P H Lahmann

..The results from this study suggest that higher birth weight is a risk factor for postmenopausal breast cancer (OR 1.06, CI 1.00-1.12, per 100 g), independent of selected early-life and adult factors...

..Our findings suggest that large adult weight gain was a significant predictor of breast cancer in postmenopausal women not taking exogenous hormones...

..This study aims to examine the association between various measures of adiposity and all-cause mortality in Swedish middle-aged and older men and women and, additionally, to describe the influences of age and sex on these associations...

..77) compared to women with low weight gain. Breast cancer risk in postmenopausal women is predicted by increased body fat and weight gain. %BF is a more discriminating risk factor for breast cancer incidence than the commonly used BMI...

..Among premenopausal women, weight and BMI showed nonsignificant inverse associations with breast cancer...

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..To examine sociodemographic factors associated with long-term adult weight gain and current general and central adiposity in women...

..To describe anthropometric characteristics of participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)...

..Previous studies of associations between diet, obesity, and blood concentrations of alpha-tocopherol and beta-carotene have been equivocal. Furthermore, most studies used only body mass index (BMI) as an obesity measure...

..Human resistin has been stated to influence preadipocyte cell numbers and to stimulate adipocyte triglyceride lipolysis in vivo and in vitro. However, its role in human obesity remains unclear...

..This methodological study compares data of identified cancer cases in the EPIC-Potsdam study with those generated through the record linkage...

..To examine the association between anthropometry and endometrial cancer, particularly by menopausal status and exogenous hormone use subgroups...

..This study provides additional evidence for a protective effect of physical activity on breast cancer risk...

..Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake...

..This discrepancy may be related to differences in fat distribution between sexes or to the use of hormone replacement therapy (HRT) in women...

..Nevertheless, among older, postmenopausal women, hyperinsulinemia might contribute to increasing breast cancer risk...

..The relative risk reductions are most apparent for household activities...

..Using data from 274,688 women participating in the European Prospective Investigation into Cancer and Nutrition study (EPIC), we investigated the relation between alcohol intake and the risk of breast cancer...

..The relationship of specific fruit and vegetable subgroups with RCC risk warrant further investigation...

..Our data indicate that the relationship of adiposity with breast cancer in postmenopausal women could be partially explained by the increases in endogenous estrogens, and by a decrease in levels of SHBG...

..The association between consumption of fruit and vegetables and risk of ovarian cancer is still unclear from a prospective point of view...

..We strongly recommend to use anthropometric measurements updated during follow-up to assess the effect of weight, BMI on breast cancer risk...

..In particular, future studies need to address the effect of milk products according to fat content and possible biological mechanisms to explain observed effects...

..CONCLUSION: Although the period of follow-up is limited for now, the results suggest that total or specific vegetable and fruit intake is not associated with risk for breast cancer...

..We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort to examine associations among premenopausal serum concentrations of sex steroids and subsequent breast cancer risk...

..Independent of adiposity and insulin, IGF-I was associated with decreased SHBG levels, and increased concentrations of androgens and postmenopausal estrogens...

..Our data give further credence to public health efforts aiming to reduce the prevalence of obesity to prevent RCC, in addition to other chronic diseases...

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..In conclusion, relatively high blood concentrations of estrogens and free testosterone are associated with an increased endometrial cancer risk in postmenopausal women...

..To describe the prevalence and to assess type and indicators of hormone replacement therapy (HRT) use in the two German EPIC-cohorts...

..95 (0.87-1.03). Overall, the findings provide further unbiased evidence of the lack of an adverse effect of induced abortion on breast cancer risk...