Cell Regulation, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    J Biol Chem 276:35123-32. 2001
    ....
  15. ncbi request reprint Plakophilins 1a and 1b: widespread nuclear proteins recruited in specific epithelial cells as desmosomal plaque components
    A Schmidt
    Division of Cell Biology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Cell Tissue Res 290:481-99. 1997
    ..Possible functions of plakophilins are discussed in relation to recent reports of the involvement of other members of the armadillo/plakoglobin multigene family of proteins in cell surface-gene regulation signalling pathways...
  16. doi request reprint Characterization and expression analysis of the hair keratin associated protein KAP26.1
    M A Rogers
    Division of Molecular Genetics, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Br J Dermatol 159:725-9. 2008
    ..Recently, four new KAP family members KAP24.1, KAP25.1, KAP26.1 and KAP27.1 were identified from the genome, but the expression of only one, KAP24.1, was investigated and shown in hair follicles...
  17. ncbi request reprint Hair keratins and hair follicle-specific epithelial keratins
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
    Methods Cell Biol 78:413-51. 2004
  18. ncbi request reprint A splice site mutation in the gene of the human type I hair keratin hHa1 results in the expression of a tailless keratin isoform
    H Winter
    German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 272:32345-52. 1997
    ..This finding confirms the view of a noninvolvement of the keratin tail domain in filament assembly and explains the lack of a pathological hair phenotype in hHa1-t positive individuals...
  19. ncbi request reprint Drebrin particles: components in the ensemble of proteins regulating actin dynamics of lamellipodia and filopodia
    W K Peitsch
    Division of Cell Biology, German Cancer Research Center, Heidelberg
    Eur J Cell Biol 80:567-79. 2001
    ....
  20. ncbi request reprint Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix
    H Winter
    Division of Tumour Cell Regulation, German Cancer Research Center, Heidelberg, Germany
    Nat Genet 16:372-4. 1997
    ..These mutations provide the first direct evidence for involvement of hair keratins in hair disease...
  21. ncbi request reprint Human hair keratin-associated proteins (KAPs)
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    Int Rev Cytol 251:209-63. 2006
    ....
  22. ncbi request reprint Hair keratin associated proteins: characterization of a second high sulfur KAP gene domain on human chromosome 21
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 122:147-58. 2004
    ..Primary among these were binding elements for the ETS, heat shock factor, AML, and HOX families of transcription factors...
  23. ncbi request reprint Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 124:536-44. 2005
    ..All 26 human type II keratins found on this domain as well as K18, dtype 1 Keratin, are identified at the genomic and transcriptional level. This appears to be the total complement of functional type II keratins in humans...
  24. ncbi request reprint K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle
    Lutz Langbein
    German Cancer Research Center, Department of Cell Biology, Heidelberg, Germany
    J Invest Dermatol 120:512-22. 2003
    ..We provide evidence that Flügelzellen penetrate the Henle layer actively and may play a role in conferring plasticity and resilience to the otherwise rigid upper Henle layer...
  25. ncbi request reprint Integrity and barrier function of the epidermis critically depend on glucosylceramide synthesis
    Richard Jennemann
    Department of Cellular und Molecular Pathology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 282:3083-94. 2007
    ..We conclude that the transient formation of GlcCer is vital for a regular arrangement of lipids and proteins in lamellar bodies and for the maintenance of the epidermal barrier...
  26. ncbi request reprint Characterization of human KAP24.1, a cuticular hair keratin-associated protein with unusual amino-acid composition and repeat structure
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 127:1197-204. 2007
    ..The structure of the KRTAP24, its proximity to the chromosome 21q22.1 KAP gene domain, the presence of repeat motifs in the protein and its localization in the hair cuticle points to KAP24.1 being a novel human KAP family member...
  27. ncbi request reprint The human type I keratin gene family: characterization of new hair follicle specific members and evaluation of the chromosome 17q21.2 gene domain
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Im Neuenheimer Feld 280, 69210 Heidelberg, Germany
    Differentiation 72:527-40. 2004
    ..Together with K18, a type I keratin gene found on the type II keratin domain, this seems to be the entire complement of functional type I keratins in humans...
  28. pmc New consensus nomenclature for mammalian keratins
    Jurgen Schweizer
    Section of Normal and Neoplastic Epidermal Differentiation, Division of Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
    J Cell Biol 174:169-74. 2006
    ....
  29. pmc Alternative splicing of human papillomavirus type-16 E6/E6* early mRNA is coupled to EGF signaling via Erk1/2 activation
    Simone Rosenberger
    Deutsches Krebsforschungszentrum Heidelberg DKFZ Im Neuenheimer Feld 242, Research Program Infection and Cancer, Viral Transformation Mechanisms, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 107:7006-11. 2010
    ..Because there is a natural gradient of EGF and EGF receptor expression in the stratified epithelium, it is reasonable to assume that EGF modulates E6/E7 splicing during the viral life cycle and transformation...
  30. ncbi request reprint Cytokeratins as markers of follicular differentiation: an immunohistochemical study of trichoblastoma and basal cell carcinoma
    H Kurzen
    Department of Dermatology, University of Heidelberg, Heidelberg, Germany
    Am J Dermatopathol 23:501-9. 2001
    ..This indicates a differentiation toward the outer root sheath epithelium or the companion layer and not toward the inner root sheath, matrix, or cortex...
  31. ncbi request reprint Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5
    M A Rogers
    Research Program, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 107:633-8. 1996
    ..Our results confirm the type specific clustering of keratin genes and indicate that the human type I hair keratin subfamily contains more members than previously assumed...
  32. ncbi request reprint Molecular characterization of the body site-specific human epidermal cytokeratin 9: cDNA cloning, amino acid sequence, and tissue specificity of gene expression
    L Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg
    Differentiation 55:57-71. 1993
    ..We discuss the molecular properties of CK 9 and its cell type- and body site-specific expression in relation to the special differentiation of palmar/plantar epidermis and to diseases specific for this body site...
  33. ncbi request reprint Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1
    Michael A Rogers
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 277:48993-9002. 2002
    ..1 region revealed varying degrees and regions of expression of 11 members of the high tyrosine-glycine genes and 6 members of the high sulfur KAP genes in the hair forming compartment...
  34. pmc Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy
    Thomas Herrmann
    Dept of Internal Medicine IV, University of Heidelberg, Bergheimer Str 58, 69115 Heidelberg, Germany
    J Cell Biol 161:1105-15. 2003
    ..These findings reveal a previously unknown, essential function of Fatp4 in the formation of the epidermal barrier...
  35. ncbi request reprint Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg
    Eur J Cell Biol 81:419-35. 2002
    ..The significance of these structures and their possible biological importance are discussed...
  36. ncbi request reprint HOXC13 is involved in the regulation of human hair keratin gene expression
    Luis Felipe Jave-Suarez
    Divisions of Tumor Cell Regulation and Cell Biology, German Cancer Research Center, 69120 Heidelberg, Germany
    J Biol Chem 277:3718-26. 2002
    ..Collectively, our data speak for a direct involvement of HOXC13 in the control of hair keratin expression during early trichocyte differentiation...
  37. ncbi request reprint Disturbed epidermal structure in mice with temporally controlled fatp4 deficiency
    Thomas Herrmann
    Department of Internal Medicine IV, University of Heidelberg, Heidelberg, Germany
    J Invest Dermatol 125:1228-35. 2005
    ..These changes resemble the histological abnormalities in the epidermis of newborn mice with total Fatp4 deficiency. We conclude that Fatp4 in epidermal keratinocytes is essential for the maintenance of a normal epidermal structure...
  38. ncbi request reprint Keratins of the human hair follicle
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Int Rev Cytol 243:1-78. 2005
    ..A closing outlook highlights issues that need to be explored further to deepen our insight into the biology and genetics of the hair follicle...
  39. ncbi request reprint Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas
    Lutz Langbein
    Division of Cell Biology, German Cancer Research Center, Heidelberg, Germany
    Eur J Cell Biol 82:385-400. 2003
    ..It is proposed to include the determination of the presence or absence of such proteins and structures in the diagnostic program of tumor pathology...
  40. ncbi request reprint Hair follicle-specific keratins and their diseases
    Jurgen Schweizer
    Section of Normal and Neoplastic Epidermal, Differentiation A145, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Exp Cell Res 313:2010-20. 2007
    ....
  41. ncbi request reprint Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas
    Nikolaus Gassler
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Pathol 207:295-300. 2005
    ....
  42. ncbi request reprint The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7
    Markus Ladwein
    Department of Tumor Progression and Tumor Defense, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Exp Cell Res 309:345-57. 2005
    ..This is the first report on an association between EpCAM and claudins in both non-transformed tissues and metastasizing tumor cell lines...
  43. ncbi request reprint An unusual Ala12Thr polymorphism in the 1A alpha-helical segment of the companion layer-specific keratin K6hf: evidence for a risk factor in the etiology of the common hair disorder pseudofolliculitis barbae
    Hermelita Winter
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 122:652-7. 2004
    ....
  44. ncbi request reprint Androgen regulation of the human hair follicle: the type I hair keratin hHa7 is a direct target gene in trichocytes
    Luis F Jave-Suarez
    Section of Normal and Neoplastic Epidermal Differentiation, German Cancer Research Center, Heidelberg, Germany
    J Invest Dermatol 122:555-64. 2004
    ..As such, hHa7 represents a marker for androgen action on hair follicles and might be a suitable tool for investigations of androgen-dependent hair disorders...
  45. ncbi request reprint Polymorphisms in the human high sulfur hair keratin-associated protein 1, KAP1, gene family
    Yutaka Shimomura
    Department of Dermatology, Niigata University School of Medicine, Asahimachi Dori, Japan
    J Biol Chem 277:45493-501. 2002
    ..In addition, by means of a pan-hKAP1 antibody, we confirm the previous hKAP1 family mRNA localization data in the middle to upper cortex of the human anagen hair follicle...
  46. ncbi request reprint Novel type I hair keratins K39 and K40 are the last to be expressed in differentiation of the hair: completion of the human hair keratin catalog
    Lutz Langbein
    J Invest Dermatol 127:1532-5. 2007
  47. pmc Rac1 is crucial for hair follicle integrity but is not essential for maintenance of the epidermis
    Anna Chrostek
    Heisenberg Group Regulation of Cytoskeletal Organization, Max Planck Institute of Biochemistry, Martinsried, Germany
    Mol Cell Biol 26:6957-70. 2006
    ..These data show that Rac1 plays an important role in sustaining the integrity of the lower part of hair follicles but not in maintenance of the epidermis...
  48. ncbi request reprint hKAP1.6 and hKAP1.7, two novel human high sulfur keratin-associated proteins are expressed in the hair follicle cortex
    Yutaka Shimomura
    Department of Dermatology, Niigata University School of Medicine, Asahimachi Dori, Niigata, Japan
    J Invest Dermatol 118:226-31. 2002
    ..RNA in situ hybridization studies of human anagen hair follicles using a conserved probe for these four keratin-associated protein 1 members demonstrated the expression of this group in the differentiated portions of the hair cortex...
  49. ncbi request reprint Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle
    Hisham Bazzi
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Differentiation 74:129-40. 2006
    ....
  50. pmc Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin
    Xunwei Wu
    Max Planck Institute of Biochemistry, Heisenberg Group Regulation of Cytoskeletal Organization, Department of Molecular Medicine, 82152 Martinsried, Germany
    Genes Dev 20:571-85. 2006
    ..These data suggest that Cdc42 regulation of beta-catenin turnover is important for terminal differentiation of HF progenitor cells in vivo...
  51. ncbi request reprint Type II epithelial keratin 6hf (K6hf) is expressed in the companion layer, matrix, and medulla in anagen-stage hair follicles
    Zhiling Wang
    Department of Biological Chemistry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Invest Dermatol 121:1276-82. 2003
    ..They also have obvious implications for the epithelial alterations associated with defects in keratin 6 genes...
  52. pmc The human keratins: biology and pathology
    Roland Moll
    Institute of Pathology, Philipps University, 35033, Marburg, Germany
    Histochem Cell Biol 129:705-33. 2008
    ..Future research might open further fields of clinical application for this remarkable protein family...
  53. pmc Integrin-linked kinase is required for epidermal and hair follicle morphogenesis
    Katrin Lorenz
    Department of Molecular Medicine, Max Planck Institute of Biochemistry, Martinsried, Germany
    J Cell Biol 177:501-13. 2007
    ..We conclude that ILK plays important roles for epidermis and hair follicle morphogenesis by modulating integrin-mediated adhesion, actin reorganization, and plasma membrane dynamics in keratinocytes...
  54. ncbi request reprint Characterization of human keratin-associated protein 1 family members
    Yutaka Shimomura
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Investig Dermatol Symp Proc 8:96-9. 2003
    ..The sum of the data analyzed suggests that human keratin-associated protein 1 family genes may have arisen mainly through gene duplication of the cysteine-repeat motifs during evolution...
  55. ncbi request reprint Expression patterns of hair and epithelial keratins and transcription factors HOXC13, LEF1, and beta-catenin in a malignant pilomatricoma: a histological and immunohistochemical study
    Bernard Cribier
    Department of Dermatology, University Hospital, Strasbourg, France
    J Cutan Pathol 33:1-9. 2006
    ..In contrast, hHa1 expression in the upper transitional cell compartment is uncoupled from the nuclear co-expression of the LEF1/beta-catenin complex seen in normal hair follicles (Cribier et al., J Invest Dermatol 2004; 122: 1078)...
  56. ncbi request reprint A 4.2 kb upstream region of the human corneodesmosin gene directs site-specific expression in hair follicles and hyperkeratotic epidermis of transgenic mice
    Helene Gallinaro
    UMR 5165 CNRS UPS Epidermis Differentiation and Rheumatoid Autoimmunity, Purpan School of Medicine, Toulouse III University, Toulouse, France
    J Invest Dermatol 122:730-8. 2004
    ....
  57. ncbi request reprint On the regulation of hair keratin expression: lessons from studies in pilomatricomas
    Bernard Cribier
    Clinique Dermatologique, Hopital Civil, Strasbourg, France
    J Invest Dermatol 122:1078-83. 2004
    ..These data imply that unlike the normal hair follicle, cortical differentiation in pilomatricomas is not under the control of the canonical Wnt signaling pathway...